CN102754827A - Food for hyperuricemia - Google Patents
Food for hyperuricemia Download PDFInfo
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- CN102754827A CN102754827A CN2012102076769A CN201210207676A CN102754827A CN 102754827 A CN102754827 A CN 102754827A CN 2012102076769 A CN2012102076769 A CN 2012102076769A CN 201210207676 A CN201210207676 A CN 201210207676A CN 102754827 A CN102754827 A CN 102754827A
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Abstract
The invention relates to a food for hyperuricemia, which is prepared from the following raw materials: poria cocos, plantain, desmodium, grifola, lophatherum gracile, bighead atractylodes rhizome, dried orange peel, watermeion peel, waxgourd peel, semen coicis, medicated leaven and pumpkin.
Description
Technical field
The present invention relates to field of food, be specifically related to a kind of food that is used for hyperuricemia.
Background technology
Uric acid is through RE.Hyperuricemia be purine metabolic disturbance and/or uric acid generate increase with (or) drain the metabolic disease due to reducing, can cause diseases such as gout, uric acid property kidney stone and gouty nephropathy.In recent years, hyperuricemia more and more receives clinical attention.High lithemia is the independent hazard factor of disease of cardiovascular system, and it and metabolic syndrome, coronary heart disease, hypertension, (AS) is closely related for atherosclerotic.Research in recent years mainly concentrates on the pass of diseases such as hyperuricemia and hyperlipidemia, hypertension, coronary heart disease, insulin resistance and diabetes, heart failure, kidney damage and fastens.Because UA is the key factor that causes disease of cardiovascular system unusually.
Hyperuricemia is the extracellular fluid lithate over-saturation state that a kind of physico-chemical examination is found, can not cause any symptom clinically, is called asymptomatic hyperuricemia, can cause that also the characteristic acute arthritis shows effect repeatedly, is called the gouty hyperuricemia.Because this disease has silent, occur often being repeated relapsing after the symptom, under many patient's imperceptions, the lithate deposition causes damage to its tissue and internal organ.There is big side effect in anti-trioxypurine medicine commonly used at present.Regulate diet style, can prevent the generation and the development of hyperuricemia.
The adjusting diet style comprises: mainly be meant and reduce the absorption of being rich in purine food, the absorption that reduces fat, the picked-up of increase basic food, many drinking-water.
Summary of the invention
The object of the invention provides a kind of food that is used for hyperuricemia and preparation method thereof.
A kind of food that is used for hyperuricemia of the present invention, because following raw material is processed:
Poria cocos, Asiatic plantain, desmodium, umbellate pore furgus, lophatherum gracile, the bighead atractylodes rhizome, dried orange peel, watermelon peel, waxgourd peel, coix seed, Divine Comedy, pumpkin.
A kind of food that is used for hyperuricemia of the present invention, its preparation method is:
Get Poria cocos 1-5 gram, Asiatic plantain 1-5 gram, desmodium 1-5 gram, umbellate pore furgus 1-5 gram, lophatherum gracile 2-10 gram, bighead atractylodes rhizome 2-10 gram, dried orange peel 15-30 gram, watermelon peel 15-30 gram, waxgourd peel 15-30 gram, coix seed 150-300 gram, Divine Comedy 1-5 gram, pumpkin 1500-3000 gram
Raw material blending, pulverizing that will be except that pumpkin; Sterilization is opened a little openning, with joining in the mixture in the pumpkin on pumpkin under germ-free condition; Under germ-free condition, the otch on the pumpkin is sealed; At room temperature, germ-free condition held 3-7 days, just obtain the food that is used for hyperuricemia of the present invention.
