Five, the specific embodiment:
The drug effect of each component:
Radix Salviae Miltiorrhizae: 1, its effect to cardiovascular system of the effect of Radix Salviae Miltiorrhizae is following: a, heart tonifying strengthen myocardial contraction, improve cardiac function, do not increase myocardial oxygen consumption b, to the blood vessel function coronary artery dilating, increase myocardial flow; The expansion peripheral blood vessel, blood flow increases; Cerebral blood flow decline c, antithrombotic form and improve plasmin activity; Prolong, clotting time; Anticoagulant (it is synthetic to improve the interior cAMP level inhibition of platelet TXA2); Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time shorten) d, microcirculation improvement
2, the food therapy value of Radix Salviae Miltiorrhizae:
The ability coronary artery dilator increases coronary flow, improves myocardial ischemia, infraction and cardiac function, regulates the rhythm of the heart, and can expand peripheral blood vessel, microcirculation improvement; Can improve body's hypoxia tolerance; Anticoagulation is arranged, promote fibrinolytic, suppress platelet aggregation, suppress thrombotic effect; The ability blood fat reducing suppresses coronary atherosclerosis and forms; Can suppress or alleviate hepatocellular degeneration, necrosis and inflammatory reaction, promote liver cell regeneration, and anti-fibrosis effect is arranged; Can shorten the convalescent period of erythrocyte and hematochrome, Reticulocyte is increased, can promote the reparation of tissue, quicken the healing of fracture; There is nervus centralis that inhibitory action is arranged; Antitumor action is arranged; Ability enhancing human body immunity function; The ability blood sugar lowering; Various bacteria such as tubercule bacillus there is inhibitory action.
Fructus Lycii: claiming Fructus Lycii, red ear pendant again, is that the ripe son of Solanaceae undershrub Fructus Lycii is real, both can be used as nut and has eaten; It is again the distinguished Chinese medicine material of effect simply; Be exactly that the top grade of people supported in nourishing from top to bottom, have and prolong the anti-ageing effect that declines, to have another name called " but I ".Contain 14 seed amino acids in the Fructus Lycii, and contain special dietary compositions such as betanin, beautiful another name for Sichuan Province flavin, physalin, make it have outstanding health-care efficacy.Fructus Lycii have bring high blood pressure down, the effect of blood fat and blood glucose, can prevent atherosclerosis, the liver protecting resists fatty liver, promotes liver cell regeneration.
Radix Puerariae: the Radix Puerariae whole body is precious, in China long applicating history is arranged, and kudzu, Folium Puerariae loatae, Flos puerariae lobatae all have the method for application.Medical family constantly sums up and test through the successive dynasties, draws Radix Puerariae and has: cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.Show with further analysis of modern medicine method, be rich in nearly 13 kinds of isoflavone like substance in the Radix Puerariae, comprise puerarin, Miroestrol., puerarin xyloside, daidzein etc., puerarin is effective in cure to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.Radix Puerariae total flavones can make cerebral blood flow significantly increase, and the coronary vasodilator blood flow is increased.Puerarin can make that the speed of heartbeat slows down, myocardial contraction strengthens, aortic pressure reduces.To heart disease, especially coronary heart disease, osteoporosis, climacteric syndrome and alzheimer disease etc. have prevention and therapeutical effect simultaneously, rescue the acute cardiac patient with regard to useful puerarin injection clinically.
Rhizoma Alismatis: the effect for reducing blood fat of Rhizoma Alismatis: the fat-soluble part of Rhizoma Alismatis has tangible cholesterol reducing effect and study of anti-atherogenic effect to experimental hypercholesterolemia rabbit; By wherein separate Alisol A, B and Alisol A, B, the acetas of C; Except that alisol B, significant cholesterol reducing effect is arranged all.Content with 0.1% adds in the feedstuff of experimental hyperlipidemia rat, and cholesterolemia is descended more than 50%, and is wherein the strongest with Alisol A-24-acetas effect.The ethanol extraction of Rhizoma Alismatis, the ethyl acetate extract of ethanol extract etc. all have effect for reducing blood fat to experimental hypercholesterolemia rabbit and rat.Ethyl acetate extract is the strongest with its residual fraction effect that is insoluble in acetic acid one water.Ethyl acetate extract oral 1g/kg every day also has tangible cholesterol reducing effect to the normal rat of raising with normal diet.Prove that with coordination list notation method Alisol A has the ability that suppresses the mouse small intestine esterified cholesterol, and can make the absorbance of cholesterol in rat small intestine reduce by 34%, but do not influence linoleic absorption.Rhizoma Alismatis is to the effect of cardiovascular system: Rhizoma Alismatis extractum is given dog and rabbit vein injection, and slight hypotensive effect is arranged, and lasting about about 30 minutes.The Rhizoma Alismatis alcohol that rubs has slight hypotensive effect to various laboratory animals, its hypotensive effect and not obvious plasma renin and ACE activity or the aldosterone level of influencing.The Rhizoma Alismatis ethanol extract shrinks in the external rabbit isolated aorta condition that epinephrine is caused has relexation slowly.The rub contraction of the tame rabbit aorta strip that alcohol can suppress to be caused by angiotensin of Rhizoma Alismatis, its contraction has dose dependent.Rhizoma Alismatis rubs alcohol with isolated heart perfusion technology visible minimizing cardiac output and heart rate and left ventricular pressure, but can increase coronary flow.
