CN102772595B - 一种治疗慢性乙型肝炎的中药组合物 - Google Patents
一种治疗慢性乙型肝炎的中药组合物 Download PDFInfo
- Publication number
- CN102772595B CN102772595B CN201210293813.5A CN201210293813A CN102772595B CN 102772595 B CN102772595 B CN 102772595B CN 201210293813 A CN201210293813 A CN 201210293813A CN 102772595 B CN102772595 B CN 102772595B
- Authority
- CN
- China
- Prior art keywords
- parts
- liver
- chronic hepatitis
- traditional chinese
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000002672 hepatitis B Diseases 0.000 title claims abstract description 23
- 208000000419 Chronic Hepatitis B Diseases 0.000 title claims abstract description 19
- 239000000203 mixture Substances 0.000 title claims abstract description 10
- 239000003814 drug Substances 0.000 claims abstract description 17
- 229940079593 drug Drugs 0.000 claims abstract description 6
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 4
- 210000004185 liver Anatomy 0.000 abstract description 13
- 239000008280 blood Substances 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 6
- 210000000952 spleen Anatomy 0.000 abstract description 5
- 208000004880 Polyuria Diseases 0.000 abstract description 4
- 230000035619 diuresis Effects 0.000 abstract description 4
- 231100000614 poison Toxicity 0.000 abstract description 3
- 210000002784 stomach Anatomy 0.000 abstract description 3
- 241000213006 Angelica dahurica Species 0.000 abstract description 2
- 235000009917 Crataegus X brevipes Nutrition 0.000 abstract description 2
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 abstract description 2
- 235000009685 Crataegus X maligna Nutrition 0.000 abstract description 2
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 abstract description 2
- 235000009486 Crataegus bullatus Nutrition 0.000 abstract description 2
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 abstract description 2
- 235000009682 Crataegus limnophila Nutrition 0.000 abstract description 2
- 235000004423 Crataegus monogyna Nutrition 0.000 abstract description 2
- 240000000171 Crataegus monogyna Species 0.000 abstract description 2
- 235000002313 Crataegus paludosa Nutrition 0.000 abstract description 2
- 235000009840 Crataegus x incaedua Nutrition 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 240000001659 Oldenlandia diffusa Species 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 241000270666 Testudines Species 0.000 abstract 1
- 240000000038 Ziziphus mauritiana Species 0.000 abstract 1
- 235000006545 Ziziphus mauritiana Nutrition 0.000 abstract 1
