CN102754827B - Food for hyperuricemia - Google Patents
Food for hyperuricemia Download PDFInfo
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- CN102754827B CN102754827B CN2012102076769A CN201210207676A CN102754827B CN 102754827 B CN102754827 B CN 102754827B CN 2012102076769 A CN2012102076769 A CN 2012102076769A CN 201210207676 A CN201210207676 A CN 201210207676A CN 102754827 B CN102754827 B CN 102754827B
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Abstract
The invention relates to a food for hyperuricemia, which is prepared from the following raw materials: poria cocos, plantain, desmodium, grifola, lophatherum gracile, bighead atractylodes rhizome, dried orange peel, watermeion peel, waxgourd peel, semen coicis, medicated leaven and pumpkin.
Description
Technical field
The present invention relates to field of food, be specifically related to a kind of food for hyperuricemia.
Background technology
Uric acid is through RE.Hyperuricemia be purine metabolic disturbance and/or uric acid generate increase and (or) drain the metabolic disease due to reducing, can cause the diseases such as gout, uric acid kidney stone and gouty nephropathy.In recent years, hyperuricemia more and more is subject to clinical attention.High lithemia is the independent hazard factor of disease of cardiovascular system, and it and metabolic syndrome, coronary heart disease, hypertension, (AS) is closely related for atherosclerotic.Research in recent years mainly concentrates on the pass of the diseases such as hyperuricemia and hyperlipidemia, hypertension, coronary heart disease, insulin resistance and diabetes, heart failure, kidney damage and fastens.Because UA is the key factor that causes disease of cardiovascular system unusually.
Hyperuricemia is the extracellular fluid lithate over-saturation state that a kind of physico-chemical examination is found, can not cause any symptom clinically, is called asymptomatic hyperuricemia, can cause that also the characteristic acute arthritis shows effect repeatedly, is called the gouty hyperuricemia.Because this disease has asymptomatic, occur often being repeated relapsing after the symptom, under many patient's imperceptions, the lithate deposition causes damage to its tissue and internal organ.There is larger side effect in anti-trioxypurine medicine commonly used at present.Regulate diet style, can prevent generation and the development of hyperuricemia.
The adjusting diet style comprises: mainly refer to reduce the absorption of being rich in purine food, fall low-fat absorption, increase the basic food picked-up, drink more water.
Summary of the invention
The object of the invention provides a kind of food for hyperuricemia and preparation method thereof.
A kind of food for hyperuricemia of the present invention, because following raw material is made:
Poria cocos, Asiatic plantain, desmodium, umbellate pore furgus, lophatherum gracile, the bighead atractylodes rhizome, dried orange peel, watermelon peel, waxgourd peel, coix seed, Divine Comedy, pumpkin.
A kind of food for hyperuricemia of the present invention, its preparation method is:
Get Poria cocos 1-5 gram, Asiatic plantain 1-5 gram, desmodium 1-5 gram, umbellate pore furgus 1-5 gram, lophatherum gracile 2-10 gram, bighead atractylodes rhizome 2-10 gram, dried orange peel 15-30 gram, watermelon peel 15-30 gram, waxgourd peel 15-30 gram, coix seed 150-300 gram, Divine Comedy 1-5 gram, pumpkin 1500-3000 gram
With the raw material blending except pumpkin, pulverizing, sterilization, under germ-free condition, open a little openning at pumpkin, mixture is joined in the pumpkin, under germ-free condition, the otch on the pumpkin is sealed, at room temperature, under germ-free condition, placed 3-7 days, just obtain the food for hyperuricemia of the present invention.
A kind of food for hyperuricemia of the present invention, its preferred preparation method is:
Get Poria cocos 3 grams, Asiatic plantain 3 grams, desmodium 3 grams, umbellate pore furgus 3 grams, lophatherum gracile 8 grams, the bighead atractylodes rhizome 8 grams, dried orange peel 20 grams, watermelon peel 20 grams, waxgourd peel 20 grams, coix seed 200 grams, Divine Comedy 3 grams, pumpkin 2000 grams,
With the raw material blending except pumpkin, pulverizing, sterilization, under germ-free condition, open a little openning at pumpkin, mixture is joined in the pumpkin, under germ-free condition, the otch on the pumpkin is sealed, at room temperature, under germ-free condition, placed 5 days, just obtain the food for hyperuricemia of the present invention.
The specific embodiment
Embodiment 1
A kind of food for hyperuricemia of the present invention, its preparation method is:
Get Poria cocos 1 gram, Asiatic plantain 1 gram, desmodium 1 gram, umbellate pore furgus 1 gram, lophatherum gracile 2 grams, the bighead atractylodes rhizome 2 grams, dried orange peel 15 grams, watermelon peel 15 grams, waxgourd peel 15 grams, coix seed 150 grams, Divine Comedy 1 gram, pumpkin 1500 grams,
With the raw material blending except pumpkin, pulverizing, sterilization, under germ-free condition, open a little openning at pumpkin, mixture is joined in the pumpkin, under germ-free condition, the otch on the pumpkin is sealed, at room temperature, under germ-free condition, placed 3 days, just obtain the food for hyperuricemia of the present invention.