Wherein Rhizoma Alismatis also has a protective effect to liver
Embodiment one:
A kind of natural medicine-food homology raw material with hypolipemic function is made up of following weight portion raw material: Radix Salviae Miltiorrhizae 470g Fructus Lycii 300 g Radix Puerariae 300g Rhizoma Alismatis 330 g.
Above-mentioned a kind of method for preparing with natural medicine-food homology raw material of hypolipemic function may further comprise the steps:
Step 1): the clean system of above-mentioned four Chinese medicine material difference, with the alcohol dipping 20min of Rhizoma Alismatis, drain with percentage by weight 75%, dry under 80 ℃, 100 mesh sieves are also crossed in pulverizing, collect 100g fine powder and residue coarse powder, and are subsequent use;
Step 2): Radix Salviae Miltiorrhizae, Radix Puerariae are with percentage by weight 80% alcohol solvent reflux, extract, 2 times, and 5 times of amount solvent extraction 2h add 4 times of amount solvent extraction 1h for the second time for the first time; Merge filtrating twice, medicinal residues are preserved in addition, and the 60 ℃ of recover ethanol that reduce pressure, solution are to be concentrated into 1.32-1.35 clear paste under 60 ℃ in temperature, and are subsequent use;
Step 3): Rhizoma Alismatis coarse powder, Fructus Lycii and step 2) the medicinal residues decocte with water in 2 times adds 10 times of water gagings for the first time and decocts 2h, adds 8 times of water gagings for the second time and decocts 1h, collects volatile oil simultaneously; Merge twice filtrating (medicinal residues are abandoned), being evaporated to temperature under 70 ℃ is that 60 ℃ of relative densities are 1.32-1.35 clear paste, carries clear paste, Rhizoma Alismatis fine powder mixing with ethanol; 65 ℃ of dryings are pulverized and are crossed into 80 order fine powders, and volatile oil is used ethanol dilution; Evenly spray in the dry powder grain vexed 12h, mixing; The capsule of packing into No. 0 promptly gets every 0.35g.
Embodiment two:
A kind of natural medicine-food homology raw material with hypolipemic function is made up of following weight portion raw material: Radix Salviae Miltiorrhizae 670g Fructus Lycii 500 g Radix Puerariaes 450 g Rhizoma Alismatis 480 g.
Above-mentioned a kind of method for preparing with natural medicine-food homology raw material of hypolipemic function may further comprise the steps:
Step 1): the clean system of above-mentioned four Chinese medicine material difference, with the alcohol dipping 20min of Rhizoma Alismatis, drain with percentage by weight 75%, dry under 80 ℃, 100 mesh sieves are also crossed in pulverizing, collect 100g fine powder and residue coarse powder, and are subsequent use;
Step 2): Radix Salviae Miltiorrhizae, Radix Puerariae are with percentage by weight 80% alcohol solvent reflux, extract, 2 times, and 5 times of amount solvent extraction 2h add 4 times of amount solvent extraction 1h for the second time for the first time; Merge filtrating twice, medicinal residues are preserved in addition, and the 60 ℃ of recover ethanol that reduce pressure, solution are to be concentrated into 1.32-1.35 clear paste under 60 ℃ in temperature, and are subsequent use;
Step 3): Rhizoma Alismatis coarse powder, Fructus Lycii and step 2) the medicinal residues decocte with water in 2 times adds 10 times of water gagings for the first time and decocts 2h, adds 8 times of water gagings for the second time and decocts 1h, collects volatile oil simultaneously; Merge twice filtrating (medicinal residues are abandoned), being evaporated to temperature under 70 ℃ is that 60 ℃ of relative densities are 1.32-1.35 clear paste, carries clear paste, Rhizoma Alismatis fine powder mixing with ethanol; 65 ℃ of dryings are pulverized and are crossed into 80 order fine powders, and volatile oil is used ethanol dilution; Evenly spray in the dry powder grain vexed 12h, mixing; The capsule of packing into No. 0 promptly gets every 0.35g.
