CN102759481A - Multi-cell mechanical simulation experiment platform - Google Patents
Multi-cell mechanical simulation experiment platform Download PDFInfo
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- CN102759481A CN102759481A CN2012102117928A CN201210211792A CN102759481A CN 102759481 A CN102759481 A CN 102759481A CN 2012102117928 A CN2012102117928 A CN 2012102117928A CN 201210211792 A CN201210211792 A CN 201210211792A CN 102759481 A CN102759481 A CN 102759481A
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Abstract
The invention provides a multi-cell mechanical loading device. The loading device comprises a piston of which the upper end is provided with a brace and a loading box of which one side is provided with an opening, wherein the specification of the piston is consistent with the internal specification of the loading box; the bottom of the loading box is provided with a sensor; and a signal acquisition instrument is arranged outside the loading box. The invention also provides a multi-cell mechanical simulation experiment platform. The experiment platform comprises the multi-cell mechanical loading device as mentioned above, a computer system and a universal material testing machine with a clamp, wherein the multi-cell mechanical loading device is fixed on the clamp; and the computer system is connected with the universal material testing machine. The invention has the following advantages: through the up-and-down movement of the piston, air is compressed to load pressure to cells, the stress uniformity of the cells can be ensured, and the accuracy of the determination result can be improved; the movement of the piston is controlled by the universal material testing machine, the pressure loading process can be exactly simulated, rapid response is achieved, and a complicated pressure change process can be simulated; and the multi-cell mechanical simulation experiment platform has the advantages of simple structure and convenience in operation.
Description
Technical field
The present invention relates to cell biological mechanical technology field, specifically, is a kind of cellulous mechanical simulation experiment porch.
Background technology
Cell biological mechanics (mechanocytobiology) is the forward position of current life science development; The many aspects that relate to cyto-mechanics research; Wherein one of focus be exactly cell because of the caused damage of mechanical force, and about mechanical function cell growth, reformation, mechanical signal transduction and gene expression so that cause the influence of processes such as ATP is synthetic.The further investigation of cell biological mechanics; Not only the research to biomechanics, biomechanical model and the biomaterial etc. of current cell and organizational project, molecular biosciences mechanics and bioengineering, various soft or hard tissues has played important facilitation; And, will bring into play influence difficult to the appraisal for the further developing and break through of life science.
Conventional macromechanics loading method and experimental technique can't directly be used on cell, will be the matter of utmost importance that the cell biological mechanics is faced so seek suitable cell loading method with cytomorphosis and relevant biology measurement means.Cyto-mechanics experimental technique commonly used is divided into unicellular experimental technique and many cells experimental technique; Totally can be divided into four types: 1. adopt microtechnic and micropipette aspiration method directly individual cells to be loaded; And through real time record system record in addition; Utilize Flame Image Process appearance and computing machine to carry out displacement measurement and numerical analysis on deformation, its typical case's representative is exactly the micropipette aspiration experimental technique; 2. adopt other medium, utilize rheology principle indirectly pair cell load, like flow cell, suspension technology, micropore screen method etc., mainly be to load through shearing force or pressure pair cell that fluid flow to produce; 3. the base material that utilizes pair cell to adhere to loads; After base material is loaded, the strain of base material is delivered on the cell, like the unidirectional strain loading of four-point bending beam and two-way strain loading method, gas boosting loading technique and the three-dimensional loading technique etc. of membrane material; 4. utilize direct pair cell surface receptor to apply the method for magnetic field distortion power, measure the variation of cytoskeleton rigidity.
