CN102753169A - 外用透皮右美托咪啶组合物及其应用方法 - Google Patents
外用透皮右美托咪啶组合物及其应用方法 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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| PCT/US2011/020462 WO2011085162A2 (en) | 2010-01-08 | 2011-01-07 | Topical transdermal dexmedetomidine compositions and methods of use thereof |
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| CN102753169A true CN102753169A (zh) | 2012-10-24 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105764495A (zh) * | 2013-10-07 | 2016-07-13 | 帝国制药美国公司 | 用于管理疼痛的包含右旋美托咪啶经皮组合物的方法及组合物 |
| CN105764496A (zh) * | 2013-10-07 | 2016-07-13 | 帝国制药美国公司 | 用于经皮递送非镇静量的右旋美托咪啶的方法和组合物 |
| CN107929234A (zh) * | 2017-12-25 | 2018-04-20 | 温州医科大学附属第医院 | 一种应用于烧伤创面修复的新型外用制剂膏体 |
| CN113577556A (zh) * | 2021-08-01 | 2021-11-02 | 武汉左点科技有限公司 | 一种用于阴道康复治疗的生物反馈电刺激方法及装置 |
| WO2024037545A1 (zh) * | 2022-08-17 | 2024-02-22 | 宜昌人福药业有限责任公司 | 右美托咪定经皮组合物、透皮贴剂及其制备方法和应用 |
| US12527770B2 (en) | 2016-10-31 | 2026-01-20 | Teikoku Pharma Usa, Inc. | Methods of managing pain using dexmedetomidine transdermal delivery devices |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013090278A2 (en) * | 2011-12-11 | 2013-06-20 | Recro Pharma, Inc. | Intranasal dexmedetomidine compositions and methods of use thereof |
| CA2911472A1 (en) * | 2013-05-06 | 2014-11-13 | Allergan, Inc. | Alpha adrenergic agonists for the treatment of tissue trauma |
| CA2924233C (en) | 2013-10-07 | 2018-10-23 | Teikoku Pharma Usa, Inc. | Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions |
| KR101881791B1 (ko) * | 2013-10-07 | 2018-07-25 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 비진정성 덱스메데토미딘 경피 조성물을 사용하여 금단 증후군을 치료하기 위한 방법 및 조성물 |
| KR101948779B1 (ko) * | 2013-10-07 | 2019-05-21 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법 |
| MA41689A (fr) * | 2014-10-15 | 2017-08-22 | Bioxcel Corp | Prévention ou traitement de troubles du sommeil au moyen d'une formulation de dexmédétomidine |
| IL267689B2 (en) | 2016-12-31 | 2025-05-01 | Bioxcel Therapeutics Inc | Use of sublingual dexmedetomidine for the treatment of agitation |
| BR112020026672A2 (pt) | 2018-06-27 | 2021-03-30 | Bioxcel Therapeutics, Inc. | Formulações de filme contendo dexmedetomidina e métodos para produzi-las |
| US12472158B2 (en) | 2019-02-27 | 2025-11-18 | Vanderbilt University | Methods of treating trigeminal nerve pain |
| EP3962478A1 (en) | 2019-05-01 | 2022-03-09 | Clexio Biosciences Ltd. | Methods of treating pruritus |
| US20220211672A1 (en) | 2019-05-01 | 2022-07-07 | Clexio Biosciences Ltd. | Methods of treating pruritus |
| BR112022000992A2 (pt) | 2019-07-19 | 2022-06-14 | Arx Llc | Regimes de tratamento de dexmedetomidina não sedantes |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049450A (zh) * | 1989-08-18 | 1991-02-27 | 天鹅探究有限公司 | 右旋美托咪啶经皮肤使用的方法及用具 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5217718A (en) * | 1989-08-18 | 1993-06-08 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| FI894911A0 (fi) * | 1989-10-17 | 1989-10-17 | Farmos Oy | En terapeutiskt vaerdefull foerening. |
| GB9111732D0 (en) * | 1991-05-31 | 1991-07-24 | Orion Yhtymae Oy | The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs |
