CN102755692A - Ultrasonic wave and ion conduction transdermal medicament or cosmetic conduction device - Google Patents
Ultrasonic wave and ion conduction transdermal medicament or cosmetic conduction device Download PDFInfo
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- CN102755692A CN102755692A CN2012102649525A CN201210264952A CN102755692A CN 102755692 A CN102755692 A CN 102755692A CN 2012102649525 A CN2012102649525 A CN 2012102649525A CN 201210264952 A CN201210264952 A CN 201210264952A CN 102755692 A CN102755692 A CN 102755692A
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Abstract
The invention discloses an ultrasonic wave and ion conduction transdermal medicament or cosmetic conduction device, which comprises a central processing unit, a signal generator, a piezoelectric ceramic, a pointed metal electrode and a booster circuit, wherein the central processing unit is used for receiving a control command and outputting a waveform control signal; the signal generator is used for generating high-frequency waves, low-frequency waves or high and low-frequency waves; the piezoelectric ceramic is used for converting electric energy into mechanical energy to generate mechanical vibration of corresponding frequency; the pointed metal electrode is used for making low-frequency current flow into skin in a concentrated way through an electrode tip and transmitting ultrasonic waves generated by the piezoelectric ceramic onto the skin through the electrode tip; and the booster circuit is used for providing a stable and appropriate voltage for an entire circuit system. In the device, ultrasonic wave and ion conduction methods are combined, so that medicament or cosmetic components with treatment effects are conducted into skin. Through the method, medicaments can be directly conducted into superficial focuses and have high concentrations and long acting time in local superficial tissues, and the administration amount can be decreased greatly; and moreover, the method is low in cost, and has small side effects.
Description
Technical field
The invention belongs to medicine or cosmetics leading-in technique field, relate in particular to a kind of ultrasound wave and iontophoresis transdermal drug or cosmetics gatherer.
Background technology
Existing iontophoresis generally is unidirectional importing.The shortcoming of unidirectional importing is that electric current only flows to a direction, and the mobile electrochemical reaction that causes of electric current changes the PH of skin, causes skin injury easily.In addition, get into skin corium because the existence of keratodermatitis makes general molecule be difficult to penetrate horny layer, therefore rely on iontophoresis separately, the concordance of molecule infiltration amount is poor, and infiltration capacity is little.At last, the impedance of skin is increased along with importing reducing of electric current, and often in the little current range of trapezoidal wave, the voltage of circuit can not be kept the predetermined current amplitude.
Summary of the invention
The purpose of the embodiment of the invention is to provide a kind of ultrasound wave and iontophoresis transdermal drug or cosmetics gatherer and method; The shortcoming that is intended to solve unidirectional importing is that electric current only flows to a direction; And the mobile electrochemical reaction that causes of electric current changes the PH of skin surface liquid, causes skin injury easily; Because the existence of keratodermatitis makes general molecule be difficult to penetrate horny layer and gets into skin corium, therefore rely on iontophoresis separately, the concordance of molecule infiltration amount is poor, and infiltration capacity is little; The impedance of skin is increased along with importing reducing of electric current, and often in the little current range of trapezoidal wave, the voltage of circuit can not be kept the problem of predetermined current amplitude.In addition, ultrasound wave can make the horny layer of skin loosening, and permeability strengthens; Together use with iontophoresis, importing efficient is greatly increased, import volume increases, and concordance is strong, shortens to import required time.