- 235000008529 Ziziphus vulgaris Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002574 poison Substances 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 10
- 230000003908 liver function Effects 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000005856 abnormality Effects 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002481 ethanol extraction Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 208000035126 Facies Diseases 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010041519 Spider naevus Diseases 0.000 description 1
- 229960001997 adefovir Drugs 0.000 description 1
- -1 adefovir ester Chemical class 0.000 description 1
- 230000001064 anti-interferon Effects 0.000 description 1
- 230000001147 anti-toxic effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明提供了一种治疗慢性乙型肝炎的中药组合物，由以下重量份的原药材制备而成：白花蛇舌草10；白芍10；黄芩5；山楂10；当归10；枸杞子10；鳖甲15；茯苓12；泽泻10；大枣10；甘草5，本发明具有清热解毒，养血柔肝，滋阴潜阳、渗水利湿，疏肝益气，健脾和胃的功效，从而使肝气条达，共同起到杀菌抗毒，保肝护肝的作用。
Description
技术领域
本发明涉及一种治疗乙肝的药物，具体涉及一种治疗慢性乙型肝炎的中药组合物。
背景技术
慢性乙型肝炎是目前人类最严重的传染病之一，全球约有2亿人感染乙肝病毒，大部分为慢性携带状态。目前，我国的慢性乙肝病毒携带者高达1.2亿人，慢性乙型肝炎患者约有3500万人，每年有大约40万人死于乙肝引起的相关疾病，防治任务相当艰巨。目前，对于慢性乙型肝炎的治疗，西医一般采用抗干扰素治疗，但是很难达到彻底治疗的理想效果，中医药治疗因其具有标本兼治，毒副作用小而成为治疗乙肝的首选，但是现有治疗慢性乙型肝炎的中药品种却不是很多，越来越不能满足临床治疗的需要。
发明内容
为了解决上述技术问题，本发明提供了一种治疗慢性乙型肝炎的中药组合物。
本发明的技术方案如下：
一种治疗慢性乙型肝炎的中药组合物，其特征在于，由以下重量份的原药材制备而成：白花蛇舌草10； 白芍 10；黄芩5 ；山楂10； 当归10； 枸杞子10 ；鳖甲15； 茯苓12； 泽泻10 ；大枣10 ；甘草5。
按重量份称取以上药材，取鳖甲加8倍、6倍量60%乙醇提取两次，每次两小时，合并滤液，浓缩，干燥，粉碎得鳖甲提取物；取其余各味，加入10倍、8倍量的水提取两次，每次2小时，合并滤液，浓缩，干燥，粉碎，与鳖甲提取物混合，备用。
方中白花蛇舌草清热解毒，活血利尿；白芍养血柔肝，缓中止痛，平抑肝阳；黄芩清热燥湿，泻火解毒；用于湿温、暑湿黄疸等；山楂消食健胃，行气散瘀，化浊降脂；当归补血活血；枸杞子滋补肝肾；鳖甲具有滋阴潜阳，退热除蒸，软坚散结的作用；茯苓利水渗湿，健脾，宁心；泽泻利水渗湿，泄热；大枣补中益气；甘草补脾和胃，调和诸药。以上各药合用共凑清热解毒，养血柔肝，滋阴潜阳、渗水利湿，疏肝益气，健脾和胃的功效，从而使肝气条达，共同起到杀菌抗毒，保肝护肝的作用。
临床资料
1. 诊断标准：
诊断符合2010年中华医学会肝病学分会与感染病学分会所修订的“2010版慢性乙型肝炎防治指南”标准。
2. 临床疗效标准：
1）.显效：除肝病面容、肝掌、蜘蛛痣以外，其余症状和体征显著好转或接近消失；肝功能显著改善，甚至接近正常；伴或不伴其他化验及辅助检查项目的改善；
2）.有效：介于显效和无效之间的治疗转归；
3）.无效：临床症状、体征、实验室检查及辅助检查中80%以上的指标无改善，甚或加重。实际操作中，凡介于两级疗效之间者，均纳入疗效较好的一级，彼此间不重复统计。
3. 临床试验：
我们从2010年3月至2012年3月间来诊的慢性乙型肝炎患者中选取同意接受该研究方法的慢性乙型肝炎(轻~中度)患者196例，服用本发明药物，一重量份为1剂，1剂/天，4周为一个疗程，治疗6个疗程后观察治疗情况。其中显效154例，有效27例，无效15例，总有效率为92.3%。说明本发明药物对慢性乙型肝炎具有显著的疗效。
具体实施方式
下面结合具体实施例对本发明做进一步的说明。
实施例1
称取白花蛇舌草10g； 白芍 10g；黄芩5g ；山楂10g； 当归10g； 枸杞子10g ；鳖甲15g； 茯苓12g； 泽泻10g ；大枣10g ；甘草5g；取鳖甲加8倍、6倍量60%乙醇提取两次，每次两小时，合并滤液，浓缩，干燥，粉碎得鳖甲提取物；取其余各味，加入10倍、8倍量的水提取两次，每次2小时，合并滤液，浓缩，干燥，粉碎，与鳖甲提取物混合，备用。
典型病例
病例1
潘某，男，十年前患上慢性乙型肝炎，反复乏力、纳差、尿黄及肝功能异常，曾多处求医诊疗用药，均疗效不佳。病后三年来我院就医，患者当时乏力、纳差症状明显，伴轻度尿黄，面色晦暗，查肝功能中度异常，乙肝五项指标呈大三阳，HBV-DNA阳性，B超提示肝实质损害声像图。患者服用本发明方药治疗1个月，肝功能就基本恢复正常；3个月后HBV-DNA阴转；6个月后大三阳转小三阳；医嘱患者可停止治疗。但患者要求继续服用，1年后患者竟然HBsAg阴转，仅HBcAb及HBeAb两项阳性。6年后随访患者仍健康生活。
病例2.