A kind of food that is used for hyperuricemia of the present invention, its preferred for preparation method is:
Get Poria cocos 3 grams, Asiatic plantain 3 grams, desmodium 3 grams, umbellate pore furgus 3 grams, lophatherum gracile 8 grams, the bighead atractylodes rhizome 8 grams, dried orange peel 20 grams, watermelon peel 20 grams, waxgourd peel 20 grams, coix seed 200 grams, Divine Comedy 3 grams, pumpkin 2000 grams,
Raw material blending, pulverizing that will be except that pumpkin; Sterilization is opened a little openning, with joining in the mixture in the pumpkin on pumpkin under germ-free condition; Under germ-free condition, the otch on the pumpkin is sealed; At room temperature, germ-free condition held 5 days, just obtain the food that is used for hyperuricemia of the present invention.
The specific embodiment
Embodiment 1
A kind of food that is used for hyperuricemia of the present invention, its preparation method is:
Get Poria cocos 1 gram, Asiatic plantain 1 gram, desmodium 1 gram, umbellate pore furgus 1 gram, lophatherum gracile 2 grams, the bighead atractylodes rhizome 2 grams, dried orange peel 15 grams, watermelon peel 15 grams, waxgourd peel 15 grams, coix seed 150 grams, Divine Comedy 1 gram, pumpkin 1500 grams,
Raw material blending, pulverizing that will be except that pumpkin; Sterilization is opened a little openning, with joining in the mixture in the pumpkin on pumpkin under germ-free condition; Under germ-free condition, the otch on the pumpkin is sealed; At room temperature, germ-free condition held 3 days, just obtain the food that is used for hyperuricemia of the present invention.
Embodiment 2
A kind of food that is used for hyperuricemia of the present invention, its preparation method is:
Get Poria cocos 5 grams, Asiatic plantain 5 grams, desmodium 5 grams, umbellate pore furgus 5 grams, lophatherum gracile 10 grams, the bighead atractylodes rhizome 10 grams, dried orange peel 30 grams, watermelon peel 30 grams, waxgourd peel 30 grams, coix seed 300 grams, Divine Comedy 5 grams, pumpkin 3000 grams,
Raw material blending, pulverizing that will be except that pumpkin; Sterilization is opened a little openning, with joining in the mixture in the pumpkin on pumpkin under germ-free condition; Under germ-free condition, the otch on the pumpkin is sealed; At room temperature, germ-free condition held 7 days, just obtain the food that is used for hyperuricemia of the present invention.
Embodiment 3
A kind of food that is used for hyperuricemia of the present invention, its preparation method is:
Get Poria cocos 3 grams, Asiatic plantain 3 grams, desmodium 3 grams, umbellate pore furgus 3 grams, lophatherum gracile 8 grams, the bighead atractylodes rhizome 8 grams, dried orange peel 20 grams, watermelon peel 20 grams, waxgourd peel 20 grams, coix seed 200 grams, Divine Comedy 3 grams, pumpkin 2000 grams,
Raw material blending, pulverizing that will be except that pumpkin; Sterilization is opened a little openning, with joining in the mixture in the pumpkin on pumpkin under germ-free condition; Under germ-free condition, the otch on the pumpkin is sealed; At room temperature, germ-free condition held 5 days, just obtain the food that is used for hyperuricemia of the present invention.
Embodiment 4
Get Poria cocos 4 grams, Asiatic plantain 4 grams, desmodium 4.5 grams, umbellate pore furgus 4.5 grams, lophatherum gracile 7 grams, the bighead atractylodes rhizome 7 grams, dried orange peel 20 grams, watermelon peel 20 grams, waxgourd peel 20 grams, coix seed 300 grams, Divine Comedy 5 grams, pumpkin 3000 grams,
Raw material blending, pulverizing that will be except that pumpkin; Sterilization is opened a little openning, with joining in the mixture in the pumpkin on pumpkin under germ-free condition; Under germ-free condition, the otch on the pumpkin is sealed; At room temperature, germ-free condition held 6 days, just obtain the food that is used for hyperuricemia of the present invention.
