CN106038806A - Traditional Chinese medicine composition for treating leucoderma and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating leucoderma. The traditional Chinese medicine composition is prepared from, by weight, 0.5-1 part of musk, 15-30 parts of American ginseng, 7.5-15 parts of cornua cervi pantotrichum, 300-600 parts of fructus psoraleae, 65-130 parts of polygonum multiflorum, 30-60 parts of prepared rhizome of rehmannia, 100-200 parts of cortex dictamni, 100-200 parts of radix sophorae flavescentis, 30-60 parts of caulis spatholobi, 15-30 parts of safflower carthamus, 50-100 parts of radix salviae miltiorrhizae, 50-100 parts of black sesame seeds, 100-200 parts of tribulus terrestris, 15-30 parts of lithospermum, 15-30 parts of felwort and 15-30 parts of milkvetch roots. A corresponding preparation method comprises the steps that the medicinal materials are mixed proportionally and smashed, 95% ethyl alcohol is added, and the mixture is mixed to be uniform. The traditional Chinese medicine composition can enhance microcirculation of skin at the focus portion, improve skin photosensitization and activate tyrosinase activity, directly acts on melanocyte, the melanocyte of the skin at the wound is proliferated, the melanocyte surface receptors are increased, and leucoderma can be treated and does not relapse.

Description

One treats leukodermic external medicine composition and preparation method thereof

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to one and treat leukodermic external medicine composition and preparation thereof Method.

Background technology

Vitiligo is a kind of persistent ailment, easily examines refractory, is the most again vitiligo, is a kind of common limitation or the general day after tomorrow The property sent out human body skin depigmentation disease, is disappeared by the melanocyte function of skin and causes, and each position of whole body all can occur, and is common in Referring to the back of the body, wrist, forearm, face, neck and surrounding genital etc., cutaneous lesion is pure white patch, sized by grade, shape be not One, clear-cut patch, general no conscious sympton, there is local scratchiness in small number of patients affected part when premorbid or morbidity.Doctor The Therapeutic Method sought and effective medicine are being explored always by educational circles, but, western medical treatment leucoderma prevailing custom lacks special Therapeutic Method and effective medicine, though Chinese medical discrimination method for the treatment of obtains certain curative effect, but effective patent medicine preparation is still little, existing Chinese patent medicine compound preparation can not effectively treat vitiligo, and repeatable poor, it not only affects the appearance of patient, and gives trouble Person brings heavy thought, mental pressure.

Summary of the invention

Present invention aim at providing one to treat leukodermic external medicine composition, provide it to prepare accordingly simultaneously Method is another goal of the invention of the present invention.

Based on object above, the present invention takes techniques below scheme:

One treats leukodermic external medicine composition, is made up of the medical material of following weight portion: Moschus 0.5-1 part, Radix Panacis Quinquefolii 15-30 part, Cornu Cervi Pantotrichum 7.5-15 part, Fructus Psoraleae 300-600 part, Radix Polygoni Multiflori 65-130 part, Radix Rehmanniae Preparata 30-60 part, Cortex Dictamni 100-200 Part, Radix Sophorae Flavescentis 100-200 part, Caulis Spatholobi 30-60 part, Flos Carthami 15-30 part, Radix Salviae Miltiorrhizae 50-100 part, Semen Sesami Nigrum 50-100 part, thorn puncture Herba chenopodii 100-200 part, Radix Arnebiae (Radix Lithospermi) 15-30 part, Radix Gentianae 15-30 part, Radix Astragali 15-30 part.

Preferably, be made up of the medical material of following weight portion: Moschus 0.5-0.8 part, Radix Panacis Quinquefolii 15-22 part, Cornu Cervi Pantotrichum 8-13 part, Fructus Psoraleae 350-420 part, Radix Polygoni Multiflori 80-110 part, Radix Rehmanniae Preparata 30-50 part, Cortex Dictamni 110-160 part, Radix Sophorae Flavescentis 100-140 part, Sanguis Gallus domesticus Rattan 40-55 part, Flos Carthami 15-25 part, Radix Salviae Miltiorrhizae 70-100 part, Semen Sesami Nigrum 50-80 part, Fructus Tribuli 140-180 part, Radix Arnebiae (Radix Lithospermi) 15-24 Part, Radix Gentianae 18-26 part, Radix Astragali 20-30 part.