Above-mentioned four types of experimental techniques commonly used be applicable to separately the cell type that will study and its relative merits are respectively arranged, as not reflecting physiological status of cells, complex structure, costing an arm and a leg etc.Like Chinese periodical " Chinese Tissue Engineering Study and clinical rehabilitation "; The 13rd volume, the 22nd phase, the article of publishing " development and the application of cell in vitro compressive stress charger "; A kind of cell in vitro compressive stress charger is disclosed; The principle of work of this device is: cultivation article and the cultured cells thereof that will keep cells in vitro existence and growth are put into cell culture chamber, and the gases at high pressure in high-pressure gas chamber (steel cylinder) get in the cell culture chamber, when the pressure in the cell culture chamber reaches predetermined value with pressure stable after the two-stage decompression device reduces pressure certain pressure; Close the air inlet solenoid valve, form stable closed environment in the cell culture chamber.Compressive stress loading section principle makes the periodicity air pressure change that forms certain frequency, size in the cell culture chamber, thereby makes the cell in the cell culture chamber receive corresponding action of compressive stress for utilizing the pressurization of branch line step motor drive cylinder.Experiment finishes, and opens exhaust solenoid valve, and gas is discharged through it.The device can be the size of loading stress, the role of the frequency and duration of action of quantitative control, etc., but the device has the following defects: (1) cell culture chamber of the cylinder through the pipe connection through the gas by-pass pipe end into the cell culture After the diffusion chamber, and the gas diffusion promotion of diffusion of both the front, but also the surrounding dispersion, which leads to cell culture chamber by the force of a cell is not uniform, there is an error simulation results; (2) to multi-stage pressure relief devices, solenoid valve to control the size of the gas frequency and pressure, the reaction components are working long hours, poor sensitivity for more complex mechanical loading process is difficult to simulate, for example, the old Chinese inventor Ding Jifeng "Rolling Dagon Law" Operation kinetic curves show: Rolling Dagon Law vertical wave amplitude is high, ascending branch steep rise angle, sharp peaks, descending branch of the wave amplitude swing back up to the main wave (before the swing wave) 1/3 to 1 / 2, a sharp peak, and the process is complicated because the mechanical loading of pressure adjacent the gap between the process, therefore the use of the device will not be accurately simulated.In sum, need a kind of mechanics loading procedure of accurately Simulation of Complex badly, pressure-loaded is installed uniformly, but does not also appear in the newspapers about this type device at present.
Biomaterial pilot system (MTS); Claim universal testing machine, the test of multiaxis biomechanics and sport simulated system again; Adopt the electronic technology mode that combines with mechanical drive, the measurement and the control of load, distortion, displacement is had higher precision and sensitivity, can carry out that constant speed loads, the automatic control of constant speed distortion, constant speed displacement tests; And the function of hanging down all load cycle, distortion circulation, displacement cycle is arranged, be widely used in the biomechanics experiment of tissue.It can also export variable pressure as requested; The kinetic curve of complex pressure change procedures such as simulation massage manipulation; This provides possibility for mechanics loading procedure and uniform device of pressure-loaded of developing above-mentioned accurately Simulation of Complex, thereby is that the gimmick simulation experiment platform that makes up based on the cell biological mechanics provides possibility.
Summary of the invention
The objective of the invention is provides a kind of mechanics loading procedure, pressure-loaded many cells mechanical loading unit even, simple in structure, easy and simple to handle of accurately Simulation of Complex to deficiency of the prior art.
Another purpose of the present invention is that a kind of cellulous mechanical simulation experiment porch is provided.
For realizing above-mentioned purpose, the technical scheme that the present invention takes is:
A kind of many cells mechanical loading unit; Described charger comprises that the upper end is provided with the piston of brace and the loading case of an opening; The specification of described piston is consistent with loading case internal specifications, and described loading case bottom is provided with sensor, and the outside is provided with signal sampler.
Described piston all is cylindrical with loading case.
Described loading case is to be processed by organic glass.
Described sensor is a wireless senser.
Described sensor is a wired sensor, and described sensor is connected with signal sampler through lead.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is:
A kind of cellulous mechanical simulation experiment porch; Described experiment porch comprises as above arbitrary described many cells mechanical loading unit, computer system and is provided with the universal testing machine of anchor clamps; Described many cells mechanical loading unit is fixed on the anchor clamps, and described computer system is connected with universal testing machine.
