CN110201264A - A kind of multi-functional analgesia instrument comprising analgesia pump - Google Patents
A kind of multi-functional analgesia instrument comprising analgesia pump Download PDFInfo
- Publication number
- CN110201264A CN110201264A CN201910572583.8A CN201910572583A CN110201264A CN 110201264 A CN110201264 A CN 110201264A CN 201910572583 A CN201910572583 A CN 201910572583A CN 110201264 A CN110201264 A CN 110201264A
- Authority
- CN
- China
- Prior art keywords
- analgesia
- functional
- head
- controller
- pump
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000036592 analgesia Effects 0.000 title claims abstract description 115
- 238000002604 ultrasonography Methods 0.000 claims abstract description 18
- 208000002193 Pain Diseases 0.000 claims abstract description 15
- 230000036407 pain Effects 0.000 claims abstract description 15
- 230000000202 analgesic effect Effects 0.000 claims abstract description 12
- 238000012544 monitoring process Methods 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims description 19
- 230000010412 perfusion Effects 0.000 claims description 7
- 239000013078 crystal Substances 0.000 claims description 3
- 239000000523 sample Substances 0.000 claims description 3
- 206010019233 Headaches Diseases 0.000 claims description 2
- 230000003444 anaesthetic effect Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 208000027418 Wounds and injury Diseases 0.000 abstract description 3
- 230000006378 damage Effects 0.000 abstract description 2
- 208000014674 injury Diseases 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000001802 infusion Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011982 device technology Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
Abstract
The invention discloses a kind of multi-functional analgesia instrument comprising analgesia pump belongs to medical instruments field, including analgesia stick, controller, connecting line, camera and analgesia pump, eases pain stick and analgesia pump is distinguished the controllable processor telecommunication with controller and connect；Firstly, the setting of the electronic analgesia pump on basis, ensure that the continuous analgesia to patient；The stick secondly, combined type is eased pain, avoids human injury and its bring side effect of anaesthetic, and provides ultrasound and two kinds of analgesia means of electric current, improves selection face and applicable surface；Finally, setting camera, provides monitoring system, can monitor patient's states in real time, and doctor's analgesic effect is reminded in time, increase promotion, analgesia instrument is reliable for operation, and various ways ease pain, and improve use and promoted extension.
Description
Technical field
The present invention relates to medical device technology more particularly to a kind of multi-functional analgesia instrument comprising analgesia pump.
Background technique
When human body will be performed an operation by wound or when other pain conditions need physical therapy, generally requires and town is done to affected part
Pain or anaesthetic treatment.Traditional anesthesia often leads to the appearance of the subsequent ill symptoms of patient.Therefore need one kind that can guarantee
Basic analgesic solution analgesia, and not by the analgesia means or technology of anaesthetic, to help patient to mitigate pain and postoperative
Good recovery effects.In addition, traditional analgesia or anaesthetic treatment cannot achieve the real time monitoring to patient's states, can not mention in time
Awake doctor's analgesic effect.
Summary of the invention
For overcome the deficiencies in the prior art, the multi-functional analgesia comprising analgesia pump that the purpose of the present invention is to provide a kind of
Instrument.
The purpose of the present invention is implemented with the following technical solutions:
A kind of multi-functional analgesia instrument comprising analgesia pump, including analgesia stick, controller, connecting line, camera and analgesia pump,
The analgesia stick is connected to the controller by the connecting line, and the analgesia pump is arranged in the shell of the controller
Portion.The controller include the power knob being arranged on controller housing, menu control key, scram button, touching display screen,
Adjusting knob, jack, indicator light and setting are connected to the control in the intracorporal processor of shell, the camera through signal wire
Device, the controllable processor telecommunication with the controller of the analgesia pump is connect, and the analgesia pump is defeated by a plug-in type
The controllable outside output medical fluid of liquid pipe.
Preferably, the analgesia stick is combined type analgesia stick, including functional head, handle and switch, the functional head setting
In the end of the handle, the switch is arranged on the shell of the handle, includes electric current town in the disk of the functional head
Pain head and ultrasound analgesia head.
Preferably, the probe outer boundary of the electric current analgesia head is the nonmetallic anchor ring of crystal.