Preferably, it is made up of the medical material of following weight portion: 0.7 part of Moschus, Radix Panacis Quinquefolii 15 parts, 8.5 parts of Cornu Cervi Pantotrichum, Fructus Psoraleae 400 parts, Radix Polygoni Multiflori 95 parts, 30 parts of Radix Rehmanniae Preparata, Cortex Dictamni 120 parts, Radix Sophorae Flavescentis 105 parts, Caulis Spatholobi 40 parts, 20 parts of Flos Carthami, Radix Salviae Miltiorrhizae 100 Part, Semen Sesami Nigrum 50 parts, Fructus Tribuli 150 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, Radix Gentianae 20 parts, the Radix Astragali 20 parts.

Treat the preparation method of leukodermic external medicine composition, comprise the following steps:

1) each medical material is mixed in proportion, pulverizes, and makes mixture；

2) step 1) mixture being added concentration is the ethanol of 95%, mixes, seals；Mixture with the amount ratio of ethanol is: 200g: 450-550ml, the finished product after making is commonly called as Moschus ginseng and pilose antler tincture liquid.

In the Chinese medicine composition of the present invention, Moschus is warm in nature, GUIXIN, spleen channel, has refreshment of having one's ideas straightened out, blood circulation promoting and dispersing pathogen accumulation, hastens parturition down Effect of tire, be used for having one's ideas straightened out, refreshment, invigorate blood circulation, eliminating stagnation；Radix Panacis Quinquefolii hardship sweet, micro-, returns spleen, liver, heart channel, has boosting qi and nourishing yin, relieves inflammation or internal heat The effect promoted the production of body fluid, for enhancing immunity；Cornu Cervi Pantotrichum is sweet, salty, warm in nature, return kidney, Liver Channel, has kidney-replenishing, benefiting essence-blood, bone and muscle strengthening Effect, for invigorating YANG, Gu Yin；Fructus Psoraleae is bitter, pungent, warm greatly, returns kidney, Liver Channel, has effect of reinforcing the kidney and supporting YANG, warming the spleen, antidiarrheal, uses In complementary color, hyperchromic；Radix Polygoni Multiflori is sweet, bitter, puckery, tepor, returns liver,spleen,kidney warp, has tonifying liver, kidney, benefiting essence-blood, the merit of relieving constipation removing toxic substances Effect, for hyperchromic, liver, suffers from a deficiency of the kidney thanks to, early whitening of beard and hair；Radix Rehmanniae Preparata is sweet, tepor, returns liver, the heart, kidney channel, the effect have YIN nourishing, enriching blood, For hyperchromic, promoting generation of vital essence and blood, promoting blood circulation；Cortex Dictamni is bitter, cold, returns spleen, stomach warp, has heat-clearing and toxic substances removing, effect except wind damp eliminating, is used for Antipruritic；Radix Sophorae Flavescentis is bitter, cold, GUIXIN, liver, stomach, large intestine, bladder warp, have heat clearing away, dampness, dispel the wind, parasite killing, effect of diuresis, be used for Skin pruritus；Caulis Spatholobi is pungent, sweet, warm, returns liver, kidney channel, have enrich blood, promoting the circulation of blood, relaxing muscles and tendons, active effect, for complementary color, benefit Blood, promoting the circulation of blood；Flos Carthami is pungent, tepor, returns liver, heart channel, have invigorate blood circulation, blood stasis dispelling, effect of stimulating the menstrual flow, for hyperchromic, blood circulation promoting and blood stasis dispelling；Purple red Join sweet, be slightly cold, GUIXIN, pericardium, Liver Channel, there is blood circulation promoting and blood stasis dispelling, effect that removing heat from blood, eliminating carbuncle, relieving restlessness are calmed the nerves, Radix Salviae Miltiorrhizae is used for improving Microcirculation, promote tissue repair and regeneration, hyperchromic；Semen Sesami Nigrum is sweet, fragrant, warm, returns spleen, stomach warp, have YIN nourishing, nourish blood, moisturize logical Just effect, for hyperchromic, early whitening of beard and hair；Fructus Tribuli is bitter, pungent, flat, returns Liver Channel, have suppressing the hyperactive liver, soothing the liver, dispel the wind, the merit of improving eyesight Effect, is used for dispeling the wind, antipruritic；Radix Arnebiae (Radix Lithospermi) is sweet, cold, return gallbladder, liver, stomach warp, have removing heat from blood, invigorate blood circulation, detoxify, effect of rash, be used for increasing Color, removing heat from blood, invigorate blood circulation；Radix Gentianae is bitter, cold, returns gallbladder, liver, stomach warp, has effect of heat clearing and damp drying, removing fire from the liver, for complementary color, only Itch, heat clearing away；The Radix Astragali is sweet, tepor, returns spleen, lung meridian, has tonifying Qi and lifting yang, benefit defends consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, effect of diuresis detumescent, For expanding blood vessel, improving cutaneous circulation.

