CN102727611A - Topical Chinese medicinal composition/preparation with antibacterial, antipruritic and repairing effects, and preparation method thereof - Google Patents
Topical Chinese medicinal composition/preparation with antibacterial, antipruritic and repairing effects, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a topical Chinese medicinal composition/preparation with antibacterial, antipruritic and repairing effects, and a preparation method of the topical Chinese medicinal composition/preparation. The composition comprises the following raw materials by weight: 20-50 parts of Flos Caryophylli, 20-50 parts of Salviae Miltiorrhizae Radix, 20-50 parts of Folium Artemisiae Argyi, 10-20 parts of Fructus Crataegi, 10-20 parts of Fructus Hippophae, and10-20 parts of Fructus Atriplicis Sibiricae. The preparation method has the advantages of simple operation, low production cost, and high activity and yield of product. The obtained plant extract is easily soluble in glycerol, and shows red color. Cosmetic prepared from the extract has antibacterial, antifungal, antiallergic, repairing and moisturizing effects.
Description
Technical field
The present invention relates to a kind of external medicine composition, specifically a kind of external medicine composition and preparation method thereof and preparation with anti-bacterial, anti-itching reparation effect.
Background technology
In recent years, Along with people's is pursued " natural, non-stimulated " strong desire, and the raw material of daily use chemicals industry is also synthetic gradually to the natural plants development from chemical industry, and demand grows with each passing day.Because the synthetic antipathogenic composition of chemical industry (antibacterial, antiseptic) contains country and limits with material, to reasons such as the zest of skin, various side effect; Therefore the research of natural plants antimicrobial component is more and more hotter; Its advantage mainly give prominence to natural, gentle, non-stimulated, effect is remarkable etc.; Therefore daily use chemicals industry (bath foam, handwashing liquid, shampoo) is urgent to the demand of natural plants antibacterial, and demand is big.
Medicament or skin protection cleaning supplies to treatments such as acne seat skin ulcer erythra in the prior art are a lot, and kind is different, still contain compositions such as hormone more, cure the symptoms, not the disease, and can not improve the skin microenvironment and thoroughly healing at all.
Summary of the invention
Primary and foremost purpose of the present invention provides a kind of Chinese medicine composition that anti-bacterial, anti-itching is repaired effect that has.
Second purpose of the present invention is to propose the method for preparing of above-mentioned Chinese medicine composition.
Invention thinking of the present invention is: the present invention selects for use Flos Caryophylli, Radix Salviae Miltiorrhizae, Folium Artemisiae Argyi, Fructus Crataegi, Fructus Hippophae, Fructus Atriplicis Sibiricae assembly to extract and obtains the effect that activity extract has the antipruritic reparation skin of excellent antibiotic.Compositions increases Herba Artemisiae Annuae, Rhizoma Polygoni Cuspidati assembly effect is better.
To achieve these goals, the present invention adopts following concrete technical scheme:
A kind of external medicine composition with anti-bacterial, anti-itching reparation effect, said compositions is made up of following weight parts proportion raw material medicine:
Flos Caryophylli 20～50 weight portions, Radix Salviae Miltiorrhizae 20～50 weight portions, Folium Artemisiae Argyi 20～50 weight portions, Fructus Crataegi 10～20 weight portions, Fructus Hippophae 10～20 weight portions, Fructus Atriplicis Sibiricae 10～20 weight portions.
A kind of method for preparing above-mentioned external medicine composition, concrete steps are following:
(1) takes by weighing each crude drug according to said weight portion proportioning;
(2) wherein Flos Caryophylli, Radix Salviae Miltiorrhizae, Fructus Crataegi and Fructus Hippophae mix, and the adding percent by volume is 80%～95% ethanol, and solid-liquid ratio g/ml is 1:20～1:30; Extracting temperature is 40～70 ℃, and extraction time is that 0.5～3h gets alcohol extract; Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae mix, and extracting in water, solid-liquid ratio are 1:20～1:30; Extracting temperature is 50～90 ℃, and the time of getting is that 1～4h gets the water extract;
(3) alcohol extract and the water extract that step (2) are obtained filter respectively, and two kinds of extracting solution mix homogeneously are concentrated into 1～5g/ml and get concentrated solution then; Concentrated solution mix with glycerol mixed liquor, the volume ratio of concentrated solution and glycerol is 1:1～2:1;
(4) mixed liquor is filtered, get activity extract.
