Purpose of the present invention is exactly the deficiency that exists at above-mentioned prior art and provide a kind of roach effect of killing excellent, and the preparation method is simple, to people and animals' nonhazardous effect, is cockroach killing compound powder of main component and preparation method thereof with the Chinese herbal medicine.

The present inventor is morphosis and the self-cleaning habit (paper " self-cleaning habit of cockroach and medication effect observation " the research cockroach, Chinese media biology and control magazine 1992, (5)) on the basis, determine to select for use pulvis as pharmaceutically-active research formulation, follow the principle of compound of hygienic insecticide simultaneously; In safety, effectively, rationally, under the economic condition, select for use to the nontoxic Chinese herbal medicine of human body economize rattan, sheep hoof, the tuber of stemona and big empty (playing stomach toxicity, food calling) and the pyrethroid (playing action of contace poison) that is widely used composite, and carry out synergy and food calling is handled, thus successfully composite (effective lastingly) double action that has tag (quick-acting killing) and stomach toxicity simultaneously of having synthesized, and safety non-toxic, cockroach killing powder agent free from environmental pollution.Thereby reach and kill cockroach reduction worm density and the lasting purpose of killing achievement of consolidating rapidly.This medicine has solved: 1. kill the reduction cockroach density fast, 2. dauer effect is killed remaining cockroach, 3. keeps for a long time, consolidates and kills achievement, and 4. convenient several the pasts of dispenser go out and obviously disconnect in the roach work, but the several problems that are closely related.Certainly, hygienic insecticide should be with to the person poultry safety, and free from environmental pollution is prerequisite, and cockroach killing powder of the present invention detects through sanitary toxicology teaching and research room of Beijing Medical University: small white mouse per os LD ₅₀, select the LDCA mouse for use, 18-22 gram, each 20 of male and female.The testing result cockroach killing powder is to its mouse oral LD ₅₀Greater than the 12.5g/kg body weight, the acute toxicity grade belongs to nontoxic.Safety, effectively, easy to use (dispenser is at the indoor cockroach place that often haunts; Become to be no more than the medicated thread of 1cm simultaneously along indoor corner area spray all around, form efficacy of a drug encirclement and get final product.But should guard against damp and keep), during dispenser, staff's operate as normal is unaffected.Tag, food calling, the stomach toxicity Trinity is the outstanding feature of cockroach killing powder of the present invention, the cockroach in the certain environment thoroughly can be killed (cutting off) or its density is controlled in the scope of no cockroach sanitary standard permission of national Commission for the Patriotic Health Campaign defined.

Cockroach killing powder of the present invention is paid researcher's detection through Inst. of Epidemiology and Microbiology, Chinese Academy of Preventive Medicine's media biology and the control Wang Meixiu researcher of research department and five media biologies of Military Medical Science Institute with controlling the Li Bei of research department think of, and the result shows: cockroach killing powder of the present invention has the quick-acting double stomach poison functions of tagging to Groton bug and American cockroach; And kill the roach effect and be better than that commercially available match is excellent and kill (in Beijing defendance give birth to scientific and technological development company produce) and first by (the Guangxi Yulin is protected peaceful welfare Industrial Co., Ltd. product) (seeing survey report).

Cockroach killing compound powder of the present invention is mainly formed specifically fill a prescription following (is unit with parts by weight) by economizing Teng, sheep hoof, the tuber of stemona, big sky, EXTHIN, talcum powder and high-quality ground rice:

Economize Teng 6-32

Sheep hoof 7-35

Tuber of stemona 10-25

Big empty 5-30

EXTHIN 3-15

Talcum powder 20-40

High-quality ground rice 10-50

Chinese medicine is economized Teng, sheep hoof, the tuber of stemona and big empty grinding and processing respectively, cross 200 mesh sieves and be fine powder, standby.The import EXTHIN, grinding and processing is crossed 200 mesh sieves and is fine powder, and is standby.Selected bait high-quality ground rice, grinding and processing, it is standby that mistake 200 mesh sieves are fine powder.The auxiliary type agent talcum powder, grinding and processing is crossed 200 mesh sieves and is fine powder, and is standby.These seven kinds of composition powder are mixed at normal temperatures and pressures by above-mentioned parts by weight proportioning, stir the 30-90 branch and plant, be mixed, integral body is crossed 200 mesh sieves and promptly is made into cockroach killing powder of the present invention then.