Preferably, the disk center of the functional head, multiple electric currents analgesia headrings are arranged in the ultrasound analgesia head
Around the ultrasound analgesia head setting.
Preferably, the electric current analgesia head is set as 4.
Preferably, the analgesia stick includes two functional heads being oppositely arranged, the electric current analgesia head and ultrasound analgesia head
In the independent disk for being set to two functional heads.
Preferably, state instruction screen is additionally provided on the shell of the handle, the state instruction screen shows ultrasonic town
Pain state or electric current subject's analgesic state.
Preferably, the camera is removably connected on the shell of the controller by rotational positioning bar, and is led to
It crosses signal wire and is connected to the processor, and the status of patient of camera head monitor is transferred on the touching display screen and is shown.
Preferably, the multi-functional analgesia instrument further includes master station, and the controller passes through signal wire or wireless transmission system
System is connected to the master station, is achieved in the state that the master station remotely monitors patient.
Preferably, the analgesia pump be electronic analgesia pump comprising multiple plunger type medical fluid cylinders, multiple flow control valves,
Safety valve and electronic pump, the electronic pump optionally drive one or more of plunger type medical fluid cylinder under the control of the controller
Medical fluid is conveyed to perfusion tube.
Compared with prior art, the beneficial effects of the present invention are: using the multi-functional analgesia comprising analgesia pump of the application
Instrument, firstly, the setting of the electronic analgesia pump on basis, ensure that the continuous analgesia to patient；The stick secondly, combined type is eased pain, avoids
The human injury of anaesthetic and its bring side effect, and ultrasound and electric current two kinds of analgesia means are provided, improve selection
Face and applicable surface；Finally, setting camera, provides monitoring system, can monitor patient's states in real time, and remind doctor in time
Analgesic effect, increases promotion, and analgesia instrument is reliable for operation.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of the multi-functional analgesia instrument comprising analgesia pump of the present invention；
Fig. 2 is the structural schematic diagram of present invention analgesia stick；
Fig. 3 is the structural schematic diagram of analgesia pump of the present invention.
In figure: 100, ease pain stick；1, functional head；11, electric current analgesia head；12, ultrasound analgesia head；2, handle；3, it switchs；4,
State instruction screen；200, controller；201, power knob；202, menu control key；203, scram button；204, touch-control is shown
Screen；205, adjusting knob；206, jack；300, connecting line；400, camera；500, master station；600, analgesia pump；601, plunger
Formula medical fluid cylinder；602, electronic pump；603, flow control valve；604, flow control valve；605, safety valve；700, perfusion tube.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiments of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill people
Member's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
Referring to Fig. 1, a kind of multi-functional analgesia instrument comprising analgesia pump, including analgesia stick 100, controller 200, connecting line
300, camera 400, master station 500 and analgesia pump 600.
Wherein, analgesia stick 100 is connected to controller 200 by connecting line 300, and controller 200 includes being arranged in controller
Power knob 201, menu control key 202, scram button 203, touching display screen 204, adjusting knob 205, jack on shell
206, in the intracorporal processor of shell, camera 400 is connected to the controller 200 by signal wire for indicator light and setting, analgesia
Pump 600 is a kind of electronic analgesia pump, is connect by signal wire with 200 telecommunication of controller, and output end is connected by perfusion tube 700
Connect simultaneously outside controllable output medical fluid.
In order to realize the real time monitoring to status of patient, camera 400 is set, specifically, camera 400 is fixed by rotation
Position bar is removably connected on the shell of the controller 200, is used for adjustable alignment patient face or affected part.Camera
400 are also connected to the processor by signal wire, and the status of patient that camera 400 monitors is transferred to the touch-control and is shown
It is shown on screen 204.
Further, multi-functional analgesia instrument further includes master station 500, and controller 200 passes through signal wire or wireless transmission system
System is connected to the master station 500, and the information real-time Transmission that camera 400 is monitored is achieved in master control to master station 500
Platform 500 remotely monitors the state of patient.
For the stick 100 that eases pain, referring to fig. 2, a kind of combined type analgesia stick is used, specifically, analgesia stick 100 includes function
First 1, handle 2, switch 3 and state instruction screen 4.
