CN102754669A - 一种杀灭跳蚤的药物 - Google Patents
一种杀灭跳蚤的药物 Download PDFInfo
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- CN102754669A CN102754669A CN2012102772464A CN201210277246A CN102754669A CN 102754669 A CN102754669 A CN 102754669A CN 2012102772464 A CN2012102772464 A CN 2012102772464A CN 201210277246 A CN201210277246 A CN 201210277246A CN 102754669 A CN102754669 A CN 102754669A
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- 239000002917 insecticide Substances 0.000 title abstract description 7
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims abstract description 8
- 240000002234 Allium sativum Species 0.000 claims abstract description 8
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 8
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 8
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims abstract description 8
- 229930101531 artemisinin Natural products 0.000 claims abstract description 8
- 235000004611 garlic Nutrition 0.000 claims abstract description 8
- 229960004125 ketoconazole Drugs 0.000 claims abstract description 8
- 239000002795 scorpion venom Substances 0.000 claims abstract description 8
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims abstract description 8
- 229960002722 terbinafine Drugs 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 9
- 229930183339 qinghaosu Natural products 0.000 claims description 7
- 230000002265 prevention Effects 0.000 abstract description 2
- 241000132011 Atractylodes lancea Species 0.000 abstract 1
- 229960004191 artemisinin Drugs 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
- 239000007788 liquid Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 231100000225 lethality Toxicity 0.000 description 3
- 238000002791 soaking Methods 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000004884 grey matter Anatomy 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002903 organophosphorus compounds Chemical class 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 208000007865 relapsing fever Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012422 test repetition Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
本发明公开了一种杀灭跳蚤的药物，属于卫生防疫技术领域。它由下述重量份的原料制成：苍术10-50，黄连20-80，青蒿素1-4，特比萘芬1-4，酮康唑1-4，蝎毒2-5，大蒜100-300，红糖500-1000。本发明使用安全，对人、畜无毒，无污染，且跳蚤死亡率高达98.7％。
Description
技术领域
本发明涉及一种杀灭跳蚤的药物，属于卫生防疫技术领域。
背景技术
跳蚤对人类的健康危害严重，跳蚤是多种疾病的产生和传播根源，可传播虱传斑疹伤寒、鼠疫、回归热等危险疾病，它携带鼠疫杆菌、痢疾杆菌、大肠杆菌、脊椎灰质火病毒和黄曲霉毒等40多种病原体，而且其分泌物和粪便中还含有多种致癌物质。虱子可受杀虫剂的影响，通常使用的化学杀虫剂主要为有机磷化合物及拟菊脂 类，施用这些杀虫剂不但杀死了害虫，也同时杀死了有益昆虫及害虫的天敌，造成了生态平衡的破坏，对人畜产生危害。 因此，开发杀灭跳蚤的药物非常有意义。
发明内容
为了克服上述现有杀灭跳蚤的化学药物的缺点，本发明的提供一种安全、环保的杀灭跳蚤的药物。
本发明的一种杀灭跳蚤的药物，由下述重量份的原料制成：由下述重量份的原料制成：苍术10-50，黄连20-80，青蒿素1-4，特比萘芬1-4，酮康唑1-4，蝎毒2-5，大蒜100-300，红糖500-1000。
本发明的一种杀灭跳蚤的药物的制备方法：按上述重量份称取原料，
其制法是：
第1步将：特比萘芬、酮康唑用75％乙醇溶解后加入月桂氮酮过滤除菌,再加75％乙醇，混合均匀，得到液体1，备用。
第2步将：蝎毒、青蒿素，混合，用75％乙醇溶解，得到液体2，备用，
第3步将：苍术、黄连、大蒜，用75％乙醇冷浸，过滤，得到液体3，，备用。
第4步将：液体1、2、3与红糖混合，干燥，就得到本发明的产品
使用方法：将本发明药物放于跳蚤将常出没的地方，跳蚤食用后行动缓慢、无力，3-4天后死亡，死亡率达92.7％。
