CN102716383A - 一种治疗克罗恩病的中药组合物 - Google Patents
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Abstract
一种治疗克罗恩病的中药组合物，该中药组合物是由丹参，赤芍，白芍，白术，炒当归，红花，川芎，党参，炙枳壳，木香，陈皮，半夏，甘草，黄连，焦三仙制成。临床可用于治疗克罗恩病。
Description
技术领域
本发明属于中药技术领域，尤其是涉及一种治疗克罗恩病的中药组合物。
背景技术
克罗恩病（Crohn，s disease，CD）是一种病因尚不十分清楚的慢性非特异性胃肠道肉芽肿性炎症。病变以末端回肠和邻近结肠多见，但从口腔至肛门各段消化道均可受累，呈节段性或跳跃式分布。临床以腹痛、腹泻、腹块、瘘管形成和肠梗阻为特点，可伴有发热、贫血、营养障碍以及关节、皮肤、眼、口腔粘膜、肝脏等肠外损害。本病有终生复发倾向，重症患者往往迁延不愈，预后不良。西医目前的治疗有很大的局限性。
发明内容
本发明的目的在于提供一种治疗效果好、有效率高、复发率低、对人体无毒副作用的治疗克罗恩病的中药组合物。
本发明的目的是这样实现的，根据中医药理论，利用中药独特的药性，采用丹参，赤芍，白芍，白术，炒当归，红花，川芎，党参，炙枳壳，木香，陈皮，半夏，甘草，黄连，焦三仙，按照一定的配伍要求，经过加工制成。
制备本发明中药组合物由下述原料药制成：丹参10-30份，赤芍10-20份，白芍10-20份，白术5-15份，炒当归5-15份，红花7-12份，川芎10-15份，党参10-15份，炙枳壳5-15份，木香10-15份，陈皮5-15份，半夏10-15份，甘草7-12份，黄连5-15份，焦三仙各20-30份。
本发明中药组合物原料药的最佳重量份为：丹参20份，赤芍15份，白芍15份，白术10份，炒当归10份，红花9份，川芎12份，党参12份，炙枳壳10份，木香12份，陈皮10份，半夏12份，甘草9份，黄连10份，焦三仙各25份。
本发明中药的药理作用如下：
丹参：苦、微寒。归心、肝经。活血调经，凉血消痈，安神。用于血瘀之心胸、脘腹疼痛及癥瘕积聚，风湿痹痛，疮疡痈肿等。
赤芍：苦、微寒。归肝、脾经。清热凉血，活血祛瘀。用于温毒发斑，肠风下血，痈肿疮疡等。
白芍：苦、酸，微寒，归肝，脾经。养血和营，缓急止痛，敛阴平肝。主治血虚寒热，脘腹疼痛，头痛眩晕。
白术：苦、甘、温。归脾、胃经。补气健脾，燥湿利水，止汗，安胎。用于脾胃气虚，运化无力，食少便溏，脘腹胀满，脾虚水停，而为痰饮、水肿、小便不利，胎动不安等。
当归：甘、辛、温，归肝、心、脾经。补血，活血，调经，止痛。用于心肝血虚、痈疽疮疡。
红花：辛、温。归心、肝经。活血通经，祛瘀止痛。主治血瘀经闭，胸痹心痛，癥瘕积聚，关节疼痛等。
川芎：辛、温，归肝、胆、心经。活血行气，祛风止痛。用于血瘀气滞、风湿痹痛。
党参：甘、平。归脾、肺经。益气、生津、养血。用于中气不足的体虚倦怠，肺气亏虚的咳嗽气促，气津两伤的气短口渴，头晕心悸等。
枳壳：苦、酸、微寒。归肺、脾、胃、大肠经。理气宽胸，行滞消积。用于胸膈痞满，胁肋胀痛，脘腹胀满等证。
木香：辛、苦、温。归脾、胃、肝、肺经。行气止痛，调中导滞。主治胸胁胀满，脘腹胀痛，呕吐泄泻等。
陈皮：辛、苦、温，归脾、胃、肺经。理气调中，降逆止呕，燥湿化痰。用于胸膈满闷，脘腹胀痛，不思饮食，呕吐等。
半夏：辛、温、有毒。归脾、胃、肺经。燥湿化痰，降逆止呕，消痞散结。主治咳喘痰多，胸脘痞满，头痛眩晕等。
甘草：甘、平，归心、肺、脾、胃经。益气补中，清热解毒，祛痰止咳，缓急止痛，调和药性。用于心气不足的心动悸、脉结代，热毒疮疡，咽喉肿痛。
黄连：苦、寒。归心、肝、胃、大肠经。清热泻火，燥湿，解毒。主治热病邪入心经之高热，烦躁，湿热胸痞，消谷善饥，肝火目赤肿痛等。
麦芽：甘、平。归脾、胃经。消积化食，回乳。主治食积，腹满泄泻，恶心呕吐，食欲不振等。
山楂：酸、甘、微温。归脾、胃、肝经。消食健胃，行气散瘀。用于饮食积滞，脘腹胀痛，泄泻痢疾，疝气肿痛等。
神曲：甘、辛、温。归脾、胃经。消食和胃。用于饮食积滞证，脘腹胀满、食少纳呆、肠鸣腹泻等。
祖国医学根据其病因、病机及临床表现，将其归属于“肠澼”、“泄泻”、“腹痛”、“肠痈”等范畴。饮食不节、感受外邪，情志不畅、久病体虚等都可导致脾胃运化失调、小肠分清别浊功能失司，大肠传导失常而致泄泻。方中丹参、赤芍益气养血、化痰通络，白芍理气化瘀止痛，当归、白术健脾益气，川芎、红花、党参养血活血，枳壳、木香、陈皮理气消食，防补药壅滞，半夏、甘草酸甘化阴，缓急止痛，黄连清热解毒，焦三仙泄热行气消食。诸药共奏益气健脾、温补脾肾、清肠消痈，化瘀生肌之功效。
本发明中药组合物于2008年至2011年临床观察克罗恩31例患者，临床报告如下：
