Five, the specific embodiment:
The drug effect of each component:
Radix Salviae Miltiorrhizae: 1, its effect to cardiovascular system of the effect of Radix Salviae Miltiorrhizae is as follows: a, heart tonifying are strengthened myocardial contraction, improved cardiac function, does not increase myocardial oxygen consumption b, to blood vessel function coronary artery dilating, increases myocardial flow; Expansion peripheral blood vessel, blood flow increases; Cerebral blood flow decline c, antithrombotic form and improve plasmin activity; Extend, clotting time; Anticoagulant (improving cAMP level inhibition TXA2 in platelet synthesizes); Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time shorten) d, improve microcirculation
2, the food therapy value of Radix Salviae Miltiorrhizae:
Energy coronary artery dilator, increases coronary flow, improves myocardial ischemia, infraction and cardiac function, regulates the rhythm of the heart, and can expand peripheral blood vessel, improves microcirculation; Can improve body's hypoxia tolerance; There is anticoagulation, promote fibrinolytic, suppress platelet aggregation, suppress thrombotic effect; Can reduce blood fat, suppress coronary atherosclerosis and form; Can suppress or alleviate hepatocellular degeneration, necrosis and inflammatory reaction, promote liver cell regeneration, and have anti-fibrosis effect; Can shorten the convalescent period of erythrocyte and hematochrome, Reticulocyte is increased, can promote the reparation of tissue, accelerate the healing of fracture; There is nervus centralis to have inhibitory action; There is antitumor action; Energy enhancing human body immunity function; Can reduce blood glucose; The various bacteria such as tubercule bacillus are had to inhibitory action.
Fructus Lycii: claiming again Fructus Lycii, red ear pendant, is that maturation of Solanaceae undershrub Fructus Lycii is real, both can be used as nut edible, it is again the distinguished Chinese medicine material of effect simply, be exactly that the top grade of people supported in nourishing from top to bottom, have and prolong the anti-ageing effect that declines, having another name called " but I ".In Fructus Lycii, contain 14 seed amino acids, and contain the special dietary compositions such as betanin, beautiful another name for Sichuan Province flavin, physalin, make it have outstanding health-care effect.Fructus Lycii have reduce blood pressure, the effect of blood fat and blood glucose, can atherosclerosis, the liver protecting, resists fatty liver, promotes liver cell regeneration.
Radix Puerariae: Radix Puerariae whole body is precious, has long applicating history in China, and Pueraria lobata, Folium Puerariae loatae, Flos puerariae lobatae have the method for application.Through the successive dynasties, medical family constantly sums up and test, show that Radix Puerariae has: cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.By modern medicine method, further analyze and show, be rich in nearly 13 kinds of isoflavone like substance in Radix Puerariae, comprise puerarin, Miroestrol., puerarin xyloside, daidzein etc., puerarin is effective in cure to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.Radix Puerariae total flavones can make cerebral blood flow significantly increase, and can make coronary vasodilator blood flow increase.Puerarin can make that the speed of heartbeat slows down, myocardial contraction strengthens, aortic pressure reduces.To heart disease, especially coronary heart disease, osteoporosis, climacteric syndrome and alzheimer disease etc. have preventive and therapeutic action simultaneously, rescue acute cardiac patient clinically with regard to useful puerarin injection.
Rhizoma Alismatis: the effect for reducing blood fat of Rhizoma Alismatis: the fat-soluble part of Rhizoma Alismatis has obvious cholesterol reducing effect and study of anti-atherogenic effect to experimental hypercholesterolemicrabbits rabbit, by wherein separated Alisol A, B and Alisol A, the acetas of B, C, except alisol B, there is significant cholesterol reducing effect.Content with 0.1% adds in the feedstuff of experimental atherosclerosis rats, can make cholesterolemia decline more than 50%, wherein the strongest with the effect of Alisol A-24-acetas.The ethanol extraction of Rhizoma Alismatis, the ethyl acetate extract of ethanol extract etc., have effect for reducing blood fat to experimental hypercholesterolemicrabbits rabbit and rat.Ethyl acetate extract and its residual fraction effect being insoluble in acetic acid one water are the strongest.Ethyl acetate extract oral 1g/kg every day, also has obvious cholesterol reducing effect to the normal rat of raising with normal diet.By coordination list notation method, prove, Alisol A has the ability that suppresses mouse small intestine esterified cholesterol, and can make the absorbance of cholesterol in rat small intestine reduce by 34%, but does not affect linoleic absorption.The effect of Rhizoma Alismatis to cardiovascular system: Rhizoma Alismatis extractum, to dog and rabbit vein injection, has slight hypotensive effect, and continues about approximately 30 minutes.The Rhizoma Alismatis alcohol that rubs has slight hypotensive effect to various laboratory animals, its hypotensive effect not obvious plasma renin and ACE activity or the aldosterone level of affecting.The rabbit isolated aorta condition that alisol extract causes epinephrine is in vitro shunk relexation slowly.The rub contraction of the Rabbit thoracic aorta that alcohol can suppress to be caused by angiotensin of Rhizoma Alismatis, its contraction has dose dependent.The Rhizoma Alismatis alcohol that rubs reduces cardiac output and heart rate and left ventricular pressure as seen with isolated heart Perfusion, but can increase coronary flow.