Another kind has the external medicine composition that anti-bacterial, anti-itching is repaired effect, and said compositions is made up of following weight parts proportion raw material medicine:
Flos Caryophylli 20～50 weight portions, Radix Salviae Miltiorrhizae 20～50 weight portions, Folium Artemisiae Argyi 20～50 weight portions, Fructus Crataegi 10～20 weight portions, Fructus Hippophae 10～20 weight portions, Fructus Atriplicis Sibiricae 10～20 weight portions, Herba Artemisiae Annuae 10～20 weight portions, Rhizoma Polygoni Cuspidati 10～20 weight portions.
A kind of method for preparing above-mentioned external medicine composition, concrete steps are following:
(1) takes by weighing each crude drug according to said weight portion proportioning;
(2) wherein Flos Caryophylli, Radix Salviae Miltiorrhizae, Fructus Crataegi and Fructus Hippophae mix, and adding percent by volume is the ethanol of 80%-95%, and solid-liquid ratio g/ml is 1:20～1:30; Extracting temperature is 40～70 ℃, and extraction time is that 0.5～3h gets alcohol extract; Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae, Herba Artemisiae Annuae and Rhizoma Polygoni Cuspidati mix, and extracting in water, solid-liquid ratio are 1:20～1:30; Extracting temperature is 50～90 ℃, and extraction time is that 1～4h gets the water extract;
(3) alcohol extract and the water extract that step (2) are obtained filter respectively, and two kinds of extracting solution mix homogeneously are concentrated into 1～5g/ml and get concentrated solution then;
(4) concentrated solution mix with glycerol mixed liquor, the volume ratio of concentrated solution and glycerol is 1:1～2:1;
(5) mixed liquor is filtered, get activity extract.
In above-mentioned two kinds of said steps of method (1), it is 60～80 orders that the Flos Caryophylli in the weighting raw materials, Radix Salviae Miltiorrhizae, Folium Artemisiae Argyi and Fructus Atriplicis Sibiricae are crushed to granularity, and all the other crude drug are crushed to 20～40 orders.
A kind of external Chinese medicine extract with anti-bacterial, anti-itching reparation effect, said extract is obtained by the said method extraction.
Described Chinese medicine extract has anti-bacterial, anti-itching in preparation and repairs the purposes in the skin protection cleaning formulation of effect.
Said skin protection cleaning formulation is cleaning supplies such as handwashing liquid or bath foam.
The inventive method is simple to operate, and production cost is low, and the product of preparation has higher activity, and productive rate is high.The plant extract of this method preparation is soluble in glycerol, and color takes on a red color.Adopt the bathing product of this extract preparation, have antibacterium, fungus effect, and have significant antiallergic to repair scar eliminating and moistening effect.
Description of drawings
Fig. 1 has shown the fungistatic effect of the antipruritic renovation agent stock solution of plants antimicrobial;
Fig. 2 has shown the fungistatic effect of the anti-bacterial, anti-itching renovation agent of variable concentrations;
Fig. 3 is the bar diagram of the antipruritic renovation agent hyaluronic acid of the plants antimicrobial of variable concentrations suppression ratio;
Fig. 4 is the clinical effectiveness figure of the antipruritic renovation agent of plants antimicrobial.
The specific embodiment
Method among the following embodiment if no special instructions, is conventional method.Crude drug of the present invention market is all on sale.
Embodiment 1 Chinese medicine extract preparation of the present invention
(1) takes by weighing each crude drug according to said weight portion proportioning;
Flos Caryophylli 30g, Radix Salviae Miltiorrhizae 30g, Folium Artemisiae Argyi 30g, Fructus Crataegi 20g, Fructus Hippophae 20g, Fructus Atriplicis Sibiricae 20g.
(2) Radix Salviae Miltiorrhizae, Flos Caryophylli, Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae are pulverized.(disintegrating apparatus: multifunctional crusher GX-04, Gao Xiang, Shanghai food machinery factory) also crossed 60 mesh sieves and obtained powder, and other crude drug are crushed to 20 order fineness, places aeration-drying place to preserve, and be subsequent use;
(3) extract: Flos Caryophylli, Radix Salviae Miltiorrhizae, Fructus Crataegi, Fructus Hippophae are mixed, add 90% ethanol according to the 1:30 solid-liquid ratio, 55 ℃ are extracted 2h and get alcohol extract; Folium Artemisiae Argyi and Fructus Atriplicis Sibiricae are mixed, add deionized water according to the 1:30 solid-liquid ratio, 80 ℃, extraction time is that 2h gets the water extract.(firing equipment: the electric heater 98-1-B type that adjusts the temperature electronically, Tianjin Tai Site Instr Ltd.)
