CN106177262A - One is used for treating the uremic Chinese medicine composition of nephropathy - Google Patents

One is used for treating the uremic Chinese medicine composition of nephropathy Download PDF

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CN106177262A
CN106177262A CN201610679499.2A CN201610679499A CN106177262A CN 106177262 A CN106177262 A CN 106177262A CN 201610679499 A CN201610679499 A CN 201610679499A CN 106177262 A CN106177262 A CN 106177262A
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radix
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chinese medicine
medicine composition
alcohol
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仲卫行
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Abstract

The invention provides a kind of nephrotic syndrome and uremic Chinese medicine composition, it is made up of the crude drug of following weight portion: Rhizoma Alismatis 5 10, Cortex Moutan 6 15, Radix Asparagi 6 15, Radix Codonopsis 10 30, Rhizoma Acori Graminei 3 10, Poria 10 15, Rhizoma Imperatae 15 30, Carapax et Plastrum Testudinis 10 25, Bulbus Fritillariae Cirrhosae 3 10, ink Herba Ecliptae 6 15, Concha Ostreae 10 30, the Radix Astragali 10 30, Radix Scrophulariae 10 15, Fructus Gardeniae 3 10, the Radix Paeoniae Alba 5 15, Herba Cirsii 10 15, the Radix Rehmanniae 10 15, Os Draconis 10 30, Cortex Acanthopancis 5 10, Radix Ophiopogonis 6 15, Radix Curcumae 5 15, Folium Bambusae 6 15.

Description

One is used for treating the uremic Chinese medicine composition of nephropathy
One technical field
The present invention relates to the field of Chinese medicines, specifically, the present invention relates to treat the uremic Chinese medicine composition of nephropathy.
Two background technologies
Renal failure is the chronic progressive external Renal lesion caused due to many reasons, and it causes kidney not maintain In its basic function, nitrogenous waste and other metabolite retention bodies, water, electrolyte and acid base imbalance.The end eventually of chronic kidney hypofunction Phase is the uremia that it has often been said.Uremia is not an independent disease, but total the facing of the nephropathy in various late period Bed syndrome, the syndrome that when being the chronic renal failure entrance end stage eventually, the series of clinical manifestations of appearance is formed.
The whole world has more than 500,000,000 people and suffers from chronic kidney disease in various degree, and chronic kidney disease has become the tumor that continues, heart and brain After angiopathy, diabetes, the important diseases of another threat human health, become global important public hygiene problem (generation Health organization website, boundary, 2014 annual datas)；China's chronic kidney disease sickness rate is about 7%, and wherein suffering from uremia needs blood Dialysis or nearly million (Chinese residents nourishment and chronic disease status report 2015 national health and the family planning of patient of peritoneal dialysis Committee official website).Uremia's course of disease is long, and remedy measures cost of especially dialysing is high, has become as many families and society is public The heavy burden of health services altogether.
Doctor trained in Western medicine aspect mainly takes hemodialysis and peritoneal dialysis method to treat uremia, and ripe dialysis can have Effect extends patient's life-span, and peritoneal dialysis can also largely reduce the impact on minimal invasive treatment.But owing to principle is limited, thoroughly The side effect such as analysis anemia, fluctuation of blood pressure, easy infection risk are difficult to eliminate, and expense also cannot be greatly reduced.