| GB9913677D0 (en) * | 1999-06-11 | 1999-08-11 | Imperial College | Formulation |
| AUPR184500A0 (en) * | 2000-12-01 | 2001-01-04 | Drug Delivery Solutions Pty Ltd | Dispensing device |
| WO2002089794A1 (en) * | 2001-05-07 | 2002-11-14 | Universite Catholique De Louvain | Method for treating neuropathic pain and pharmaceutical preparation therefor |
| IL147921A0 (en) * | 2002-01-31 | 2002-08-14 | Abdulrazik Mohammad | A method for treating central nervous system disorders by ocular dosing |
| US20050058696A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
| GB0611241D0 (en) * | 2006-06-07 | 2006-07-19 | Daniolabs Ltd | The treatment of increased sebum production |
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2011
- 2011-01-07 US US13/520,959 patent/US20130072532A1/en not_active Abandoned
- 2011-01-07 WO PCT/US2011/020462 patent/WO2011085162A2/en not_active Ceased
- 2011-01-07 NZ NZ703808A patent/NZ703808A/en not_active IP Right Cessation
- 2011-01-07 NZ NZ601195A patent/NZ601195A/en not_active IP Right Cessation
- 2011-01-07 EP EP11732180.2A patent/EP2521544A4/en not_active Withdrawn
- 2011-01-07 CN CN2011800088869A patent/CN102753169A/zh active Pending
- 2011-01-07 RU RU2012133969/15A patent/RU2012133969A/ru not_active Application Discontinuation
- 2011-01-07 AU AU2011204315A patent/AU2011204315A1/en not_active Abandoned
- 2011-01-07 JP JP2012548137A patent/JP2013516482A/ja active Pending
- 2011-01-07 MX MX2012007933A patent/MX2012007933A/es not_active Application Discontinuation
- 2011-01-07 CA CA2786598A patent/CA2786598A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049450A (zh) * | 1989-08-18 | 1991-02-27 | 天鹅探究有限公司 | 右旋美托咪啶经皮肤使用的方法及用具 |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105764495A (zh) * | 2013-10-07 | 2016-07-13 | 帝国制药美国公司 | 用于管理疼痛的包含右旋美托咪啶经皮组合物的方法及组合物 |
| CN105764496A (zh) * | 2013-10-07 | 2016-07-13 | 帝国制药美国公司 | 用于经皮递送非镇静量的右旋美托咪啶的方法和组合物 |
| CN110604728A (zh) * | 2013-10-07 | 2019-12-24 | 帝国制药美国公司 | 用于管理疼痛的包含右旋美托咪啶经皮组合物的方法及组合物 |
| US12527770B2 (en) | 2016-10-31 | 2026-01-20 | Teikoku Pharma Usa, Inc. | Methods of managing pain using dexmedetomidine transdermal delivery devices |
| CN107929234A (zh) * | 2017-12-25 | 2018-04-20 | 温州医科大学附属第医院 | 一种应用于烧伤创面修复的新型外用制剂膏体 |
| CN107929234B (zh) * | 2017-12-25 | 2021-07-23 | 温州医科大学附属第一医院 | 一种应用于烧伤创面修复的外用制剂膏体 |
| CN113577556A (zh) * | 2021-08-01 | 2021-11-02 | 武汉左点科技有限公司 | 一种用于阴道康复治疗的生物反馈电刺激方法及装置 |
| WO2024037545A1 (zh) * | 2022-08-17 | 2024-02-22 | 宜昌人福药业有限责任公司 | 右美托咪定经皮组合物、透皮贴剂及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
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| WO2011085162A2 (en) | 2011-07-14 |
| CA2786598A1 (en) | 2011-07-14 |
| WO2011085162A3 (en) | 2011-11-17 |
| EP2521544A2 (en) | 2012-11-14 |
| MX2012007933A (es) | 2012-08-15 |
| NZ703808A (en) | 2016-01-29 |
| NZ601195A (en) | 2015-02-27 |
| RU2012133969A (ru) | 2014-02-20 |
| EP2521544A4 (en) | 2013-08-21 |
| JP2013516482A (ja) | 2013-05-13 |
| AU2011204315A1 (en) | 2012-08-02 |
| US20130072532A1 (en) | 2013-03-21 |
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Application publication date: 20121024 |