CN102772428A - Oral disinfectant antibacterial gargle - Google Patents
Oral disinfectant antibacterial gargle Download PDFInfo
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- CN102772428A CN102772428A CN2012102603659A CN201210260365A CN102772428A CN 102772428 A CN102772428 A CN 102772428A CN 2012102603659 A CN2012102603659 A CN 2012102603659A CN 201210260365 A CN201210260365 A CN 201210260365A CN 102772428 A CN102772428 A CN 102772428A
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- gargarism
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- chlorhexidine
- hibitane
- gargle
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Abstract
The invention relates to an oral disinfectant antibacterial gargle. The purpose of the invention is to provide an oral disinfectant antibacterial gargle with characteristics of easy use, easy preparation, good stability and good taste; the gargle has antibacterial and disinfectant effects on oral pathogens to effectively prevent oral diseases. The technical solution provided by the invention is follows: the oral disinfectant antibacterial gargle is characterized in that the gargle has the following components in percentage by weight: 10-20 parts of boric acid; 0.5-1.1 parts of chlorhexidine or chlorhexidine acetate or chlorhexidine hydrochloride or chlorhexidine citrate or 3-5 parts of 20% chlorhexidine gluconate solution; 20-40 parts of glycerol; 1-3 parts of polysorbate 20; and the balance of purified water. The oral disinfectant antibacterial gargle provided by the invention is applicable to the oral disinfection for oral cavity, nasopharynx, and before and after periodontal surgeries.
Description
Technical field
The present invention relates to the antibiotic gargarism of a kind of oral disinfecting.Be applicable to the disinfecting, antimicrobial rinsing the mouth and position, the oral cavity routine care at position, oral cavity.Be applied to the oral disinfecting of oral cavity, nasopharynx and periodontal surgery front and back; Radiotherapy chemotherapy, Pneumology Department, contagious department patient and oral transmucosal intubate patient; After intensive care unit, the various operation and lying on bed for a long time be inconvenient to the patient that brushes teeth, diabetics and daily oral cavity and pharyngeal sterilization, the oral disinfecting of child's hand-foot-mouth disease is antibiotic.
Background technology
Oral disease is a kind of common frequently-occurring disease, and sickness rate is high, and is very big to human health damage property, but often do not paid attention to by extensive patients.Its main pathogenic factor of oral disease is that the accumulation owing to gum edge district dental plaque causes the breeding of a large amount of pathogenic bacterium, and bacteriotoxin that it discharges and metabolite are to due to periodontal, the gingiva infringement.Common oral disease has gingivitis, oral mucositis, pharyngitis etc.; The sickness rate of oral disease in the crowd is very high; Almost everyone has oral problem; Crowd about 60% suffers from oral ulcer, halitosis, pharyngitis in various degree, and obstinate recurrent oral ulceration reaches about 10%, particularly behind oral cavity, nasopharynx and the periodontal surgery; Radiotherapy chemotherapy, Pneumology Department, contagious department patient and oral transmucosal intubate patient; After intensive care unit, the various operation and lying on bed for a long time be inconvenient to the patient that brushes teeth, diabetics and suffer from the child of hand-foot-mouth disease, its oral disease more is prone to take place.
Carry out disinfection antibiotic with gargarism to intraoral pathogenic bacterium; It is a kind of the most frequently used method that the prevention oral disease takes place; Be the incidence rate that a kind of gargarism that good disinfecting, antimicrobial arranged can effectively reduce oral disease, and the mouthfeel of gargarism have key influence to patient's medication initiative, therefore; The adjusting of mouthfeel in the prescription research, i.e. the screening study of correctives and consumption thereof will be very important.
Summary of the invention
The technical problem that the present invention will solve is: to the problem of above-mentioned existence; The antibiotic gargarism of oral disinfecting of a kind of easy to use, easy, good stability of preparation and features good taste is provided; It is antibiotic that intraoral pathogenic bacterium are carried out disinfection, and takes place with effective prevention oral disease.
The technical scheme that the present invention adopted is: the antibiotic gargarism of a kind of oral disinfecting is characterized in that the component of said gargarism and weight percent content are:
Boric acid 10 ~ 20;
Hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane 0.5 ~ 1.1
Or 20% chlorhexidine gluconate solution 3 ~ 5;
Glycerol 20 ~ 40;
Polysorbate 20 1 ~ 3;
The purified water surplus.