The traditional Chinese medical science think the uremic cause of disease be acute bleed profusely, sudden attack of spouting diarrhea, high heat etc., body fluid loses in a large number, so that oliguria Or anuria, turbid urine must not leak, and accumulates in turbid poison, covers and closes brain god；Or nephropathy is with the passing of time, cause kidney qi exhaustion, disturbance in functioning of QI, turbid damp uremic Must not let out down, upper general illiteracy closes brain god, forms kidney and faints.Disturb on turbid poison, cover and close that brain god is the most drowsiness, coma, delirium；Turbid YIN failing to descend, clearly Sun does not rises, adverse rising of stomach-QI then vomiting and nausea；Negative and positive are maintained mutually, form the depletion syndrome to dissociation of YIN from YANG eventually.Therefore the traditional Chinese medical science is mainly let out to have one's ideas straightened out It is sick that turbid Dialectical Method treats this.The field of Chinese medicines has been provided for a large amount of Traditional Chinese medicine composition formula, and some have listed Chinese patent medicine, common are NIAODUQING KELI (Kang Chen pharmacy etc., mainly become include Radix Et Rhizoma Rhei, the Radix Astragali, Radix Sophorae Flavescentis, the Rhizoma Atractylodis Macrocephalae, Poria, The Radix Paeoniae Alba, Radix Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Plantaginis etc.), SHENSHUAINING sheet (the new Pharmaceutical in east, Shenyang etc., main component includes) Radix Pseudostellariae, Rhizoma Coptidis, The Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Poria, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Flos Carthami, Radix Glycyrrhizae etc..The uremic major defect for the treatment of by Chinese herbs is curative effect, especially It is that curative effect uremic for middle severe be not relatively low even clear and definite, is typically only capable of being used alone to control at the chronic nephropathy initial stage PD, or auxiliary dialysis treatment.
Three summary of the invention
On the one hand, the invention provides a kind of for treating the uremic Chinese medicine composition of nephropathy, including following weight portion Raw material: Rhizoma Alismatis 5-10, Poria 10-15, Radix Astragali 10-30, Os Draconis 10-30, Cortex Acanthopancis 5-10.
Further aspect, being used for of the present invention treat the uremic Chinese medicine composition of nephropathy, and it is by following weight portion Crude drug is made: Rhizoma Alismatis 5-10, Cortex Moutan 6-15, Radix Asparagi 6-15, Radix Codonopsis 10-30, Rhizoma Acori Graminei 3-10, Poria 10-15, Rhizoma Imperatae 15-30, Carapax et Plastrum Testudinis 10-25, Bulbus Fritillariae Cirrhosae 3-10, Herba Ecliptae 6-15, Concha Ostreae 10-30, Radix Astragali 10-30, Radix Scrophulariae 10-15, Fructus Gardeniae 3- 10, Radix Paeoniae Alba 5-15, Herba Cirsii 10-15, Radix Rehmanniae 10-15, Os Draconis 10-30, Cortex Acanthopancis 5-10, Radix Ophiopogonis 6-15, Radix Curcumae 5-15, bamboo Leaf 6-15.
Further aspect, being used for of the present invention treat the uremic Chinese medicine composition of nephropathy, former by following weight portion Material medicine is made: Rhizoma Alismatis 7, Cortex Moutan 10, Radix Asparagi 15, Radix Codonopsis 15, Rhizoma Acori Graminei 10, Poria 10, Rhizoma Imperatae 15, Carapax et Plastrum Testudinis 20, Bulbus Fritillariae Cirrhosae 10, Herba Ecliptae 6, Concha Ostreae 10, the Radix Astragali 15, Radix Scrophulariae 10, Fructus Gardeniae 3, the Radix Paeoniae Alba 10, Herba Cirsii 10, the Radix Rehmanniae 10, Os Draconis 10, Cortex Acanthopancis 5, Radix Ophiopogonis 12, Radix Curcumae 5, Folium Bambusae 6.
Further aspect, being used for of the present invention treat the uremic Chinese medicine composition of nephropathy, and it is in accordance with the following methods Make: weigh various medical material by weight；The second that Poria, Radix Codonopsis, Carapax et Plastrum Testudinis, Bulbus Fritillariae Cirrhosae, the Radix Astragali, Radix Scrophulariae, Os Draconis are added 40% Alcohol extraction 3 times, each alcohol adding amount is 5 times of medical material gross weight, and each extraction time is 2 hours, united extraction liquid, reclaims ethanol To without alcohol taste, obtain alcohol extract, alternatively, described alcohol extract is concentrated into solid or semisolid obtains ethanol extract；By Rhizoma Alismatis, pellet Skin, Radix Asparagi, Rhizoma Acori Graminei, Rhizoma Imperatae, Herba Ecliptae, Concha Ostreae, Fructus Gardeniae, the Radix Paeoniae Alba, Herba Cirsii, the Radix Rehmanniae, Cortex Acanthopancis, Radix Ophiopogonis, Radix Curcumae, Folium Bambusae extracting in water 3 times, each amount of water is respectively 10 times amount of medical material gross weight, and each extraction time is 3 hours, and merging carries Taking liquid, being concentrated into relative density is about 1.1, adds ethanol and makes alcohol content be 50 volume %, and mixing is placed 48 hours, taken Clear liquid, recovery ethanol, to without alcohol taste, obtains water extracting liquid, alternatively, described water extracting liquid is concentrated into solid further Or semi-solid, obtain water extract；Gained alcohol extract and water extracting liquid are mixed, or gained ethanol extract and water extract are mixed Close, obtain Chinese medicine composition.