(4) water extract and alcohol extract are carried out filtering with the fine straining plate respectively.(the sensible filter material device factory of Dongli District buys the fine straining plate from Tianjin); Water extract and alcohol extract after filtering are mixed, mixture is placed be concentrated into 1g/ml concentrated solution (g represents the crude drug amount, and the ml representative concentrates the back liquid volume) under 70 ℃ of conditions; (concentrator: rotary evaporator RE2000 type, Shanghai Yarong Biochemical Instrument Plant).
(5) with concentrated solution and the glycerol mixed of 4:3 by volume, stir.
(6) mixed liquor is carried out sucking filtration (pumping and filtering device: SHZ-III type circulation ability of swimming is used vacuum pump, and the reliable Instr Ltd. that tests is known in Shanghai) more, obtain Chinese medicine extract.
(1) takes by weighing each crude drug according to said weight portion proportioning;
Flos Caryophylli 20, Radix Salviae Miltiorrhizae 50g, Folium Artemisiae Argyi 20g, Fructus Crataegi 15g, Fructus Hippophae 15g, Fructus Atriplicis Sibiricae 15g.
(2) Radix Salviae Miltiorrhizae, Flos Caryophylli, Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae are pulverized, and 80 mesh sieves obtain powder excessively, other crude drug are crushed to 40 order fineness, place aeration-drying place to preserve, and are subsequent use;
(3) extract: Flos Caryophylli, Radix Salviae Miltiorrhizae, Fructus Crataegi, Fructus Hippophae are mixed, add 80% ethanol according to the 1:20 solid-liquid ratio, 70 ℃ are extracted 0.5h and get alcohol extract; Folium Artemisiae Argyi and Fructus Atriplicis Sibiricae are mixed, add deionized water according to the 1:20 solid-liquid ratio, 50 ℃, extraction time is that 4h gets the water extract.
(4) water extract and alcohol extract are carried out filtering with the fine straining plate respectively.Water extract and alcohol extract after filtering are mixed, mixture is placed be concentrated into 3g/ml concentrated solution (g represents the crude drug amount, and the ml representative concentrates the back liquid volume) under 70 ℃ of conditions;
(5) with concentrated solution and the glycerol mixed of 1:1 by volume, stir.
(6) mixed liquor is carried out the fine straining plate and filter (the sensible filter material device factory of Dongli District buys the fine straining plate from Tianjin), obtain Chinese medicine extract.
Embodiment 3 Chinese medicine extract preparations of the present invention
(1) takes by weighing each crude drug according to said weight portion proportioning;
Flos Caryophylli 50, Radix Salviae Miltiorrhizae 20g, Folium Artemisiae Argyi 50g, Fructus Crataegi 10g, Fructus Hippophae 10g, Fructus Atriplicis Sibiricae 10g.
(2) Radix Salviae Miltiorrhizae, Flos Caryophylli, Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae are pulverized, and 60 mesh sieves obtain powder excessively, other crude drug are crushed to 40 order fineness, place aeration-drying place to preserve, and are subsequent use;
(3) extract: Flos Caryophylli, Radix Salviae Miltiorrhizae, Fructus Crataegi, Fructus Hippophae are mixed, add 95% ethanol according to the 1:30 solid-liquid ratio, 40 ℃ are extracted 0.5h and get alcohol extract; Folium Artemisiae Argyi and Fructus Atriplicis Sibiricae are mixed, add deionized water according to the 1:20 solid-liquid ratio, 90 ℃, extraction time is that 1h gets the water extract.
(4) water extract and alcohol extract are carried out filtering with the fine straining plate respectively.Water extract and alcohol extract after filtering are mixed, mixture is placed under 80 ℃ of conditions be concentrated into the 5g/ml concentrated solution;
(5) with concentrated solution and the ethohexadiol mixed of 2:1 by volume, stir.
(6) mixed liquor is carried out sucking filtration, obtain Chinese medicine extract.