Wherein Rhizoma Alismatis also has a protective effect to liver
Embodiment mono-:
A kind of natural medicine-food homology raw material with hypolipemic function is comprised of following weight portion raw material: Radix Salviae Miltiorrhizae 470g Fructus Lycii 300 g Radix Puerariae 300g Rhizoma Alismatis 330 g.
Above-mentioned a kind of preparation method with the natural medicine-food homology raw material of hypolipemic function, comprises the following steps:
Step 1): above-mentioned four Chinese medicine material is clean system respectively, and the alcohol dipping 20min by Rhizoma Alismatis with percentage by weight 75%, drains, and dry, pulverize and cross 100 mesh sieves at 80 ℃, collects 100g fine powder and residue coarse powder, standby;
Step 2): Radix Salviae Miltiorrhizae, Radix Puerariae percentage by weight 80% alcohol solvent reflux, extract, 2 times, 5 times of amount solvent extraction 2h, add 4 times of amount solvent extraction 1h for the second time for the first time; Merge filtrate twice, medicinal residues are preserved in addition, reduce pressure at 60 ℃ and reclaim ethanol, and solution is at 60 ℃, to be concentrated into 1.32-1.35 clear paste in temperature, standby;
Step 3): Rhizoma Alismatis coarse powder, Fructus Lycii and step 2) medicinal residues in decoct with water 2 times, add for the first time 10 times of water gagings and decoct 2h, add for the second time 8 times of water gagings and decoct 1h, collect volatile oil simultaneously; Merge twice filtrate (medicinal residues are abandoned), at 70 ℃, being evaporated to temperature is 60 ℃ of clear paste that relative density is 1.32-1.35, carry clear paste with ethanol, Rhizoma Alismatis fine powder mixes, 65 ℃ dry, pulverize and cross into 80 order fine powders, volatile oil ethanol dilution, evenly spray in dry powder grain, vexed 12h, mixes, pack capsule into No. 0, obtain every 0.35g.
Embodiment bis-:
A kind of natural medicine-food homology raw material with hypolipemic function is comprised of following weight portion raw material: Radix Salviae Miltiorrhizae 670g Fructus Lycii 500 g Radix Puerariae 450 g Rhizoma Alismatis 480 g.
Above-mentioned a kind of preparation method with the natural medicine-food homology raw material of hypolipemic function, comprises the following steps:
Step 1): above-mentioned four Chinese medicine material is clean system respectively, and the alcohol dipping 20min by Rhizoma Alismatis with percentage by weight 75%, drains, and dry, pulverize and cross 100 mesh sieves at 80 ℃, collects 100g fine powder and residue coarse powder, standby;
Step 2): Radix Salviae Miltiorrhizae, Radix Puerariae percentage by weight 80% alcohol solvent reflux, extract, 2 times, 5 times of amount solvent extraction 2h, add 4 times of amount solvent extraction 1h for the second time for the first time; Merge filtrate twice, medicinal residues are preserved in addition, reduce pressure at 60 ℃ and reclaim ethanol, and solution is at 60 ℃, to be concentrated into 1.32-1.35 clear paste in temperature, standby;
Step 3): Rhizoma Alismatis coarse powder, Fructus Lycii and step 2) medicinal residues in decoct with water 2 times, add for the first time 10 times of water gagings and decoct 2h, add for the second time 8 times of water gagings and decoct 1h, collect volatile oil simultaneously; Merge twice filtrate (medicinal residues are abandoned), at 70 ℃, being evaporated to temperature is 60 ℃ of clear paste that relative density is 1.32-1.35, carry clear paste with ethanol, Rhizoma Alismatis fine powder mixes, 65 ℃ dry, pulverize and cross into 80 order fine powders, volatile oil ethanol dilution, evenly spray in dry powder grain, vexed 12h, mixes, pack capsule into No. 0, obtain every 0.35g.