The end of the handle 2 is arranged in functional head 1, and the handle 2 is arranged in the switch 3 and state instruction screen 4
It include electric current analgesia head 11 and ultrasound analgesia head 12 on shell, in the disk of the functional head 1.
Wherein state instruction screen 4 shows ultrasonic subject's analgesic state or electric current subject's analgesic state.It is such as aobvious by color or text difference
Show that currently employed is ultrasonic subject's analgesic state or electric current subject's analgesic state.
The probe outer boundary of electric current analgesia head 11 is the nonmetallic anchor ring of crystal, this is than traditional metal anchor ring better effect.
The disk center of the functional head 1 is arranged in ultrasound analgesia head 12, and multiple electric current analgesia heads 11 are around described
Ultrasound analgesia head 12 is arranged.Preferably, the electric current analgesia head 11 is set as 4.
Alternatively, analgesia stick 100 includes that two functional heads 1 being oppositely arranged are not shown, electric current analgesia 11 He of head
In the ultrasound analgesia independent disk for being set to two functional heads 1 of head 12.
Referring to Fig. 3, analgesia pump 600 is electronic analgesia pump comprising multiple plunger type medical fluid cylinders 601, multiple flows are adjusted
Valve (603,604), safety valve 605 and electronic pump 602.
In one embodiment, plunger type medical fluid cylinder 601 is arranged side by side three, their bottom end is respectively by an electronic pump
602 by the controllable drivings of transmission mechanism, their upper end, which is in charge of by going out liquid, is connected to liquid outlet, it is each go out liquid be in charge of
One flow control valve 603 is set, a flow control valve 604 and a safety valve 605 are also provided on liquid outlet, finally
Medical fluid connect with perfusion tube 700 and exports analgesic solution outward.
Wherein, according to the actual demand of infusion, three plunger type medical fluid cylinders 601 can choose one of those, two or
Three carrying medical fluids are simultaneously run.And plunger type medical fluid cylinder 601 is replaceable is configured.
Wherein, flow control valve (603,604) is electromagnetic flow valve, and controls to adjust aperture by controller 200 to adjust
Flow.
Electronic pump 602 is connect with the processor telecommunication of controller 200, optionally drives column under the control of the controller 200
It is one or more to the conveying medical fluid of perfusion tube 700 in plug medical fluid cylinder 601.
Whole, the enclosure interior lower end of controller 200 is arranged in analgesia pump 600.
Working principle passes through the menu control key 202 of controller 200 first or directly selects on touching display screen 204
Operating mode is that the ultrasound of lasting infusion mode or medical staff's execute-in-place analgesia stick 100 by analgesia pump 600 is eased pain
Or electric current Mode of analgesia.Corresponding required running parameter is adjusted by adjusting knob 205 or touching display screen 204, such as using analgesia
Pump 600 then adjusts type, dosage, the flow velocity etc. of analgesia medical fluid.When needing ultrasound analgesia or electric current analgesia, then by medical staff
Ease pain in the 3 pairs of affected parts of switch opened on analgesia stick 100.400 real-time monitoring patient's states of camera are simultaneously transmitted to controller
On 200 touching display screen 204 and master station 500.
Further, it is also possible to make above-mentioned ultrasound analgesia be converted to ultrasonic sterilization or antivirus mode by parameter regulation.Increase
Application range.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: it still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；
And these are modified or replaceed, technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution spirit and
Range.
Claims (10)
1. a kind of multi-functional analgesia instrument comprising analgesia pump, including ease pain stick (100), controller (200), connecting line (300), take the photograph
As head (400) and analgesia pump (600), the analgesia stick (100) is connected to the controller by the connecting line (300)
(200), enclosure interior of analgesia pump (600) setting in the controller (200), it is characterised in that: the controller
It (200) include the power knob (201), menu control key (202), scram button (203), touch-control being arranged on controller housing
Display screen (204), adjusting knob (205), jack (206), indicator light and setting are in the intracorporal processor of shell, the camera
(400) be connected to the controller (200) by signal wire, the analgesia pump (600) it is controllable with the controller (200)
Processor telecommunication connection, and the outside output medical fluid that the analgesia pump (600) is controllable by a plug-in type perfusion tube (700).