Embodiment 4 Chinese medicine extract preparations of the present invention
(1) takes by weighing each crude drug according to said weight portion proportioning;
Flos Caryophylli 30g, Radix Salviae Miltiorrhizae 30g, Folium Artemisiae Argyi 30g, Fructus Crataegi 20g, Fructus Hippophae 20g, Fructus Atriplicis Sibiricae 20g, Herba Artemisiae Annuae 10g, Rhizoma Polygoni Cuspidati 10g.
(2) Radix Salviae Miltiorrhizae, Flos Caryophylli, Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae are pulverized, and 60 mesh sieves obtain powder excessively, other crude drug are crushed to 40 order fineness, place aeration-drying place to preserve, and are subsequent use;
(3) extract: Flos Caryophylli, Radix Salviae Miltiorrhizae, Fructus Crataegi, Fructus Hippophae are mixed, add 80% ethanol according to the 1:30 solid-liquid ratio, 60 ℃ are extracted 2h and get alcohol extract; Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae, Herba Artemisiae Annuae, Rhizoma Polygoni Cuspidati are mixed, add deionized water according to the 1:20 solid-liquid ratio, 90 ℃, extraction time is that 2h gets the water extract.
(4) water extract and alcohol extract are carried out filtering with the fine straining plate respectively.Water extract and alcohol extract after filtering are mixed, mixture is placed under 80 ℃ of conditions be concentrated into the 1g/ml concentrated solution;
(5) with concentrated solution and the glycerol mixed of 4:3 by volume, stir.
(6) mixed liquor is carried out sucking filtration, obtain Chinese medicine extract.
(1) takes by weighing each crude drug according to said weight portion proportioning;
Flos Caryophylli 20g, Radix Salviae Miltiorrhizae 50g, Folium Artemisiae Argyi 20g, Fructus Crataegi 10g, Fructus Hippophae 15g, Fructus Atriplicis Sibiricae 15g, Herba Artemisiae Annuae 20g, Rhizoma Polygoni Cuspidati 20g.
(2) Radix Salviae Miltiorrhizae, Flos Caryophylli, Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae are pulverized, and 80 mesh sieves obtain powder excessively, other crude drug are crushed to 20 order fineness, place aeration-drying place to preserve, and are subsequent use;
(3) extract: Flos Caryophylli, Radix Salviae Miltiorrhizae, Fructus Crataegi, Fructus Hippophae are mixed, add 95% ethanol according to the 1:20 solid-liquid ratio, 70 ℃ are extracted 3h and get alcohol extract; Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae, Herba Artemisiae Annuae, Rhizoma Polygoni Cuspidati are mixed, add deionized water according to the 1:30 solid-liquid ratio, 50 ℃, extraction time is that 4h gets the water extract;
(4) water extract and alcohol extract are carried out filtering with the fine straining plate respectively.Water extract and alcohol extract after filtering are mixed, mixture is placed under 60 ℃ of conditions be concentrated into 5g/ml;
(5) with concentrated solution and the glycerol mixed of 2:1 by volume, stir.
(6) mixed liquor is carried out sucking filtration, obtain Chinese medicine extract.
Embodiment 6 the present invention prepare the bathing product
Raw material and consumption (wt%)
Method for preparing: water, dodecyl alcohol ether sodium sulfate, lauric acid amide of ethanol, cocoyl CAB, glycerol are mixed, be stirred and heated to 80 ℃, add the card ripple and stir, cool to 60 ℃ of adding citric acids and extract.40 ℃ add MTI, essence.
Embodiment 7 the present invention prepare the bacteriostatic experiment of the antipruritic reparation extract of plants antimicrobial
(1) fungistatic effect of the antipruritic renovation agent stock solution of embodiment 4 preparation plants antimicrobials
No. 1 sample: extracting solution and ethohexadiol 3:1 mixed;
No. 2 samples: extracting solution and ethohexadiol 2:1 mixed;
No. 3 samples: extracting solution and glycerol 2:1 mixed;
No. 4 samples: extracting solution and glycerol 4:3 mixed;
The different samples of table 1 are to the bacteriostatic diameter mm of antibacterial, fungus
Shown in Fig. 1 and table 1, No. 4 the sample antibacterial effect is best, and No. 4 sample processing costs are lower simultaneously, and are better to the effective ingredients in plant solubility property, and stability is preferably arranged.Fig. 1 upper left for yeast experiment, upper rightly test for mycete; In the left side for testing for escherichia coli in Candida albicans experiment, the right side; A left side is the fungus combined experiments down, and the bottom right is the antibacterial combined experiments.The inventor utilizes embodiment 1,2,3,5 extracting solution to repeat above-mentioned experiment, and experimental result shows that all fungistatic effect is good.