The cockroach killing compound powder of the inventive method preparation is tested in Inst. of Epidemiology and Microbiology, Chinese Academy of Preventive Medicine (, is reported as follows:

(A) Interventions Requested: cockroach killing powder is to the toxic effect of cockroach

At the indoor cockroach killing powder that carries out of testing experiment the cockroach toxic effect is tested.

One, for the examination material:

1. for reagent product: 1. cockroach killing powder (the present invention)

2. match excellent killing: defendance is given birth to scientific and technological development company (contrast) is provided in Beijing.

3. cockroach (first by) ant repellent goes out: the Guangxi Yulin is protected peaceful welfare Industrial Co., Ltd. (contrast).

2. for the examination insect: 1. Groton bug (Blattella germanica) adult.

2. American cockroach (Deripeaneta americuna) adult.

Two kinds of examination worms are all this media biology and the control hand-feeding propagation's of research department sensitive strain.

Two, test method: adopt the glass cabinet method (to put into 50 of Groton bugs (20 of male and female half and half or American cockroaches) glass cabinet top edge in 40 * 40 * 25CM) glass cabinets and be coated with vaseline (2CM is wide), cover with gauze above, put a little scraps of paper in the cabinet, put into poison bait (malicious powder) for one group, put into normal edible material piece for one group and compare, regularly observe the examination worm and knock down and death condition, every group of test repeats once, 25 ± 1 ℃ of indoor temperatures, relative temperature 60-65%.

Three, result of the test:

1. cockroach killing powder is to Groton bug and American cockroach toxic effect: see Table 1

Table 1: cockroach killing powder is knocked down situation to Groton bug and American cockroach

Different time (branch) examination worm rate of knockdown (%) lethality (%)

The examination worm

10 30 60 70 80 90 120 150 4.5h 24h

Groton bug 15 45 55 64 70 87 100 100

American cockroach 000 10 80 100 100

As seen from Table 1: cockroach killing powder all has stronger knockdown effect and toxic effect preferably to Groton bug and American cockroach.

2. three kinds of cockroach poison product relatively see Table 2 to the Groton bug KT:

Table 2: three kinds of cockroach poisons to the Groton bug KT relatively

Nomenclature of drug KT ₅₀95% fiducial limit regression equation lethality (%)

24h 72h

Cockroach killing powder 56(minute) 47.8-65.7 Y=4.01X-2.018 100

Match excellent killing 4.94(days) 4.51-5.41 Y=7.00X+0.13 0 20

First was by 3.98(days) 3.62-4.37 Y=6.80X+0.91 2 28

2 results find out from watch: (1) three kind kill the roach medicine with cockroach killing powder Groton bug is knocked down the fastest, its KT ₅₀Only be 56 minutes, match excellent kill with first by to Groton bug KT ₅₀Be respectively both KT of back 4.94 and 3.98 days ₅₀Value is than cockroach killing powder KT ₅₀Value exceeds tens times so that hundreds of times.(2) cockroach killing powder reaches 100% death to killing effect of blattella germanica in 24 hours.Then two kinds of medicines tried the only dead 20-28% of worm after 72 hours.

Brief summary:

1. cockroach killing powder has very fast knockdown effect to Groton bug, and the examination worm contacts medicinal powder 1.2 and tries the worm rate of knockdown after 2.5 hours and is respectively 45%, 87%, 100%.

2. cockroach killing powder has very strong knockdown effect to American cockroach, and the examination worm was all knocked down in 1.5 hours, examination worm 100% death after 4.5 hours.

3. cockroach killing powder is to the KT of Groton bug ₅₀And the dead result of 24 hours or 72 hours all be better than matching excellent kill and first by, its KT ₅₀Be respectively 4.94 days and 3.98 days 56 minutes.