On the other hand, the invention provides described for treating the preparation method of the uremic Chinese medicine composition of nephropathy, bag Include: weigh various medical material by weight；The ethanol that Poria, Radix Codonopsis, Carapax et Plastrum Testudinis, Bulbus Fritillariae Cirrhosae, the Radix Astragali, Radix Scrophulariae, Os Draconis are added 40% Extracting 3 times, each alcohol adding amount is 5 times of medical material gross weight, and each extraction time is 2 hours, united extraction liquid, reclaims ethanol extremely Taste without alcohol, obtains alcohol extract, alternatively, described alcohol extract is concentrated into solid or semisolid obtains ethanol extract；By Rhizoma Alismatis, pellet Skin, Radix Asparagi, Rhizoma Acori Graminei, Rhizoma Imperatae, Herba Ecliptae, Concha Ostreae, Fructus Gardeniae, the Radix Paeoniae Alba, Herba Cirsii, the Radix Rehmanniae, Cortex Acanthopancis, Radix Ophiopogonis, Radix Curcumae, Folium Bambusae extracting in water 3 times, each amount of water is respectively 10 times amount of medical material gross weight, and each extraction time is 3 hours, and merging carries Taking liquid, being concentrated into relative density is about 1.1, adds ethanol and makes alcohol content be 50 volume %, and mixing is placed 48 hours, taken Clear liquid, recovery ethanol, to without alcohol taste, obtains water extracting liquid, alternatively, described water extracting liquid is concentrated into solid further Or semi-solid, obtain water extract；Gained alcohol extract and water extracting liquid are mixed, or gained ethanol extract and water extract are mixed Close, obtain Chinese medicine composition.
Four detailed description of the invention
The preparation of embodiment 1 Chinese medicine composition of the present invention
Weigh Rhizoma Alismatis 7, Cortex Moutan 10, Radix Asparagi 15, Radix Codonopsis 15, Rhizoma Acori Graminei 10, Poria 10, Rhizoma Imperatae 15, Testudinis by weight Plate 20, Bulbus Fritillariae Cirrhosae 10, Herba Ecliptae 6, Concha Ostreae 10, the Radix Astragali 15, Radix Scrophulariae 10, Fructus Gardeniae 3, the Radix Paeoniae Alba 10, Herba Cirsii 10, the Radix Rehmanniae 10, raw dragon Bone 10, Cortex Acanthopancis 5, Radix Ophiopogonis 12, Radix Curcumae 5, Folium Bambusae 6；
The ethanol extraction adding 40% by Poria, Radix Codonopsis, Carapax et Plastrum Testudinis, Bulbus Fritillariae Cirrhosae, the Radix Astragali, Radix Scrophulariae, Os Draconis 3 times, adds alcohol every time 5 times that amount is medical material gross weight, each extraction time is 2 hours, united extraction liquid, and recovery ethanol, to without alcohol taste, obtains alcohol extraction Liquid；
By Rhizoma Alismatis, Cortex Moutan, Radix Asparagi, Rhizoma Acori Graminei, Rhizoma Imperatae, Herba Ecliptae, Concha Ostreae, Fructus Gardeniae, the Radix Paeoniae Alba, Herba Cirsii, the Radix Rehmanniae, five Cortex Acanthopanacis Radicis, Radix Ophiopogonis, Radix Curcumae, Folium Bambusae extracting in water 3 times, each amount of water is respectively 10 times amount of medical material gross weight, extracts every time Time is 3 hours, united extraction liquid, and being concentrated into relative density is about 1.1, adds ethanol and makes alcohol content be 50 volume %, mixed Even, to place 48 hours, take supernatant, recovery ethanol, to without alcohol taste, obtains water extracting liquid；
Gained alcohol extract and water extracting liquid are mixed, obtains Chinese medicine composition.
