CN109706079A - It is a kind of for simulating the flow cavity of flowing environment after bracket - Google Patents
It is a kind of for simulating the flow cavity of flowing environment after bracket Download PDFInfo
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- CN109706079A CN109706079A CN201811509283.7A CN201811509283A CN109706079A CN 109706079 A CN109706079 A CN 109706079A CN 201811509283 A CN201811509283 A CN 201811509283A CN 109706079 A CN109706079 A CN 109706079A
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- bracket
- flow cavity
- cavity
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- slide bar
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Abstract
The present invention is a kind of for simulating the flow cavity of flowing environment after bracket, it is characterized by comprising external screw rods, sliding cavity is equipped among the external screw rod, rotation is equipped with slide bar in the sliding cavity, described slide bar one end is equipped with bracket tab, and the external screw rod is equipped with flow cavity close to one end of bracket tab, is equipped with groove among the flow cavity, glass slide is equipped in the groove, the slide bar passes through the sliding cavity and is located in the flow cavity.The present invention realize to after stenter to implant host blood vessel blood flow environment it is in-vitro simulated, for flow cavity bottom culture cell provide blood flow disturb mechanical stimulation.The invention lumen inner height can reconcile that scaffolding thread height of projection is adjustable to make the more flexible simulation bracket of this flow cavity enter a variety of mechanical environments after host blood vessel；By flow cavity bottom can quantitative observation the more true biological response of cell is cultivated under the mechanical environment, thus for research the bad phenomenons such as bracket postoperative restenosis and thrombus new tool is provided.
Description
Technical field
The present invention relates to a kind of for simulating the flow cavity of flowing environment after bracket, is a kind of to fill for biomedicine experiment
It sets, in particular to flow cavity is used in a kind of biofluid experiment.
Background technique
Intervention support is a kind of very common and efficient treatment method for treating occlusive arterial atherosclerotic condition.Though
Right intravascular stent has greatly been sent out in terms of its configuration, material, placement process and postoperative antithrombotic reagent
Exhibition, but the incidence of the postoperative higher Restenosis of the treatment method and advanced thrombus still affects its treatment effect so far
Fruit.The study found that the variation of Hemodynamic response occurs with stenting adverse events (restenosis and thrombus etc.), there is close
The relationship cut.
Flow cavity is the very effective tool of flowing environment in analogue body, however existing flat pattern flat flow chamber is insufficient
To simulate the mechanical environment after stenting.The bracket of blood vessel and different-thickness that the present invention is directed to different-diameter has invented one kind
New flow cavity is for simulating the flowing environment after stenting.
Summary of the invention
The present invention simulates the flowing environment after implantation stenting, and the present invention provides a kind of for simulating flowing environment after bracket
Flow cavity, including external screw rod, the external screw rod is equipped with sliding cavity, and sliding is equipped with slide bar, the slide bar in the sliding cavity
One end is equipped with bracket tab, and the external screw rod is equipped with flow cavity close to one end of bracket tab, and the flow cavity is equipped with and is used for
The groove of glass slide is placed, the slide bar passes through the sliding cavity, and is located in the flow cavity, and the flow cavity two sides are symmetrical
Equipped with inlet and outlet.
Preferably, the bracket tab is made of several bracket items and matrix, several bracket items are uniformly fixed on
One end of described matrix, the described matrix other end are fixed on the slide bar.The bracket tab gives the flowing intracavity liquid
Apply pressure, simulates different liquid environments.
Further, the external screw rod passes through the shell of screw thread and the flow cavity close to one end of the bracket tab
Connection.The flow cavity can be rotated by screw thread, the height in flow cavity be adjusted, to reach different experimental rings
Border.
Preferably, the slide bar is equipped with rubber ring, the rubber ring and the sliding cavity piston type sliding.The rubber
Cushion rubber seals, and prevents the liquid in the flow cavity from flowing out, meanwhile, the rubber ring is fixed on the slide bar, institute
Stating slide bar can slide up and down.
Further, the external screw rod is equipped with end cap far from one end of the flow cavity, and the end cap is fixed by screw
On the external screw rod, the end cap is equipped with the hole for being connected to the sliding cavity, and the slide bar is slided across the hole
It is arranged in sliding cavity.
Preferably, the slide bar is equipped with limited block far from one end of the bracket tab, the limited block diameter is greater than
The diameter in the hole.The limited block prevents the sliding bar from destroying the bacterium on the glass slide.
Further, the flow cavity is transparent resin glass material.
Preferably, the bracket tab is made of stainless steel or magnesium alloy.