The embodiment of the invention is achieved in that a kind of ultrasound wave and iontophoresis transdermal drug or cosmetics gatherer, and this gatherer comprises:
CPU is used to receive control instruction, the output waveform control signal;
Signal generator receives the control signal of said CPU, produces also output high frequency waves;
Piezoelectric ceramics or piezoquartz are used to receive the signal of telecommunication of said signal generator, and electric energy is converted into mechanical energy, produce the mechanical vibration of corresponding frequencies, to strengthen the effect of iontophoresis; And
Be with sharp metal electrode, be used to be used in 1) the concentrated eletrode tip inflow skin that passes through of low-frequency current; 2) ultrasound wave that piezoelectric ceramics or piezoquartz is produced is launched to skin through eletrode tip; While two interpolar low-frequency voltages of metal electric or electric current constitute preset electromotive force or the electric current that drives iontophoresis; Iontophoresis and ultrasound wave import simultaneously and take place, and make medicine and the cosmetics deep that better penetrates to the skin;
Booster circuit, being used to the entire circuit system provides and stablizes suitable voltage, makes system works in stable voltage environment.
Further, be with sharp surface of metal electrode that the inert metal of plating coating is arranged, electrode surface can not corroded because of electrochemical reaction.
Further, drive the preset electromotive force or the current cycle sex reversal of iontophoresis, it is little that the PH of the medicine that causes in the iontophoresis process or cosmetics is changed, and guarantees that skin acid and alkali alkalescence stimulates.
Further; The electric current that drives iontophoresis in amplitude less than 0.1 milliampere to 0.001 MAH; The sense of current directly reverses, and skin impedance under low current uprises, and makes that to keep the electric current required voltage too high; Possibly surpass the voltage that circuit can provide, therefore this waveform can avoid circuit to break down because of enough voltage can not be provided.
Further, the sharp metal electrode of said band can be used and be with sharp carbon rubber electrode to substitute.
Further, power knob and model selection button also are installed on the user interface of said gatherer.
Further, said CPU adopts single-chip microcomputer or microcontroller.
Further, adopt booster circuit to strengthen output power of circuit, further strengthen hyperacoustic importing effect.
The present invention combines ultrasound wave and ion treatment to import and intravitally makes medicative ingredient, and medicine can directly import and show shallow intralesional, shows higher, the long action time of concentration in the shallow tissue in the part.The method is more efficient than general iontophoresis, and dosage can reduce greatly, and this method expense is low, and side effect is little, and curative effect is good more than general ointment.
Description of drawings
Fig. 1 is the parallel transdermal drug of the ultrasound wave that provides of the embodiment of the invention and iontophoresis or the structured flowchart of cosmetics gatherer; Fig. 2 is the parallel transdermal drug of the ultrasound wave that provides of the embodiment of the invention and iontophoresis or the flow chart of cosmetics introduction method;
Fig. 3 is the oscillogram of the skin surface current variation that provides of the embodiment of the invention;
Fig. 4 is the parallel transdermal drug of the ultrasound wave that provides of the embodiment of the invention and iontophoresis or the structure principle chart of cosmetics gatherer.
Among the figure: 1, power knob and mode button; 2, CPU; 3, booster circuit; 4, signal generator; 5, piezoelectric ceramics; 6, be with sharp metal electrode.
The specific embodiment
In order to make the object of the invention, technical scheme and advantage clearer,, the present invention is further elaborated below in conjunction with accompanying drawing and embodiment.Should be appreciated that specific embodiment described herein only in order to explanation the present invention, and be not used in qualification the present invention.
Fig. 1 and Fig. 4 show ultrasound wave and parallel transdermal drug or the cosmetics introduction method system of iontophoresis that case study on implementation of the present invention provides.
This system comprises:
Power knob and model selection button 1, the user can pass through these buttons, selects the pattern oneself liked, and these signals directly are transferred to CPU 2 then, accomplish the pattern that users want by CPU 2 then;
Signal generator 4, the control signal of reception CPU, the corresponding signal of generation is communicated to the piezoelectric ceramics 5 of back;
Duty mainly contains the generation of low frequency wave, the generation of high frequency waves, and the low-and high-frequency ripple produces simultaneously, for example circuit such as MAX038.
