CN102723118A - Novel cobalt-60gamma source for after-loading therapy and manufacturing method thereof - Google Patents
Novel cobalt-60gamma source for after-loading therapy and manufacturing method thereof Download PDFInfo
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- CN102723118A CN102723118A CN2012102109847A CN201210210984A CN102723118A CN 102723118 A CN102723118 A CN 102723118A CN 2012102109847 A CN2012102109847 A CN 2012102109847A CN 201210210984 A CN201210210984 A CN 201210210984A CN 102723118 A CN102723118 A CN 102723118A
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Abstract
The invention discloses a novel cobalt-60gamma source for after-loading therapy. The novel cobalt-60gamma source comprises an envelope, a sealing plug and a source core, wherein the source core is nickel cobalt-60 plated particles and is arranged in the envelope; and the sealing plug is arranged in an opening of the envelope and is connected with the envelope in a sealed mode. The invention also discloses a method for manufacturing the novel cobalt-60gamma source for after-loading therapy. The method comprises the following steps of: processing the envelope and the sealing plug, cleaning and drying the envelope and the sealing plug for later use; cleaning the nickel cobalt-60 plated particles of which the radioactive activity ranges from 18.5 GBq to 46.2 GBq, airing for later use; filling the selected nickel cobalt-60 plated particles in a stainless steel envelope, mounting the stainless steel sealing plug in the opening of the stainless steel envelope, and sealing through argon arc welding; and checking, and obtaining the novel cobalt-60gamma source for after-loading therapy after the checked product is qualified. The novel cobalt-60gamma source is independent of direct irradiation of a reactor, is manufactured by the cobalt-60 particles with gamma radioactivity, and is easily manufactured and high in speed, and the requirements of a patient can be met.
Description
Technical field
The present invention relates to a kind of after-loading therapy with cobalt-60 γ source and preparation method thereof, relate in particular to a kind of novel after-loading therapy that does not rely on the direct irradiation of reactor with cobalt-60 γ source and preparation method thereof.
Background technology
After-loading therapy is radiocurable a kind of method.So-called back dress is placed radiocurable applicating device in place earlier exactly or is planted suitable position executing source cushion; Film making is confirmed then; Through the treatment planning systems calculated dose distribution; Obtain restart switch behind the satisfactory result, radioactive source is delivered to automatically carried out radiocurable method in applicating device or the pin, so be afterloading radiotherapy.After-loading therapy belongs to brachytherapy, is for remote radiotherapy is external exposure.It is short that it has the treatment distance, and source week local dose is very high, the characteristics that peripheral dosage falls rapidly, thereby can improve the tumor by local exposure dose, effectively protect peripheral normal tissues and vitals, and the function of therapentic part keeps also good than simple external exposure.Because radioactive source was put into by machine afterwards automatically, staff's compartment is operated, and has avoided staff's radiation insult.
After-loading therapy comprises in the chamber, manages interior, tissue space implantation by the clinical practice branch, and mid-pipe of art and model are applied ointment or plaster five types.Wherein most widely used is intracavitary radiotherapy, promptly utilizes human body natural's cavity and pipeline such as nasopharynx, oesophagus, tracheae, rectum, vagina and uterine neck etc. to put the treatment pipe, treats by corresponding steps then.It can treat nasopharyngeal carcinoma, the cancer of the esophagus, tracheocarcinoma, bronchiolar carcinoma, the carcinoma of the rectum, cervical carcinoma etc.The after-loading therapy of this paper introduction is only applicable to intracavitary radiotherapy with cobalt-60 γ source.
The preparation method who is used for the cobalt-60 γ source of intracavitary radiotherapy at present is to be the cobalt-59 titanium involucrum of packing into cold cobalt silk, and welded seal is processed target spare then and put into reactor and carry out irradiation; Cobalt-59 intercept neutrons changes into and has radioactive cobalt-60 and promptly launch gamma-rays, and through behind the irradiation of planned time, target spare goes out heap; Cutting is disintegrated; Taking out cobalt-60 γ source, measure activity, leakage and pollute check and stepping is deposited, packs into and supplies treatment to use behind the pigtail of source in qualified source.Involucrum by the cobalt-60 γ source of above-mentioned classic method preparation is a titanium, belongs to rare noble metal, and cost is higher.
Because present domestic reactor self irradiation task is heavier; Can not guarantee to provide target spare irradiation channel; Target spare complex manufacturing technology in addition, the influence of factors such as radioactive source titanium involucrum welding quality instability has seriously restricted the production supply of material of intracavitary radiotherapy with cobalt-60 afterloading source; Patient usually need pass through wait as long for and just can effectively be treated, and causes the part patient to miss best occasion for the treatment and increase the weight of the state of an illness.
