CN102793723A - Superfine grinding method for animal used as medicine - Google Patents
Superfine grinding method for animal used as medicine Download PDFInfo
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- CN102793723A CN102793723A CN2012103181936A CN201210318193A CN102793723A CN 102793723 A CN102793723 A CN 102793723A CN 2012103181936 A CN2012103181936 A CN 2012103181936A CN 201210318193 A CN201210318193 A CN 201210318193A CN 102793723 A CN102793723 A CN 102793723A
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Abstract
The invention relates to a superfine grinding method for an animal used as medicine and belongs to the technical field of grinding of the animal used as the medicine. According to the superfine grinding method, by treatment of liquid nitrogen flash freezing, superfine grinding, freeze drying and the like on the animal used as the medicine, the active ingredients of the animal used as the medicine are furthest stored, the active ingredients contained in the animal used as the medicine are sufficiently adsorbed and the medicine performance of the animal used as the medicine is sufficiently played. The invention solves the problems that in an existing grinding process, the animal used as the medicine cannot be subjected to superfine grinding, the active ingredients are easy to lose the activity in the drying process, the active ingredients of tissues of the animal used as the medicine cannot be completely stored and the effect of applying the animal to the medicine is poor. The superfine grinding method for the animal used as the medicine can ensure the active ingredients of the tissues of the animal used as the medicine to be completely released, is beneficial for a patient to adsorb the active ingredients of the animal used as the medicine and can also further improve the treatment effect after the animal used as the medicine and other medicaments are compatible.
Description
Technical field
The present invention relates to a kind of animal body superfine grinding method that is used as medicine, belong to the animal body crushing technology field of being used as medicine.
Background technology
The animal body that can be used as medicine like Hirudo, Pheretima etc., is the good medicine of blood circulation promoting and blood stasis dispelling, and diseases such as hypertension, apoplexy, coronary heart disease, arterial thrombus are had certain therapeutic effect.But
The pulverizing to the animal body that is used as medicine at present only limits to general breaking method, heavy damage many active component of the animal body that is used as medicine itself, the feasible effect of being used as medicine is poor, is unfavorable for that the patient absorbs, and has a strong impact on therapeutic effect.
Summary of the invention
The objective of the invention is to; Providing a kind of handles through liquid nitrogen flash freezer, micronizing, lyophilization; Preserve the effective ingredient of the animal body that is used as medicine to greatest extent, can make that contained active ingredient lets patient fully absorb in the animal body that is used as medicine, improve therapeutic effect special preparation technology greatly and process; Solve and have the active component that to preserve the animal body that is used as medicine to the disintegrating process of the animal body that is used as medicine fully, the animal body superfine grinding method that is used as medicine of the problem of the weak effect that is used as medicine now.
The present invention realizes above-mentioned purpose through following technical scheme:
A kind of animal body superfine grinding method that is used as medicine is characterized in that it is made up of following step:
The first step, medical material are handled:
The animal body that will be used as medicine cleans up with clear water.
Second step, cryotherapy:
The animal body that will be used as medicine is put into refrigerated cylinder, the amount of putting into≤refrigerated cylinder volume half the, and inwards charges into liquid nitrogen again, and the liquid nitrogen amount of charging into reaches four of refrigerated cylinder volume/three and o'clock stops to charge into, and keeps 20 minutes, and taking-up is for use behind the animal body adfreezing of waiting to be used as medicine.
The 3rd step, pulverizing:
The animal body that is used as medicine that will pass through the liquid nitrogen quick freezing is packed into and is had in the super micron mill of refrigerating plant, pulverizes temperature and is controlled at below 4 ℃, is crushed to 1～10 micron, and pulverizing the back, to collect powder for use.
The 4th step, lyophilization:
The lyophilizing in the freezer dryer of packing into of powder after above-mentioned the 3rd step pulverized detects moisture＜10% back of powder and takes out.
The 5th step, sterilization:
Powder after the 4th step lyophilizing was shone 1 minute under the Co60 ray; Perhaps powder is packed in the sealing rustless steel container that has agitating device; Powder charge weight≤container volume half the charges into the ozone gas of 20000～33000ppm again in powder, stir while charging into; Sealing was stirred 30 minutes after ozone gas was full of rustless steel container; Collect powder, packing warehouse-in, room temperature preservation.
The present invention's beneficial effect compared with prior art is:
This animal body superfine grinding method that is used as medicine adopts the animal body that will be used as medicine to use the liquid nitrogen quick freezing; Pulverizer through the band refrigerating plant is pulverized; Preserved the effective active composition of the animal body that is used as medicine to greatest extent; The animal tissue that has solved the animal body that is used as medicine can not be by micronizing, the problem of effective ingredient easy devitalization in dry run.The effective ingredient of the animal body tissue that is used as medicine is discharged fully, more help the patient and absorb, can further improve therapeutic effect after making be used as medicine animal body and other drug compatibility.
The specific embodiment
With the specific embodiment that Hirudo is carried out micronizing this animal body superfine grinding method that is used as medicine further is described below below:
The first step, medical material are handled:
The live body Hirudo is cleaned up with clear water.
Second step, cryotherapy:
The live body Hirudo is put into refrigerated cylinder, the amount of putting into≤refrigerated cylinder volume half the, general addition so that half of refrigerated cylinder volume be advisable; Inwards charges into liquid nitrogen again, and the amount of charging into of liquid nitrogen reaches four of refrigerated cylinder volume/three and o'clock stops to charge into, and keeps then 20 minutes, treats to take out behind the live body Hirudo adfreezing for use.