Be with sharp metal electrode 6; Make and be added in piezoelectric ceramics 5 and piezoelectric ceramics 5 propagated with the ultrasound wave that the electric current vibrations produce through its tip to skin with high frequency electric between the sharp metal electrode 6 or voltage; Simultaneously two interpolar voltages of metal electric (+VPP with-VPP) constitute preset electromotive force or the electric current that drives iontophoresis; Like this, iontophoresis and ultrasound wave import simultaneously and take place, and make medicine and the cosmetics deep that better penetrates to the skin.
Fig. 2 shows ultrasound wave and parallel transdermal drug or the cosmetics introduction method of iontophoresis that case study on implementation of the present invention provides, and this method comprises:
In step S101, at first the user can select the pattern oneself liked through power knob and model selection button 1, and these signals directly are transferred to CPU 2 then, accomplish the pattern that users want by CPU 2 then.
In step S102, CPU 2 control signal generators 4 produce the corresponding signal of telecommunication;
In step S103; Be added in piezoelectric ceramics 5 and make piezoelectric ceramics 5 produce ultrasound wave with the electric current vibrations with high frequency electric between the sharp metal tape point metal electrode 6 or voltage; And through propagating to skin with the tip of sharp metal electrode 6 with point, simultaneously two interpolar voltages of metal electric (+VPP with-VPP) constitute preset electromotive force or the electric current that drives iontophoresis, like this; Iontophoresis and ultrasound wave import simultaneously and take place, and make medicine and the cosmetics deep that better penetrates to the skin.
Piezoelectric ceramics itself has can be with mechanical energy and the electric energy function of conversion mutually, so when the signal of telecommunication was communicated to piezoelectric ceramics, the mechanical vibration that have corresponding frequencies produced, and then drive face pastes vibrations, to reach the effect of iontophoresis.
Piezoelectric ceramics itself can not produce ultrasound wave, except piezoelectric ceramics or piezoquartz, also has the electrode of oneself in the supersonic generator.With the electrode in sharp metal electrode and the supersonic generator is not one.Effect with sharp electrode is to let ultrasound wave concentrate on point go up to the skin emission, and electric current also can be concentrated to skin from point and flow in addition.
As shown in Figure 3; When the present invention specifically uses; At first the user can select the pattern oneself liked through power knob and model selection button 1, and these signals directly are transferred to CPU 2 then, accomplish the pattern that users want by CPU 2 then; The power-supply system of whole system is provided by booster circuit 3, can stablize suitable voltage for the entire circuit system provides, and makes system works in stable voltage environment; CPU 2 control signal generators 4 produce the corresponding signal of telecommunication; Being added in high frequency electric on the supersonic generator 5 of piezoelectric ceramics or piezoquartz manufacturing or voltage makes supersonic generator 5 produce ultrasound wave with the electric current vibrations; And through propagating to skin with the tip of sharp metal electrode 6; Simultaneously two interpolar voltages of metal electric (+VPP with-VPP) constitute preset electromotive force or the electric current that drives iontophoresis; Like this, iontophoresis and ultrasound wave import simultaneously and take place, and make medicine and the cosmetics deep that better penetrates to the skin.
Transdermal drug or cosmetics introduction method that ultrasound wave that the embodiment of the invention provides and iontophoresis are parallel; At first the user can select the pattern oneself liked through power knob and model selection button 1; These signals directly are transferred to CPU 2 then, accomplish the pattern that the user wants by CPU 2 then; The power-supply system of whole system is provided by booster circuit 3, can stablize suitable voltage for the entire circuit system provides, and makes system works in stable voltage environment; CPU 2 control signal generators 4 produce the corresponding signal of telecommunication; Being added in by the supersonic generator 5 of piezoelectric ceramics or piezoquartz manufacturing with the high frequency voltage between the sharp metal electrode 6 makes supersonic generator produce ultrasound wave; And through propagating to skin with the tip of sharp metal electrode 6; Simultaneously two interpolar voltages of metal electric (+VPP with-VPP) constitute preset electromotive force or the electric current that drives iontophoresis; Like this, iontophoresis and ultrasound wave import simultaneously and take place, and make medicine and the cosmetics deep that better penetrates to the skin.