Hereinafter in experiment, Wistar rat is provided by Beijing Experimental Amimal Research Centre, and general reagent is purchased from Shanghai traditional Chinese medicines collection Group, hydrochlorothiazide tablet, NIAODUQING KELI, SHENSHUAINING sheet are purchased from regular pharmacy (using dosage converts to specifications), the most greatly Mus feedstuff is pulled together feed corporation,Ltd purchased from Beijing Australia of section, and not specified specific experiment step and parameter are done according to this area routine Method is carried out.
The therapeutical effect of the chronic renal failure that adenine is caused by embodiment 2 Chinese medicine composition of the present invention.
Take the healthy normal Wistar rats 100 of body weight 200-250g, be equally divided into 5 groups.Normal rats forage feed Outside respectively every every day, hydrochlorothiazide tablet powder suspension (Guangdong three just stone discrimination system of gavage Chinese medicine composition of the present invention 0.3ml/ Medicine, 0.2mg/ every every day, 0.3ml), SHENSHUAINING sheet powder suspension (the new Pharmaceutical in east, Shenyang, 15mg/ every every day, 0.4ml), NIAODUQING KELI powder suspension (Kang Chen pharmacy, 12mg/ every every day, 0.4ml), every every day of normal saline 0.3ml/, continuously One week.Continuously gavage medicine is after one week, and gastric infusion gavage simultaneously gives every every day of adenine 50mg/, continuous 2 weeks.Thereafter Continuing independent gavage medicine one week, fasting subsequently is not intake 2 days, collects twenty-four-hour urine liquid and measures urine protein, and measures in blood Blood urea nitrogen, creatinine.
Table 1: the blood urea nitrogen in the chronic renal failure experiment that adenine causes, creatinine level
Table 2: the twenty-four-hour urine protein level in the chronic renal failure experiment that adenine causes
Twenty-four-hour urine albumen g
Chinese medicine composition of the present invention 65.23±18.75
Hydrochlorothiazide tablet 69.74±6.12
SHENSHUAINING sheet 95.77±22.71
NIAODUQING KELI 88.91±35.89
Normal saline 193.54±23.43
Test result indicate that, the Chinese medicine composition of the present invention, the disease of the Chronic Renal Failure Rats that adenine is caused Shape has mitigation, can effectively reduce rat serum BUN, Cr and twenty-four-hour urine protein level, and effect is significantly better than SHENSHUAINING sheet Chinese patent medicine is commonly used with NIAODUQING KELI both, can be compared with the Western medicine hydrochlorothiazide tablet of clear curative effect, and in the present invention The each component of drug composition is conventional Chinese medicine kind, without substantially having no side effect, can avoid the hyperglycemia of hydrochlorothiazide tablet, white The side effect such as Leukopenia.Additionally, through rough Statistics, pharmaceutical composition of the present invention can also be effectively improved erythrocyte and blood red Protein level, thus alleviate Anemia, hydrochlorothiazide tablet there is no significantly this effect (data do not show).
Embodiment 3 Chinese medicine composition of the present invention causes the therapeutical effect of Chronic Renal Failure Rats to kidney 5/6 excision
Take the healthy normal Wistar rats 60 of body weight 200-250g, use 5/6 nephrectomy method to prepare uremic rats Model: rat is ventricumbent position after the chloral hydrate 0.3mL/100g intramuscular injection anesthesia of 10%, 1cm under the left back rib of row, the other 0.5cm of ridge cut Mouthful, expose nephropathy and divest the pole up and down about 2/3 of the thin film left kidney of trapezoidal excision, after 1 week, rat is on the same descending right side of position Otch, ligatures the kidney base of a fruit at the right hilus renalis and excises right kidney.Taking arteria caudalis blood after postoperative 5 weeks and survey serum creatinine, serum creatinine value is normal 52 rats that rat is more than 2-3 times be considered modeling success, choose wherein 50 test.
