CN102772763A - Traditional Chinese medicinal composition for resisting tumor metastasis and method for preparing traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for resisting tumor metastasis and method for preparing traditional Chinese medicinal composition Download PDFInfo
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- CN102772763A CN102772763A CN2012102421896A CN201210242189A CN102772763A CN 102772763 A CN102772763 A CN 102772763A CN 2012102421896 A CN2012102421896 A CN 2012102421896A CN 201210242189 A CN201210242189 A CN 201210242189A CN 102772763 A CN102772763 A CN 102772763A
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- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims abstract description 12
- 206010028980 Neoplasm Diseases 0.000 title abstract description 12
- 206010027476 Metastases Diseases 0.000 title abstract description 9
- 230000009401 metastasis Effects 0.000 title abstract description 8
- 239000003814 drug Substances 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 230000002001 anti-metastasis Effects 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 8
- 239000006228 supernatant Substances 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 206010017758 gastric cancer Diseases 0.000 abstract description 2
- 210000004072 lung Anatomy 0.000 abstract description 2
- 201000011549 stomach cancer Diseases 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 230000008901 benefit Effects 0.000 abstract 2
- 235000009917 Crataegus X brevipes Nutrition 0.000 abstract 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 abstract 1
- 235000009685 Crataegus X maligna Nutrition 0.000 abstract 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 abstract 1
- 235000009486 Crataegus bullatus Nutrition 0.000 abstract 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 abstract 1
- 235000009682 Crataegus limnophila Nutrition 0.000 abstract 1
- 235000004423 Crataegus monogyna Nutrition 0.000 abstract 1
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 235000002313 Crataegus paludosa Nutrition 0.000 abstract 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 abstract 1
- 241000234314 Zingiber Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 230000005180 public health Effects 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- UUTKICFRNVKFRG-WDSKDSINSA-N (4R)-3-[oxo-[(2S)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic acid Chemical compound OC(=O)[C@@H]1CSCN1C(=O)[C@H]1NC(=O)CC1 UUTKICFRNVKFRG-WDSKDSINSA-N 0.000 description 1
- 241000934856 Daphne Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010064390 Tumour invasion Diseases 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000009400 cancer invasion Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000000496 gastric squamous cell carcinoma Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
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- 238000012797 qualification Methods 0.000 description 1
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- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicinal composition for resisting tumor metastasis and a method for preparing the traditional Chinese medicinal composition. The traditional Chinese medicinal composition for resisting tumor metastasis consists of dried ginger, hawthorn and radix scrophulariae. The traditional Chinese medicinal composition is combined with basic research result of the active ingredients of the conventional traditional Chinese medicinal composition, and is based on the active ingredient group of the traditional Chinese medicinal composition, thereby having the efficacy of resisting tumor metastasis. The traditional Chinese medicinal composition is suitable for treating most patients, and can be orally taken for a long time after gastric cancer, lung caner and other surgeries or radiotherapy and chemotherapy; the traditional Chinese medicinal composition is low in cost, so the medical cost can be saved, and the national medical treatment and public health investment can be directly reduced; and the traditional Chinese medicinal composition has the advantage of curative effect, and good economic benefit can be obtained.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of anti metastasis and preparation method thereof.
Background technology
Tumor is one of healthy main illness of current harm humans.Tumor invasion is the most general a kind of biological behaviour of malignant tumor and the most essential characteristic with shifting, and also is to influence tumor patient existence and prognosis key factor.
Summary of the invention
The objective of the invention is to according to the deficiency that exists in the prior art, a kind of Chinese medicine composition of new anti metastasis is provided.
Another purpose of the present invention is to provide the method for preparing of the Chinese medicine composition of above-mentioned anti metastasis.
Above-mentioned purpose of the present invention is achieved through following technical scheme:
A kind of Chinese medicine composition of anti metastasis is by forming according to the component of mass fraction meter as follows: Rhizoma Zingiberis 10 ~ 30, Fructus Crataegi 10 ~ 30, Radix Scrophulariae 10 ~ 30.
The method for preparing of the Chinese medicine composition of the above-mentioned anti metastasis of the present invention comprises the steps:
(1) by weight ratio, it is subsequent use to take by weighing each crude drug Rhizoma Zingiberis, Fructus Crataegi and Radix Scrophulariae;
(2) add Rhizoma Zingiberis, Fructus Crataegi and 8 ~ 10 times of water gagings of Radix Scrophulariae gross weight and soaked 2 ~ 3 hours, heating decocts, and decoction liquor is filtered; Medicinal residues add 8 ~ 10 times of water gaging heating again, and decoction liquor is filtered, and filtrating merges, and gets supernatant;
(3) supernatant concentration to relative density is 1.05 ~ 1.06 o'clock, advances spray dryer, 140 ~ 160 ℃ of EAT controls, and 100 ~ 110 ℃ of leaving air temps, charging rate is 3 ~ 6 ml/ minutes, gets the Chinese medicine composition that spray drying powder is anti metastasis.