The embodiment of the invention combines ultrasound wave and ion treatment and imports the intravital medicative ingredient that makes,, and medicine can directly import and show shallow intralesional, shows higher, the long action time of concentration in the shallow tissue in the part.The method is more efficient than general iontophoresis, and dosage can reduce greatly, and this method expense is low, and side effect is little, and curative effect is good more than general ointment.
The above is merely preferred embodiment of the present invention, not in order to restriction the present invention, all any modifications of within spirit of the present invention and principle, being done, is equal to and replaces and improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. a ultrasound wave and iontophoresis transdermal drug or cosmetics gatherer is characterized in that this gatherer comprises:
CPU is used to receive control instruction, the output waveform control signal;
Signal generator receives the control signal of said CPU, the high frequency waves that generation and output and ultrasonic frequency are suitable;
Piezoelectric ceramics or piezoquartz are used to receive the signal of telecommunication of said signal generator, and electric energy is converted into mechanical energy, produce the mechanical vibration of corresponding frequencies,, to strengthen the effect that imports; And be with sharp metal electrode, and be used to make 1) the concentrated eletrode tip inflow skin that passes through of low-frequency current; 2) ultrasound wave that piezoelectric ceramics is produced is launched to skin through eletrode tip; Iontophoresis and ultrasound wave import simultaneously and take place, and make medicine and the cosmetics deep that better penetrates to the skin;
Booster circuit, being used to the entire circuit system provides and stablizes suitable voltage, makes system works in stable voltage environment.
2. gatherer as claimed in claim 1 is characterized in that, is with sharp surface of metal electrode that the inert metal of plating coating is arranged, and electrode surface can not corroded because of electrochemical reaction.
3. gatherer as claimed in claim 1 is characterized in that, drives the preset electromotive force or the current cycle sex reversal of iontophoresis, and it is little that the PH of the medicine that causes in the iontophoresis process or cosmetics is changed, and guarantees that skin acid and alkali alkalescence stimulates.
4. gatherer as claimed in claim 1 is characterized in that, the electric current that drives iontophoresis amplitude less than 0.1 milliampere to 0.001 MAH, the sense of current directly reverses.
5. gatherer as claimed in claim 1 is characterized in that, the sharp metal electrode of said band can be used and be with sharp carbon rubber electrode to substitute.
6. gatherer as claimed in claim 1 is characterized in that, power knob and model selection button also are installed on the user interface of said gatherer.
7. gatherer as claimed in claim 1 is characterized in that, said CPU adopts single-chip microcomputer or microcontroller.
8. gatherer as claimed in claim 1 is characterized in that, adopts booster circuit to strengthen output power of circuit, further strengthens hyperacoustic importing effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2012102649525A CN102755692A (en) | 2012-07-30 | 2012-07-30 | Ultrasonic wave and ion conduction transdermal medicament or cosmetic conduction device |
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| CN2012102649525A CN102755692A (en) | 2012-07-30 | 2012-07-30 | Ultrasonic wave and ion conduction transdermal medicament or cosmetic conduction device |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104107503A (en) * | 2014-08-01 | 2014-10-22 | 北京中美联医学科学研究院有限公司 | Intermediate-frequency-modulated low frequency sonophoresis system |