Cockroach killing powder to the toxic effect of Groton bug be better than matching excellent kill and first by.

(B) Interventions Requested: cockroach killing powder is to rabbit skin, eye, schneiderian membrane safety test

Packing Condition: pulvis is bottled

One, for the examination animal: new zealand rabbit is provided by this laboratory animal room.

Two, test method: cut off 20CM respectively in rabbit belly both sides before the test ²(4 * 5CM) area hairs are as being subjected to the medicine position, and eye, nose are with one of the each drops physic liquor of micro syringe.Rabbit belly unhairing place is coated with soup every day and once connects and be coated with three days, and eye, nose drops physic liquor also connect and dripped three days.The back is normal raised five days.

Three, result: cockroach killing powder glues the irritation test result to rabbit skin, eye nose film: see the following form.

Compile examination precursor examination back body skin and be coated with dose eye, the nose amount of dripping result of the test

Heavy (the gram) (g/m of number weight (gram) ²) (mg/ day) skin eye schneiderian membrane

1 2,650 2,500 200 0.2 no abnormal discharge of eye increase

Many, have a running nose

2 2,400 2,400 40 0.2 is no abnormal the same

Contrast the no abnormal reaction of 2,250 2310 tap waters

Eye, nose drip behind the medicine and to respond transference cure after the drug withdrawal in second day.

Estimate: cockroach killing powder has no stimulation to rabbit skin, owing to drip dose greatly to eye, some stimulation of schneiderian membrane, if by positive usual amounts, spread effect can not take place.

It is as follows to cockroach killing powder hygienic insecticide test report that microorganism of military medical sciences academy is learned epidemiological study institute:

(A) sample title: cockroach killing powder, testDate: 1992.5.22-26

The test insect: sensitive strain is cultured in American cockroach (P americana) normalization

The 7th generation, female, hero, nymph.

Method of testing:

Contact method.Use the 500ml beaker, put into 0.20 gram medicinal powder, evenly roll one deck medicinal powder, female, male, each 10 of nymphs are put into beaker respectively.Polypide touches soup and promptly moves into clean plastics mouse cylinder, observes counting with stopwatch, asks KT ₅₀Observe lethality, death standard dials with acupuncture that polypide is reactionless to be as the criterion.Three groups, three are repeated.（T：25℃，RH：60%）。

Test result:

♀ KT ₅=2.16(95% fiducial limit: 1.388465-3.361564)

KT ₅₀=7.39(95% fiducial limit: 6.157512-8.877687)

KT ₉₅=25.30(95% fiducial limit: 18.835559-33.990326)

♂ KT ₅=1.74(95% fiducial limit: 1.184958-2.546857)

KT ₅₀=4.30(95% fiducial limit: 3.676102-5.020115)

KT ₉₅=10.62(95% fiducial limit: 8.358597-13.500865)

Nymph KT ₅=2.20(95% fiducial limit: 1.441405-3.350893)

KT ₅₀=7.56(95% fiducial limit: 6.303062-9.071760)

KT ₉₅=26.02(95% fiducial limit: 19.946681-33.936656)

(1) polypide on average be subjected to dose be 3.78mg/ only.

(2) no longer upset after polypide is knocked down by medicine, only pin has fine motion, and observation to 96 hours three groups of lethality all reach 100%.

Preliminary assessment:

This medicine is to the American cockroach double stomach poison function of tagging that has immediate effect, as long as polypide contact medicinal powder promptly knocked down in 30 minutes substantially, and no longer upset.KT ₅₀Male worm is 4.3 minutes.Female worm is 7.39 minutes; Nymph is 7.56 minutes; Observed all to knock down in 24 hours to 72 hours and do not see upset, only part pin fine motion, thoroughly dead to 96 hours.Prepare spraying tool, carry out the purpose that the science dispenser can reach the roach that efficiently goes out.

(B) sample title: cockroach killing powder, testDate: 1992.5.21-26 tests insect: in 36 generations such as sensitive strain, cultured in Groton bug (B germarica) normalization, and are female, male (2-3 age in week), nymph (4-5 age in week).