Embodiment tri-:
A kind of natural medicine-food homology raw material with hypolipemic function is comprised of following weight portion raw material: Radix Salviae Miltiorrhizae 570g Fructus Lycii 400 g Radix Puerariae 400g Rhizoma Alismatis 400 g.
Above-mentioned a kind of preparation method with the natural medicine-food homology raw material of hypolipemic function, comprises the following steps:
Step 1): above-mentioned four Chinese medicine material is clean system respectively, and the alcohol dipping 20min by Rhizoma Alismatis with percentage by weight 75%, drains, and dry, pulverize and cross 100 mesh sieves at 80 ℃, collects 100g fine powder and residue coarse powder, standby;
Step 2): Radix Salviae Miltiorrhizae, Radix Puerariae percentage by weight 80% alcohol solvent reflux, extract, 2 times, 5 times of amount solvent extraction 2h, add 4 times of amount solvent extraction 1h for the second time for the first time; Merge filtrate twice, medicinal residues are preserved in addition, reduce pressure at 60 ℃ and reclaim ethanol, and solution is at 60 ℃, to be concentrated into 1.32-1.35 clear paste in temperature, standby;
Step 3): Rhizoma Alismatis coarse powder, Fructus Lycii and step 2) medicinal residues in decoct with water 2 times, add for the first time 10 times of water gagings and decoct 2h, add for the second time 8 times of water gagings and decoct 1h, collect volatile oil simultaneously; Merge twice filtrate (medicinal residues are abandoned), at 70 ℃, being evaporated to temperature is 60 ℃ of clear paste that relative density is 1.32-1.35, carry clear paste with ethanol, Rhizoma Alismatis fine powder mixes, 65 ℃ dry, pulverize and cross into 80 order fine powders, volatile oil ethanol dilution, evenly spray in dry powder grain, vexed 12h, mixes, pack capsule into No. 0, obtain every 0.35g.
Its preparation method be by said herbal medicine through screening concoct, pulverize, extract, concentrated, dry, the processing of putting together of its Radix Ginseng medicated powder in small, broken bits, dried is granulated, then by every 0.35 gram of filled capsules.
This product is made to capsule and for hyperlipidemia, hyperpietic, take, every day three times, each 2, take continuously 3 months.Observe altogether various types of hyperlipemia 100 examples, take continuously this product through 3 months, follow the tracks of and pay a return visit, 98% has blood fat in various degree to reduce.
Case 1 is according to embodiment mono-: grandson so-and-so, man, 47 years old, hospital diagnosis cholesterolemia and triglyceride are all higher, cholesterol (TC) 6.5mmol/L, triglyceride (TG) 2.4 mmol/L, Symptoms for headache, uncomfortable in chest, breathe hard, take blood fat reducing Western medicine always, curative effect is not good enough.Through 3 months, take continuously after this product, test cholesterol 4.2mmol/L, triglyceride (TG) 1.7 mmol/L, continue to follow the tracks of and pay a return visit 3 months, and remission, without other untoward reaction.
Case 2 is according to embodiment tri-: Zhang, and female, 40 years old, hospital diagnosis hyperlipidemia, hypertension, T-CHOL 6.7mmol/L, blood pressure 160/100mmHg, Symptoms is that sensation of oppression over the chest with shortness of breath, headache are dizzy, limbs fatigue, takes blood fat reducing Western medicine always, curative effect is not good enough.Through 3 months, take continuously after this product, test T-CHOL is 5.3mmol/L, and blood pressure 130/98mmHg continues to follow the tracks of and pays a return visit 3 months, every remission, and blood pressure obviously declines, without other untoward reaction.
Case 3 is according to embodiment bis-: Wu, man, 52 years old, hospital diagnosis blood pressure 150/110mmHg, cholesterol 7.2mmol/L, Symptoms is regular headache, and very violent, feel sick and feel sick again simultaneously, ears tinnitus, the persistent period is longer, and difficulty falling asleep, early awakening, sleep be not steady and sure, easily have horrible nightmares, easily wake up with a start, take hypertension and hyperlipemia Western medicine, curative effect is not good enough always.Take continuously this product 3 months, test blood pressure is 140/92mmHg, and cholesterol 4.2mmol/L continues to follow the tracks of and pays a return visit 3 months, remission, and blood fat, blood pressure obviously decline, without other untoward reaction.