The Chinese medicine composition of anti metastasis according to the invention can add the conventional formulation of this area, prepares oral formulations according to conventional method.
Compared with prior art, the present invention has following beneficial effect:
Chinese medicine composition of the present invention is formed three herbal medicines; Embody detoxicating and resolving stagnation of pathogens, the blood-activating and qi-promoting effect is to " stasis of blood, the poison " pathological state in tumor patient later stage; Rule of treatment compatibility Chinese medicine composition of the present invention with detoxicating and resolving stagnation of pathogens, blood circulation promoting and blood stasis dispelling plays inhibiting effect on tumor metastasis.Present openly Chinese medicine patent is main to neoplasm metastasis patient " void ", is main with rule of treatment such as QI invigorating.
The specific embodiment
Come further to explain the present invention below in conjunction with embodiment, but embodiment does not do any type of qualification to the present invention.
The Chinese medicine composition that embodiment 1 has inhibiting effect on tumor metastasis prepares water decoction
1. the raw material medicines in portions by weight proportioning is following: Rhizoma Zingiberis 100 grams, Fructus Crataegi 100 grams, Radix daphnes odorae Radix Scrophulariae gram;
2. method for preparing is following:
(1) gets crude drug by above-mentioned weight portion proportioning;
(2) add Rhizoma Zingiberis, Fructus Crataegi and 8 times of water gagings of Radix Scrophulariae gross weight and soaked 2 hours, heating decocts, and after-filtration boils; Medicinal residues add 8 times of water gagings again and are heated to and boil, the after-filtration that boils, and filtrating merges, and is water decoction.
Embodiment 2
1. the raw material medicines in portions by weight proportioning is following
:Rhizoma Zingiberis 300, Fructus Crataegi 300, Radix Scrophulariae 300.
2. method for preparing is following:
(1) gets crude drug by above-mentioned weight portion proportioning;
(2) adding Rhizoma Zingiberis, Fructus Crataegi, 10 times of water gagings of Radix Scrophulariae gross weight soaked 3 hours, and heating decocts, and after-filtration boils; Medicinal residues add 10 times of water gagings again and are heated to and boil, the after-filtration that boils, filtrating merges, supernatant;
(3) supernatant concentration to relative density is 1.05 o'clock, advances spray dryer, 140 ℃ of EAT controls, and 100 ℃ of leaving air temps, charging rate is 3ml/ minute, gets spray drying powder 180 grams.
With spray drying powder, can process oral formulations by common process, like oral liquid, capsule, tablet or electuary etc.
Embodiment 3
1. the raw material medicines in portions by weight proportioning is following
:Rhizoma Zingiberis 150, Fructus Crataegi 150, Radix Scrophulariae 150.
2. method for preparing is following:
(1) gets crude drug by above-mentioned weight portion proportioning;
(2) adding Rhizoma Zingiberis, Fructus Crataegi, 10 times of water gagings of Radix Scrophulariae gross weight soaked 3 hours, and heating decocts, and after-filtration boils; Medicinal residues add 10 times of water gagings again and are heated to and boil, the after-filtration that boils, filtrating merges, supernatant;
(3) supernatant concentration to relative density is 1.05 o'clock, advances spray dryer, 140 ℃ of EAT controls, and 100 ℃ of leaving air temps, charging rate is 3ml/ minute, gets spray drying powder 35 grams.
With spray drying powder, can process oral formulations by common process, like oral liquid, capsule, tablet or electuary etc.
Embodiment 4 Chinese medicine compositions of the present invention are to the influence of FC gastric cancer mouse tumor metastasis inhibition rate
The compositions that the used Chinese medicine composition of present embodiment makes for embodiment 3.Inbred line 615 mices, male, body weight 18 ~ 22g, 40.Get portable preceding squamous cell carcinoma of stomach (FC) tissue of transplanting back 8 ~ 10d, be prepared into 1 * 10
10The cell suspension of/L, in the right axil subcutaneous injection of mice cell suspension 0.2ml/ only.Be divided into 4 groups at random after the strain of mouse inoculation tumor, 10 every group.Grouping comprises matched group (blank control group), high dose group (20g/kg), middle dose groups (10g/kg), low dose group (5g/kg).Every treated animal is second day difference gastric infusion after connecing tumor, and be administered once every day, and in continuous 3 weeks, matched group filling stomach gives equivalent and gets normal saline.Experiment finishes back anatomy experiment mice, takes out lungs, the total MET number of counting pulmonary.MET is ecru, edge polishing, similar round tuberosity.Metastasis inhibition rate=(blank control group MET number-administration group MET number)/blank control group MET number * 100%.The result sees the following form.