Optimization formula is following: the component of described gargarism and weight percent content are:
Boric acid 12 ~ 18;
Hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane 0.5 ~ 1.1
Or 20% chlorhexidine gluconate solution 3 ~ 5;
Glycerol 25 ~ 35;
Polysorbate 20 1 ~ 2.5;
The purified water surplus.
Most preferably prescription is as follows: the component of described gargarism and weight percent content are:
Boric acid 14 ~ 16;
Hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane 0.5 ~ 1.1
Or 20% chlorhexidine gluconate solution 3 ~ 5;
Glycerol 28 ~ 34;
Polysorbate 20 1.5 ~ 2.5;
The purified water surplus.
The HCl or the NaOH that also comprise 0.01mol/L in the described gargarism, regulating the pH value scope is 3.5 ~ 7.0.
The HCl or the NaOH that also comprise 0.01mol/L in the described gargarism, regulating the pH value scope is 4.0 ~ 6.5.
Also comprise 0.5～1.5% dense aqua methnae of total amount, 0.05～0.15% steviosin of total amount and 0.0001%～0.0004% pigment of total amount in the described gargarism.
The invention has the beneficial effects as follows: the antibiotic gargarism of oral disinfecting of the present invention is easy to use, easy, the good stability of preparation, to the disinfecting, antimicrobial that intraoral pathogenic bacterium carry out, effectively prevents oral disease to take place.And the present invention adds pH regulator agent (HCl of 0.01mol/L or NaOH) in gargarism, and the control pH value is 3.5 ~ 7.0 or 4 ~ 6.5, thereby makes gargarism steady quality in room temperature storage 24 months, but long term storage.Gargarism comprises dense aqua methnae, steviosin; The coupling of two correctivess has overcome the discomfort of hibitane or chlorhexidine acetate or chlorhexidine gluconate or chlorhexidine hydrochloride or the taste of citric acid hibitane own; Make the gargarism taste fragrant and sweet good to eat, and safety coefficient is high.Gargarism also can add pigment (lemon yellow) as the color and luster dressing agent, makes the outer article of product pleasing more soft, is easier to consumer and patient and accepts.
The specific embodiment
Prepare oral disinfecting of the present invention antibiotic gargarism needed raw material component such as following table 1,1000mL is an example with preparation:
Table 1
The processing step of the foregoing description is following:
(1) by the boric acid of measuring in the table 1, add in 60 ℃ of an amount of purified water, fully stirring makes it to dissolve fully, gets solution 1;
(2) get a preparing tank again, add the purified water of full dose 60%, add all the other raw materials in the component, stirring and dissolving gets solution 2;
(3) solution 1 is added in the preparing tank, add purified water and be settled to 1000mL, stirring and evenly mixing gets intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and the HCl or the NaOH solution that add 0.01mol/L to be to regulate in pH value to 3.5 ~ 7.0 scopes, and preferred pH value scope is 4 ~ 6.5;
(5) filtration, fill make finished product.
In the above-mentioned processing step, can add dense aqua methnae 10ml, steviosin 1g, pigment (lemon yellow) 0.002g during solution 2 preparations, two correctivess (dense aqua methnae, steviosin) are regulated the gargarism taste, make the gargarism taste fragrant and sweet good to eat, and safety coefficient is high; Pigment (lemon yellow) makes product colour be easier to consumer and patient's acceptance as the color and luster dressing agent.
In the foregoing description, said boric acid, hibitane or chlorhexidine acetate or chlorhexidine gluconate or chlorhexidine hydrochloride or citric acid hibitane solution, glycerol, polysorbate 20, dense aqua methnae, steviosin, pigment (lemon yellow) and purified water are the commercially available prod.
Boric acid is the disinfection antiseptic, and various bacteria, mycete are all had the bactericidal effect, and it can combine with the amino in the bacterioprotein and play a role, and can be used for the irrigation and disinfection of mucocutaneous, oral cavity, vagina, bladder.
Hibitane or chlorhexidine acetate or chlorhexidine gluconate or chlorhexidine hydrochloride or citric acid hibitane; Their corresponding another names are respectively hibitane, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, citrate hibitane; Five kinds of hibitane are cationic surfactant; Broad-spectrum sterilization, bacteriostasis are arranged, and antimicrobial spectrum comprises Grain-positive and negative bacterium, fungus and some virus.After it is adsorbed in cell wall, change its surface texture and Osmotic balance, endochylema composition seepage can make endochylema solidify during high concentration, suppressed the reparation of cell wall, and this model of action is difficult for producing drug resistance, is used for hands, skin, mucosa, wound surface and sterilization of instruments.