以下以试验数据来进一步说明其有益效果。
检测环境条件：温度：20±2℃，相对湿度50％±4％；方箱型号：0.2m×0.2m×0.2m；
1、试虫：跳蚤，2周龄成虫，雌雄各半。
2、试验方法：
室内实验方法：
方箱装置试验方法：根据使用方法，取2克本发明杀灭跳蚤的药物放入玻璃方箱一角，对角放正常饲养用小鼠用料，中间放清洁进水海绵皿和模拟跳蚤屋。将跳蚤放入玻璃方箱装置，并计时，逐日观察试虫死亡数量， 取出死虫，直至全部试虫死亡。试验重复3次，设空白对照。
表1本发明药物诱杀跳蚤试验结果
| 试验天数(天) | 1 | 2 | 3 | 4 | 5 | 6 |
| 死亡率(％) | 54.1 | 67.9 | 74.3 | 82.5 | 92.4 | 98.7％ |
注：对照组试虫100只，试验6天死亡1只，死亡率为1％。
具体实施方式
实施例1：
一种杀灭跳蚤的药物，由下述重量份（克）的原料制成：由下述重量份的原料制成：苍术10，黄连20，青蒿素1，特比萘芬1，酮康唑1，蝎毒2，大蒜100，红糖500。
其制法是：
第1步将：特比萘芬、酮康唑用75％乙醇20ml溶解后加入月桂氮酮过滤除菌,再加75％乙醇至100ml并混合均匀，得到液体1，备用。
第2步将：蝎毒、青蒿素，混合，用75％乙醇20ml溶解，得到液体2，备用。
第3步将：苍术、黄连、大蒜，用75％乙醇500ml冷浸，过滤，得到液体3，备用。
第4步将：液体1、2、3与红糖混合，真空干燥，就得到本发明的产品。
实施例2：
本发明的一种杀灭跳蚤的药物，由下述重量份（克）的原料制成：由下述重量份的原料制成：苍术50，黄连80，青蒿素4，特比萘芬4，酮康唑4，蝎毒5，大蒜300，红糖1000。
其制法是：
第1步将：特比萘芬、酮康唑用75％乙醇40ml溶解后加入月桂氮酮过滤除菌,再加75％乙醇至200ml并混合均匀，得到溶液1，备用。
第2步将：蝎毒、青蒿素，混合，用75％乙醇40ml溶解，得到液体2，备用。
第3步将：苍术、黄连、大蒜，用75％乙醇1000ml冷浸，过滤，得到液体3，备用。
第3步将：溶液1、2、3与红糖混合，真空干燥，就得到本发明的产品。
Claims (1)
1.一种杀灭跳蚤的药物，其特征是，由下述重量份的原料制成：由下述重量份的原料制成：苍术10-50，黄连20-80，青蒿素1-4，特比萘芬1-4，酮康唑1-4，蝎毒2-5，大蒜100-300，红糖500-1000。
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| CN201210277246.4A CN102754669B (zh) | 2012-08-07 | 2012-08-07 | 一种杀灭跳蚤的药物 |
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| CN201210277246.4A CN102754669B (zh) | 2012-08-07 | 2012-08-07 | 一种杀灭跳蚤的药物 |
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| CN102754669A true CN102754669A (zh) | 2012-10-31 |
| CN102754669B CN102754669B (zh) | 2014-03-05 |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110145A (zh) * | 1994-03-19 | 1995-10-18 | 舒毅 | 一种用于治疗皮肤病的蝎毒油 |
| US6096329A (en) * | 1996-03-29 | 2000-08-01 | Merial | Insecticidal combination to control mammal fleas, in particular fleas on cats and dogs |
| CN1628520A (zh) * | 2004-09-22 | 2005-06-22 | 车维新 | 用于家庭宠物杀虫及灭菌的外用制剂 |
| CN101279064A (zh) * | 2008-05-28 | 2008-10-08 | 陈士芳 | 凹凸棒醇基灭虱制剂 |
| CN101313969A (zh) * | 2008-07-17 | 2008-12-03 | 王跃进 | 一种顽癣喷剂 |
| CN101564519A (zh) * | 2009-06-05 | 2009-10-28 | 中国人民解放军军事医学科学院军事兽医研究所 | 一种治疗宠物寄生虫、真菌、细菌感染的外用药剂及其制备方法 |
| CN102018944A (zh) * | 2010-05-07 | 2011-04-20 | 王红芳 | 防止昆虫和动物侵害人体的驱避剂及该驱避剂制成的贴片 |
-
2012
- 2012-08-07 CN CN201210277246.4A patent/CN102754669B/zh not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110145A (zh) * | 1994-03-19 | 1995-10-18 | 舒毅 | 一种用于治疗皮肤病的蝎毒油 |
| US6096329A (en) * | 1996-03-29 | 2000-08-01 | Merial | Insecticidal combination to control mammal fleas, in particular fleas on cats and dogs |
| CN1628520A (zh) * | 2004-09-22 | 2005-06-22 | 车维新 | 用于家庭宠物杀虫及灭菌的外用制剂 |
| CN101279064A (zh) * | 2008-05-28 | 2008-10-08 | 陈士芳 | 凹凸棒醇基灭虱制剂 |
| CN101313969A (zh) * | 2008-07-17 | 2008-12-03 | 王跃进 | 一种顽癣喷剂 |
| CN101564519A (zh) * | 2009-06-05 | 2009-10-28 | 中国人民解放军军事医学科学院军事兽医研究所 | 一种治疗宠物寄生虫、真菌、细菌感染的外用药剂及其制备方法 |
| CN102018944A (zh) * | 2010-05-07 | 2011-04-20 | 王红芳 | 防止昆虫和动物侵害人体的驱避剂及该驱避剂制成的贴片 |
Non-Patent Citations (3)
| Title |
|---|
| 《四川农业科技》 19901231 吴泽全 青蒿-饲料与良药 第27页 1 , 第04期 * |
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