The invention has the advantages that:
1, many cells mechanical loading unit of the present invention utilize piston the pressurized air that moves up and down with the pair cell on-load pressure, can guarantee that cell is stressed evenly, improve the accuracy of measuring the result;
What 2, cellulous mechanical simulation experiment porch of the present invention adopted is the motion of universal testing machine control piston, simulated pressure loading procedure accurately, and being quick on the draw, pressure change procedure that can Simulation of Complex;
3, cellulous mechanical simulation experiment porch of the present invention is simple in structure, and controllability is good, and is easy and simple to handle.
Description of drawings
Accompanying drawing 1 is a kind of many cells mechanical loading unit structural representation of the present invention.
Accompanying drawing 2 is a kind of cellulous mechanical simulation experiment porch structural representations of the present invention.
Figure 3 is a Ding Jifeng medium-sized rolling manipulation? Act dynamic curves.
Figure 4 is an analog rolling manipulation? Law curve.
Figure 5 is a simulation of rolling manipulation? France curve running track.
Accompanying drawing 6 is sinusoidal curve running orbits.
[embodiment]
Below in conjunction with accompanying drawing embodiment provided by the invention is elaborated.
The Reference numeral and the ingredient that relate in the accompanying drawing are as follows:
1. load case 2. pistons
3. brace 4. sensors
5. signal sampler 10. many cells mechanical loading units
20. universal testing machine 30. computer systems
6. anchor clamps 61. first anchor clamps
62. second anchor clamps
Embodiment 1 a kind of many cells mechanical loading unit of the present invention
Please with reference to Fig. 1, Fig. 1 is a kind of many cells mechanical loading unit structural representation of the present invention.Described many cells mechanical loading unit is provided with one and loads case 1, and described loading case 1 is processed by organic glass, and is cylindrical, outer dia 13cm, and inside diameter 10cm, high 13cm, the one side of upper end is an opening.Described many cells mechanical loading unit also is provided with a piston 2, and described piston 2 is cylindrical, and diameter is identical with the internal diameter that loads case 1, thickness 3cm.The central authorities of the upper end of described piston 2 are provided with brace 3, and described brace 3 also is a right cylinder, is processed by stainless steel material.The bottom of described loading case 1 is provided with the through hole (not shown), closely chimeric sensor 4 in the described through hole, and described sensor 4 is wireless sensers, end face and the bottom surface that loads case 1 are on a surface level.The outside of described loading case 1 also is provided with signal sampler 5.Described signal sampler 5 and sensor 4 are connected through wireless signal.
Embodiment 2 a kind of cellulous mechanical simulation experiment porchs of the present invention
Please with reference to Fig. 2, Fig. 2 is a kind of cellulous mechanical simulation experiment porch structural representation of the present invention.Described cellulous mechanical simulation experiment porch is provided with like the described many cells mechanical loading unit of embodiment 1 10, universal testing machine 20 and computer system 30.Described universal testing machine 20 is produced for American MTS company, and model is MTS858, is provided with anchor clamps 6, and described anchor clamps 6 comprise first anchor clamps 61 and second anchor clamps 62.Described many cells mechanical loading unit 10 is fixed between first anchor clamps 61 and second anchor clamps 62, and promptly the brace 3 and first anchor clamps 61 are fixing, and the bottom and second anchor clamps 62 that load case 1 are fixing.Described computer system 30 is connected with universal testing machine 20, in the described computer system 30 waveform compilation software is installed.
The method of application and the principle of work thereof of a kind of cellulous mechanical simulation experiment porch of the present invention are:
1. with many cells mechanical loading unit 10 usefulness ultraviolet ray irradiation of the present invention 1 hour, sterilization;
2. with cell inoculation in sterile petri dish, add cell culture fluid;
3. many cells mechanical loading unit 10 of the present invention is fixed on the anchor clamps 6 of universal testing machine 20, opens data collecting instrument 5, regulate zero point, in loading case 1, put into the double dish that contains cell culture fluid;
4. use universal testing machine 20 to load the 700N load, inspection loads case 1 and has or not gas leakage, and whether data collecting instrument 5 operations are normal;
5. utilize the waveform compilation software in the computer system 30, editor's simulation mechanics loading curve;
6. it is stressed that sensor 4 inductions load case 1 bottom, and send stress value to signal sampler 5 through wireless signal, and the output of regulation and control mechanics combines waveform and mechanics output, edits out the experiment working procedure.