The 3rd step, pulverizing:
The live body Hirudo that will pass through the liquid nitrogen quick freezing is packed into and is with in the super micron mill of refrigerating plant, pulverizes temperature and is controlled at below 4 ℃, is crushed to 1～10 micron, and pulverizing the back, to collect powder for use.
The 4th step, lyophilization:
The lyophilizing in the freezer dryer of packing into of live body Leech after above-mentioned the 4th step pulverized, freeze dried examination criteria is moisture＜10% of live body Leech, take out back up to standard.
The 5th step, sterilization:
Live body Leech after the 4th step lyophilizing was shone 1 minute under the Co60 ray; Perhaps the live body Leech being packed into has in the rustless steel container that can seal of agitating device, live body Leech charge weight≤container volume half the, with the live body Leech install to container volume half the for well; In powder, charge into the ozone gas of 20000～33000ppm again; Stir while filling, be full of the back sealing and stirred 30 minutes, regather powder; The packing warehouse-in, room temperature preservation.
Above-mentioned the live body Hirudo is carried out after special preparation technology pulverizes through the animal body superfine grinding method that is used as medicine; Can preserve the active component of live body Hirudo to greatest extent, be beneficial to absorption, good effect; Has blood circulation promoting and blood stasis dispelling, the resultant effect of anticoagulant, blood pressure lowering, blood fat reducing, antiplatelet aggregation, thrombolytic.
The above is the specific embodiment of this invention; Above-mentioned not illustrating constitutes restriction to flesh and blood of the present invention; Under the those of ordinary skill of technical field after having read this description, can make an amendment or be out of shape the above-mentioned specific embodiment, and do not deviate from essence of the present invention and scope.
Claims (1)
1. animal body superfine grinding method that is used as medicine is characterized in that it is made up of following step:
The first step, medical material are handled:
The animal body that will be used as medicine cleans up with clear water;
Second step, cryotherapy:
The animal body that will be used as medicine is put into refrigerated cylinder, the amount of putting into≤refrigerated cylinder volume half the, and inwards charges into liquid nitrogen again, and the liquid nitrogen amount of charging into reaches four of refrigerated cylinder volume/three and o'clock stops to charge into, and keeps 20 minutes, and taking-up is for use behind the animal body adfreezing of waiting to be used as medicine;
The 3rd step, pulverizing:
The animal body that is used as medicine that will pass through the liquid nitrogen quick freezing is packed into and is had in the super micron mill of refrigerating plant, pulverizes temperature and is controlled at below 4 ℃, is crushed to 1～10 micron, and pulverizing the back, to collect powder for use;
The 4th step, lyophilization:
The lyophilizing in the freezer dryer of packing into of powder after above-mentioned the 3rd step pulverized detects moisture＜10% back of powder and takes out;
The 5th step, sterilization:
Powder after the 4th step lyophilizing was shone 1 minute under the Co60 ray; Perhaps powder is packed in the sealing rustless steel container that has agitating device; Powder charge weight≤container volume half the charges into the ozone gas of 20000～33000ppm again in powder, stir while charging into; Sealing was stirred 30 minutes after ozone gas was full of rustless steel container; Collect powder, packing warehouse-in, room temperature preservation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103181936A CN102793723A (en) | 2012-09-01 | 2012-09-01 | Superfine grinding method for animal used as medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103181936A CN102793723A (en) | 2012-09-01 | 2012-09-01 | Superfine grinding method for animal used as medicine |
Publications (1)
| Publication Number | Publication Date |
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| CN102793723A true CN102793723A (en) | 2012-11-28 |
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| CN2012103181936A Pending CN102793723A (en) | 2012-09-01 | 2012-09-01 | Superfine grinding method for animal used as medicine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038605A (en) * | 2016-05-26 | 2016-10-26 | 重庆市中药研究院 | Preparation method of hirudo nipponia preparation and preparation prepared by preparation method |
| CN108077190A (en) * | 2017-12-29 | 2018-05-29 | 黄河三角洲京博化工研究院有限公司 | A kind of selenium-enriched earthworm powder and its application |
-
2012
- 2012-09-01 CN CN2012103181936A patent/CN102793723A/en active Pending
Non-Patent Citations (4)
| Title |
|---|
| 《中国中药杂志》 20010425 吕文海等 "炮制与超微粉碎对水蛭药效影响的初步实验研究" 第241-244页 1 第26卷, 第4期 * |
| 《中药材》 20070325 王厚伟 "低温炮制工艺对水蛭水溶性蛋白组成及纤溶活性的影响" 第272-275页 1 第30卷, 第3期 * |
| 吕文海等: ""炮制与超微粉碎对水蛭药效影响的初步实验研究"", 《中国中药杂志》 * |
| 王厚伟: ""低温炮制工艺对水蛭水溶性蛋白组成及纤溶活性的影响"", 《中药材》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038605A (en) * | 2016-05-26 | 2016-10-26 | 重庆市中药研究院 | Preparation method of hirudo nipponia preparation and preparation prepared by preparation method |
| CN106038605B (en) * | 2016-05-26 | 2019-07-09 | 重庆市中药研究院 | The preparation method and its preparation of Hirudo japonica preparation |
| CN108077190A (en) * | 2017-12-29 | 2018-05-29 | 黄河三角洲京博化工研究院有限公司 | A kind of selenium-enriched earthworm powder and its application |
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| PB01 | Publication | ||
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Application publication date: 20121128 |