Purified water H
2The water of 18.02 article of O hyoscine that to be drinking water make through the way of distillation, ion exchange, hyperfiltration or other suitable methods does not contain any additives.Dense aqua methnae, steviosin are correctives, and pigment (lemon yellow) is the color and luster dressing agent.Glycerol, the another name glycerin is sweeting agent and wetting agent.
Claims (6)
1. antibiotic gargarism of oral disinfecting is characterized in that the component of said gargarism and weight percent content are:
Boric acid 10 ~ 20;
Hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane 0.5 ~ 1.1
Or 20% chlorhexidine gluconate solution 3 ~ 5;
Glycerol 20 ~ 40;
Polysorbate 20 1 ~ 3;
The purified water surplus.
2. the antibiotic gargarism of oral disinfecting according to claim 1, it is characterized in that: the component of described gargarism and weight percent content are:
Boric acid 12 ~ 18;
Hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane 0.5 ~ 1.1
Or 20% chlorhexidine gluconate solution 3 ~ 5;
Glycerol 25 ~ 35;
Polysorbate 20 1 ~ 2.5;
The purified water surplus.
3. the antibiotic gargarism of oral disinfecting according to claim 1, it is characterized in that: the component of described gargarism and weight percent content are:
Boric acid 14 ~ 16;
Hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane 0.5 ~ 1.1
Or 20% chlorhexidine gluconate solution 3 ~ 5;
Glycerol 28 ~ 34;
Polysorbate 20 1.5 ~ 2.5;
The purified water surplus.
4. according to the antibiotic gargarism of the arbitrary described oral disinfecting of claim 1 ~ 3, it is characterized in that: also comprise HCl or the NaOH of 0.01mol/L in the described gargarism, regulating the pH value scope is 3.5 ~ 7.0.
5. according to the antibiotic gargarism of the arbitrary described oral disinfecting of claim 1 ~ 3, it is characterized in that: also comprise HCl or the NaOH of 0.01mol/L in the described gargarism, regulating the pH value scope is 4.0 ~ 6.5.
6. according to the antibiotic gargarism of the arbitrary described oral disinfecting of claim 1 ~ 3, it is characterized in that: also comprise 0.5～1.5% dense aqua methnae of total amount, 0.05～0.15% steviosin of total amount and 0.0001%～0.0004% pigment of total amount in the described gargarism.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102603659A CN102772428A (en) | 2012-07-25 | 2012-07-25 | Oral disinfectant antibacterial gargle |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102603659A CN102772428A (en) | 2012-07-25 | 2012-07-25 | Oral disinfectant antibacterial gargle |
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| CN102772428A true CN102772428A (en) | 2012-11-14 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179722A (en) * | 2019-07-09 | 2019-08-30 | 许富明 | A kind of gargle and preparation method thereof with bacteria resistance function |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304715A (en) * | 2000-11-25 | 2001-07-25 | 余照恩 | Process for preparing gargle |
| CN102335102A (en) * | 2010-07-28 | 2012-02-01 | 重庆健能医药开发有限公司 | Chlorhexidine gluconate gargle |
-
2012
- 2012-07-25 CN CN2012102603659A patent/CN102772428A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304715A (en) * | 2000-11-25 | 2001-07-25 | 余照恩 | Process for preparing gargle |
| CN102335102A (en) * | 2010-07-28 | 2012-02-01 | 重庆健能医药开发有限公司 | Chlorhexidine gluconate gargle |
Non-Patent Citations (4)
| Title |
|---|
| 宋传莲等: "自体造血干细胞移植患者并发症分析及护理", 《中国民康医学》, vol. 20, no. 2, 31 January 2008 (2008-01-31), pages 136 - 137 * |
| 张英涛: "含漱液及其配制", 《河南科技》, 31 January 1991 (1991-01-31), pages 16 - 17 * |
| 李家仁等: "洗必泰制剂及其临床应用", 《中级医刊》, no. 11, 31 December 1986 (1986-12-31), pages 40 - 42 * |
| 谢玲等: "复方甲硝唑漱口液配方的改进", 《首都医药》, vol. 8, no. 11, 31 December 2001 (2001-12-31), pages 37 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179722A (en) * | 2019-07-09 | 2019-08-30 | 许富明 | A kind of gargle and preparation method thereof with bacteria resistance function |
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Application publication date: 20121114 |