Embodiment three:
A kind of natural medicine-food homology raw material with hypolipemic function is made up of following weight portion raw material: Radix Salviae Miltiorrhizae 570g Fructus Lycii 400 g Radix Puerariae 400g Rhizoma Alismatis 400 g.
Above-mentioned a kind of method for preparing with natural medicine-food homology raw material of hypolipemic function may further comprise the steps:
Step 1): the clean system of above-mentioned four Chinese medicine material difference, with the alcohol dipping 20min of Rhizoma Alismatis, drain with percentage by weight 75%, dry under 80 ℃, 100 mesh sieves are also crossed in pulverizing, collect 100g fine powder and residue coarse powder, and are subsequent use;
Step 2): Radix Salviae Miltiorrhizae, Radix Puerariae are with percentage by weight 80% alcohol solvent reflux, extract, 2 times, and 5 times of amount solvent extraction 2h add 4 times of amount solvent extraction 1h for the second time for the first time; Merge filtrating twice, medicinal residues are preserved in addition, and the 60 ℃ of recover ethanol that reduce pressure, solution are to be concentrated into 1.32-1.35 clear paste under 60 ℃ in temperature, and are subsequent use;
Step 3): Rhizoma Alismatis coarse powder, Fructus Lycii and step 2) the medicinal residues decocte with water in 2 times adds 10 times of water gagings for the first time and decocts 2h, adds 8 times of water gagings for the second time and decocts 1h, collects volatile oil simultaneously; Merge twice filtrating (medicinal residues are abandoned), being evaporated to temperature under 70 ℃ is that 60 ℃ of relative densities are 1.32-1.35 clear paste, carries clear paste, Rhizoma Alismatis fine powder mixing with ethanol; 65 ℃ of dryings are pulverized and are crossed into 80 order fine powders, and volatile oil is used ethanol dilution; Evenly spray in the dry powder grain vexed 12h, mixing; The capsule of packing into No. 0 promptly gets every 0.35g.
Its preparation method be with said herbal medicine through screening concoct, pulverize, extract, concentrate, dry, the processing of putting together of its Radix Ginseng medicated powder in small, broken bits, dried is granulated, then by every 0.35 gram filled capsules.
These article are processed capsule supply hyperlipidemia, hyperpietic to take, every day three times, each 2, took continuously 3 months.Observe various types of hyperlipemia 100 examples altogether, took these article through 3 months continuously, follow the tracks of and pay a return visit, 98% has blood fat in various degree to reduce.
Case 1 is according to embodiment one: grandson so-and-so, man, 47 years old; Hospital diagnosis cholesterolemia and triglyceride are all higher, cholesterol (TC) 6.5mmol/L, triglyceride (TG) 2.4 mmol/L; Symptom show as headache, uncomfortable in chest, breathe hard, take the blood fat reducing Western medicine always, curative effect is not good enough.After taking these article continuously in 3 months, test cholesterol 4.2mmol/L, triglyceride (TG) 1.7 mmol/L continue to follow the tracks of and paid a return visit 3 months, and remission does not have other untoward reaction.
Case 2 is according to embodiment three: Zhang, and the woman, 40 years old, hospital diagnosis hyperlipidemia, hypertension, T-CHOL 6.7mmol/L, blood pressure 160/100mmHg, symptom shows as sensation of oppression over the chest with shortness of breath, dizzy, the limbs fatigue of headache, takes the blood fat reducing Western medicine always, and curative effect is not good enough.After taking these article continuously in 3 months, the testing total cholesterol is 5.3mmol/L, and blood pressure 130/98mmHg continues to follow the tracks of and paid a return visit 3 months, each item remission, and blood pressure obviously descends, and does not have other untoward reaction.
Case 3 is according to embodiment two: Wu, man, 52 years old, hospital diagnosis blood pressure 150/110mmHg; Cholesterol 7.2mmol/L, symptom shows as regular headache, and very violent; Feel sick again simultaneously and feel sick, ears tinnitus, the persistent period is longer; Difficulty falling asleep, early awakening, sleep be not steady and sure, be prone to have horrible nightmares, be prone to wake up with a start, and takes the hypertension and hyperlipemia Western medicine always, and curative effect is not good enough.Took these article continuously 3 months, the test blood pressure is 140/92mmHg, and cholesterol 4.2mmol/L continues to follow the tracks of and paid a return visit 3 months, remission, and blood fat, blood pressure obviously descend, and do not have other untoward reaction.