In the whole process; Along with the variation of the load of exerting pressure, the piston 2 in the many cells mechanical loading unit 10 of the present invention moves up and down, through airtight gaseous conductance; Pressure load is applied on the cell that loads in the case 1 bottom double dish, causes cell stressed.
To the foregoing description 1-2; Need to prove; Many cells mechanical loading unit of the present invention is to adopt piston 2 to loading case 1 internal compression air on-load pressure of the same size with it, and the direction of motion of air is consistent downward, so the suffered pressure of cell is uniform; Because the loading of pressure is to realize through piston 2, and the motion of piston 2 only needs by universal testing machine 20 controls, thus simulated pressure loading procedure accurately, and also can accurately simulate for the pressure change procedure of complicacy; The shape of described loading case 1 and piston 2 is not limited only to cylindrical, and the two shape is consistent, piston 2 specifications are identical with loading case 1 internal specifications guarantees that the leakproofness that loads case 1 gets final product, as is designed to the fillet quadrilateral, but pref. cylindrical, to make things convenient for modeling; Described loading case 1 adopts organic glass to process, and its inner wall smooth can fit tightly with piston 2 all around, prevents gas leakage; Described piston 2 can use all-aluminium piston, cast-iron piston, cast-steel piston, aluminum matrix composite piston etc., is choice criteria with wear-resisting and good seal performance; For further guaranteeing to load the sealing of case 1, can around piston 2, be coated with the aseptic glycerine of one deck; The end face of described sensor 4 will remain on the surface level with the bottom surface that loads case 1, guarantees that the force value of sensor 4 impressions is identical with cell; Described sensor 4 also can adopt wired sensor, when using wired sensor, connects the transmission signal through lead between sensor 4 and the data collecting instrument 5; Described universal testing machine 20 is not limited only to embodiment 2, also can use the equipment of other producers, with the deformation measurement wide ranges, to be out of shape relative error of indicating value little be choice criteria.
Example 3 present invention is a multi-platform simulation cell mechanics simulation curve rolling manipulation France
1, experimental technique
In clinical trials screening Rolling Dagon France optimal kinetic parameters (power 4kg, frequency of 120 beats / min, time 10min) as the basic parameters, combined Ding Jifeng medium-sized rolling manipulation Act dynamic curves (Figure 3) and universal testing machine 20 of the technical requirements, the use of computer system 30 waveform editing program to design and regulate many cell mechanics loading force loading device 10 outputs, specific steps are:
1. the many cells mechanical loading unit 10 behind the ultraviolet irradiation is fixed on the universal testing machine 20, connects the power supply of the sensor 4 that loads case 1 bottom, open data collecting instrument 5, regulate zero point, will contain PBS damping fluid double dish and put into loading case 1 bottom;
2. start universal testing machine 20; Operation Basic Test Ware program; Be provided with displacement protection for (10mm ,-60mm), actuator is directed downwards and is negative value; Opening the Meters window after selecting Auto Offset program with the zeroing of MTS system deviation, is 0.1 with precision setting in the Sensitive option;
3. open hydraulic pressure, select manual control program, handle actuator drive piston 2 and in loading case 1, move up and down; Numerical value according to data collecting instrument 5 shows; Confirm the corresponding relation of applied force output and piston 2 displacements, and, be (100N between the load zones that experiment needs finally by the output of displacement range designation mechanics;-660N)/(160N ,-660N);
4. in the waveform compilation program, select Axial Displacement and Axial Command, be set at the curve of output longitudinal axis, in Plot Mode, select Time then as the curve of output transverse axis and with Auto Offset skew zeroing as control model;
⑤ According to the experimental requirements, the input analog rolling manipulation Act curve parameters / sine curve parameters, the output frequency of 2 Hz curve, the curve is output for 10 minutes, the output waveform editing program within 1200 cycles;
6. the curve output error of using the compensation of Pvc correction to program to cause because of factors such as skews, the fair curve waveform is removed the enable option in manually controlling, and selects the Interlock lock program, begins test;
7. open oscillograph, stable waveform is kept in the system, and observe its fitting effect;
8. save routine and curve behind the EOT, removal many cells mechanical loading unit 10 is closed hydraulic pressure at last, withdraws from the waveform compilation program.