| CN106868049A (en) * | 2016-12-29 | 2017-06-20 | 天津大学 | A kind of gatherer and introduction method |
| CN109157745A (en) * | 2017-10-30 | 2019-01-08 | 武汉奇致激光技术股份有限公司 | Piezoelectric ceramic piece is used for the control system and control method of beauty |
| CN110201264A (en) * | 2019-06-28 | 2019-09-06 | 上海市第四人民医院 | A kind of multi-functional analgesia instrument comprising analgesia pump |
| WO2020098601A1 (en) * | 2018-11-12 | 2020-05-22 | 深圳大学 | Percutaneous vaccine delivery device employing acoustically induced micropore array |
| CN111773532A (en) * | 2020-07-16 | 2020-10-16 | 河北医科大学第二医院 | Skin penetration promoting method for plastic and beauty |
| CN111939453A (en) * | 2019-05-17 | 2020-11-17 | 成都植行合一健康科技有限公司 | Portable transdermal absorption therapeutic apparatus and control method thereof |
| CN115887815A (en) * | 2022-12-27 | 2023-04-04 | 北京大学 | Medicine injection pump and manufacturing method thereof |
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| CN1218697A (en) * | 1997-12-05 | 1999-06-09 | 李灵山 | Tumor curing instrument importing Chinese drug ion at high temperature |
| CN2460122Y (en) * | 2000-06-19 | 2001-11-21 | 翁春晓 | Therapeutic head of microsonic conductometric skin-through dosage device |
| CN1357394A (en) * | 2000-12-14 | 2002-07-10 | 上海大学 | Chinese medicine acupoint introducing method and device |
| CN101810908A (en) * | 2009-02-25 | 2010-08-25 | 四川大学华西医院 | Rapid transdermal drug delivery system for local anesthetic |
| CN101920064A (en) * | 2009-06-13 | 2010-12-22 | 翁春晓 | Method and instrument of ultrasonic and electric field superposition target medicine penetration |
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2012
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1218697A (en) * | 1997-12-05 | 1999-06-09 | 李灵山 | Tumor curing instrument importing Chinese drug ion at high temperature |
| CN2460122Y (en) * | 2000-06-19 | 2001-11-21 | 翁春晓 | Therapeutic head of microsonic conductometric skin-through dosage device |
| CN1357394A (en) * | 2000-12-14 | 2002-07-10 | 上海大学 | Chinese medicine acupoint introducing method and device |
| CN101810908A (en) * | 2009-02-25 | 2010-08-25 | 四川大学华西医院 | Rapid transdermal drug delivery system for local anesthetic |
| CN101920064A (en) * | 2009-06-13 | 2010-12-22 | 翁春晓 | Method and instrument of ultrasonic and electric field superposition target medicine penetration |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104107503A (en) * | 2014-08-01 | 2014-10-22 | 北京中美联医学科学研究院有限公司 | Intermediate-frequency-modulated low frequency sonophoresis system |
| CN104107503B (en) * | 2014-08-01 | 2017-03-22 | 北京中美联医学科学研究院有限公司 | Intermediate-frequency-modulated low frequency sonophoresis system |
| CN106868049A (en) * | 2016-12-29 | 2017-06-20 | 天津大学 | A kind of gatherer and introduction method |
| CN109157745A (en) * | 2017-10-30 | 2019-01-08 | 武汉奇致激光技术股份有限公司 | Piezoelectric ceramic piece is used for the control system and control method of beauty |
| WO2020098601A1 (en) * | 2018-11-12 | 2020-05-22 | 深圳大学 | Percutaneous vaccine delivery device employing acoustically induced micropore array |
| CN111939453A (en) * | 2019-05-17 | 2020-11-17 | 成都植行合一健康科技有限公司 | Portable transdermal absorption therapeutic apparatus and control method thereof |
| CN110201264A (en) * | 2019-06-28 | 2019-09-06 | 上海市第四人民医院 | A kind of multi-functional analgesia instrument comprising analgesia pump |
| CN111773532A (en) * | 2020-07-16 | 2020-10-16 | 河北医科大学第二医院 | Skin penetration promoting method for plastic and beauty |
| CN115887815A (en) * | 2022-12-27 | 2023-04-04 | 北京大学 | Medicine injection pump and manufacturing method thereof |
| CN115887815B (en) * | 2022-12-27 | 2023-11-21 | 北京大学 | Medicine injection pump and manufacturing method thereof |
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Application publication date: 20121031 |