Case 4 is according to embodiment one: Liao, and the man, 48 years old, the hospital diagnosis hyperlipidemia caused coronary heart disease, cholesterol 6.8mmol/L, that symptom shows as is uncomfortable in chest, breathe hard, cardiopalmus, often breathes hard that it is awake to suppress midnight, and difficulty falling asleep is taken the blood fat reducing Western medicine always, and effect is not good enough.Took these article continuously 3 months, test cholesterol 5.0mmol/L continues to follow the tracks of and paid a return visit 3 months, and coronary heart disease symptom is alleviated, and blood fat obviously descends, and blood pressure is normal, does not have other untoward reaction.
Case 5 is according to embodiment three: Chen, woman, 43 years old; Hospital diagnosis hyperlipidemia, myocardial ischemia, cholesterol 6.8mmol/L, symptom shows as and the precordial fullness pain often occurs; Or tighten appearance pain, and shoulder, left upper arm radiation left, back spontaneous remission person has a rest; The time with profuse sweating, sensation of oppression over the chest with shortness of breath appears during physical exertion.Once obeyed the blood fat reducing Western medicine, curative effect is not good enough.Took these article continuously 3 months, test cholesterol 4.2mmol/L, triglyceride 0.8 mmol/L continues to follow the tracks of and paid a return visit 3 months, remission, blood fat obviously descends, and myocardial ischemia improves, and does not have other untoward reaction.
Case 6 is according to embodiment one: Ma, man, 42 years old, hospital diagnosis hypertension, hyperlipidemia; T-CHOL 6.6mmol/L, blood pressure 150/95mmHg, symptom is dizzy, uncomfortable in chest; Spiritlessness and weakness, insomnia forgetfulness, numb limbs and tense tendons were once taken blood pressure lowering, blood fat reducing Western medicine, and effect is undesirable.Take these article continuously 3 months, and detected blood pressure 130/90mmHg, T-CHOL 3.8mmol/L.Continue to follow the tracks of and paid a return visit 2 months, blood fat, blood pressure drops, remission, patient's readme is felt good.
Case 7 is according to embodiment two: Wang, woman, 55 years old, hospital diagnosis angina pectoris, hypertension, hyperlipidemia; Press 148/98mmHg through having a blood test, cholesterol 6.9mmol/L, dizziness, chest pain is felt sick; Insomnia forgetfulness, behind the angina pectoris attacks, painful is with a face streaming with sweat, and readme is overwhelmed with sorrow.Once obeyed the angina pectoris first aid medicine, blood pressure lowering, blood fat reducing Western medicine, effect is not good enough.These article of taking 3 months, the minimizing of angina pectoris attacks number of times is had a blood test and is pressed 130/90mmHg, and T-CHOL 3.1mmol/L continues to follow the tracks of and pays a return visit, and blood pressure, blood fat are stablized, and doing well,improving is obvious, does not have various untoward reaction.
Case 8 is according to embodiment two: poplar, man, 46 years old; The hospital diagnosis hyperlipidemia, the apoplexy sign is obvious, cholesterol 6.9mmol/L; Triglyceride 2.6 mmol/L, the symptom insomnia forgetfulness, uncomfortable in chest, breathe hard, have palpitation, symptom such as chest pain, weak, distortion of commissure, numb limbs and tense tendons; Once obeyed blood circulation promoting and blood stasis dispelling Chinese patent medicine, blood fat reducing Western medicine, effect is not good enough.These article of taking 3 months, T-CHOL 4.1mmol/L, triglyceride 1.6 mmol/L continue to follow the tracks of and pay a return visit, rate and blood-lipid decreased, doing well,improving is obvious, does not find any apoplexy sign so far, the conscious no any untoward reaction of health.
Case 9 is according to embodiment one: why certain, man 32 years old, the hospital diagnosis blood fat is higher, T-CHOL 6.4mmol/L, triglyceride 2.5mmol/L, symptom is dizzy, uncomfortable in chest, often feels limbs fatigue, poor sleeping quality, clothes blood fat reducing Western medicine, effect is not good enough.These article of taking 3 months are looked into T-CHOL 4.4mmol/L, and triglyceride 1.5mmol/L continues to follow the tracks of and pays a return visit, rate and blood-lipid decreased, and doing well,improving is obvious, does not have any untoward reaction.
Case 10 is according to embodiment three: Zheng, woman, 45 years old, hospital diagnosis hypertension, hyperlipidemia, cerebral thrombosis.Cholesterol 7.0mmol/L, triglyceride 2.7mmol/L, blood pressure 150/95mmHg.Dizzy, the distending pain of symptom performance, nauseating, dizzy, it is poor to have a sleepless night, inappetence, spiritlessness and weakness.These article of taking 3 months are looked into T-CHOL 6.4mmol/L, and triglyceride 1.4mmol/L continues to follow the tracks of and pays a return visit, rate and blood-lipid decreased, and blood pressure is normal, and doing well,improving is obvious, does not have any untoward reaction.