Embodiment 2
A kind of food for hyperuricemia of the present invention, its preparation method is:
Get Poria cocos 5 grams, Asiatic plantain 5 grams, desmodium 5 grams, umbellate pore furgus 5 grams, lophatherum gracile 10 grams, the bighead atractylodes rhizome 10 grams, dried orange peel 30 grams, watermelon peel 30 grams, waxgourd peel 30 grams, coix seed 300 grams, Divine Comedy 5 grams, pumpkin 3000 grams,
With the raw material blending except pumpkin, pulverizing, sterilization, under germ-free condition, open a little openning at pumpkin, mixture is joined in the pumpkin, under germ-free condition, the otch on the pumpkin is sealed, at room temperature, under germ-free condition, placed 7 days, just obtain the food for hyperuricemia of the present invention.
Embodiment 3
A kind of food for hyperuricemia of the present invention, its preparation method is:
Get Poria cocos 3 grams, Asiatic plantain 3 grams, desmodium 3 grams, umbellate pore furgus 3 grams, lophatherum gracile 8 grams, the bighead atractylodes rhizome 8 grams, dried orange peel 20 grams, watermelon peel 20 grams, waxgourd peel 20 grams, coix seed 200 grams, Divine Comedy 3 grams, pumpkin 2000 grams,
With the raw material blending except pumpkin, pulverizing, sterilization, under germ-free condition, open a little openning at pumpkin, mixture is joined in the pumpkin, under germ-free condition, the otch on the pumpkin is sealed, at room temperature, under germ-free condition, placed 5 days, just obtain the food for hyperuricemia of the present invention.
Embodiment 4
Get Poria cocos 4 grams, Asiatic plantain 4 grams, desmodium 4.5 grams, umbellate pore furgus 4.5 grams, lophatherum gracile 7 grams, the bighead atractylodes rhizome 7 grams, dried orange peel 20 grams, watermelon peel 20 grams, waxgourd peel 20 grams, coix seed 300 grams, Divine Comedy 5 grams, pumpkin 3000 grams,
With the raw material blending except pumpkin, pulverizing, sterilization, under germ-free condition, open a little openning at pumpkin, mixture is joined in the pumpkin, under germ-free condition, the otch on the pumpkin is sealed, at room temperature, under germ-free condition, placed 6 days, just obtain the food for hyperuricemia of the present invention.
Embodiment 5
Hypoxanthine is led to the impact of mouse hyperuricemia
Be chosen in the mouse of 20g-22g, male and female half and half,
Precursor compound hypoxanthine 1000mg/kg lumbar injection with uric acid causes hyperuricemia model.In modeling front 2 days, respectively mouth raise food 2g/kg, 4g/kg to embodiment 4,8g/kg (be called little, in, heavy dose of administration group), Allopurinol 50g/kg (Allopurinol group) or probenecid 200g/kg (probenecid group), once a day, And is administered once half an hour before modeling again; Other establishes not to any processing, only to the Normal group (normal group) of equal-volume distilled water.After modeling the 3rd hour gathers respectively urine and the blood of Mei Ma animal, measures respectively the uric acid content in urine and the blood.From the results shown in Table 1, the food of embodiment 4 can reduce serum Uric Acid Concentration, improve the acid concentration of urinating; The food of embodiment 4 has the effect that uricosuric is drained.
The food of embodiment 4 is led to the impact of mouse hyperuricemia on hypoxanthine
| Group | Number of animals | Serum Uric Acid Concentration (mmol/L) | The acid concentration of urinating (mmol/L) |
| Normal group | 10 | 0.1352±0.0879 | 0.0021± 0.0501 |
| The modeling group | 10 | 0.2987± 0.0325 | 1.2366± 1.9786 |
| The food 2g/kg of embodiment 4 | 10 | 0.1312± 0.0198 | 1.3256± 1.4563 |
| The food 4g/kg of embodiment 4 | 10 | 0.1236± 0.0196 | 1.4322± 1.7896 |
| The food 8g/kg of embodiment 4 | 10 | 0.1013± 0.0356 | 1.5563± 1.9232 |
| Allopurinol 50mg/kg | 10 | 0.0048± 0.0112 | 0.2456± 0.2453 |
| Probenecid 200mg/kg | 10 | 0.0963± 0.0693 | 1.7986± 1.6589 |
Embodiment 6
Uricosuric to hyperuricemia is drained
Get the healthy male Wistar rat of body weight between 250g-300g, lead to hyperuricemia with uric acid 500mg/kg dosage lumbar injection.
Modeling the first two day beginning, mouth is raised the food 4g/kg that gives embodiment 4 respectively, and mouth is raised and is suppressed uric acid synthetic drug Allopurinol 50mg/kg, and all once a day, be administered once half an hour again before the modeling.
Other establishes the intact animal control group.With the modeling while, every animal mouth is raised distilled water 6ml.Animal is placed respectively metabolic cage, collect twenty-four-hour urine liquid; And after modeling 24 hours gathers blood.Measure the uric acid content of urine and blood sample.