This Chinese medicine composition usage and consumption: be applied to affected part, keep 20-30min, and then sun tan or ultraviolet irradiate 5- 15min, 2-3 time on the one, 3 months courses for the treatment of.

The Chinese medicine composition of the present invention is applicable to: the case that neopathy has just been made a definite diagnosis, and the youngster that the course of disease was less than 3-6 month Virgin, teenager；Once it was EM to transplant not more and prove to be the patient of isomorphic response body constitution；Medicine for external use allergy, cureless disease People；The leukodermic patient of acra type；The vitiligo patient of mucocutaneous type.

Compared with prior art, the method have the advantages that

1) in the present invention, Radix Panacis Quinquefolii and the Radix Astragali be QI invigorating medicine, Fructus Psoraleae and Cornu Cervi Pantotrichum be YANG invigorating medicine, Radix Rehmanniae Preparata, Caulis Spatholobi and what The Radix Polygoni Multiflori is medicament for enriching blood, and Semen Sesami Nigrum is nourishing YIN and benefiting blood, moisturizes medicine, and Flos Carthami and Radix Salviae Miltiorrhizae are blood circulation promoting and blood stasis dispelling medicine, Radix Sophorae Flavescentis and dragon Radix Gentianae is heat clearing and damp drying medicine, and Radix Arnebiae (Radix Lithospermi) is clearing away heat and cooling blood medicine, and Cortex Dictamni is detoxifying and relieving itching medicine, and Fructus Tribuli is suppressing the hyperactive liver warming YANG medicine Thing, Moschus is refreshment medicine of having one's ideas straightened out, and is combined after the mixing of each flavour of a drug, has refreshment of having one's ideas straightened out, dispelling wind for relieving itching, blood circulation promoting and blood stasis dispelling, dampness removing disappear Speckle, with color complementary color, temperature husband's coloring, QI invigorating row is stagnant, functions of nourishing hair and growing hair, YIN nourishing and YANG strengthening, effect of QI invigorating skin care, is applied to affected part, it is possible to Strengthen lesions position skin microcirculation, improve the photosensitization of skin, activity of tyrosinase, directly act on melanocyte thin Born of the same parents so that illing skin melanocyte proliferation, melanocyte surface receptor increases, and can cure vitiligo, and not recur.

2) preparation method of the present invention is simply, easily operate, and reduces production cost, and the patent medicine made is effective.

3) utilizing the traditional Chinese medicine composition for treating vitiligo of the present invention, cure rate reaches 100%, evident in efficacy, easy to use, Clinical treatment 90 example, before treatment, clinical symptoms is: after epidermal melanophore is transplanted, and the colour of skin recovers uneven, and melanocyte is raw Long the best, the colour of skin is all cured in flower point-like, this 90 example, and has no recurrence, wherein after healing: 2 people treat 5 courses for the treatment of, and 1 rules by men Treating 1 course for the treatment of, remaining treats 2-3 the course for the treatment of.

According to clinical case, efficacy evaluation and to take effect as follows:

Recovery from illness: affected part white macula all disappears, the colour of skin is recovered normal, is not recurred.

Effective: affected part white macula all disappears, the colour of skin recovers uneven.

Effective: affected part white spot area reduces, the colour of skin recovers uneven.

Invalid: affected part white macula is not improved.

Detailed description of the invention

Embodiment 1-10

For making description brief, provide each embodiment with tabular form below, thus the present invention is described in further details.

The preparation method of embodiment 1-10, comprises the following steps:

1) each medical material is mixed in proportion, pulverizes, and makes mixture；

2) take 200g step 1) mixture adding 500 ml concentration is the ethanol of 95%, mixes, seals and get final product.