Embodiment 5
Hypoxanthine is led to the influence of mouse hyperuricemia
Be chosen in the mouse of 20g-22g, male and female half and half,
Precursor compound hypoxanthine 1000mg/kg lumbar injection with uric acid causes hyperuricemia model.In modeling preceding 2 days; Respectively mouth raise food 2g/kg to embodiment 4,4g/kg, 8g/kg (be called respectively little, in, heavy dose of administration group); Allopurinol 50g/kg (Allopurinol group) or probenecid 200g/kg (probenecid group), once a day, and before modeling half an hour be administered once again; Other establishes the normal control group (normal group) of not to any processing, only giving equal-volume distilled water.In the third hour after modeling, Ma were collected from each animal's urine and blood were measured in urine and blood levels of uric acid.Can find out that from the result of table 1 food of embodiment 4 can reduce blood uric acid concentration, improve the acid concentration of urinating; The food of embodiment 4 has the effect that uricosuric is drained.
The food of embodiment 4 is led to the influence of mouse hyperuricemia to hypoxanthine
| Group | Number of animals | Blood uric acid concentration (mmol/L) | The acid concentration of urinating (mmol/L) |
| Normal group | 10 | 0.1352±0.0879 | 0.0021± 0.0501 |
| The modeling group | 10 | 0.2987± 0.0325 | 1.2366± 1.9786 |
| The food 2g/kg of embodiment 4 | 10 | 0.1312± 0.0198 | 1.3256± 1.4563 |
| The food 4g/kg of embodiment 4 | 10 | 0.1236± 0.0196 | 1.4322± 1.7896 |
| The food 8g/kg of embodiment 4 | 10 | 0.1013± 0.0356 | 1.5563± 1.9232 |
| Allopurinol 50mg/kg | 10 | 0.0048± 0.0112 | 0.2456± 0.2453 |
| Probenecid 200mg/kg | 10 | 0.0963± 0.0693 | 1.7986± 1.6589 |
Embodiment 6
Uricosuric to hyperuricemia is drained
Get the healthy male Wistar rat of body weight between 250g-300g, lead to hyperuricemia with uric acid 500mg/kg dosage lumbar injection.
Modeling the first two day beginning, mouth is raised the food 4g/kg that gives embodiment 4 respectively, and mouth is raised and is suppressed uric acid synthetic drug Allopurinol 50mg/kg, and all once a day, be administered once half an hour again before the modeling.
Other establishes the intact animal control group.With the modeling while, every animal mouth is raised distilled water 6ml.Animal is placed metabolic cage respectively, collect twenty-four-hour urine liquid; And after modeling 24 hours, gather blood.Measure the uric acid content of urine and blood sample.
Shown in the result: give the food of the embodiment 4 of institute's amount of reagent, the excretion of uric acid in the twenty-four-hour urine liquid is increased
| Group | Number of animals | Body weight (g) | Urine amount (ml) | The acid concentration of urinating (mmol/L) | Uric acid discharge rate (mmol*10 -3) | Blood uric acid concentration (mmol/L) |
| Normal group | 10 | 261.2±19.0 | 11.49±1.79 | 0.109±0.029 | 1.178±0.623 | 0.187±0.019 |
| The modeling group | 10 | 264.3±16.7 | 12.56±2.18 | 0.117±0.053 | 1.578±0.598 | 0.247±0.039 |
| Administration group 25mg/kg | 10 | 259.9±15.2 | 12.46±2.59 | 0.189±0.043 | 1.956±0.456 | 0.219±0.033 |
| Allopurinol 50mg/kg | 10 | 267.3±18.1 | 12.93±2.57 | 0.159±0.087 | 1.723±0.763 | 0.228±0.052 |
Embodiment 7
The field, man, 57 years old, first visit.Medical history: because of the little joint congestion and swelling pain of left hand little finger of toe 3 years, increased the weight of 2 days, blood uric acid 589 μ mol/L, renal function is normal; Urine is conventional: albumen (-), red blood cell (+), leucocyte (++), 19 HP of leucocyte under the mirror.Irritated to Allopurinol.
The food of oral embodiment 4, each 50g, every day 3 times, continuous 30 days, check urine was conventional normal, and blood uric acid is reduced to 298 μ mol/L, and the joint is not bitterly.