Shown in the result: give the food of the embodiment 4 of institute's amount of reagent, the excretion of uric acid in the twenty-four-hour urine liquid is increased
| Group | Number of animals | Body weight (g) | Urine amount (ml) | The acid concentration of urinating (mmol/L) | Uric acid discharge rate (mmol*10 -3) | Serum Uric Acid Concentration (mmol/L) |
| Normal group | 10 | 261.2±19.0 | 11.49±1.79 | 0.109±0.029 | 1.178±0.623 | 0.187±0.019 |
| The modeling group | 10 | 264.3±16.7 | 12.56±2.18 | 0.117±0.053 | 1.578±0.598 | 0.247±0.039 |
| Administration group 25mg/kg | 10 | 259.9±15.2 | 12.46±2.59 | 0.189±0.043 | 1.956±0.456 | 0.219±0.033 |
| Allopurinol 50mg/kg | 10 | 267.3±18.1 | 12.93±2.57 | 0.159±0.087 | 1.723±0.763 | 0.228±0.052 |
Embodiment 7
The field, man, 57 years old, first visit.Medical history: because of the little joint congestion and swelling pain of left hand little finger of toe 3 years, increased the weight of blood uric acid 589 μ mol/L, normal renal function 2 days; Urine is conventional: albumen (-), red blood cell (+), leucocyte (++), 19 HP of leucocyte under the mirror.Irritated to Allopurinol.
The food of oral embodiment 4, each 50g, every day 3 times, continuous 30 days, check urine was conventional normal, and blood uric acid is reduced to 298 μ mol/L, and the joint is not bitterly.
Embodiment 8
Carry out maximum dosage-feeding test in a day in the acute toxicity test food of a per os gavage of mouse embodiment 4, its result is that total amount reaches 25g/kg in one day, and still overt toxicity reaction and dead appears in the end in 7 days, and the weight of animals is also without significant change.Giving the continuous per os gavage of rat dosage in the long term toxicity test is 4,8 and 16g/kg,, medication every day 2 times is used in conjunction 90 days, continues after stopping to observe 120 days again.In medication the 45th day and detected indices in 90 days, its result shows: the histopathologic examination to ordinary circumstance, body weight, food ration, peripheral hemogram, liver, renal function, haemocyanin, each Main Organ Coefficients and each main organs thereof of rat all has no significant effect.Compare no significant difference with Normal group.
Claims (1)
1. a preparation method who is used for the food of hyperuricemia is:
Get Poria cocos 1-5 gram, Asiatic plantain 1-5 gram, desmodium 1-5 gram, umbellate pore furgus 1-5 gram, lophatherum gracile 2-10 gram, bighead atractylodes rhizome 2-10 gram, dried orange peel 15-30 gram, watermelon peel 15-30 gram, waxgourd peel 15-30 gram, coix seed 150-300 gram, Divine Comedy 1-5 gram, pumpkin 1500-3000 gram
With the raw material blending except pumpkin, pulverizing, sterilization is opened a little openning at pumpkin under germ-free condition, mixture is joined in the pumpkin, under germ-free condition, the otch on the pumpkin is sealed, at room temperature, under germ-free condition, placed 3-7 days, just obtain the food for hyperuricemia.
2. according to claim 1 a kind of preparation method of the food for hyperuricemia is:
Get Poria cocos 3 grams, Asiatic plantain 3 grams, desmodium 3 grams, umbellate pore furgus 3 grams, lophatherum gracile 8 grams, the bighead atractylodes rhizome 8 grams, dried orange peel 20 grams, watermelon peel 20 grams, waxgourd peel 20 grams, coix seed 200 grams, Divine Comedy 3 grams, pumpkin 2000 grams,
With the raw material blending except pumpkin, pulverizing, sterilization is opened a little openning at pumpkin under germ-free condition, mixture is joined in the pumpkin, under germ-free condition, the otch on the pumpkin is sealed, at room temperature, under germ-free condition, placed 5 days, just obtain the food for hyperuricemia.
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758920A (en) * | 2015-04-29 | 2015-07-08 | 唐凯 | Gout health care product based on homology of medicine and food |
| CN105943958A (en) * | 2016-06-03 | 2016-09-21 | 黑龙江省玄鸟生物科技股份有限公司 | Inonotus obliquus composite solid particles for treating gout and preparing method thereof |
| CN105994489A (en) * | 2016-07-28 | 2016-10-12 | 福建万亿店中店电子商务有限责任公司 | Healthy food for patients with hyperuricemia |
| CN109430602B (en) * | 2018-11-13 | 2021-11-23 | 何少明 | Four-peel three-seed deacidification beverage and preparation process thereof |
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| CN1144668A (en) * | 1995-03-17 | 1997-03-12 | 孙枫淦 | Ganshenning-medicine for hepato-renal |
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| CN101011544A (en) * | 2007-01-22 | 2007-08-08 | 尹政德 | Gout rapid recovery pill(capsule) and preparation technique thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1144668A (en) * | 1995-03-17 | 1997-03-12 | 孙枫淦 | Ganshenning-medicine for hepato-renal |
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