2, experimental result
2.1 Analog rolling manipulation Act curve results
Simulated rolling manipulation Method shown in Figure 4.Universal testing machine set maximum pressure output 660N, minimum pressure output 100N, corresponding to the absolute displacement calibration is (-43.43mm,-47.50mm), analog rolling manipulation Method trajectory curve shown in Figure 5.
2.2 sinusoidal curve result
Rolling Dagon as an analog sine curve Law curve control, the universal testing machine maximum pressure output 600N, minimum pressure output 160N, corresponding to the relative displacement calibration is (-7.00mm, 7.00mm), frequency of 120 beats / min, duration of 10 minutes, the curve of the trajectory shown in Figure 6.
Can find out that from The above results many cells mechanical simulation experiment porch of the present invention is the simulated pressure loading procedure accurately.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; Can also make some improvement and replenish, these improvement and replenish and also should be regarded as protection scope of the present invention.
Claims (6)
1. many cells mechanical loading unit; It is characterized in that described charger comprises that the upper end is provided with the piston of brace and the loading case of an opening, the specification of described piston is consistent with loading case internal specifications; Described loading case bottom is provided with sensor, and the outside is provided with signal sampler.
2. many cells mechanical loading unit according to claim 1 is characterized in that, described piston all is cylindrical with loading case.
3. many cells mechanical loading unit according to claim 1 is characterized in that, described loading case is to be processed by organic glass.
4. according to the arbitrary described many cells mechanical loading unit of claim 1-3, it is characterized in that described sensor is a wireless senser.
5. according to the arbitrary described many cells mechanical loading unit of claim 1-3, it is characterized in that described sensor is a wired sensor, described sensor is connected with signal sampler through lead.
6. cellulous mechanical simulation experiment porch; It is characterized in that; Described experiment porch comprises like the arbitrary described many cells mechanical loading unit of claim 1-3, computer system and is provided with the universal testing machine of anchor clamps; Described many cells mechanical loading unit is fixed on the anchor clamps, and described computer system is connected with universal testing machine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109706079A (en) * | 2018-12-11 | 2019-05-03 | 江苏理工学院 | It is a kind of for simulating the flow cavity of flowing environment after bracket |
| CN111057640A (en) * | 2019-12-09 | 2020-04-24 | 西北工业大学 | Experimental device for in-situ research cell mechanical characteristics |
| US11603516B2 (en) | 2017-03-21 | 2023-03-14 | Centre National De La Recherche Scientifique | Device for mechanically characterizing an element of interest such as an oocyte |
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| CN101717719A (en) * | 2009-12-08 | 2010-06-02 | 四川大学 | In-vitro cell pressure loading device and in-vitro cell pressure loading method thereof |
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| CN1834220A (en) * | 2005-07-07 | 2006-09-20 | 重庆大学 | Microstress applicator for in vitro cell |
| CN101092595A (en) * | 2006-06-23 | 2007-12-26 | 上海交通大学医学院附属第九人民医院 | Experimental apparatus for loading cell through digital controlled mechanical strain |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11603516B2 (en) | 2017-03-21 | 2023-03-14 | Centre National De La Recherche Scientifique | Device for mechanically characterizing an element of interest such as an oocyte |
| CN109706079A (en) * | 2018-12-11 | 2019-05-03 | 江苏理工学院 | It is a kind of for simulating the flow cavity of flowing environment after bracket |
| CN109706079B (en) * | 2018-12-11 | 2022-03-25 | 江苏理工学院 | Flow cavity for simulating flowing environment behind bracket |
| CN111057640A (en) * | 2019-12-09 | 2020-04-24 | 西北工业大学 | Experimental device for in-situ research cell mechanical characteristics |
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