(2) fungistatic effect of the antipruritic renovation agent of plants antimicrobial of variable concentrations
Table 2
Shown in Fig. 2 and table 2, can find out under the situation of No. 4 sample variable concentrations, fungus, antibacterial are all had fungistatic effect, the high more fungistatic effect of concentration is good more.Left side figure is that antibacterial mixes among Fig. 2, and right figure is that fungus mixes.The inventor utilizes embodiment 1,2,3,5 extracting solution to repeat above-mentioned experiment, and experimental result is with above-mentioned.The antiallergic reparation experiment of the antipruritic renovation agent of embodiment 8 plants antimicrobials
(1) hyaluronic acid suppresses experiment: hyaluronidase is anaphylactoid participant, and it can the intravital hyaluronic acid of enzymolysis, makes it become low-molecular-weight acid stimulus, induces body to produce responsive symptom.Research shows that hyaluronidase and inflammation, allergy have strong correlation, and many Claritins have the effect of strong hyaluronidase inhibitor.This method adopts hyaluronidase vitro inhibition method to measure the antiallergic effect of the antipruritic renovation agent of plants antimicrobial.
As can beappreciated from fig. 3, embodiment 4 extracting solution increase the hyaluronidase activity suppression ratio along with the increase of concentration gradually, and effect is obvious.The inventor utilizes embodiment 1,2,3,5 extracting solution to repeat above-mentioned experiment, and experimental result is with above-mentioned.
(2) the antipruritic renovation agent repair of plants antimicrobial:
The antipruritic renovation agent of plants antimicrobial has the effect of the impaired skin of maintenance.Balanced intrafollicular ecological balance enhances metabolism, and repairs the local microcirculation of being obstructed, and calms down cicatrix after the acne.
1) physical data
This group is totally 166 examples, male 88 examples, women 78 examples, the oldest 46 years old, minimum 16 years old.The course of disease is the longest 11 years, and is the shortest 3 months.Pimple appears in the clinical face, breast, back of mainly showing as, majority darkly, hoary hair's acne appearance, color is red, pimple or cyst appear in the top, conscious slight pruritus or pain are difficult repeatedly.
2) method
Clean of every day or have a bath after, on the pimple of skin and acne and be prone to send out a position and be coated with embodiment 4 extracting solution stock solutions, sooner or later respectively once.3 days, 7 days, 1 month, 3 months each statistics once.
3) standard
Cure: clinical symptom disappearance, deflorescence, erythra seat scar trace is removed;
Effectively: clinical symptom relief, erythra partly disappear or disappear, and reduce or reduce, and erythra seat scar trace subtracts light or disappears;
Invalid: the commentaries on classics of not getting better of clinical symptoms, erythra.
4) result: as shown in Figure 4, instant effect of the present invention, 3 days, 7 days effective percentage can reach that 90.16%, 3 month erythra is cured, the scar removal rate is 70.21%, and the skin damage tissue is had the certain repairing effect, can effectively calm down cicatrix.The inventor utilizes embodiment 1,2,3,5 extracting solution to repeat above-mentioned experiment, and experimental result is with above-mentioned.
Claims (8)
1. one kind has the external medicine composition that anti-bacterial, anti-itching is repaired effect, it is characterized in that said compositions is made up of following weight parts proportion raw material medicine:
Flos Caryophylli 20～50 weight portions, Radix Salviae Miltiorrhizae 20～50 weight portions, Folium Artemisiae Argyi 20～50 weight portions, Fructus Crataegi 10～20 weight portions, Fructus Hippophae 10～20 weight portions, Fructus Atriplicis Sibiricae 10～20 weight portions.
2. one kind has the external medicine composition that anti-bacterial, anti-itching is repaired effect, it is characterized in that said compositions is made up of following weight parts proportion raw material medicine:
Flos Caryophylli 20～50 weight portions, Radix Salviae Miltiorrhizae 20～50 weight portions, Folium Artemisiae Argyi 20～50 weight portions, Fructus Crataegi 10～20 weight portions, Fructus Hippophae 10～20 weight portions, Fructus Atriplicis Sibiricae 10～20 weight portions, Herba Artemisiae Annuae 10～20 weight portions, Rhizoma Polygoni Cuspidati 10～20 weight portions.