Below in conjunction with case, the therapeutical effect of the Chinese medicine composition of the present invention is described further:

Case 1

Zhang, man, 16 years old, student, was Zhongmou County white sand village people, suffers from vitiligo 183 cm in left upper arm in 2009²(his father is also It is patients with vitiligo), transplant (prior art) through epidermal melanophore (EM), the colour of skin recovers not ideal enough, and cell growth is the best, The colour of skin, in flower point-like, is come here and is gone to a doctor.

Prescription: the medicine made by Example 1, is applied to affected part, 3 times on the one.

Treating 2 first quarter moons, the state of an illness heals entirely, and the affected part colour of skin is normal, follows up a case by regular visits to vitiligo and does not recurs.

Case 2

Poplar, man, 23 years old, university student, was Henan people from Huixian City, both hands generation acra type vitiligo, in many ways cures and has no result, comes Go to a doctor in here.

Prescription: the medicine made by Example 2, is applied to affected part, 3 times on the one.

Treating 5 months, normal skin tone is recovered in affected part, follows up a case by regular visits to vitiligo and does not recurs.

Case 3

Xue so-and-so, female, 21 years old, be people from Taikang County, Henan, occurs that egg is big in right cervical region in 2011, and ovalize white macula comes me Place is medical.

Prescription: the medicine 100ml made by Example 3, is applied to affected part, 3 times on the one.

Treating 1 course for the treatment of, normal skin tone is recovered in affected part, does not recurs so far.

Claims (4)

1. treat leukodermic external medicine composition for one kind, it is characterised in that be made up of the medical material of following weight portion: Moschus 0.5-1 part, Radix Panacis Quinquefolii 15-30 part, Cornu Cervi Pantotrichum 7.5-15 part, Fructus Psoraleae 300-600 part, Radix Polygoni Multiflori 65-130 part, Radix Rehmanniae Preparata 30-60 Part, Cortex Dictamni 100-200 part, Radix Sophorae Flavescentis 100-200 part, Caulis Spatholobi 30-60 part, Flos Carthami 15-30 part, Radix Salviae Miltiorrhizae 50-100 part, black Semen Sesami 50-100 part, Fructus Tribuli 100-200 part, Radix Arnebiae (Radix Lithospermi) 15-30 part, Radix Gentianae 15-30 part, Radix Astragali 15-30 part.

2. the leukodermic external medicine composition for the treatment of as claimed in claim 1, it is characterised in that by the medicine of following weight portion Material is made: Moschus 0.5-0.8 part, Radix Panacis Quinquefolii 15-22 part, Cornu Cervi Pantotrichum 8-13 part, Fructus Psoraleae 350-420 part, Radix Polygoni Multiflori 80-110 part, Radix Rehmanniae Preparata 30-50 part, Cortex Dictamni 110-160 part, Radix Sophorae Flavescentis 100-140 part, Caulis Spatholobi 40-55 part, Flos Carthami 15-25 part, Radix Salviae Miltiorrhizae 70- 100 parts, Semen Sesami Nigrum 50-80 part, Fructus Tribuli 140-180 part, Radix Arnebiae (Radix Lithospermi) 15-24 part, Radix Gentianae 18-26 part, Radix Astragali 20-30 part.

3. the leukodermic external medicine composition for the treatment of as claimed in claim 2, it is characterised in that by the medicine of following weight portion Material is made: 0.7 part of Moschus, Radix Panacis Quinquefolii 15 parts, 8.5 parts of Cornu Cervi Pantotrichum, Fructus Psoraleae 400 parts, Radix Polygoni Multiflori 95 parts, 30 parts of Radix Rehmanniae Preparata, Cortex Dictamni 120 parts, Radix Sophorae Flavescentis 105 parts, Caulis Spatholobi 40 parts, 20 parts of Flos Carthami, Radix Salviae Miltiorrhizae 100 parts, Semen Sesami Nigrum 50 parts, Fructus Tribuli 150 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, Radix Gentianae 20 parts, the Radix Astragali 20 parts.

4. the preparation method treating leukodermic external medicine composition as described in claim 1-3, it is characterised in that include Following steps:

1) each medical material is mixed in proportion, pulverizes, and makes mixture；

2) step 1) mixture being added concentration is the ethanol of 95%, mixes, seals；Mixture with the amount ratio of ethanol is: 200g∶450-550ml。