The utility model has the advantages that the present invention realize to after stenter to implant host blood vessel blood flow environment it is in-vitro simulated, be flow cavity bottom
The culture cell in portion provides the mechanical stimulation of blood flow disturbance.The invention lumen inner height can reconcile that scaffolding thread height of projection is adjustable to be made
It obtains the more flexible simulation bracket of this flow cavity and enters a variety of mechanical environments after host blood vessel；Pass through quantifying for flow cavity bottom
The more true biological response of cell is cultivated in observation under the mechanical environment (after stenter to implant), thus after for research stenting
The bad phenomenons such as restenosis and thrombus provide new tool.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is Slide bar structure schematic diagram of the invention；
Fig. 3 is flow cavity structural schematic diagram of the invention；
Fig. 4 is external screw rod structural schematic diagram of the invention；
1, flow cavity；2, external screw rod；3, rubber ring；4, bracket tab；5, slide bar；6, end cap；7, groove；8, limited block；
9, sliding cavity；10, import；11, it exports；12, matrix；13, bracket item.
Specific embodiment
As shown in Figure 1, a kind of for simulating the flow cavity 1 of flowing environment after bracket, it is characterised in that: including external screw rod 2,
The external screw rod 2 is equipped with sliding cavity 9, and sliding is equipped with slide bar 5 in the sliding cavity 9, and described 5 one end of slide bar is equipped with bracket tab
4, the bracket tab 4 is made of stainless steel or magnesium alloy, and the bracket tab 4 is made of several bracket items 13 and matrix 12,
Several bracket items 13 are uniformly fixed on one end of described matrix 12, and 12 other end of described matrix is fixed on the slide bar 12
On.The bracket tab 4 applies pressure to liquid in the flow cavity 1, simulates different liquid environments.
The external screw rod 2 passes through the cage connection of screw thread and the flow cavity 1, the stream close to one end of bracket tab 4
Dynamic chamber 1 is transparent resin glass material, and the flow cavity 1 can be rotated by screw thread, adjusts the height in flow cavity 1,
To reach different experimental situations.The groove 7 for placing glass slide is equipped among the flow cavity 1, the slide bar 5 passes through described
Sliding cavity 9 is located in the flow cavity 1.The slide bar 5 is equipped with rubber ring 3, and the rubber ring 3 is slided with the sliding cavity 9
Connection.The rubber ring 3 seals, and prevents the liquid in the flow cavity 1 from flowing out, meanwhile, the rubber ring 3 is fixed on
On the slide bar 5, the slide bar 5 can be slided up and down.The external screw rod 2 is equipped with end cap 6 far from one end of the flow cavity 1,
The end cap 6 is fixed by screws on the external screw rod 2, and the end cap 6 is equipped with for being connected to the sliding cavity 9
Hole, the slide bar 5 pass through the hole and are slidably arranged in sliding cavity 9.1 two sides of flow cavity are symmetrically arranged with import 10 and outlet
11.The slide bar 5 is equipped with limited block 8 far from one end of the bracket tab 4, and 8 diameter of limited block is greater than the straight of the hole
Diameter.The limited block 8 prevents the sliding of slide bar 5 beyond stroke, to destroy the bacterium on the glass slide.
Concrete mode: adjusting slide bar 5 when testing using equipment first reaches bracket tab 4 in flow cavity 1, complies with
Needed for experiment, it then in 1 base channel of cell glass slide flow cavity with endothelial cell, will then adjust external screw rod 2 and to flow
Dynamic 1 inner height of chamber is identical as host blood vessel after stenting, and flow cavity 1 is connected in perfusion circuit, is observed by inverted microscope
The growth conditions of endothelial cell.
Claims (8)
1. a kind of for simulating the flow cavity of flowing environment after bracket, it is characterised in that: including external screw rod (2), the external screw rod
(2) sliding cavity (9) are equipped with, sliding is equipped with slide bar (5) in the sliding cavity (9), and described slide bar (5) one end is equipped with bracket tab
(4), the external screw rod (2) is equipped with flow cavity (1) close to the one end of bracket tab (4), and the flow cavity (1) is equipped with for putting
The groove (7) of glass slide is set, the slide bar (5) passes through the sliding cavity (9), and is located in the flow cavity (1), the flowing
Chamber (1) two sides are symmetrically arranged with import (10) and outlet (11).
2. according to claim 1 a kind of for simulating the flow cavity of flowing environment after bracket, it is characterised in that: the branch
Frame protrusion (4) is made of several bracket items (13) and matrix (12), and several bracket items (13) are uniformly fixed on described matrix
(12) one end, described matrix (12) other end are fixed on the slide bar (12).
3. according to claim 1 a kind of for simulating the flow cavity of flowing environment after bracket, it is characterised in that: described
External screw rod (2) passes through the cage connection of screw thread and the flow cavity (1) close to the one end of the bracket tab (4).
4. according to claim 1 a kind of for simulating the flow cavity of flowing environment after bracket, it is characterised in that: the cunning
Bar (5) is equipped with rubber ring (3), and the rubber ring (3) is slidably connected with the sliding cavity (9).