师某，男，患者起病隐匿，6年前因患皮肤病住他院治疗时查出患者同时合并“慢性乙型肝炎”。患者出院后即来我院就医，查肝功能轻度异常，HbsAg、HbeAg、抗-HBc及HBV-DNA均阳性，B超提示肝实质损害声像图。诊断为慢性乙型肝炎，并应用干扰素500万单位，隔日肌肉注射一次，持续治疗1年，效果不佳。后改用阿德福韦酯加服本发明药物联合抗HBV及护肝治疗2年，肝功能完全正常，HBV-DNA阴转，大三阳转小三阳。3年后随访，患者仍病情稳定，作息如常。
病例3
李某，男，患者起病隐匿，3年前因外伤手术治疗时查出肝功能异常，乙肝大三阳，但当时患者无明显自觉症状。1年后来我院就医，查肝功能中度异常，HbsAg、HbeAg、抗-HBc阳性， HBV-DNA：1.0E+06IU/ml，B超提示肝内光点增粗。诊断为“慢性乙型肝炎（中度）”，并应用干扰素500万单位，隔日肌肉注射一次，持续治疗半年，肝功能仍轻度异常，HBV-DNA：1.0E+05IU/ml，下降不明显。随后加服本发明药物联合治疗半年，肝功能正常，HBV-DNA阴转，大三阳转小三阳。停用干扰素，再继续服用本发明药物治疗半年，竟然HBsAg阴转，但HbsAb尚未转阳性。1年后随访仍健康工作。
Claims (1)
1.一种治疗慢性乙型肝炎的中药组合物，其特征在于，由以下重量份的原药材制备而成：白花蛇舌草10； 白芍 10；黄芩5 ；山楂10； 当归10； 枸杞子10 ；鳖甲15； 茯苓12； 泽泻10 ；大枣10 ；甘草5。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210293813.5A CN102772595B (zh) | 2012-08-17 | 2012-08-17 | 一种治疗慢性乙型肝炎的中药组合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210293813.5A CN102772595B (zh) | 2012-08-17 | 2012-08-17 | 一种治疗慢性乙型肝炎的中药组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102772595A CN102772595A (zh) | 2012-11-14 |
| CN102772595B true CN102772595B (zh) | 2014-01-15 |
Family
ID=47117852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210293813.5A Expired - Fee Related CN102772595B (zh) | 2012-08-17 | 2012-08-17 | 一种治疗慢性乙型肝炎的中药组合物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102772595B (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623276B (zh) * | 2013-12-13 | 2015-09-30 | 马振滨 | 一种治疗乙型肝炎的中药口服制剂 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1233483A (zh) * | 1998-04-30 | 1999-11-03 | 高云渌 | 一种治疗肝硬化、肝癌的药物 |
| CN101185747A (zh) * | 2007-10-17 | 2008-05-28 | 门连社 | 一种治疗肝病的方剂 |
| CN101897904A (zh) * | 2009-05-27 | 2010-12-01 | 燕西营 | 一种治疗肝炎的中药制剂 |
-
2012
- 2012-08-17 CN CN201210293813.5A patent/CN102772595B/zh not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1233483A (zh) * | 1998-04-30 | 1999-11-03 | 高云渌 | 一种治疗肝硬化、肝癌的药物 |
| CN101185747A (zh) * | 2007-10-17 | 2008-05-28 | 门连社 | 一种治疗肝病的方剂 |
| CN101897904A (zh) * | 2009-05-27 | 2010-12-01 | 燕西营 | 一种治疗肝炎的中药制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102772595A (zh) | 2012-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102755594B (zh) | 一种治疗急慢性乙肝的中药组合物及其制备方法 | |
| CN103463528B (zh) | 一种治疗慢性湿疹的中药组合物 | |
| CN103007191B (zh) | 一种治疗黄疸的中药组合物 | |