Also do not occur in patent documentation and non-patent literature about after-loading therapy other preparation method with cobalt-60 γ source at present, preparation method's the after-loading therapy that also is not different from above-mentioned traditional structure is with cobalt-60 γ source public use.
Summary of the invention
The object of the invention just is that providing a kind of in order to address the above problem does not rely on the direct irradiation of reactor and prepare fireballing novel after-loading therapy with cobalt-60 γ source and preparation method thereof.
In order to achieve the above object, the present invention has adopted following technical scheme:
Novel after-loading therapy according to the invention comprises involucrum, sealing-plug and source core with cobalt-60 γ source, and said source core is nickel plating cobalt-60 particle, and said source core places in the said involucrum, and said sealing-plug is installed in the opening of said involucrum and with said involucrum and is tightly connected.
The titanium involucrum size in the size of involucrum according to the invention and traditional cobalt-60 γ source is different; Be satisfy radioactive source can with the prerequisite of domestic after-loading therapy matched under; Take into full account welding process requirement, guarantee to obtain to greatest extent and be able to confirm after the technical requirements such as high-quality welded seal quality.Owing to directly nickel plating cobalt-60 particle is packed in the stainless steel cladding, so the later stage is no longer carried out reactor irradiation, also just needn't use the titanium involucrum, make the reduction of involucrum and product cost.
As preferably, the purity of said nickel plating cobalt-60 particle is greater than 99%, and radioactivity is 18.5GBq～92.5GBq; The best is 31.4GBq.
Particularly, said involucrum is a stainless steel cladding, and said sealing-plug is the stainless steel sealing-plug; Adopt the argon arc welding between said involucrum and the said sealing-plug.
Novel after-loading therapy according to the invention may further comprise the steps with the preparation method in cobalt-60 γ source:
(1) presses design drawing processing stainless steel involucrum and stainless steel sealing-plug, use acetone, except that drying for standby behind degreasing and the oxide;
(2) measure the radioactivity of single purity, choose nickel plating cobalt-60 particle of radioactivity scope between 18.5GBq～46.2GBq greater than 99% nickel plating cobalt-60 particle, subsequent use with drying after the washed with de-ionized water;
(3) opening of nickel plating cobalt-60 particle of choosing through stainless steel cladding is filled in the stainless steel cladding, again the stainless steel sealing-plug is installed in the opening of stainless steel cladding, and through the argon arc welded seal;
(4) carry out radioactive contamination, leakage, activity measurement check, promptly get novel after-loading therapy with cobalt-60 γ source after qualified.
Beneficial effect of the present invention is:
The present invention adopts directly in stainless steel cladding, to load has the method for gamma active cobalt-60 particle preparation after-loading therapy with cobalt-60 γ source; Do not rely on the direct irradiation of reactor, so making is simple, speed is fast, the production cycle is shorter; Radioactive source activity is suitable, can satisfy patients ' demand; And cobalt-60 particle in recovery capable of using waste and old cobalt-60 radioactive source, reduced production cost.
Description of drawings
Accompanying drawing is the cut-open view of novel after-loading therapy according to the invention with cobalt-60 γ source.
Embodiment
Below in conjunction with accompanying drawing the present invention is made further specific descriptions:
Shown in accompanying drawing; Novel after-loading therapy according to the invention comprises stainless steel cladding 1, stainless steel sealing-plug 2 and source core 3 with cobalt-60 γ source; Source core 3 for purity greater than 99%, radioactivity is nickel plating cobalt-60 particle of 31.4GBq; Source core 3 places in the stainless steel cladding 1, stainless steel sealing-plug 2 be installed in the opening of stainless steel cladding 1 and and stainless steel cladding 1 between adopt argon arc to be welded to connect.
In conjunction with accompanying drawing, novel after-loading therapy according to the invention may further comprise the steps with the preparation method in cobalt-60 γ source:
(1) presses design drawing processing stainless steel involucrum and stainless steel sealing-plug, use acetone, except that drying for standby behind degreasing and the oxide;
(2) measure the radioactivity of single purity, choose nickel plating cobalt-60 particle of radioactivity scope between 18.5GBq～46.2GBq greater than 99% nickel plating cobalt-60 particle, subsequent use with drying after the washed with de-ionized water;
(3) opening of nickel plating cobalt-60 particle of choosing through stainless steel cladding is filled in the stainless steel cladding, again the stainless steel sealing-plug is installed in the opening of stainless steel cladding, and through the argon arc welded seal;
(4) carry out radioactive contamination, leakage, activity measurement check, promptly get novel after-loading therapy with cobalt-60 γ source after qualified.