50 successful rats of modeling are equally divided into 5 groups, outside normal rats forage feed in the difference gavage present invention Drug composition 0.3ml/ every every day, hydrochlorothiazide tablet powder suspension (Guangdong three just stone discrimination pharmacy, 0.2mg/ every every day, 0.3ml), SHENSHUAINING sheet powder suspension (the new Pharmaceutical in east, Shenyang, 15mg/ every every day, 0.4ml), NIAODUQING KELI powder suspension (Kang Chen pharmacy, 12mg/ every every day, 0.4ml), every every day of normal saline 0.3ml/, successive administration 3 weeks.Measure big after 3 weeks Mus blood osmotic pressure and osmotic pressure of urine, fasting subsequently is not intake 2 days, collects twenty-four-hour urine liquid and measures urine protein, and measures in blood Blood urea nitrogen, creatinine.
Table 3: kidney 5/6 excision causes the blood urea nitrogen in chronic renal failure experiment, creatinine level
Blood urea nitrogen (BUN) mmol/L Creatinine (Cr) μm ol/L
Chinese medicine composition of the present invention 12.42±4.63 73.41±15.98
Hydrochlorothiazide tablet 8.75±4.21 70.66±9.50
SHENSHUAINING sheet 19.76±9.32 93.98±9.20
NIAODUQING KELI 19.36±9.23 88.55±12.45
Normal saline 30.74±8.67 135.43±11.33
Table 4: kidney 5/6 excision causes the twenty-four-hour urine protein level in chronic renal failure experiment
Twenty-four-hour urine albumen g
Chinese medicine composition of the present invention 83.44±17.70
Hydrochlorothiazide tablet 70.20±18.12
SHENSHUAINING sheet 131.09 ± 36,21
NIAODUQING KELI 125.3±40.51
Normal saline 200.55±36.72
Table 5: kidney 5/6 excision causes osmotic pressure of urine and blood osmotic pressure in chronic renal failure experiment
Osmotic pressure of urine mOsm/Kg H2O Blood osmotic pressure mOsm/Kg H2O
Chinese medicine composition of the present invention 437.80±25.41 325.88±30.54
Hydrochlorothiazide tablet 470.01±19.54 294.21±44.98
SHENSHUAINING sheet 395.20±26.11 360.85±48.22
NIAODUQING KELI 400.99±49.58 339.90±19.85
Normal saline 332.78±38.00 405.33±37.90
Test result indicate that, the Chinese medicine composition of the present invention, the disease of the Chronic Renal Failure Rats that adenine is caused Shape has mitigation, can effectively reduce rat serum BUN, Cr and twenty-four-hour urine protein level, and effect is significantly better than SHENSHUAINING sheet Chinese patent medicine is commonly used with NIAODUQING KELI both, the poorest compared with the Western medicine hydrochlorothiazide tablet of clear curative effect.And can show Writing and improve the osmotic pressure of urine level of uremia's rat model and reduce its blood osmotic pressure level, effect is far above SHENSHUAINING sheet and urine The clear granule of poison, even part is better than hydrochlorothiazide tablet, has good therapeutic effect to uremia.
Embodiment 4 actual patient compliance test result
Collect uremic patient totally 40 example as state class, age men and women half and half, age 40-50 year, interior granulation promoting acid anhydride is removed Rate 15-20mL/min, serum creatinine 250-320 μm ol/L (relates to hospital and patients ' privacy, concrete source is underground).
10 examples take hydrochlorothiazide tablet by hospital's doctor's advice dosage, and 10 examples take NIAODUQING KELI by hospital's doctor's advice dosage, and 10 Example is taken, by doctor's advice, the Chinese medicinal formulae that Beijing Chinese herbalist clinic opens and (three times a day, is taken after the meal, include through identification main component Poria, Radix Codonopsis, the Radix Astragali, the Radix Paeoniae Alba, Cortex Moutan, concrete formula consumption is failed to understand), the Chinese medicine composition liquid that 10 examples take the present invention is (every Day 2 times, take after the meal, 500ml), in addition to said medicine, do not take other Chinese medicines or health product.After 2 weeks, granulation promoting in measuring Acid anhydride clearance rate and serum creatinine also inquire the state of an illness.Effectively it is defined as readme symptom to alleviate, and in index, has endogenous creatinine clearance rate Increase by 20% or serum creatinine reduce by 20%.
