CN102727724A - Traditional Chinese medicine composition for dissolving thrombus and preparation method of composition - Google Patents
Traditional Chinese medicine composition for dissolving thrombus and preparation method of composition Download PDFInfo
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- CN102727724A CN102727724A CN201210235757XA CN201210235757A CN102727724A CN 102727724 A CN102727724 A CN 102727724A CN 201210235757X A CN201210235757X A CN 201210235757XA CN 201210235757 A CN201210235757 A CN 201210235757A CN 102727724 A CN102727724 A CN 102727724A
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Abstract
The invention relates to a traditional Chinese medicine composition for dissolving thrombus and the preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition has good effect of dissolving thrombus. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 8 to 12 parts of pepper roasted along with vinegar, 8 to 12 parts of leech roasted along with vinegar, 8 to 12 parts of pseudo-ginseng, 8 to 12 parts of American ginseng, 4 to 6 parts of daemonorops draco, 4 to 6 parts of resina toxicodendri, 8 to 12 parts of rhizoma typhonii roasted along with vinegar, and 8 to 12 parts of fried myrrh. The preparation method of the traditional Chinese medicine composition comprises the steps of weighing the raw material medicaments in a proportion, and crushing the raw material medicament to reach 120 meshes and then uniformly mixing.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, particularly relate to a kind of thrombolytic Chinese medicine composition and preparation method thereof.
Background technology
Thrombosis be in movable body heart or the blood vessel certain part because of blood constituent is separated out, coagulation and solidify formed solid, shaped material; Thrombosis is made up of insoluble fibrin, sedimentary platelet, the leukocyte that gathers and the erythrocyte that is absorbed in, and the cardiovascular system diseases that is caused by thrombosis is one of the human main cause of death and disease.
Existing thrombolytic medicine is that direct or indirect activation fiber albumen lyase is former, makes it change plasmin into, the fibrin of plasmin in can thrombus, thus thrombus makes the blood vessel of obstruction unobstructed once again.Traditional thrombolytic agent has streptokinase, urokinase and Agkistrodon halys kinases etc., and these curative effect of medication are remarkable, but than being easier to cause bleeding complication, cause the untoward reaction of systems such as skin, blood, therefore needs to continue to explore the new dissolved thrombus medicine of exploitation.
Summary of the invention
The technical problem that the present invention will solve provides good thrombolytic Chinese medicine composition of a kind of therapeutic effect and preparation method thereof.
A kind of thrombolytic Chinese medicine composition is processed by following crude drug by weight: processed with vinegar Pericarpium Zanthoxyli 8-12 part, processed with vinegar Hirudo 8-12 part, Radix Notoginseng 8-12 part, Radix Panacis Quinquefolii 8-12 part, Sanguis Draxonis 4-6 part, Resina Toxicodendri 4-6 part, processed with vinegar Rhizoma Typhonii 8-12 part and Myrrha (parched) 8-12 part.
The thrombolytic Chinese medicine composition of the present invention, 10 parts of 10 parts in wherein said processed with vinegar Pericarpium Zanthoxyli, 10 parts of processed with vinegar Hirudos, 10 parts of Radix Notoginseng, 10 parts of Radix Panacis Quinquefoliis, 5 parts of Sanguis Draxonis, 5 parts of Resina Toxicodendri, 10 parts of processed with vinegar Rhizoma Typhoniis and Myrrha (parched).
The method for preparing of the thrombolytic Chinese medicine composition of the present invention may further comprise the steps: weighting raw materials in proportion is crushed to 120 orders and mix homogeneously.
Take the thrombolytic Chinese medicine composition of the present invention every day 3 after the meal, and each 2.5-4g adds and subtracts with disease, is mixed with suspension with pure water before using and takes.
The present invention has adopted 8 flavor medical materials, wherein: the effect that Pericarpium Zanthoxyli has blood vessel dilating, brings high blood pressure down; Hirudo has the effect of treatment apoplexy, hypertension, desilting, traumatic injury; The effect that Radix Notoginseng has blood vessel dilating, brings high blood pressure down; Radix Panacis Quinquefolii has arrhythmia, resisting myocardial ischemia, anti-myocardium oxidation and strengthens the effect of cardiac muscle; Sanguis Draxonis has the effect of promoting blood circulation to remove blood stasis, hemostasia and promoting granulation; Resina Toxicodendri has the cloudy effect that stagnates of treatment blood stasis; The Rhizoma Typhonii expectorant that dispels the wind, arresting convulsion is jerked, the detoxicating and resolving stagnation of pathogens pain relieving, the processed with vinegar of Pericarpium Zanthoxyli, Hirudo and Rhizoma Typhonii is the medicine of system only to be added rice vinegar mix thoroughly, moistening, treat that vinegar is exhausted after, fry with slow fire and to do, the every 100kg of medicine with rice vinegar 20 ~ 30kg, is no more than 50kg at most; The Myrrha blood blood stasis removing that looses, subduing swelling and relieving pain, parch Myrrha are to get the Myrrha of choosing clean to put in the pot to fry with slow fire and see melting point slightly to the surface, and taking-up cools.