2. multi-functional analgesia instrument according to claim 1, it is characterised in that: the analgesia stick (100) is combined type analgesia
Stick, including functional head (1), handle (2) and switch (3), the functional head (1) setting are described to open in the end of the handle (2)
It closes (3) to be arranged on the shell of the handle (2), includes electric current analgesia head (11) and ultrasound in the disk of the functional head (1)
Ease pain head (12).
3. multi-functional analgesia instrument according to claim 2, it is characterised in that: the probe of electric current analgesia head (11) is extraneous
Face is the nonmetallic anchor ring of crystal.
4. multi-functional analgesia instrument according to claim 2, it is characterised in that: ultrasound analgesia head (12) is arranged described
The disk center of functional head (1), multiple electric current analgesias head (11) are around ultrasound analgesia head (12) setting.
5. multi-functional analgesia instrument according to claim 4, it is characterised in that: electric current analgesia head (11) is set as 4.
6. multi-functional analgesia instrument according to claim 2, it is characterised in that: the analgesia stick (100) includes two opposite
The functional head (1) of setting, electric current analgesia head (11) and ultrasound are eased pain, and head (12) are independent to be set to two functional heads
(1) in disk.
7. multi-functional analgesia instrument according to claim 2, it is characterised in that: also set up on the shell of the handle (2)
Stateful indicator panel (4), the state instruction screen (4) show ultrasonic subject's analgesic state or electric current subject's analgesic state.
8. multi-functional analgesia instrument according to claim 1, it is characterised in that: the camera (400) passes through rotational positioning
Bar is removably connected on the shell of the controller (200), and is connected to the processor by signal wire, and will camera shooting
The status of patient of head (400) monitoring, which is transferred on the touching display screen (204), to be shown.
9. multi-functional analgesia instrument according to claim 1, it is characterised in that: the multi-functional analgesia instrument further includes master station
(500), the controller (200) is connected to the master station (500) by signal wire or wireless transmitting system, is achieved in institute
State the state that master station (500) remotely monitors patient.
10. multi-functional analgesia instrument according to claim 1, it is characterised in that: the analgesia pump (600) is easing pain of electron
Pump comprising multiple plunger type medical fluid cylinders (601), multiple flow control valves (603,604), safety valve (605) and electronic pump
(602), the electronic pump (602) optionally drives one in plunger type medical fluid cylinder (601) under the control of controller (200)
Or it is multiple to perfusion tube (700) conveying medical fluid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910572583.8A CN110201264A (en) | 2019-06-28 | 2019-06-28 | A kind of multi-functional analgesia instrument comprising analgesia pump |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910572583.8A CN110201264A (en) | 2019-06-28 | 2019-06-28 | A kind of multi-functional analgesia instrument comprising analgesia pump |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110201264A true CN110201264A (en) | 2019-09-06 |
Family
ID=67795209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910572583.8A Pending CN110201264A (en) | 2019-06-28 | 2019-06-28 | A kind of multi-functional analgesia instrument comprising analgesia pump |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110201264A (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120065575A1 (en) * | 2009-03-31 | 2012-03-15 | Simone Nadia LEONARDI KADER | Method and appliance for cosmetic skincare |
| CN202207398U (en) * | 2011-07-22 | 2012-05-02 | 李娜 | Multi-contact radio frequency beauty treatment instrument |
| CN202314558U (en) * | 2011-11-03 | 2012-07-11 | 广州曼翔医疗器械有限公司 | Medical visual analgesia pump device |