Test result indicate that, effectively (wherein in 5 examples, granulation promoting acid anhydride is clear 7 example patient in the application Chinese medicine composition group Except rate and serum creatinine return under the diagnostic criteria of below more than 25mL/min and 220 μm ol/L), no less than hydrochlorothiazide tablet (8 examples are effective, and 5 example endogenous creatinine clearance raties and serum creatinine return to the diagnosis mark of below more than 25mL/min and 220 μm ol/L for group Under standard), hence it is evident that be better than NIAODUQING KELI and Chinese medicinal formulae that Beijing Chinese herbalist clinic opens (effective number of cases is only 4 examples respectively Son and 2 examples, endogenous creatinine clearance rate and serum creatinine return under the diagnostic criteria of below more than 25mL/min and 220 μm ol/L Only have 2 examples and 0 example).The application Chinese medicine composition has clear and definite good efficacy to light moderate uremic patient, hence it is evident that exceed Existing Chinese medicine, also toxic side effect is low compared with Western medicine, and patient's readme symptom improves effective advantage.

Claims (5)

1. it is used for treating the uremic Chinese medicine composition of nephropathy, including the raw material of following weight portion: Rhizoma Alismatis 5-10, Poria 10-15, Radix Astragali 10-30, Os Draconis 10-30, Cortex Acanthopancis 5-10.
2. the Chinese medicine composition described in claim 1, is made up of the crude drug of following weight portion: Rhizoma Alismatis 5-10, Cortex Moutan 6-15, sky Door winter 6-15, Radix Codonopsis 10-30, Rhizoma Acori Graminei 3-10, Poria 10-15, Rhizoma Imperatae 15-30, Carapax et Plastrum Testudinis 10-25, Bulbus Fritillariae Cirrhosae 3-10, ink drought Lotus 6-15, Concha Ostreae 10-30, Radix Astragali 10-30, Radix Scrophulariae 10-15, Fructus Gardeniae 3-10, Radix Paeoniae Alba 5-15, Herba Cirsii 10-15, Radix Rehmanniae 10-15, Os Draconis 10-30, Cortex Acanthopancis 5-10, Radix Ophiopogonis 6-15, Radix Curcumae 5-15, Folium Bambusae 6-15.
3. the Chinese medicine composition described in claim 2, is made up of the crude drug of following weight portion: Rhizoma Alismatis 7, Cortex Moutan 10, Radix Asparagi 15, Radix Codonopsis 15, Rhizoma Acori Graminei 10, Poria 10, Rhizoma Imperatae 15, Carapax et Plastrum Testudinis 20, Bulbus Fritillariae Cirrhosae 10, Herba Ecliptae 6, Concha Ostreae 10, the Radix Astragali 15, profound Ginseng 10, Fructus Gardeniae 3, the Radix Paeoniae Alba 10, Herba Cirsii 10, the Radix Rehmanniae 10, Os Draconis 10, Cortex Acanthopancis 5, Radix Ophiopogonis 12, Radix Curcumae 5, Folium Bambusae 6.