5. according to claim 1 a kind of for simulating the flow cavity of flowing environment after bracket, it is characterised in that: described outer
Screw rod (2) is equipped with end cap (6) far from the one end of the flow cavity (1), and the end cap (6) is fixed by screws in the external screw rod
(2) on, the end cap (6) is equipped with the hole for being connected to the sliding cavity (9), and the slide bar (5) is slided across the hole
Setting is in sliding cavity (9).
6. according to claim 5 a kind of for simulating the flow cavity of flowing environment after bracket, it is characterised in that: the cunning
Bar (5) is equipped with limited block (8) far from the one end of the bracket tab (4), and limited block (8) diameter is greater than the straight of the hole
Diameter.
7. according to claim 1 a kind of for simulating the flow cavity of flowing environment after bracket, it is characterised in that: the stream
Dynamic chamber (1) is transparent resin glass material.
8. according to claim 1 a kind of for simulating the flow cavity of flowing environment after bracket, it is characterised in that: the branch
Frame protrusion (4) is made of stainless steel or magnesium alloy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811509283.7A CN109706079B (en) | 2018-12-11 | 2018-12-11 | Flow cavity for simulating flowing environment behind bracket |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811509283.7A CN109706079B (en) | 2018-12-11 | 2018-12-11 | Flow cavity for simulating flowing environment behind bracket |
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| Publication Number | Publication Date |
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| CN109706079A true CN109706079A (en) | 2019-05-03 |
| CN109706079B CN109706079B (en) | 2022-03-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811509283.7A Active CN109706079B (en) | 2018-12-11 | 2018-12-11 | Flow cavity for simulating flowing environment behind bracket |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110675717A (en) * | 2019-10-10 | 2020-01-10 | 吉林大学 | Bionic equipment for simulating vascular stenosis and thrombus |
| CN113503906A (en) * | 2021-08-11 | 2021-10-15 | 清华大学 | In-vitro circulation experiment table and method for medical implant intervention body thrombosis |
| CN113503907A (en) * | 2021-08-11 | 2021-10-15 | 清华大学 | In-vitro circulation experiment table and experiment method for medical implant intervention body observation |
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| CN201217661Y (en) * | 2008-03-28 | 2009-04-08 | 天津理工大学 | Double-frequency loading bioreactor for artificial cartilage construction |
| CN201817494U (en) * | 2010-08-10 | 2011-05-04 | 中国人民解放军军事医学科学院卫生装备研究所 | Dynamic loading and circular perfusion bioreactor |
| CN202201907U (en) * | 2011-04-11 | 2012-04-25 | 中国人民解放军第二军医大学 | Cell stress culture apparatus |
| CN102759481A (en) * | 2012-06-26 | 2012-10-31 | 上海中医药大学附属岳阳中西医结合医院 | Multi-cell mechanical simulation experiment platform |
| CN102936567A (en) * | 2012-10-23 | 2013-02-20 | 重庆大学 | Microtopological-structure plate flow chamber capable of applying electric and shearing force stimulation |
| CN104007029A (en) * | 2014-05-27 | 2014-08-27 | 华南理工大学 | Dynamic mechanical experimental device and method for tissue engineering scaffold |
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2018
- 2018-12-11 CN CN201811509283.7A patent/CN109706079B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201217661Y (en) * | 2008-03-28 | 2009-04-08 | 天津理工大学 | Double-frequency loading bioreactor for artificial cartilage construction |
| CN201817494U (en) * | 2010-08-10 | 2011-05-04 | 中国人民解放军军事医学科学院卫生装备研究所 | Dynamic loading and circular perfusion bioreactor |
| CN202201907U (en) * | 2011-04-11 | 2012-04-25 | 中国人民解放军第二军医大学 | Cell stress culture apparatus |
| CN102759481A (en) * | 2012-06-26 | 2012-10-31 | 上海中医药大学附属岳阳中西医结合医院 | Multi-cell mechanical simulation experiment platform |
| CN102936567A (en) * | 2012-10-23 | 2013-02-20 | 重庆大学 | Microtopological-structure plate flow chamber capable of applying electric and shearing force stimulation |
| CN104007029A (en) * | 2014-05-27 | 2014-08-27 | 华南理工大学 | Dynamic mechanical experimental device and method for tissue engineering scaffold |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110675717A (en) * | 2019-10-10 | 2020-01-10 | 吉林大学 | Bionic equipment for simulating vascular stenosis and thrombus |
| CN113503906A (en) * | 2021-08-11 | 2021-10-15 | 清华大学 | In-vitro circulation experiment table and method for medical implant intervention body thrombosis |
| CN113503907A (en) * | 2021-08-11 | 2021-10-15 | 清华大学 | In-vitro circulation experiment table and experiment method for medical implant intervention body observation |
| CN113503906B (en) * | 2021-08-11 | 2022-12-20 | 清华大学 | In-vitro circulation experiment table and method for medical implant intervention body thrombosis |
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| CN109706079B (en) | 2022-03-25 |
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