3. method for preparing the said external medicine composition of claim 1 is characterized in that concrete steps are following:
(1) takes by weighing each crude drug according to the said weight portion proportioning of claim 1;
(2) wherein Flos Caryophylli, Radix Salviae Miltiorrhizae, Fructus Crataegi and Fructus Hippophae mix, and adding percent by volume is the ethanol of 80%-95%, and solid-liquid ratio g/ml is 1: 20～1: 30; Extracting temperature is 40～70 ℃, and extraction time is that 0.5～3h gets alcohol extract; Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae mix, and extracting in water, solid-liquid ratio are 1: 20～1: 30; Extracting temperature is 50～90 ℃, and extraction time is that 1～4h gets the water extract;
(3) alcohol extract and the water extract that step (2) are obtained filter respectively, and two kinds of extracting solution mix homogeneously are concentrated into 1～5g/ml and get concentrated solution then;
(4) concentrated solution mix with glycerol or ethohexadiol mixed liquor, the volume ratio of concentrated solution and glycerol is 1: 1～2: 1;
(5) mixed liquor is filtered, get activity extract.
4. method for preparing the said external medicine composition of claim 2 is characterized in that concrete steps are following:
(1) takes by weighing each crude drug according to the said weight portion proportioning of claim 2;
(2) wherein Flos Caryophylli, Radix Salviae Miltiorrhizae, Fructus Crataegi and Fructus Hippophae mix, and adding percent by volume is the ethanol of 80%-95%, and solid-liquid ratio g/ml is 1: 20～1: 30; Extracting temperature is 40～70 ℃, and extraction time is that 0.5～3h gets alcohol extract; Folium Artemisiae Argyi, Fructus Atriplicis Sibiricae, Herba Artemisiae Annuae and Rhizoma Polygoni Cuspidati mix, and extracting in water, solid-liquid ratio are 1: 20～1: 30; Extracting temperature is 50～90 ℃, and extraction time is that 1～4h gets the water extract;
(3) alcohol extract and the water extract that step (2) are obtained filter respectively, and two kinds of extracting solution mix homogeneously are concentrated into 1～5g/ml and get concentrated solution then;
(4) concentrated solution mix with glycerol mixed liquor, the volume ratio of concentrated solution and glycerol is 1: 1～2: 1;
(5) mixed liquor is filtered, get activity extract.
5. according to claim 3 or 4 described methods, it is characterized in that: in the said step (1), it is 60～80 orders that the Flos Caryophylli in the weighting raw materials, Radix Salviae Miltiorrhizae, Folium Artemisiae Argyi and Fructus Atriplicis Sibiricae are crushed to granularity, and all the other crude drug are crushed to 20～40 orders.
6. one kind has the external Chinese medicine extract that anti-bacterial, anti-itching is repaired effect, it is characterized in that, said extract is obtained by claim 3 or 4 said methods extractions.
7. the described Chinese medicine extract of claim 6 has anti-bacterial, anti-itching in preparation and repairs the purposes in the skin protection cleaning formulation of effect.
8. purposes according to claim 7 is characterized in that, said skin protection cleaning formulation is handwashing liquid or bath foam.
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| CN103637956A (en) * | 2013-12-18 | 2014-03-19 | 淄博齐鼎立专利信息咨询有限公司 | Shampoo |
| CN103637956B (en) * | 2013-12-18 | 2016-06-08 | 广州市帝臣日化科技有限公司 | Shampoo |
| CN104146930A (en) * | 2014-08-29 | 2014-11-19 | 宋鸟生 | Traditional Chinese medicine shower gel and preparation method thereof |
| CN107773482A (en) * | 2017-11-24 | 2018-03-09 | 兰州新区福泽生物科技有限公司 | Seabuckthorn montmorillonite liquid soap and its production technology |
| CN108158883A (en) * | 2018-01-31 | 2018-06-15 | 洁宝日化（湘西）有限责任公司 | A kind of composition and its application comprising sweet wormwood and rosemary |
| CN108158883B (en) * | 2018-01-31 | 2021-05-07 | 洁宝日化（湘西）有限责任公司 | Composition containing sweet wormwood and rosemary and application thereof |
| CN112007101A (en) * | 2020-08-06 | 2020-12-01 | 北京枢之道生物科技有限公司 | Clove antibacterial liquid |
| CN113244382A (en) * | 2021-06-11 | 2021-08-13 | 江南大学 | Itching-relieving and swelling-diminishing composition as well as preparation method and application thereof |
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