CN102755408B

CN102755408B - External liniment for treating vitiligo

Info

Publication number: CN102755408B
Application number: CN201210256166.0A
Authority: CN
Inventors: 王华柱
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-07-24
Filing date: 2012-07-24
Publication date: 2014-01-15
Anticipated expiration: 2032-07-24
Also published as: CN102755408A

Abstract

The invention discloses an external liniment for treating vitiligo. The liniment comprises radix salviae miltiorrhizae, dark plum, cnidium fruit, field dodder, malaytea scurfpea fruit, litharge, sulphur, calomel, angelica, safflower, realgar, mothball, parsnip, radix sophorae flavescentis, black sesame, honeysuckle and musk. The liniment has the efficacies of expelling the wind, relieving itching, relieving rigidity of muscles, activating collaterals, eliminating moisture, activating blood circulation, removing stasis, enriching the blood, nourishing the blood, improving skin microcirculation, reinforcing skin light sensitivity to ultraviolet rays, activating tyrosinase and promoting melanin coloring; the effective rate is 85%, and the curative rate is 75%; and the general patients need 2-5 treatment courses, and the severe patients need 6-8 treatment courses.

Description

A kind of externally-applied liniment for the treatment of leucoderma disease

Technical field

The present invention relates to a kind of externally-applied liniment for the treatment of leucoderma disease.

Background technology

Vitiligo is a kind of dermatosis of metabolism of pigment imbalance.The traditional Chinese medical science is called vitiligo." all source of disease marquis's opinions " recorded: " leucoderma person, face and neck health skin and flesh complexion changed are white, different from yellowish pink, the pain of also not itching, the leucoderma of meaning." " Shengji Zonglu " cloud: " and its shape is mottled as tinea, pestilence infections too, but do not become skin ulcer ear ... the lighter's white point, severe one is in a few days, and one-sided grizzled, hair also becomes, and is not recovered all the year round." " Golden Mirror of Medicine is recorded: this demonstrate,proves from face and neck, and yellowish pink bleaches suddenly, shape class speckle, the pain of not itching.By ailment said due to cold or exposure, refuted mutually in skin, cause make qi-blood disharmony." doctor trained in Western medicine is at present without specific treatment method, can oral or topical application light sensation medicine, psoralen and derivant thereof, this type of medicine belongs to Phototoxic agents, for oral administration or put ultraviolet outward on the skin or sun exposure can generate by stimulation melanin.Conventional methoxsalen (8-methoxyposoralen) or trioxsalen (Trimethylpsoralen).This therapy causes very large misery and financial burden to patient, and therapeutic effect is not good.The present invention inherits the elite of motherland's medical science through research for many years, according to vitiligo pathogeny, from source of disease, treats vitiligo virus, and therapeutic effect is satisfied, and treatment cost is low, is easy to extensive patients and accepts.

Summary of the invention

The object of the present invention is to provide a kind of a kind of externally-applied liniment for the treatment of leucoderma disease through evidence with satisfactory effect.The present invention has dispelling wind for relieving itching, relaxing muscles and tendons and activating QI and blood in the collateral damp eliminating, blood circulation promoting and blood stasis dispelling, and blood-supplementing blood-nourishing improves skin microcirculation and strengthens skin to ultraviolet heliosensitivity, activates tryrosinase, melanin formation promoting, the effect of promotion dye.Effective percentage 85%, cure rate 75%, general healing on average needs 2-5 the course for the treatment of, and the person of being in a bad way needs 6-8 the course for the treatment of.(be a course for the treatment of January)

The present invention addresses the above problem the technical scheme (consumption is weight portion) adopting:

Radix Salviae Miltiorrhizae 35g Fructus Mume 25g Fructus Cnidii 35g Semen Cuscutae 35g

Fructus Psoraleae 50g Lithargyrum 25g sulfur 15g Calomelas 5g

Radix Angelicae Sinensis 35g Flos Carthami 30g Realgar 5g Camphora 5g

Radix Saposhnikoviae 15g Radix Sophorae Flavescentis 35g Semen Sesami Nigrum 35g Flos Lonicerae 12g

Moschus 1g, its preparation method: will add medicine to and pulverize porphyrize, and put in container, and add 95% ethanol 3500ml to soak 7 days, filter and remove residue.