| CN103386008B (zh) | 一种治疗内分泌失调的中药组合物 | |
| CN101934052B (zh) | 一种治疗面部黄褐斑的药物及其制备方法 | |
| CN103479929A (zh) | 一种治疗瘙痒的中药组合物 | |
| CN104043050A (zh) | 一种治疗胆囊炎的中药组合物 | |
| CN102671102B (zh) | 一种治疗慢性乙型肝炎的中药组合物 | |
| CN102764337B (zh) | 一种治疗慢性乙型肝炎的中药组合物 | |
| CN103251800B (zh) | 一种治疗过敏性皮炎的中药组合物 | |
| CN104116971B (zh) | 一种治疗肝病瘙痒的中药组合物及其制备方法 | |
| CN1330355C (zh) | 一种治疗溃疡的中药组合物 | |
| CN103536850B (zh) | 一种内外兼治治疗扁平疣的中药药物 | |
| CN102772595B (zh) | 一种治疗慢性乙型肝炎的中药组合物 | |
| CN102949659B (zh) | 一种治疗乙型肝炎的中药组合物 | |
| CN105288116A (zh) | 一种治疗精神分裂症的中药组合物 | |
| CN103800689A (zh) | 一种治疗糖尿病的中药组合物 | |
| CN103550548B (zh) | 一种治疗便秘的中药组合物 | |
| CN102772575B (zh) | 一种治疗慢性乙型肝炎的中药组合物 | |
| CN105106909A (zh) | 一种治疗甲肝的中药组合物 | |
| CN104027430A (zh) | 一种治疗血瘀型子宫肌瘤的中药组合物 | |
| CN102210792A (zh) | 一种防治深静脉血栓的中药 | |
| CN103028063B (zh) | 一种治疗肾病的中药组合物 | |
| CN102846892A (zh) | 驱黄汤 | |
| CN102335243B (zh) | 一种治疗黄疸型肝炎的中药组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: GONG XIN Free format text: FORMER OWNER: ZHANG SHOUPAN Effective date: 20140512 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Gong Xin Inventor after: Shao Li Inventor after: Wang Qingwen Inventor after: Zhou Yan Inventor after: Li Xiaofei Inventor before: Zhang Shoupan Inventor before: Wang Qingwen Inventor before: Zhou Yan Inventor before: Li Xiaofei |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG SHOUPAN WANG QINGWEN ZHOU YAN LI XIAOFEI TO: GONG XIN SHAO LI WANG QINGWEN ZHOU YAN LI XIAOFEI Free format text: CORRECT: ADDRESS; FROM: 250021 JINAN, SHANDONG PROVINCE TO: 264000 YANTAI, SHANDONG PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20140512 Address after: 264000, No. 15, Lane 5, Leshan, Zhifu District, Shandong, Yantai Patentee after: Gong Xin Address before: 250021 Ji'nan blood supply and Guarantee Center, No. six, No. 127, Shizhong District, Ji'nan, Shandong Patentee before: Zhang Shoupan |
|
| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: 264000 Yantai Yuhuangding Hospital, Yantai 20 East Top Road, Shandong, China Patentee after: Gong Xin Address before: 264000, No. 15, Lane 5, Leshan, Zhifu District, Shandong, Yantai Patentee before: Gong Xin |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140115 Termination date: 20160817 |