CN102755408A

CN102755408A - External liniment for treating vitiligo

Info

Publication number: CN102755408A
Application number: CN2012102561660A
Authority: CN
Inventors: 王华柱
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-07-24
Filing date: 2012-07-24
Publication date: 2012-10-31
Anticipated expiration: 2032-07-24
Also published as: CN102755408B

Abstract

The invention discloses an external liniment for treating vitiligo. The liniment comprises radix salviae miltiorrhizae, dark plum, cnidium fruit, field dodder, malaytea scurfpea fruit, litharge, sulphur, calomel, angelica, safflower, realgar, mothball, parsnip, radix sophorae flavescentis, black sesame, honeysuckle and musk. The liniment has the efficacies of expelling the wind, relieving itching, relieving rigidity of muscles, activating collaterals, eliminating moisture, activating blood circulation, removing stasis, enriching the blood, nourishing the blood, improving skin microcirculation, reinforcing skin light sensitivity to ultraviolet rays, activating tyrosinase and promoting melanin coloring; the effective rate is 85%, and the curative rate is 75%; and the general patients need 2-5 treatment courses, and the severe patients need 6-8 treatment courses.

Description

A kind of externally-applied liniment of treating leucoderma disease

Technical field

The present invention relates to a kind of externally-applied liniment of treating leucoderma disease.

Background technology

Vitiligo is a kind of dermatosis of metabolism of pigment imbalance.The traditional Chinese medical science is called vitiligo." all source of disease marquis opinions " record: " the leucoderma person, face and neck health skin and flesh complexion changed are white, and be different with yellowish pink, the pain of also not itching, the leucoderma of meaning." " Shengji Zonglu " cloud: " and its shape is mottled like tinea, pestilence infections too, but do not become the skin ulcer ear ... The lighter's white point, weight person is in a few days, and one-sided grizzled, hair also becomes, and is not recovered all the year round." " the Golden Mirror of Medicine record: this demonstrate,proves from face and neck, and yellowish pink bleaches suddenly, shape class speckle, the pain of not itching.Refute mutually in skin by ailment said due to cold or exposure, cause make qi-blood disharmony." doctor trained in Western medicine do not have the specific treatment method at present, orally-ingestible or topical application light sensation medicine, psoralen and derivant thereof, this type of medicine belongs to light poisonous substance matter, but for oral administration or put ultraviolet outward on the skin or the sun exposure stimulation melanin generates.Methoxsalen (8-methoxyposoralen) commonly used or trioxsalen (Trimethylpsoralen).This therapy causes very big misery and financial burden to the patient, and therapeutic effect is not good.The present invention inherits the elite of motherland's medical science through research for many years, and according to the vitiligo pathogeny, from source of disease treatment vitiligo virus, and therapeutic effect is satisfied, and treatment cost is low, is easy to extensive patients and accepts.

Summary of the invention

The object of the present invention is to provide a kind of a kind of externally-applied liniment of treating leucoderma disease that has satisfactory effect through evidence.The present invention has dispelling wind for relieving itching, relaxing muscles and tendons and activating QI and blood in the collateral damp eliminating, blood circulation promoting and blood stasis dispelling, and blood-supplementing blood-nourishing improves skin microcirculation and strengthens skin to ultraviolet heliosensitivity, activates tryrosinase, melanin formation promoting, the effect of promotion dye.Effective percentage 85%, cure rate 75%, the general healing on average needs 2-5 the course of treatment, and the person of being in a bad way needs 6-8 the course of treatment.(be a course of treatment January)

The present invention addresses the above problem the technical scheme (consumption is a weight portion) that adopts:

Radix Salviae Miltiorrhizae 35g Fructus Mume 25g Fructus Cnidii 35g Semen Cuscutae 35g

Fructus Psoraleae 50g Lithargyrum 25g sulfur 15g Calomelas 5g

Radix Angelicae Sinensis 35g Flos Carthami 30g Realgar 5g Camphora 5g

Windproof 15g Radix Sophorae Flavescentis 35g Semen Sesami Nigrum 35g Flos Lonicerae 12g

Moschus 1g, its preparation method: will add medicine to and pulverize porphyrize, and put in the container, and add 95% ethanol 3500ml and soaked 7 days, filter and remove residue gets final product.