Case 4 is according to embodiment mono-: Liao, man, 48 years old, hospital diagnosis hyperlipidemia caused coronary heart disease, cholesterol 6.8mmol/L, Symptoms be uncomfortable in chest, breathe hard, cardiopalmus, often breathe hard that it is awake to suppress midnight, difficulty falling asleep is taken blood fat reducing Western medicine always, effect is not good enough.Take continuously this product 3 months, test cholesterol 5.0mmol/L, continues to follow the tracks of and pays a return visit 3 months, and coronary heart disease symptom is alleviated, and blood fat obviously declines, and blood pressure is normal, without other untoward reaction.
Case 5 is according to embodiment tri-: Chen, female, 43 years old, hospital diagnosis hyperlipidemia, myocardial ischemia, cholesterol 6.8mmol/L, for often there is precordial fullness pain in Symptoms, or tighten sample pain, and shoulder, left upper arm radiation left, spontaneous remission person after having a rest, time with profuse sweating, during physical exertion, there is sensation of oppression over the chest with shortness of breath.Once took blood fat reducing Western medicine, curative effect is not good enough.Take continuously this product 3 months, test cholesterol 4.2mmol/L, triglyceride 0.8 mmol/L, continues to follow the tracks of and pays a return visit 3 months, remission, blood fat obviously declines, and myocardial ischemia improves, without other untoward reaction.
Case 6 is according to embodiment mono-: Ma, man, 42 years old, hospital diagnosis hypertension, hyperlipidemia, T-CHOL 6.6mmol/L, blood pressure 150/95mmHg, symptom is dizzy, uncomfortable in chest, spiritlessness and weakness, insomnia forgetfulness, numb limbs and tense tendons, once took blood pressure lowering, blood fat reducing Western medicine, and effect is undesirable.Take continuously this product 3 months, detect blood pressure 130/90mmHg, T-CHOL 3.8mmol/L.Continue to follow the tracks of and pay a return visit 2 months, blood fat, blood pressure drops, remission, patient's readme is felt good.
Case 7 is according to embodiment bis-: Wang, female, 55 years old, hospital diagnosis angina pectoris, hypertension, hyperlipidemia, through having a blood test, press 148/98mmHg, cholesterol 6.9mmol/L, dizziness, chest pain, feels sick, insomnia forgetfulness, after angina pectoris attacks, pain with a face streaming with sweat, readme is overwhelmed with sorrow.Once took angina pectoris first aid medicine, blood pressure lowering, blood fat reducing Western medicine, effect is not good enough.Take this product 3 months, the minimizing of angina pectoris attacks number of times, has a blood test and presses 130/90mmHg, and T-CHOL 3.1mmol/L continues to follow the tracks of and pays a return visit, and blood pressure, blood fat are stablized, and symptom is improved obviously, without various untoward reaction.
Case 8 is according to embodiment bis-: poplar, man, 46 years old, hospital diagnosis hyperlipidemia, apoplexy sign is obvious, cholesterol 6.9mmol/L, triglyceride 2.6 mmol/L, symptom insomnia forgetfulness, uncomfortable in chest, breathe hard, have palpitation, the symptom such as chest pain, weak, distortion of commissure, numb limbs and tense tendons, once took blood circulation promoting and blood stasis dispelling Chinese patent medicine, blood fat reducing Western medicine, effect is not good enough.Take this product 3 months, T-CHOL 4.1mmol/L, triglyceride 1.6 mmol/L, continue to follow the tracks of and pay a return visit, rate and blood-lipid decreased, symptom is improved obviously, does not find so far any apoplexy sign, and health is conscious of any untoward reaction.
Case 9 is according to embodiment mono-: why certain, man 32 years old, hospital diagnosis Hyperlipidemia, T-CHOL 6.4mmol/L, triglyceride 2.5mmol/L, symptom is dizzy, uncomfortable in chest, often feels limbs fatigue, and poor sleeping quality, takes blood fat reducing Western medicine, and effect is not good enough.Take this product 3 months, look into T-CHOL 4.4mmol/L, triglyceride 1.5mmol/L, continues to follow the tracks of and pays a return visit, rate and blood-lipid decreased, and symptom is improved obviously, without any untoward reaction.
Case 10 is according to embodiment tri-: Zheng, female, 45 years old, hospital diagnosis hypertension, hyperlipidemia, cerebral thrombosis.Cholesterol 7.0mmol/L, triglyceride 2.7mmol/L, blood pressure 150/95mmHg.Symptoms is dizzy, distending pain, nauseating, dizzy, have a sleepless night poor, and inappetence, spiritlessness and weakness.Take this product 3 months, look into T-CHOL 6.4mmol/L, triglyceride 1.4mmol/L, continues to follow the tracks of and pays a return visit, rate and blood-lipid decreased, and blood pressure is normal, and symptom is improved obviously, without any untoward reaction.