Pharmacological property is analyzed: Radix Salviae Miltiorrhizae, and blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus pain relieving, controls malignant boil toxic swelling; Fructus Mume, has the effect of antiinflammatory, convergence, antidiarrheal, antifungal; Fructus Cnidii, has the effect of warming the kidney to activate YANG, removing dampness and killing parasites, antifungal; Semen Cuscutae has the effect of warming the kidney to activate YANG; Lithargyrum has parasite killing, arresting sweating, eliminates the phlegm, relieving convulsion effect, is widely used in the diseases such as treatment tinea versicolor, vitiligo; Sulfur has the effect of parasite killing antifungal; Calomelas has the effect of antibiotic life; Fructus Psoraleae, reinforcing the kidney and supporting YANG, strengthens color element; The effect that Radix Angelicae Sinensis, Flos Carthami are enriched blood and invigorated blood circulation; Realgar, has the effect of antalgesic-antipruritic; That Camphora has is antibiotic, the effect of antiinflammatory, the pain relieving of having one's ideas straightened out; Radix Saposhnikoviae, the effect of dispelling wind for relieving itching; Radix Sophorae Flavescentis heat clearing and damp drying; Semen Sesami Nigrum, invigorating the liver and kidney moistening five ZANG-organs; The effect of Flos Lonicerae heat-clearing and toxic substances removing; Moschus, has one's ideas straightened out and splits effect dirty, dredging collateral dissipating blood stasis.Energy pathogenic wind expelling damp eliminating parasite killing of the present invention, wear down mottling, impel melanin to form, promote the nutrition of skin layer, thereby reach, melanin rises and melanin granule forms, and makes skin recover normal.

The usage of medicine of the present invention, consumption: smear affected part every day 2 times, sooner or later respectively once, each 20 minutes.Points for attention: 1, must guard against pleasing to the eye, enter nose.2, place that unsuitable for children is taken part 3, skin rubefaction, the genus normal phenomenon of itching, do not use hands pruritus, prevent from scratching skin, cause infection.4, after three weeks there is wrinkle in skin, illustrates that vitiligo is just in convalescent period, please continue to smear, and gets final product rehabilitation.5, patient with severe symptoms is may the time longer, and is not interrupted, and must adhere to using by the course for the treatment of.6, indivedual patients may be excessive because of consumption, there will be blister, and patient needn't be alarmed, can continue to use.

Beneficial effect of the present invention: compatibility is rigorous, treatment is convenient, good effect, be difficult for recurrence and medicine valency cheap.

The specific embodiment

Embodiment 1, the present invention address the above problem the technical scheme (consumption is weight portion) adopting:

Fructus Psoraleae 50g Lithargyrum 25g sulfur 15g Calomelas 5g

Radix Angelicae Sinensis 35g Flos Carthami 30g Realgar 5g Camphora 5g

Moschus 1g, its preparation method: will add medicine to and pulverize porphyrize, and put in container, and add 95% ethanol 3500ml to soak 7 days, filter and remove residue.The usage of medicine of the present invention, consumption: smear affected part every day 2 times, sooner or later respectively once, each 20 minutes.Points for attention: 1, must guard against pleasing to the eye, enter nose.2, place that unsuitable for children is taken part 3, skin rubefaction, the genus normal phenomenon of itching, do not use hands pruritus, prevent from scratching skin, cause infection.4, after three weeks there is wrinkle in skin, illustrates that vitiligo is just in convalescent period, please continue to smear, and gets final product rehabilitation.5, patient with severe symptoms is may the time longer, and free of discontinuities, must adhere to using by the course for the treatment of.6, indivedual patients may be excessive because of consumption, there will be blister, and patient needn't be alarmed, can continue to use.

Clinical efficacy criterion and therapeutic outcome:

1, clinical data and Therapeutic Method:

1.1 patients with vitiligo 400 examples, male's 280 examples, women's 120 examples, course of disease 0.5-10.

Therapeutic Method: smear affected part every day 2 times, sooner or later respectively once, each 20 minutes.

1.2 diagnostic criterias: white macula is often creamy white, depigmentation, white macula size and form differs, and on it, hair can normally or bleach; According to white macula characteristic distributions, be divided into homeliness type (limitation, general hair style, distribute type, acra type) and segmental pattern.Homeliness type white macula is generally symmetrical, can be confined to some position or distribute, general whole body; Segmental pattern is generally one-sided, and white macula distributes along a certain tegumentary nerve joint domination district.According to state of an illness activity, whether be divided into for two phases: progressive stage and stable phase.

1.3 curative effect judging standards: clinical cure: white macula all disappears, pigment recovers the normal colour of skin completely;

Effective: 2/3 recovers color element; Take a turn for the better: part is recovered color element; Invalid: pigment is without changing or increasing the weight of.

1.4 therapeutic outcomes: 400 routine patients, cure 300 examples, effective 22 examples, 18 examples that take a turn for the better, invalid 60 examples, the patient that 300 examples are cured, wherein 220 routine healing times are 2-4 month, other 80 routine patient's healing times are 6-8 month.