Pharmacological property is analyzed: Radix Salviae Miltiorrhizae, and blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, the malignant boil toxic swelling is controlled in the evacuation of pus pain relieving; Fructus Mume has the effect of antiinflammatory, convergence, antidiarrheal, antifungal; Fructus Cnidii has the effect of warming the kidney to activate YANG, removing dampness and killing parasites, antifungal; Semen Cuscutae has the effect of warming the kidney to activate YANG; The Lithargyrum has parasite killing, arresting sweating, eliminates the phlegm, relieving convulsion effect, is widely used in diseases such as treatment tinea versicolor, vitiligo; Sulfur has the effect of parasite killing antifungal; Calomelas has the effect of antibiotic life; Fructus Psoraleae, reinforcing the kidney and supporting YANG, it is plain to strengthen color; The effect that Radix Angelicae Sinensis, Flos Carthami are enriched blood and invigorated blood circulation; Realgar has the effect of antalgesic-antipruritic; That Camphora has is antibiotic, the effect of antiinflammatory, the pain relieving of having one's ideas straightened out; Windproof, the effect of dispelling wind for relieving itching; The Radix Sophorae Flavescentis heat clearing and damp drying; Semen Sesami Nigrum, the invigorating the liver and kidney moistening five ZANG-organs; The effect of Flos Lonicerae heat-clearing and toxic substances removing; Moschus is had one's ideas straightened out and is split effect dirty, the collateral dredging dissipating blood stasis.The present invention can pathogenic wind expelling the damp eliminating parasite killing, wear down mottling, impel melanin to form, promote the nutrition of skin layer, melanin rises and melanin granule forms thereby reach, and makes skin recover normal.

The usage of medicine of the present invention, consumption: smear the affected part every day 2 times, sooner or later respectively once, each 20 minutes.Points for attention: 1, must guard against pleasing to the eye, go into nose.2, place that unsuitable for children is taken part 3, skin rubefaction, the genus normal phenomenon of itching, do not use the hands pruritus, prevent to scratch skin, cause infection.4, wrinkle appears in skin after three weeks, vitiligo is described just in convalescent period, please continue to smear, and gets final product rehabilitation.5, the patient with severe symptoms is maybe the time longer, and is not interrupted, and must adhere to using by the course of treatment.6, individual patient maybe be excessive because of consumption, blister can occur, and need for patient is alarmed, can continue to use.

Beneficial effect of the present invention: compatibility is rigorous, treatment is convenient, good effect, be difficult for recurrence and the medicine valency cheap.

The specific embodiment

Embodiment 1, the present invention address the above problem the technical scheme (consumption is a weight portion) that adopts:

Fructus Psoraleae 50g Lithargyrum 25g sulfur 15g Calomelas 5g

Radix Angelicae Sinensis 35g Flos Carthami 30g Realgar 5g Camphora 5g

Moschus 1g, its preparation method: will add medicine to and pulverize porphyrize, and put in the container, and add 95% ethanol 3500ml and soaked 7 days, filter and remove residue gets final product.The usage of medicine of the present invention, consumption: smear the affected part every day 2 times, sooner or later respectively once, each 20 minutes.Points for attention: 1, must guard against pleasing to the eye, go into nose.2, place that unsuitable for children is taken part 3, skin rubefaction, the genus normal phenomenon of itching, do not use the hands pruritus, prevent to scratch skin, cause infection.4, wrinkle appears in skin after three weeks, vitiligo is described just in convalescent period, please continue to smear, and gets final product rehabilitation.5, the patient with severe symptoms is maybe the time longer, and free of discontinuities, must adhere to using by the course of treatment.6, individual patient maybe be excessive because of consumption, blister can occur, and need for patient is alarmed, can continue to use.

Clinical efficacy criterion and therapeutic outcome:

1, clinical data and Therapeutic Method:

1.1 patients with vitiligo 400 examples, male's 280 examples, women's 120 examples, course of disease 0.5-10.

Therapeutic Method: smear the affected part every day 2 times, sooner or later respectively once, each 20 minutes.

1.2 diagnostic criteria: white macula often is creamy white, depigmentation, and the white macula size and form differs, and hair can normally or bleach on it; Be divided into homeliness type (limitation, general hair style, distribute type, acra type) and segmental pattern according to the white macula characteristic distributions.The homeliness type white macula generally is symmetrically distributed, can be confined to some position or distribute, general whole body; Segmental pattern is generally one-sided, and white macula distributes along a certain tegumentary nerve joint domination district.Whether be divided into for two phases according to state of an illness activity: progressive stage and stable phase.

1.3 curative effect judging standard: clinical cure: white macula all disappears, and pigment recovers the normal colour of skin fully;

Produce effects: 2/3 recovers the color element; Take a turn for the better: part is recovered the color element; Invalid: pigment does not have change or increases the weight of.

1.4 therapeutic outcome: 400 routine patients, cure 300 examples, produce effects 22 examples, 18 examples that take a turn for the better, invalid 60 examples, the patient that 300 examples are cured, wherein 220 routine healing times are 2-4 month, other 80 routine patient's healing times are 6-8 month.