The thrombolytic traditional Chinese medicine composition for treating of the present invention is effective; Preparation rat carotid artery thrombus model is used for thrombus test in the rat body; Behind the successive administration 14 days; Compare with model group, each administration group of high, medium and low dosage is along with the increase of dosage, and the thrombosis dry weight has also alleviated 32.00%, 44.7% and 54.7% respectively.Chinese medicine composition of the present invention is used for the thrombosis patient, has also brought into play thrombolytic effect.
The specific embodiment
Embodiment 1
Get 8 parts of 8 parts in processed with vinegar Pericarpium Zanthoxyli, 8 parts of processed with vinegar Hirudos, 8 parts of Radix Notoginseng, 8 parts of Radix Panacis Quinquefoliis, 4 parts of Sanguis Draxonis, 4 parts of Resina Toxicodendri, 8 parts of processed with vinegar Rhizoma Typhoniis and Myrrha (parched), be crushed to 120 orders and mix homogeneously.
Embodiment 2
Get 12 parts of 12 parts in processed with vinegar Pericarpium Zanthoxyli, 12 parts of processed with vinegar Hirudos, 12 parts of Radix Notoginseng, 12 parts of Radix Panacis Quinquefoliis, 6 parts of Sanguis Draxonis, 6 parts of Resina Toxicodendri, 12 parts of processed with vinegar Rhizoma Typhoniis and Myrrha (parched), be crushed to 120 orders and mix homogeneously.
Embodiment 3
Get 10 parts of 10 parts in processed with vinegar Pericarpium Zanthoxyli, 10 parts of processed with vinegar Hirudos, 10 parts of Radix Notoginseng, 10 parts of Radix Panacis Quinquefoliis, 5 parts of Sanguis Draxonis, 5 parts of Resina Toxicodendri, 10 parts of processed with vinegar Rhizoma Typhoniis and Myrrha (parched), be crushed to 120 orders and mix homogeneously.
Thrombus test in the embodiment 4 rat bodies
1) animal divides into groups: 50 of healthy adult male Wistar, body constitution amount 250-300g is divided into 5 groups at random, 10 every group.The 1st group is model group, the 2nd group of positive matched group, and the 3rd group is the experiment low dose group, and the 4th group is dose groups in the experiment, and the 5th group is the experiment high dose group.
2) preparation of rat carotid artery thrombus model: get above-mentioned healthy male Wistar rat, with 1 quality % pentobarbital sodium water solution with 1mlkg
-1Dosage to rat anesthesia, isolate the rat left and right sides each 10mm of common carotid artery after the anesthesia, successively press from both sides earlier and close right carotid distal end and proximal part with bulldog clamp; Make two ends at a distance of 5mm and there is blood full therein; Two ends lead to unidirectional current 3mA10min, and electricity unclamps bulldog clamp after condensing and restrainting, and right carotid begins to become kermesinus in the electric process with fixed attention; Form thrombosis, and increase the weight of gradually.
3) administering mode: model group gives normal saline; Positive controls gives XIAOSHUAN TONGLUO PIAN, and dosage is 50mgd
-1Kg
-1The experiment low dose group gives embodiment 3 gained sample 100mgd
-1Kg
-1Dose groups gives embodiment 3 gained sample 150mgd in the experiment
-1Kg
-1, the experiment high dose group gives embodiment 3 gained sample 200mgd
-1Kg
-1Above medicine is each to be mixed with gastric infusion behind the suspension with pure water before using, and successive administration 14 days divides 3 administrations after the meal every day.
4) successive administration is after 14 days, and the common carotid artery with the left and right sides downcuts simultaneously, places to inhale on the filter paper to remove surplus blood, behind dry 4h under 60 ℃, takes out and weighs, and the difference of left and right sides common carotid artery quality is the thrombosis dry weight, gets arithmetical average for every group.
5) experimental result:
Compare with model group, the thrombus weight that all the other each groups form obviously alleviates, and each administration group of high, medium and low dosage is along with the increase of dosage, and the thrombosis dry weight has also alleviated 32.00%, 44.7% and 54.7% respectively.