Embodiment 8
The food of irritating stomach embodiment 4 in the acute toxicity test per os of mouse carries out maximum dosage-feeding test in a day, and its result is that total amount reaches 25g/kg in one day, and still overt toxicity reaction and dead appears in the end in 7 days, and the weight of animals does not have significant change yet.Irritating stomach dosage in the long term toxicity test the continuous per os of rat is 4,8 and 16g/kg,, medication every day 2 times, logotype 90 days continues after stopping to observe 120 days again.In medication the 45th day and detected each item index in 90 days, its result shows: the histopathologic examination to ordinary circumstance, body weight, food ration, peripheral hemogram, liver, renal function, haemocyanin, each main organs coefficient and each main organs thereof of rat does not all have obvious influence.Compare with the normal control group, difference does not have conspicuousness.
Claims (2)
1. a kind of food that is used for hyperuricemia of the present invention, because following raw material is processed:
Poria cocos, Asiatic plantain, desmodium, umbellate pore furgus, lophatherum gracile, the bighead atractylodes rhizome, dried orange peel, watermelon peel, waxgourd peel, coix seed, Divine Comedy, pumpkin.
2. a kind of food that is used for hyperuricemia of the present invention, its preparation method is:
Get Poria cocos 1-5 gram, Asiatic plantain 1-5 gram, desmodium 1-5 gram, umbellate pore furgus 1-5 gram, lophatherum gracile 2-10 gram, bighead atractylodes rhizome 2-10 gram, dried orange peel 15-30 gram, watermelon peel 15-30 gram, waxgourd peel 15-30 gram, coix seed 150-300 gram, Divine Comedy 1-5 gram, pumpkin 1500-3000 gram
Raw material blending, pulverizing that will be except that pumpkin; Sterilization is opened a little openning, with joining in the mixture in the pumpkin on pumpkin under germ-free condition; Under germ-free condition, the otch on the pumpkin is sealed; At room temperature, germ-free condition held 3-7 days, just obtain the food that is used for hyperuricemia of the present invention.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758920A (en) * | 2015-04-29 | 2015-07-08 | 唐凯 | Gout health care product based on homology of medicine and food |
| CN105943958A (en) * | 2016-06-03 | 2016-09-21 | 黑龙江省玄鸟生物科技股份有限公司 | Inonotus obliquus composite solid particles for treating gout and preparing method thereof |
| CN105994489A (en) * | 2016-07-28 | 2016-10-12 | 福建万亿店中店电子商务有限责任公司 | Healthy food for patients with hyperuricemia |
| CN109430602A (en) * | 2018-11-13 | 2019-03-08 | 何少明 | One kind four skins, three seed deacidification drink and its preparation process |
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| CN101011544A (en) * | 2007-01-22 | 2007-08-08 | 尹政德 | Gout rapid recovery pill(capsule) and preparation technique thereof |
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- 2012-06-24 CN CN2012102076769A patent/CN102754827B/en not_active Expired - Fee Related
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| CN101011544A (en) * | 2007-01-22 | 2007-08-08 | 尹政德 | Gout rapid recovery pill(capsule) and preparation technique thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758920A (en) * | 2015-04-29 | 2015-07-08 | 唐凯 | Gout health care product based on homology of medicine and food |
| CN105943958A (en) * | 2016-06-03 | 2016-09-21 | 黑龙江省玄鸟生物科技股份有限公司 | Inonotus obliquus composite solid particles for treating gout and preparing method thereof |
| CN105994489A (en) * | 2016-07-28 | 2016-10-12 | 福建万亿店中店电子商务有限责任公司 | Healthy food for patients with hyperuricemia |
| CN109430602A (en) * | 2018-11-13 | 2019-03-08 | 何少明 | One kind four skins, three seed deacidification drink and its preparation process |
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| CN102754827B (en) | 2013-10-23 |
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Owner name: NINGBO YINZHOU FURUIDA BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: NINGBO YINZHOU HAOSI RUIPU BIOTECHNOLOGY CO., LTD. Effective date: 20131011 |
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