CN102781909B - 作为显像剂的n-烷氧基酰胺共轭物 - Google Patents

作为显像剂的n-烷氧基酰胺共轭物 Download PDF

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Publication number
CN102781909B
CN102781909B CN201080040596.8A CN201080040596A CN102781909B CN 102781909 B CN102781909 B CN 102781909B CN 201080040596 A CN201080040596 A CN 201080040596A CN 102781909 B CN102781909 B CN 102781909B
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CN
China
Prior art keywords
alkyl
aryl
mmol
amino
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080040596.8A
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English (en)
Chinese (zh)
Other versions
CN102781909A (zh
Inventor
R·R·切萨蒂
T·D·哈里斯
S·P·罗宾逊
R·J·卢比
E·H·基斯曼
P·亚拉曼基利
D·S·凯斯比尔
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Lantheus Medical Imaging Inc
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Lantheus Medical Imaging Inc
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Publication of CN102781909A publication Critical patent/CN102781909A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201080040596.8A 2009-07-08 2010-07-08 作为显像剂的n-烷氧基酰胺共轭物 Expired - Fee Related CN102781909B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22394609P 2009-07-08 2009-07-08
US61/223,946 2009-07-08
US61/223946 2009-07-08
PCT/US2010/001926 WO2011005322A2 (en) 2009-07-08 2010-07-08 N-alkoxyamide conjugates as imaging agents

Publications (2)

Publication Number Publication Date
CN102781909A CN102781909A (zh) 2012-11-14
CN102781909B true CN102781909B (zh) 2015-06-17

Family

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Family Applications (1)

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CN201080040596.8A Expired - Fee Related CN102781909B (zh) 2009-07-08 2010-07-08 作为显像剂的n-烷氧基酰胺共轭物

Country Status (7)

Country Link
US (2) US8877157B2 (https=)
EP (1) EP2451776B1 (https=)
JP (1) JP5676600B2 (https=)
CN (1) CN102781909B (https=)
AU (1) AU2010271097B2 (https=)
CA (1) CA2803520C (https=)
WO (1) WO2011005322A2 (https=)

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TWI618544B (zh) 2006-12-26 2018-03-21 藍瑟斯醫學影像公司 使心臟神經分布顯像之配位體
US8361438B2 (en) 2008-01-08 2013-01-29 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
CA2803520C (en) 2009-07-08 2019-10-22 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
AU2011253052B2 (en) 2010-05-11 2015-05-14 Lantheus Medical Imaging, Inc. Compositions, methods and systems for the synthesis and use of imaging agents
GB201102189D0 (en) 2011-02-08 2011-03-23 King S College London Materials and methods relating to cardiovascular imaging
EP2753605B1 (en) * 2011-09-09 2019-03-27 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US20150023873A1 (en) 2011-11-11 2015-01-22 Lantheus Medical Imaging, Inc. Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
TWI780082B (zh) 2016-11-18 2022-10-11 日商安斯泰來製藥股份有限公司 新穎抗人類ＭＵＣ１抗體Ｆａｂ片段
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段
MX2020012351A (es) 2018-05-17 2021-01-29 Astellas Pharma Inc Complejo que tiene fragmento fab de anticuerpo anti-muc1 de humano, enlazador peptido y/o ligando.
CA3115747A1 (en) 2018-10-10 2020-04-16 Astellas Pharma Inc. Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex
JPWO2020145228A1 (ja) * 2019-01-07 2021-11-11 アステラス製薬株式会社 配位子及びＣＥＡＣＡＭ５抗体Ｆａｂフラグメントからなる複合体
CN117486698B (zh) * 2023-10-30 2025-08-19 国网安徽省电力有限公司电力科学研究院 烯醇硅醚类化合物制备c-c键偶联产物的方法与sf6的应用

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Also Published As

Publication number Publication date
EP2451776A4 (en) 2015-04-15
CA2803520C (en) 2019-10-22
WO2011005322A2 (en) 2011-01-13
AU2010271097B2 (en) 2015-12-10
EP2451776A2 (en) 2012-05-16
WO2011005322A3 (en) 2011-04-21
US20120328514A1 (en) 2012-12-27
JP5676600B2 (ja) 2015-02-25
US20150078997A1 (en) 2015-03-19
AU2010271097A1 (en) 2012-03-01
EP2451776B1 (en) 2019-09-18
JP2012532868A (ja) 2012-12-20
HK1178511A1 (en) 2013-09-13
CN102781909A (zh) 2012-11-14
US8877157B2 (en) 2014-11-04
US9393329B2 (en) 2016-07-19
CA2803520A1 (en) 2011-01-13

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