Embodiment 5
The Meng, the man, 55 years old, angiography was diagnosed as the carotid artery thrombosis; Right hand right crus of diaphragm hemiplegia 2 months is taken embodiment 1 gained sample every day 3 after the meal, each 4g; Be mixed with suspension with pure water before using and take, take continuously that whole body recovers normal after 5 months, the ability operate as normal.
Embodiment 6
The Wang, the woman, 48 years old, Color Sonography was diagnosed as heart clot; Size is 14mm * 13mm, diastolic pressure 110mmHg, and systolic pressure 180mmHg, dizzy; Take embodiment 2 gained samples every day 3 after the meal, each 2.5g is mixed with suspension with pure water before using and takes; Take after 3 months blood pressure continuously and recover normal, dizzy disappearance, thrombosis disappears.
Above-described embodiment describes preferred implementation of the present invention; Be not that scope of the present invention is limited; Design under the prerequisite of spirit not breaking away from the present invention; Various distortion and improvement that those of ordinary skills make technical scheme of the present invention all should fall in the definite protection domain of claims of the present invention.
Claims (3)
1. a thrombolytic Chinese medicine composition is characterized in that being processed by following crude drug by weight: processed with vinegar Pericarpium Zanthoxyli 8-12 part, processed with vinegar Hirudo 8-12 part, Radix Notoginseng 8-12 part, Radix Panacis Quinquefolii 8-12 part, Sanguis Draxonis 4-6 part, Resina Toxicodendri 4-6 part, processed with vinegar Rhizoma Typhonii 8-12 part and Myrrha (parched) 8-12 part.
2. thrombolytic Chinese medicine composition according to claim 1 is characterized in that: 10 parts of 10 parts in said processed with vinegar Pericarpium Zanthoxyli, 10 parts of processed with vinegar Hirudos, 10 parts of Radix Notoginseng, 10 parts of Radix Panacis Quinquefoliis, 5 parts of Sanguis Draxonis, 5 parts of Resina Toxicodendri, 10 parts of processed with vinegar Rhizoma Typhoniis and Myrrha (parched).
3. the method for preparing of claim 1 or 2 said thrombolytic Chinese medicine compositions is characterized in that: may further comprise the steps: weighting raw materials in proportion is crushed to 120 orders and mix homogeneously.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857277A (en) * | 2015-06-01 | 2015-08-26 | 青岛友诚高新技术有限公司 | Thrombolytic pure Chinese drug preparation and preparation method thereof |
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| CN1214923A (en) * | 1997-10-17 | 1999-04-28 | 张大录 | Medicine for curing palsy and hypertension and preparation process thereof |
| CN101002917A (en) * | 2006-11-04 | 2007-07-25 | 于曼秋 | Chinese medicine for treating thromboangitis obliterans |
| CN101380412A (en) * | 2004-12-27 | 2009-03-11 | 杨俭 | Formulation for treating apoplexy |
| CN101757569A (en) * | 2010-01-19 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating cerebral thrombosis and cerebral infarction and preparation method thereof |
| CN102049013A (en) * | 2011-01-12 | 2011-05-11 | 李格英 | Traditional Chinese medicine preparation of hemiplegia recovery pill |
| CN102274378A (en) * | 2011-08-16 | 2011-12-14 | 时秀燕 | Brain-strengthening and thrombosis-resisting pills for treating cerebrovascular diseases and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE60035371D1 (en) * | 2000-09-13 | 2007-08-09 | Silverbrook Res Pty Ltd | PRINTHEAD ARRANGEMENT FOR A COMMERCIAL MODULE PRINTER |
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Patent Citations (6)
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|---|---|---|---|---|
| CN1214923A (en) * | 1997-10-17 | 1999-04-28 | 张大录 | Medicine for curing palsy and hypertension and preparation process thereof |
| CN101380412A (en) * | 2004-12-27 | 2009-03-11 | 杨俭 | Formulation for treating apoplexy |
| CN101002917A (en) * | 2006-11-04 | 2007-07-25 | 于曼秋 | Chinese medicine for treating thromboangitis obliterans |
| CN101757569A (en) * | 2010-01-19 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating cerebral thrombosis and cerebral infarction and preparation method thereof |
| CN102049013A (en) * | 2011-01-12 | 2011-05-11 | 李格英 | Traditional Chinese medicine preparation of hemiplegia recovery pill |
| CN102274378A (en) * | 2011-08-16 | 2011-12-14 | 时秀燕 | Brain-strengthening and thrombosis-resisting pills for treating cerebrovascular diseases and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857277A (en) * | 2015-06-01 | 2015-08-26 | 青岛友诚高新技术有限公司 | Thrombolytic pure Chinese drug preparation and preparation method thereof |
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