4. the Chinese medicine composition described in claim 1 or 2, it is to make in accordance with the following methods: weigh various medical material by weight； The ethanol extraction adding 40% by Poria, Radix Codonopsis, Carapax et Plastrum Testudinis, Bulbus Fritillariae Cirrhosae, the Radix Astragali, Radix Scrophulariae, Os Draconis 3 times, each alcohol adding amount is medical material 5 times of gross weight, each extraction time is 2 hours, united extraction liquid, and recovery ethanol, to without alcohol taste, obtains alcohol extract, optional Ground, is concentrated into solid by described alcohol extract or semisolid obtains ethanol extract；By Rhizoma Alismatis, Cortex Moutan, Radix Asparagi, Rhizoma Acori Graminei, Rhizoma Imperatae, Herba Ecliptae, Concha Ostreae, Fructus Gardeniae, the Radix Paeoniae Alba, Herba Cirsii, the Radix Rehmanniae, Cortex Acanthopancis, Radix Ophiopogonis, Radix Curcumae, Folium Bambusae extracting in water 3 times, add water every time Amount is respectively 10 times amount of medical material gross weight, and each extraction time is 3 hours, united extraction liquid, and being concentrated into relative density is 1.1 Left and right, adds ethanol and makes alcohol content be 50 volume %, and mixing is placed 48 hours, takes supernatant, and recovery ethanol, to without alcohol taste, obtains To water extracting liquid, alternatively, described water extracting liquid is concentrated into solid or semisolid further, obtains water extract；By institute Obtain alcohol extract and water extracting liquid mixing, or gained ethanol extract and water extract are mixed, obtain Chinese medicine composition.
5. the method for the Chinese medicine composition of preparation any one of claim 1-3, including: weigh various medical material by weight；By Fu The ethanol extraction that Siberian cocklebur, Radix Codonopsis, Carapax et Plastrum Testudinis, Bulbus Fritillariae Cirrhosae, the Radix Astragali, Radix Scrophulariae, Os Draconis add 40% 3 times, each alcohol adding amount is medical material gross weight 5 times of amount, each extraction time is 2 hours, united extraction liquid, and recovery ethanol, to without alcohol taste, obtains alcohol extract, alternatively, will Described alcohol extract is concentrated into solid or semisolid obtains ethanol extract；By Rhizoma Alismatis, Cortex Moutan, Radix Asparagi, Rhizoma Acori Graminei, Rhizoma Imperatae, ink drought Lotus, Concha Ostreae, Fructus Gardeniae, the Radix Paeoniae Alba, Herba Cirsii, the Radix Rehmanniae, Cortex Acanthopancis, Radix Ophiopogonis, Radix Curcumae, Folium Bambusae extracting in water 3 times, each amount of water divides Not Wei 10 times amount of medical material gross weight, each extraction time is 3 hours, united extraction liquid, and it is 1.1 left for being concentrated into relative density The right side, adds ethanol and makes alcohol content be 50 volume %, and mixing is placed 48 hours, takes supernatant, and recovery ethanol, to without alcohol taste, obtains Water extracting liquid, alternatively, is concentrated into solid or semisolid further by described water extracting liquid, obtains water extract；By gained Alcohol extract and water extracting liquid mixing, or gained ethanol extract and water extract are mixed, obtain Chinese medicine composition.
CN201610679499.2A 2016-08-18 2016-08-18 One is used for treating the uremic Chinese medicine composition of nephropathy Pending CN106177262A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110638973A (en) * 2019-10-14 2020-01-03 陈文学 Traditional Chinese medicine composition for treating female infertility

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104606574A (en) * 2013-11-04 2015-05-13 陈洪波 Medicament for treating nephrosis syndrome of edema due to spleen deficiency symptom
CN104645144A (en) * 2015-03-23 2015-05-27 王雪雁 Traditional Chinese medicine preparation for treating nephritis and preparation method of traditional Chinese medicine preparation
CN104721467A (en) * 2015-02-13 2015-06-24 中国中医科学院西苑医院 Traditional Chinese medicine composition for treating diabetic nephropathy and application thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104606574A (en) * 2013-11-04 2015-05-13 陈洪波 Medicament for treating nephrosis syndrome of edema due to spleen deficiency symptom
CN104721467A (en) * 2015-02-13 2015-06-24 中国中医科学院西苑医院 Traditional Chinese medicine composition for treating diabetic nephropathy and application thereof
CN104645144A (en) * 2015-03-23 2015-05-27 王雪雁 Traditional Chinese medicine preparation for treating nephritis and preparation method of traditional Chinese medicine preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110638973A (en) * 2019-10-14 2020-01-03 陈文学 Traditional Chinese medicine composition for treating female infertility

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Application publication date: 20161207