Method of testing:

Adopt contact method.25 ℃ of temperature, under the RH60% condition, get female, male, each 10 of nymphs are divided into three groups, put into one by one 0.1 gram medicinal powder tubule is housed, and polypide promptly moves in the clean 500ml glass preserving jar after touching medicine, observe timing with stopwatch, knock down death condition after the counting polypide touches medicine, observe to thoroughly death of polypide, meter lethality.(death is as the criterion with the acupuncture nonresponder).Every group is touched medicine front and back weighing pencil heavily, accurately calculates polypide and on average be subjected to dose.Every group three repetition.

Test result: on average be subjected to dose

♂ KT ₅=1.53(95% fiducial limit: 1.079589-2.180732) 0.37mg/ only

KT ₅₀=3.99(95% fiducial limit: 3.423577-4.644839)

KT ₉₅=10.36(95% fiducial limit: 8.057909-13.329641)

♀ KT ₅=4.12(95% fiducial limit: 3.378313-5.021641) 0.65mg/ only

KT ₅₀=7.88(95% fiducial limit: 7.222782-8.606571)

KT ₉₅=15.09(95% fiducial limit: 12.788449-17.811721)

Nymph KT ₅=3.19(95% fiducial limit: 2.525627-4.034434) 0.83mg/ only

KT ₅₀=6.31(95% fiducial limit: 5.689324-7.002538)

KT ₉₅=12.48(95% fiducial limit: 10.596842-14.699550)

More than knocked down 100% in 24 hours, and no longer upset, only part leg fine motion; Lethality 100% in 72 hours.

Preliminary assessment:

This medicine has the quick-acting double stomach poison functions of tagging to Groton bug, knocks down soon, and dosage is few, as long as in a single day polypide contacts medicinal powder, must knock down in 20 minutes, and no longer upset, only the part pin has fine motion, and 72 hours are thoroughly dead.As long as fine grasp cockroach ecological habit is found its place that haunts accurately, carry out the science dispenser, can reach the purpose of efficiently killing cockroach.

Cockroach killing powder The field of the present invention: in March, 92, cockroach killing powder of the present invention was respectively in residential building of worker dormitory, air force hostel to August, and the The field that scale does not wait is carried out in Qianmen, Beijing portion big restaurant, Capital Hotel dining room.Dormitory processing area 18 * 3M wherein ², offerd medicine 24 hours, killing the roach rate, to kill the roach rate in 51.4%, 36 hour be 100%, carries out regular cockroach density monitoring subsequently, to the 30th day, 60 days and the 90th day, the measuring density result still was zero.Follow up a case by regular visits to repeatedly reflection and do not find the cockroach activity.

The big restaurant processing area 500M of Qianmen portion ², Capital Hotel dining room processing area 1000M ²Cockroach is extremely many before this two places dispensing, density (only/people .5 minute) is noncountable, offerd medicine back 36 hours, killing rate all reaches more than 98%, follows up a case by regular visits to afterwards and tracing study 3 wheat harvesting periods, and minority cockroach activity (cockroach has the characteristics of hiding by day and coming out at night) is only found in reflection once in a while at night, after density obviously reduces, remaining minority cockroach, keeping medicinal powder for a long time is the best approach of dealing with problems, and also is simultaneously to consolidate the effective measure of going out and imitating.Here cockroach disappearance on daytime has obviously been controlled the preceding cockroach of dispensing and has been wreaked havoc the situation that causes harm, and the hotel manager and the staff at big restaurant are satisfied with to result.

This medicine uses (1200 through new technology new product research promotion portion of Beijing's spark technology research institute in Holland embassy in China ²); Use (400 through Dongcheng District, Beijing Commission for the Patriotic Health Campaign in national flag class of Beijing Garrison post ²) all obtain the satisfied effect of going out, be subjected to Mr. ambassador and cadres and soldiers' consistent favorable comment, and require to supply with its medicinal powder once more.

Above environment promptly toward all repeatedly handling with mechanically operated tagging property chrysanthemum ester class medicament and other drug, but does not all reach this effect.