Claims (3)
1. the Chinese medicine composition of an anti metastasis is characterized in that by forming according to the component of mass fraction meter as follows: Rhizoma Zingiberis 10 ~ 30, Fructus Crataegi 10 ~ 30, Radix Scrophulariae 10 ~ 30.
2. the method for preparing of the Chinese medicine composition of the said anti metastasis of claim 1 is characterized in that comprising the steps:
(1) by weight ratio, it is subsequent use to take by weighing each crude drug Rhizoma Zingiberis, Fructus Crataegi and Radix Scrophulariae;
(2) add Rhizoma Zingiberis, Fructus Crataegi and 8 ~ 10 times of water gagings of Radix Scrophulariae gross weight and soaked 2 ~ 3 hours, heating decocts, and decoction liquor is filtered; Medicinal residues add 8 ~ 10 times of water gaging heating again, and decoction liquor is filtered, and filtrating merges, and gets supernatant;
(3) supernatant concentration to relative density is 1.05 ~ 1.06 o'clock, advances spray dryer, 140 ~ 160 ℃ of EAT controls, and 100 ~ 110 ℃ of leaving air temps, charging rate is 3 ~ 6 ml/ minutes, gets the Chinese medicine composition that spray drying powder is anti metastasis.
3. the described Chinese medicine composition of claim 1 prepares conventional oral formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210242189 CN102772763B (en) | 2012-07-13 | 2012-07-13 | Traditional Chinese medicinal composition for resisting tumor metastasis and method for preparing traditional Chinese medicinal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210242189 CN102772763B (en) | 2012-07-13 | 2012-07-13 | Traditional Chinese medicinal composition for resisting tumor metastasis and method for preparing traditional Chinese medicinal composition |
Publications (2)
| Publication Number | Publication Date |
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| CN102772763A true CN102772763A (en) | 2012-11-14 |
| CN102772763B CN102772763B (en) | 2013-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201210242189 Active CN102772763B (en) | 2012-07-13 | 2012-07-13 | Traditional Chinese medicinal composition for resisting tumor metastasis and method for preparing traditional Chinese medicinal composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105797003A (en) * | 2016-04-20 | 2016-07-27 | 三株福尔制药有限公司 | Probiotics fermentation traditional Chinese medicine compound composition for treating colorectal cancer and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327807A (en) * | 2000-06-12 | 2001-12-26 | 吴建华 | Chinese medicine for treating neoplasm |
-
2012
- 2012-07-13 CN CN 201210242189 patent/CN102772763B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327807A (en) * | 2000-06-12 | 2001-12-26 | 吴建华 | Chinese medicine for treating neoplasm |
Non-Patent Citations (1)
| Title |
|---|
| 杜德元: "中医论治肿瘤的研究进展", 《辽宁中医杂志》, vol. 33, no. 12, 31 December 2006 (2006-12-31), pages 1655 - 1656 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105797003A (en) * | 2016-04-20 | 2016-07-27 | 三株福尔制药有限公司 | Probiotics fermentation traditional Chinese medicine compound composition for treating colorectal cancer and preparation method and application thereof |
| CN105797003B (en) * | 2016-04-20 | 2019-08-06 | 三株福尔制药有限公司 | A kind of probiotics fermention Traditional Chinese medicine compound composition and its preparation method and application for treating colon cancer |
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| Publication number | Publication date |
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| CN102772763B (en) | 2013-08-21 |
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Owner name: YUNNAN WENSHAN KUNQI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ZHANG QUN Effective date: 20140126 |
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Free format text: CORRECT: ADDRESS; FROM: 510000 GUANGZHOU, GUANGDONG PROVINCE TO: 663000 YUXI, YUNNAN PROVINCE |
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Effective date of registration: 20140126 Address after: 663000 Yunnan Province, Wenshan Zhuang and Miao Autonomous Prefecture West Yan Yanshan County Road 4 km Patentee after: Yunnan Wenshan Kunqi Pharmaceutical Co., Ltd. Address before: The Eastern Development Zone of Guangzhou City, Guangdong province 510000 two Building Room 302 Xinyuan Street Chunhui Patentee before: Zhang Qun |
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Address after: 663000 Yunnan Province, Wenshan Zhuang and Miao Autonomous Prefecture West Yan Yanshan County Road 4 km Patentee after: The female seven Pharmaceutical limited companies of Yunnan mountain of papers Address before: 663000 Yunnan Province, Wenshan Zhuang and Miao Autonomous Prefecture West Yan Yanshan County Road 4 km Patentee before: Yunnan Wenshan Kunqi Pharmaceutical Co., Ltd. |