Model case 1, an XX, man, 36 years old, Anyang, Henan Province watt shop village people.Suffered from vitiligo 1 year.Disease sites: face, white macula area 1X1.5cm ²On August 22 2009 first visit date, the main suit: a white speckle appears in the not clear inducement of face the year before, and no sufferings, nothing redness, nothing are festered.Diagnosis: vitiligo belongs to the acra type.Treatment: adopts the outer twice-daily, each 20 minutes wiped of medicine of the present invention, sooner or later each once, the reinforcement sun exposure enjoins the patient to strengthen physical training simultaneously, polyphagia contains the food of tyrosine.Treat the course of treatment (January) of institute's check afterwards.Two examine: went to a doctor on JIUYUE 25th, 2009, the patient bears in the affected part pigment island, and curative effect is pretty good, continues treatment observe the curative effect again after 30 days by former Therapeutic Method; Three examine: went to a doctor on October 28th, 2009, disappear basically through the white macula in two course of therapy (60 days) patient affected part, it is normal that the illing skin color is recovered basically.Enjoin patient's one course of treatment of after treatment again.The four diagnostic methods: went to a doctor on November 29th, 2009, affected part white macula complete obiteration, it is normal that skin color recovers, and looks steadily to attach the patient and carrying 15 days doses to consolidate curative effect.Follow up a case by regular visits to after 1 year and do not have recurrence.

Model case 2, an XX, the man, 7 years old, people from Zhoukou City, Henan Province suffered from vitiligo existing 2 years.Disease sites: cervical region, face.Pay a home visit the date: on May 6th, 2010, main suit (father patient generation tell) skin depigmentation 2 years, cervical region, the facial white speckle that not clear inducement occurs before 2 years, face have Semen Glycines size, cervical region that egg yolk size, no sufferings are arranged, do not have redness, nothing is festered, no desquamation.Diagnosis: vitiligo belongs to the acra type.Treatment: adopts the outer twice-daily, each 20 minutes wiped of medicine of the present invention, sooner or later each once, the reinforcement sun exposure enjoins the patient to strengthen physical training simultaneously, polyphagia contains the food of tyrosine.Treat two courses of treatment (60 days) of institute's check afterwards.Two examine: on July 10th, 2010 went to a doctor: white macula edge, affected part dwindles gradually, pigment is deepened, inner small amount of coloring matter island generates; After continuing again to treat 2 courses of treatment; Facial illing skin color is recovered fully; Cervical region affected part white macula area cures 80%, and remainder is kermesinus, and white macula all disappears after after treatment 2 courses of treatment again.Follow up a case by regular visits to the state of an illness after 1 year and do not have recurrence.

Model case 3, Lee XX, the woman, 29 years old, people from Kaifeng, Henan Province suffered from vitiligo 6 years.First visit on March 2 in 2007, the position; Cervical region, shirtfront, abdominal part.Diagnosis: vitiligo belongs to segmental pattern.Treatment treatment: adopts the outer twice-daily, each 20 minutes wiped of medicine of the present invention, sooner or later each once, the reinforcement sun exposure enjoins the patient to strengthen physical training simultaneously, polyphagia contains the food of tyrosine.Medication institute's check afterwards in 2 months.Two examine: on May 5th, 2007, affected part white macula area dwindles, and has the pigment island to occur in the white macula.Progressively treat check after 2 months again.Three examine: on July 9th, 2007, recover basically in the cervical region affected part, and the shirtfront cures recovers 85%, and abdominal treatment recovers 70%, then consolidates course of therapy again 2 months.The four diagnostic methods: on JIUYUE 15th, 2007.Recover fully in the cervical region affected part, and the shirtfront also cures, and abdominal part recovers area and reached 95%, looks steadily it and carry 2 medicine treatments of the going home course of treatment again.On October 20th, 2007, the patient calls and says abdominal part, cures fully.

Case 4: Zhao XX, man, 17 years old, Cheng Zhuan people from town, Minquan County, Henan Province, 2 years medical histories, disease sites; Around forehead, the lip, irregular shape white macula many places therapeutic effect is undesirable.On October 5th, 2005 went to a doctor: using Drug therapy of the present invention after 60 days, the pigment island is born in the affected part, continues treatment again after 60 days, and the affected part white macula disappears, and it is normal that skin color recovers basically.Continue to strengthen 1 course of treatment again.Follow up a case by regular visits to after half a year and do not have recurrence.

Case 5, grandson XX, woman, 25 years old, area just outside a city gate people from town, Tongxu County, Henan Province.Trunk, extremity were suffered from white macula 8 years, and how tame hospitalize DeGrain was gone to a doctor on February 28th, 2008.Diagnosis: vitiligo.Treatment: adopts the outer twice-daily, each 20 minutes wiped of medicine of the present invention, sooner or later each once, the reinforcement sun exposure enjoins the patient to strengthen physical training simultaneously, polyphagia contains the food of tyrosine.Institute's check afterwards in 2 months.Two examine: on May 1st, 2008 went to a doctor: the patient affected part has the part stain to occur, and indivedual little skin lesion disappear.Enjoin and continue treatment 2 months.Three examine: on July 5th, 2008 went to a doctor, and white macula 70% has been almost recovered, and continued treatment again and was almost recovered after 3 months, let the patient carry for 1 course of treatment again and consolidated curative effect, followed up a case by regular visits to after half a year and did not have recurrence.

Claims

1. externally-applied liniment of treating leucoderma disease, form by 17 flavor Chinese medicines:

Fructus Psoraleae 50g Lithargyrum 25g sulfur 15g Calomelas 5g

Radix Angelicae Sinensis 35g Flos Carthami 30g Realgar 5g Camphora 5g