Claims (6)
1. a novel after-loading therapy is with cobalt-60 γ source; It is characterized in that: comprise involucrum, sealing-plug and source core; Said source core is nickel plating cobalt-60 particle, and said source core places in the said involucrum, and said sealing-plug is installed in the opening of said involucrum and with said involucrum and is tightly connected.
2. novel after-loading therapy according to claim 1 is characterized in that with cobalt-60 γ source: the purity of said nickel plating cobalt-60 particle is greater than 99%, and radioactivity is 18.5GBq～92.5GBq.
3. novel after-loading therapy according to claim 2 is characterized in that with cobalt-60 γ source: the radioactivity of said nickel plating cobalt-60 particle is 31.4GBq.
4. novel after-loading therapy according to claim 1 is characterized in that with cobalt-60 γ source: said involucrum is a stainless steel cladding, and said sealing-plug is the stainless steel sealing-plug.
According to claim 1 or 4 described novel after-loading therapies with cobalt-60 γ source, it is characterized in that: adopt the argon arc welding between said involucrum and the said sealing-plug.
6. a novel after-loading therapy as claimed in claim 1 is characterized in that: may further comprise the steps with the preparation method in cobalt-60 γ source:
(1) presses design drawing processing stainless steel involucrum and stainless steel sealing-plug, use acetone, except that drying for standby behind degreasing and the oxide;
(2) measure the radioactivity of single purity, choose nickel plating cobalt-60 particle of radioactivity scope between 18.5GBq～46.2GBq greater than 99% nickel plating cobalt-60 particle, subsequent use with drying after the washed with de-ionized water;
(3) opening of nickel plating cobalt-60 particle of choosing through stainless steel cladding is filled in the stainless steel cladding, again the stainless steel sealing-plug is installed in the opening of stainless steel cladding, and through the argon arc welded seal;
(4) carry out radioactive contamination, leakage, activity measurement check, promptly get novel after-loading therapy with cobalt-60 γ source after qualified.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012102109847A CN102723118A (en) | 2012-06-26 | 2012-06-26 | Novel cobalt-60gamma source for after-loading therapy and manufacturing method thereof |
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| CN2012102109847A CN102723118A (en) | 2012-06-26 | 2012-06-26 | Novel cobalt-60gamma source for after-loading therapy and manufacturing method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961825A (en) * | 2012-12-03 | 2013-03-13 | 戴建荣 | Method for prolonging service life of external irradiation radioactive source and external irradiation medical equipment |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314679A (en) * | 2001-01-31 | 2001-09-26 | 萧祖贻 | Cobalt 60-gamma ray dot source device |
| JP2002320684A (en) * | 2001-02-15 | 2002-11-05 | Aea Technology Qsa Gmbh | Capsuled seed |
| CN2702416Y (en) * | 2004-04-29 | 2005-05-25 | 杭州华源伽玛医疗设备投资有限公司 | Single row radioactive source in straight line arrangement for gamma ray irradiation unit |
| CN202677860U (en) * | 2012-06-26 | 2013-01-16 | 成都中核高通同位素股份有限公司 | Novel cobalt-60 gamma source for after-loading therapy |
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- 2012-06-26 CN CN2012102109847A patent/CN102723118A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314679A (en) * | 2001-01-31 | 2001-09-26 | 萧祖贻 | Cobalt 60-gamma ray dot source device |
| JP2002320684A (en) * | 2001-02-15 | 2002-11-05 | Aea Technology Qsa Gmbh | Capsuled seed |
| CN2702416Y (en) * | 2004-04-29 | 2005-05-25 | 杭州华源伽玛医疗设备投资有限公司 | Single row radioactive source in straight line arrangement for gamma ray irradiation unit |
| CN202677860U (en) * | 2012-06-26 | 2013-01-16 | 成都中核高通同位素股份有限公司 | Novel cobalt-60 gamma source for after-loading therapy |
Non-Patent Citations (1)
| Title |
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| 刘歆粤等: "60Co工业辐照源生产工艺建立及百万居里级生产线的建设", 《同位素》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961825A (en) * | 2012-12-03 | 2013-03-13 | 戴建荣 | Method for prolonging service life of external irradiation radioactive source and external irradiation medical equipment |
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Application publication date: 20121010 |