Model case 1, an XX, male ，36Sui， Anyang City watt shop village people.Suffer from vitiligo 1 year.Disease sites: face, white macula area 1X1.5cm ².In August, 2009 on first visit date 22， main suit: there is a white speckle in the not clear inducement of face the year before, without sufferings, without red and swollen, without festering.Diagnosis: vitiligo belongs to acra type.Treatment: adopts the outer twice-daily, each 20 minutes wiped of medicine of the present invention, each once, strengthens sun exposure sooner or later, enjoins patient to strengthen physical training simultaneously, and polyphagia contains the food of tyrosine.Treat the course for the treatment of (January) of institute's check afterwards.Two examine: JIUYUE in 2009 25 days is medical, and patient bears in affected part pigment island, and curative effect is pretty good, by former Therapeutic Method continual cure observe the curative effect again after 30 days; Three examine: on October 28th, 2009 is medical, through the white macula in two course of therapy (60 days) patient affected part, substantially disappear, and it is normal that illing skin color is recovered substantially.Enjoin patient's one course for the treatment of of after treatment again.The four diagnostic methods: on November 29th, 2009 is medical, and affected part white macula disappears completely, it is normal that skin color recovers, and looks steadily attached patient and carrying 15 days doses to consolidate curative effect.After 1 year, follow up a case by regular visits to without recurrence.

Model case 2, an XX, man, 7 people from Zhoukou City of Sui， Henan Province, suffer from vitiligo existing 2 years.Disease sites: cervical region, face.Pay a home visit the date: on May 6th, 2010, main suit's (father patient tells in generation) skin depigmentation 2 years, there is the white speckle of not clear inducement in cervical region before 2 years, face, face have Semen Glycines size, cervical region have egg yolk size, without sufferings, without red and swollen, without festering, without desquamation.Diagnosis: vitiligo belongs to acra type.Treatment: adopts the outer twice-daily, each 20 minutes wiped of medicine of the present invention, each once, strengthens sun exposure sooner or later, enjoins patient to strengthen physical training simultaneously, and polyphagia contains the food of tyrosine.Treat two courses for the treatment of (60 days) of institute's check afterwards.Two examine: on July 10th, 2010 is medical: white macula edge, affected part dwindles gradually, pigment is deepened, inner a small amount of pigment island generates, continual cure is after 2 courses for the treatment of again, face illing skin color is recovered completely, cervical region affected part white macula area cures 80%, remainder is kermesinus, then after 2 courses for the treatment of of after treatment, white macula all disappears.After 1 year, follow up a case by regular visits to the state of an illness without recurrence.

Model case 3, people from Kaifeng of Lee XX ，Nv ，29Sui， Henan Province, suffer from vitiligo 6 years.First visit on March 2 in 2007, position; Cervical region, shirtfront, abdominal part.Diagnosis: vitiligo belongs to segmental pattern.Treatment treatment: adopts the outer twice-daily, each 20 minutes wiped of medicine of the present invention, each once, strengthens sun exposure sooner or later, enjoins patient to strengthen physical training simultaneously, and polyphagia contains the food of tyrosine.Medication institute's check afterwards in 2 months.Two examine: Mays 5 in 2007 ， affected part white macula area reducing, in white macula, have pigment island to occur.Progressively treat again check after 2 months.Three examine: on July 9th, 2007, recover substantially in cervical region affected part, and shirtfront cures recovers 85%, and abdominal treatment recovers 70%, then consolidates course of therapy 2 months again.The four diagnostic methods: on JIUYUE 15th, 2007.Recover completely in cervical region affected part, and shirtfront also cures, and abdominal part recovers area and reached 95%, looks steadily it and carry 2 medicine treatments of the going home course for the treatment of again.On October 20th, 2007, patient calls and says abdominal part, cures completely.

Case 4: Cheng Zhuan people from town, Minquan County, Zhao XX ，Nan ，17Sui， Henan Province, 2 years medical histories, disease sites; Around forehead, lip, irregular shape white macula many places therapeutic effect is undesirable.On October 5th, 2005 is medical: using Drug therapy 60Tian Hou， of the present invention affected part to bear pigment island, then continual cure 60Tian Hou， affected part white macula disappears, it is normal that skin color recovers substantially.Continue to strengthen again 1 course for the treatment of.After half a year, follow up a case by regular visits to without recurrence.

Case 5, Tongxu County area just outside a city gate people from town of grandson XX ，Nv ，25Sui， Henan Province.Trunk, extremity are suffered from white macula 8 years, and many hospitalize DeGrains are medical on February 28th, 2008.Diagnosis: vitiligo.Treatment: adopts the outer twice-daily, each 20 minutes wiped of medicine of the present invention, each once, strengthens sun exposure sooner or later, enjoins patient to strengthen physical training simultaneously, and polyphagia contains the food of tyrosine.Institute's check afterwards in 2 months.Two examine: on May 1st, 2008 is medical: patient affected part has part stain to occur, indivedual little skin lesion disappear.Enjoin continual cure 2 months.Three examine: on July 5th, 2008 is medical, and white macula 70% has been almost recovered, then continual cure is almost recovered after 3 months, allow again patient carry for 1 course for the treatment of and consolidate curative effect, follow up a case by regular visits to without recurrence after half a year.

Claims

1. treat an externally-applied liniment for leucoderma disease, its basic feature is by following ingredients:

Fructus Psoraleae 50g Lithargyrum 25g sulfur 15g Calomelas 5g

Radix Angelicae Sinensis 35g Flos Carthami 30g Realgar 5g Camphora 5g