CN102762983B - 系统性红斑狼疮（sle）的诊断 - Google Patents

系统性红斑狼疮（sle）的诊断 Download PDF

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Publication number
CN102762983B
CN102762983B CN201180009356.6A CN201180009356A CN102762983B CN 102762983 B CN102762983 B CN 102762983B CN 201180009356 A CN201180009356 A CN 201180009356A CN 102762983 B CN102762983 B CN 102762983B
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China
Prior art keywords
antigens
reactivity
sle
antigen
sample
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Expired - Fee Related
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CN201180009356.6A
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English (en)
Chinese (zh)
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CN102762983A (zh
Inventor
伊伦·R·柯亨
艾坦·多马尼
诺姆·申塔尔
伊泰·法塔尔
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Tel HaShomer Medical Research Infrastructure and Services Ltd
Yeda Research and Development Co Ltd
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Tel HaShomer Medical Research Infrastructure and Services Ltd
Yeda Research and Development Co Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/104—Lupus erythematosus [SLE]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Rehabilitation Therapy (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201180009356.6A 2010-02-12 2011-02-13 系统性红斑狼疮（sle）的诊断 Expired - Fee Related CN102762983B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30369110P 2010-02-12 2010-02-12
US61/303,691 2010-02-12
PCT/IL2011/000153 WO2011099012A1 (en) 2010-02-12 2011-02-13 Diagnosis of systemic lupus erythematosus (sle)

Publications (2)

Publication Number Publication Date
CN102762983A CN102762983A (zh) 2012-10-31
CN102762983B true CN102762983B (zh) 2016-01-20

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Family Applications (1)

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CN201180009356.6A Expired - Fee Related CN102762983B (zh) 2010-02-12 2011-02-13 系统性红斑狼疮（sle）的诊断

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US (2) US20130035254A1 (enExample)
EP (1) EP2534487B1 (enExample)
JP (1) JP5894539B2 (enExample)
CN (1) CN102762983B (enExample)
AU (1) AU2011213923A1 (enExample)
CA (1) CA2789411A1 (enExample)
ES (1) ES2560809T3 (enExample)
WO (1) WO2011099012A1 (enExample)

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EP2698636A1 (en) * 2012-08-13 2014-02-19 Fundació Institut d'Investigació Biomèdica de Bellvitge Methods and reagents for prevention and/or treatment of transplant rejection
US20160069896A1 (en) * 2012-12-16 2016-03-10 Yeda Research And Development Co., Ltd. Diagnosis of autoimmune diseases using a specific antibody profile
CN104007266B (zh) * 2013-02-27 2016-04-20 中国医学科学院基础医学研究所 含有6-n-甲基赖氨酸残基的抗原在制备辅助诊断系统性红斑狼疮试剂中的应用
US11531033B2 (en) * 2013-03-15 2022-12-20 Exagen Inc. Methods for treating and diagnosing systemic lupus erythematosus
WO2015101988A1 (en) * 2013-12-31 2015-07-09 Yeda Research And Development Co. Ltd. Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
EP3090263A4 (en) 2013-12-31 2017-08-23 Yeda Research and Development Co., Ltd. Methods for assaying immunological competence
EP2933639A1 (en) * 2014-04-16 2015-10-21 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts S100p and Hyaluronic acid as biomarkers for metastatic breast cancer
EP3134733B1 (en) * 2014-04-25 2020-10-14 The Brigham and Women's Hospital, Inc. Assay and method for treating subjects with immune-mediated diseases
CN107110861A (zh) * 2014-08-08 2017-08-29 阿勒格尼-辛格研究所 作为诊断性生物标志物的抗淋巴细胞的自身抗体
EP3265814B1 (en) * 2015-03-01 2020-11-18 Immunarray Ltd. Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens
WO2017223116A2 (en) 2016-06-20 2017-12-28 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
EP3472181A4 (en) 2016-06-20 2020-05-13 Healthtell Inc. METHOD FOR DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASES
AU2017357818A1 (en) 2016-11-11 2019-05-30 HealthTell, Inc. Methods for identifying candidate biomarkers
EP3555625A1 (en) * 2016-12-16 2019-10-23 Merck Patent GmbH Methods for the use of galectin 3 binding protein detected in the urine for monitoring the severity and progression of lupus nephritis
CN107151672B (zh) * 2017-05-11 2021-05-28 成都医学院 一种重组质粒及其用途
US11480568B2 (en) 2017-09-28 2022-10-25 Yeda Research And Development Co. Ltd. Diagnosis of autoimmune diseases
BR102018075339A2 (pt) * 2018-12-06 2021-11-16 Fundação Oswaldo Cruz Proteína recombinante, sequência de dna sintético, vetor de expressão, célula hospedeira, composição, kit para diagnóstico de rubéola, uso de pelo menos uma proteína recombinante, e, métodos para produzir uma proteína recombinante e para diagnóstico de rubéola

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US5552391A (en) * 1990-01-16 1996-09-03 La Jolla Pharmaceutical Company Chemically-defined non-polymeric valency platform molecules and conjugates thereof
AU2001259230A1 (en) * 2000-04-28 2001-11-12 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of polyclonal b cell activation and immunoglobulin class switching topathogenic autoantibodies by blocking cd1-mediated interactions
IL137460A0 (en) 2000-07-24 2001-07-24 Yeda Res & Dev Identifying antigen clusters for monitoring a global state of an immune system
DE60141171D1 (de) * 2000-11-27 2010-03-11 Intelligent Medical Devices Ll Klinische intelligente diagnostische vorrichtungen und verfahren
ES2239532B1 (es) * 2004-02-06 2006-11-01 Proyecto De Biomedicina Cima S.L. Metodo para evaluar el riesgo y la predisposicion a desarrollar una patologia relacionada con la presencia de autoanticuerpos frente a epcr.
US20050260770A1 (en) 2004-04-01 2005-11-24 Cohen Irun R Antigen array and diagnostic uses thereof
US20070141627A1 (en) * 2005-10-19 2007-06-21 Behrens Timothy W Systemic Lupus Erythematosus
EP2089712A4 (en) * 2006-11-22 2010-09-22 Life Technologies Corp BIOMARKERS OF AUTOIMMUNE DISEASES
CN101329341B (zh) * 2008-07-09 2012-06-27 北京美康生物技术研究中心 检测自身免疫疾病相关抗核抗体谱的试剂盒及其制备方法
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Non-Patent Citations (1)

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Also Published As

Publication number Publication date
JP2013519875A (ja) 2013-05-30
EP2534487A1 (en) 2012-12-19
US20140342939A1 (en) 2014-11-20
EP2534487B1 (en) 2015-11-04
AU2011213923A1 (en) 2012-08-30
WO2011099012A1 (en) 2011-08-18
US20130035254A1 (en) 2013-02-07
JP5894539B2 (ja) 2016-03-30
ES2560809T3 (es) 2016-02-22
CN102762983A (zh) 2012-10-31
CA2789411A1 (en) 2011-08-18

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