| CN102755692A (en) * | 2012-07-30 | 2012-10-31 | 王路 | Ultrasonic wave and ion conduction transdermal medicament or cosmetic conduction device |
| CN202751646U (en) * | 2012-03-15 | 2013-02-27 | 南京市妇幼保健院 | Analgesia pump for program-control dual-liquid-storage device |
| CN204337530U (en) * | 2014-12-21 | 2015-05-20 | 范晓琳 | Intelligence local ultrasound pain easing machine |
| CN205672299U (en) * | 2016-03-30 | 2016-11-09 | 南京市口腔医院 | Three capsule analgesia pumps |
| CN206120955U (en) * | 2016-08-23 | 2017-04-26 | 赵允起 | Novel electronarcosis analgesia ware |
| CN208741647U (en) * | 2018-02-10 | 2019-04-16 | 成都医学院第一附属医院 | A kind of capsule Multimodal analgesia pumps double at times |
| CN210873422U (en) * | 2019-06-28 | 2020-06-30 | 上海市第四人民医院 | Multifunctional analgesia instrument containing analgesia pump |
-
2019
- 2019-06-28 CN CN201910572583.8A patent/CN110201264A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120065575A1 (en) * | 2009-03-31 | 2012-03-15 | Simone Nadia LEONARDI KADER | Method and appliance for cosmetic skincare |
| CN202207398U (en) * | 2011-07-22 | 2012-05-02 | 李娜 | Multi-contact radio frequency beauty treatment instrument |
| CN202314558U (en) * | 2011-11-03 | 2012-07-11 | 广州曼翔医疗器械有限公司 | Medical visual analgesia pump device |
| CN202751646U (en) * | 2012-03-15 | 2013-02-27 | 南京市妇幼保健院 | Analgesia pump for program-control dual-liquid-storage device |
| CN102755692A (en) * | 2012-07-30 | 2012-10-31 | 王路 | Ultrasonic wave and ion conduction transdermal medicament or cosmetic conduction device |
| CN204337530U (en) * | 2014-12-21 | 2015-05-20 | 范晓琳 | Intelligence local ultrasound pain easing machine |
| CN205672299U (en) * | 2016-03-30 | 2016-11-09 | 南京市口腔医院 | Three capsule analgesia pumps |
| CN206120955U (en) * | 2016-08-23 | 2017-04-26 | 赵允起 | Novel electronarcosis analgesia ware |
| CN208741647U (en) * | 2018-02-10 | 2019-04-16 | 成都医学院第一附属医院 | A kind of capsule Multimodal analgesia pumps double at times |
| CN210873422U (en) * | 2019-06-28 | 2020-06-30 | 上海市第四人民医院 | Multifunctional analgesia instrument containing analgesia pump |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2653093B1 (en) | Electronically controlled high frequency jet ventilation laryngoscope | |
| CN100495278C (en) | Automatic regulating and control instrument in conduit pipe sacculus | |
| CN205697742U (en) | A kind of Cardiological automated blood pressure device | |
| CN107496172A (en) | Nutrition pump and its flow control methods | |
| CN104392650A (en) | Respirator simulation lung device for emergency nursing | |
| CN110201264A (en) | A kind of multi-functional analgesia instrument comprising analgesia pump | |
| CN210873422U (en) | Multifunctional analgesia instrument containing analgesia pump | |
| CN209864933U (en) | Oxygen atomizing inhalation device | |
| CN209033215U (en) | A kind of electronic Nasal feeding device | |
| CN202052144U (en) | Multifunctional infusion monitor | |
| CN208405589U (en) | A kind of infusion device with monitoring function | |
| CN207996352U (en) | A kind of oxygen-supplying type exempts from injecting anesthetic device | |
| CN204293631U (en) | Wall-oxygen inhalation apparatus | |
| CN208799598U (en) | Constant pressure infusing, heatable bladder irrigation equipment | |
| CN108853661A (en) | A kind of interactive system of compression atomizer operational data | |
| CN213191864U (en) | Oxygen timing control device | |
| CN204734461U (en) | Water installation is attach as an addition to dual mode control's digestion scope | |
| CN208693953U (en) | A kind of Intelligent Atomizer and intelligent atomization system | |
| CN204601314U (en) | A kind of Novel lung puncture assist control breathing equipment | |
| CN209033516U (en) | A kind of medical applicator of medical surgery | |
| CN107050614B (en) | A kind of easy-to-use internal medicine clinic multifunction breathing equipment | |
| CN208641471U (en) | A kind of clinical intubation anesthesia ancillary equipment | |
| CN203107832U (en) | Novel infusion controller | |
| CN208372220U (en) | A kind of intelligent pain-relieving pump | |
| CN208511662U (en) | A kind of device having artificial ventilation's function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |