CN102743594A

CN102743594A - Chinese medicine composition for treating chronic renal failure

Info

Publication number: CN102743594A
Application number: CN2012102515450A
Authority: CN
Inventors: 刘金彦; 张海廷
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-07-10
Filing date: 2012-07-10
Publication date: 2012-10-24
Anticipated expiration: 2032-07-10
Also published as: CN102743594B

Abstract

The invention discloses a Chinese medicine composition for treating chronic renal failure. Traditional Chinese medicine holds that the chronic renal failure belongs to the category of 'consumptive disease' and 'uroschesis', and the pathogenesis of the chronic renal failure is deficiency of spleen and kidney and turbidity blockade. Therefore, the Chinese medicine composition comprises Chinese medicines including rust-coloured crotalaria herb with root, satyrium root, dried rehmannia root, radix astragali, cinnamon, concha ostreae, radix scutellariae, philippine flemingia root, sticktight and summer purslane, and enema is prepared by a preparation room of the institution. After clinical test, the total effective rate is 97.4%, Scr (serum creatinine) and BUN (blood urea nitrogen) reduction of a control group is obviously superior to that of an existing control group, and the Chinese medicine composition is low in treatment cost, simple and convenient in method and worthy of clinical popularization and application.

Description

A kind of Chinese medicine composition of treating chronic renal failure

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition of treating chronic renal failure.

Background technology

Chronic renal failure is clinical common critical illness, and it is the severe renal material injury that various Secondary cases and constitutional nephropathy develop into the later stage, belongs to the late period of kidney disease.Adopt means such as renal transplantation, hemodialysis to treat for uremic patient more, but high medical expense, and donor kidney source difficulty, for the actual clinical treatment has brought very big trouble.Therefore, take active and effective treatment means, can delay the progress of disease in early stage, the mid-term of chronic renal failure.At present uremic Therapeutic Method is adopted the intestinal dialysis Drug therapy more,, realize the discharge of uremic toxins such as carbamide, guanidine class, creatinine etc. through the excretory function of intestinal.Clinical practice proves, utilizes the herbal drug enema in treatment chronic renal failure to have good effect, cost is low, side effect is little advantage.

According to chronic renal failure early, the pathogenesis of mid-term asthenia of both the spleen and kidney, turbid tired retardance drafted the spleen reinforcing kidney and promoting blood circulation and let out turbid side.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition of treating chronic renal failure.The traditional Chinese medical science thinks that chronic renal failure belongs to " asthenia " " difficulty in urination " category, and its pathogenesis is asthenia of both the spleen and kidney, turbid tired retardance.Chinese traditional treatment is with invigorating spleen and kidney, and damp eliminating the turbid descending, promoting blood circulation and detoxication are the rule of treatment.

The objective of the invention is to realize that through following technical scheme this a kind of Chinese medicine composition of treating chronic renal failure is processed by following parts by weight of Chinese traditional medicine: Herba Crotalariae Ferrugineae 15-20 part, Radix Satyrii nepalensis 15-20 part, Radix Rehmanniae 10-15 part, Radix Astragali 10-15 part, Cortex Cinnamomi 5-7 part, Concha Ostreae 15-18 part, Radix Scutellariae 12-15 part, Radix Flemingiae Philippinensis 12-15 part, Herba Bidentis Bipinnatae 18-20 part, Herba portulacae 11-13 part.

Preferably, 18 parts of Herba Crotalariae Ferrugineaes, 18 parts of Radix Satyrii nepalensiss, 14 parts of Radix Rehmanniae, 14 parts of the Radixs Astragali, 6 parts of Cortex Cinnamomis, 16 parts of Concha Ostreaes, 13 parts of Radix Scutellariaes, 13 parts of Radix Flemingiae Philippinensiss, 19 parts of Herba Bidentis Bipinnatae, 12 parts of Herba portulacaes.

In the side: Herba Crotalariae Ferrugineae: go into lung; The gas of astringing the lung, spleen reinforcing kidney, diuresis, detumescence poison.

Radix Satyrii nepalensis: go into kidney channel; The kidney invigorating is nourished heart, and controls sexual impotence, chronic nephritis.

Radix Rehmanniae: GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.

The Radix Astragali: return spleen, lung meridian; Tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema.

Cortex Cinnamomi: return kidney, spleen, the heart, Liver Channel; It is supporing yang to mend fire, dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian.

Concha Ostreae: go into liver, kidney channel; Suppressing the hyperactive liver and subsiding YANG, restrain astringent or styptic treatment for spontaneous sweating, hard masses softening and resolving.

Radix Scutellariae: return lung, gallbladder, stomach, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.

Radix Flemingiae Philippinensis: go into lung, kidney, urinary bladder channel; Expelling wind and removing dampness, bone and muscle strengthening, promoting blood circulation and detoxication.

Herba Bidentis Bipinnatae: go into Liver Channel, lung meridian, large intestine channel; Heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and detumescence.

Herba portulacae: return large intestine, Liver Channel; Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.

Clinical data

All cases of physical data are outpatient service and the inpatient who goes to a doctor at my institute's Urology Department in November, 2008～2009 year November, select to meet diagnostic criteria and 156 examples of including standard in, are divided into respectively 78 examples of treatment group and matched group at random.Matched group man 50 examples, women 28 examples; 23～66 years old age, average 44.5 years old; Male 42 examples are organized in treatment, women 36 examples; 24～67 years old age, average 45.5 years old; Two groups of not statistically significants (P＜0.05) aspect sex, age, sick kind composition have comparability.

Therapeutic Method treatment group adopts Chinese medicine composition coloclysis of the present invention, gets Herba Crotalariae Ferrugineae 18 grams, Radix Satyrii nepalensis 18 grams, Radix Rehmanniae 14 grams, the Radix Astragali 14 grams, Cortex Cinnamomi 6 grams, Concha Ostreae 16 grams, Radix Scutellariae 13 grams, Radix Flemingiae Philippinensis 13 grams, Herba Bidentis Bipinnatae 19 grams, Herba portulacae 12 grams, adds 500 milliliters in water; Water boiling concentration to 200 milliliter treats that fluid temperature drops to human body temperature to be adapted to coloclysis when suitable that the patient gets lateral position; Raise buttocks, aseptic enema tube is slowly inserted anus, insert 3-5cm; When coloclysis finishes the flat buttocks that crouches of patient is raised 10～15cm; Medicament was kept 30 minutes at enteral, and every day 1 time, 7 days is 1 course of treatment; The oral love Seat of matched group; All treat for two groups and add up curative effect three courses of treatment.

Criterion of therapeutical effect is evaluated referring to national renal failure conservative treatment special topic academic conference in 1989 and Clinical Researches of New Drugs guideline specified standard.Sx or disappearance, endogenous creatinine clearance rate (Ccr) increases >=30%, and serum creatinine (Scr) decline >=30% is produce effects; Sx or disappearance, endogenous creatinine clearance rate increases (Ccr) >=20%, and serum creatinine (Scr) decline >=20% is effective; Treatment back subjective symptoms and sign do not alleviate or increase the weight of to invalid.

Renal function changed two groups of treatment back Scr before and after 1. therapeutic outcome treated, BUN all obviously descend, and relatively reaching before and after the treatment more all has significant difference (P＜0.05) between group, but with matched group difference relatively (P＜0.01).See table 2

The variation

of renal function before and after table 2 treatment

Annotate: compare * * P＜0.01) with matched group

2. two groups of treatment two all backs curative effects are relatively seen table 2.

Table 2 liang group curative effect is [example (%)] relatively

The treatment group always has rate to reach 97.4%, and the matched group total effective rate reaches 80.8%, and the treatment group obviously is superior to matched group, and two groups of cure rates, total effective rates have significant difference (P＜0.05).

The specific embodiment

Embodiment one: take by weighing Herba Crotalariae Ferrugineae 18g, Radix Satyrii nepalensis 18g, Radix Rehmanniae 14g, Radix Astragali 14g, Cortex Cinnamomi 6g, Concha Ostreae 16g, Radix Scutellariae 13g, Radix Flemingiae Philippinensis 13g, Herba Bidentis Bipinnatae 19g, Herba portulacae 12g.Add 500 milliliters in water, water boiling concentration to 200 milliliter is treated before the coloclysis that fluid temperature drops to human body temperature to be adapted to coloclysis when suitable; The patient gets lateral position, raises buttocks, and aseptic enema tube is slowly inserted anus; Insert 3-5cm, when coloclysis finishes the flat buttocks that crouches of patient is raised 10～15cm, make medicament keep 30～60min at enteral; Every day 1 time, 7 days is 1 course of treatment.

Embodiment two: take by weighing Herba Crotalariae Ferrugineae 15g, Radix Satyrii nepalensis 15g, Radix Rehmanniae 10g, Radix Astragali 10g, Cortex Cinnamomi 5g, Concha Ostreae 15g, Radix Scutellariae 12g, Radix Flemingiae Philippinensis 12g, Herba Bidentis Bipinnatae 18g, Herba portulacae 11g.Add 600 milliliters in water, water boiling concentration to 230 milliliter is treated that fluid temperature drops to human body temperature to be adapted to coloclysis when suitable; The patient gets lateral position, raises buttocks, and aseptic enema tube is slowly inserted anus; Insert 3-5cm, when coloclysis finishes the flat buttocks that crouches of patient is raised 10～15cm, make medicament keep 30～60min at enteral; Every day 1 time, 7 days is 1 course of treatment.

Embodiment three: take by weighing Herba Crotalariae Ferrugineae 20g, Radix Satyrii nepalensis 20g, Radix Rehmanniae 15g, Radix Astragali 15g, Cortex Cinnamomi 7g, Concha Ostreae 18g, Radix Scutellariae 15g, Radix Flemingiae Philippinensis 15g, Herba Bidentis Bipinnatae 19g, Herba portulacae 13g.Add 550 milliliters in water, water boiling concentration to 210 milliliter is treated that fluid temperature drops to human body temperature to be adapted to coloclysis when suitable; The patient gets lateral position, raises buttocks, and aseptic enema tube is slowly inserted anus; Insert 3-5cm, when coloclysis finishes the flat buttocks that crouches of patient is raised 10～15cm, make medicament keep 30～60min at enteral; Every day 1 time, 7 days is 1 course of treatment.

Claims

1. Chinese medicine composition of treating chronic renal failure is characterized in that this Chinese medicine composition processed by following parts by weight of Chinese traditional medicine: Herba Crotalariae Ferrugineae 15-20 part, Radix Satyrii nepalensis 15-20 part, Radix Rehmanniae 10-15 part, Radix Astragali 10-15 part, Cortex Cinnamomi 5-7 part, Concha Ostreae 15-18 part, Radix Scutellariae 12-15 part, Radix Flemingiae Philippinensis 12-15 part, Herba Bidentis Bipinnatae 18-20 part, Herba portulacae 11-13 part.

2. a kind of Chinese medicine composition of treating chronic renal failure according to claim 1 is characterized in that this Chinese medicine composition processed by following parts by weight of Chinese traditional medicine: 18 parts of Herba Crotalariae Ferrugineaes, 18 parts of Radix Satyrii nepalensiss, 14 parts of Radix Rehmanniae, 14 parts of the Radixs Astragali, 6 parts of Cortex Cinnamomis, 16 parts of Concha Ostreaes, 13 parts of Radix Scutellariaes, 13 parts of Radix Flemingiae Philippinensiss, 19 parts of Herba Bidentis Bipinnatae, 12 parts of Herba portulacaes.