1、一般资料
31例患者中，女性15例，男性16例，年龄最小20岁，最大69岁，发病时间多在1-4年，平均年龄42.3岁。
2、诊断标准
排除标准：以各种有效的诊断方法排除溃疡性结肠炎、感染性肠炎、缺血性肠炎、放射学肠炎、淋巴瘤、癌症等。
纳入标准：根据世界卫生组织推荐的诊断标准。①非连续性或阶段性病变②铺路石样表现或纵行溃疡③全壁性炎症病变④非干酪性肉芽肿⑤裂沟、瘘管⑥肛门部病变。①、②、③加上④、⑤、⑥三项中任何1项都可以确诊，④加上①、②、③三项中任何2项可确诊。
3、治疗方法
3.1处方：丹参20g，赤芍15g，白芍15g，白术10g，炒当归10g，红花9g，川芎12g，
党参12g，炙枳壳10g，木香12g，陈皮10g，半夏12g，甘草9g，黄连10g，焦三仙各25g。
3.2制备方法：上述药物按常规工艺制成汤剂。
3.3服用方法：每次1剂，每日1次，15天为1个疗程，连服3个疗程。
4、治疗结果：
4.1治愈标准
临床缓解：经治疗后临床症状消失，X 线或结肠镜检查炎症趋于稳定，或克罗恩活动指数（CDAI）计算法CDAI<150分；有效：经治疗后临床症状减轻，X 线或结肠镜检查见炎症减轻，或CDAI减少70分以上；无效：经治疗后临床症状、X 线、内镜和病理检查无改善，或CDAI>150分，减少未达上述指标；如CDAI增加70 分以上为恶化或复发。
4.2结果：临床缓解26 例(83.9%)，有效5 例(16.1%)。
表1 治疗前后克罗恩指数比较
| n | Harvey-Bradshow | Best | |
 |
31 | 15.20 ±3.11 | 488.44 ±41.02 |
| 治疗后 | 31 | 3.91 ±0.74 | 76.10 ±15.11 |
5、典型病例
5.1 刘某，女，52 岁，2005 年8 月10 日初诊。患者反复腹泻、腹痛、体重减轻2年余，右下腹发现包块半年，行走时腹痛加重。经当地及周边医院补液及口服消炎、止泻、止痛等治疗，症状无明显减轻。在三甲医院经电子结肠镜及粘膜活检诊断为CD，口服美拉沙嗪及应用柳氮磺吡啶栓纳肛等治疗3月，病情仍无明显改善。查舌淡红，苔中后部微黄腻，脉弦无力，辨证为厥阴寒热、虚实错杂。2008年服用本发明药物治疗，服药5 剂，腹泻、腹痛明显减轻，行走时未感腹痛。继续服用，2个疗程后，腹泻、腹痛等症消失，体重增加；继续服用1 个疗程，行电子结肠镜复查报告，肠粘膜病变基本恢复正常，随访至今未复发。
5.2宋某，男，30 岁。因腹痛、腹胀、停止排气排便10小时于2009年3月2日入院。患有克罗恩病史1 年，浅表性胃炎病史1 年，20天前因肠梗阻手术治疗痊愈；该病人于10小时前无明显诱因出现腹痛，以脐周为著，阵发性绞痛，每次持续1～2分钟，间隔15～20 分钟发作一次，伴轻度腹胀、恶心，未呕吐，停止排气排便，无发热，无咳嗽、咳痰，无心悸、气短，无放射性痛，未经治疗而来院，急诊以克罗恩病伴肠梗阻收入院。用本发明药物治疗，服药2 剂，腹痛明显减轻，行走时未感腹痛。继续服用，2个疗程后，腹痛等症消失，体重增加；继续服用1 个疗程，经检查发现基本恢复正常，随访至今未复发。
具体实施方式
下面结合实施例对本发明作进一步的说明，下述该实施例仅用于说明本发明而对本发明没有限制。
实施例1，一种治疗克罗恩病的中药组合物，是由丹参20g，赤芍15g，白芍15g，白术10g，炒当归10g，红花9g，川芎12g，党参12g，炙枳壳10g，木香12g，陈皮10g，半夏12g，甘草9g，黄连10g，焦三仙各25g制成。
实施例2，一种治疗克罗恩病的中药组合物，是由丹参10g，赤芍10g，白芍10g，白术5g，炒当归5g，红花7g，川芎10g，党参10g，炙枳壳5g，木香10g，陈皮5g，半夏10g，甘草7g，黄连5g，焦三仙各20g制成。
实施例3，一种治疗克罗恩病的中药组合物，是由丹参30g，赤芍20g，白芍20g，白术15g，炒当归15g，红花12g，川芎15g，党参15g，炙枳壳15g，木香15g，陈皮15g，半夏15g，甘草12g，黄连15g，焦三仙各30g制成。
Claims (2)
1.一种治疗克罗恩病的中药组合物，其特征在于它是由下述原料药制成：
丹参10-30份，赤芍10-20份，白芍10-20份，白术5-15份，炒当归5-15份，红花7-12份，
川芎10-15份，党参10-15份，炙枳壳5-15份，木香10-15份，陈皮5-15份，半夏10-15份，
甘草7-12份，黄连5-15份，焦三仙各20-30份。
2.根据权利要求1所述的中药组合物，其特征在于它是由下述原料药制成：
丹参20份，赤芍15份，白芍15份，白术10份，炒当归10份，红花9份，
川芎12份，党参12份，炙枳壳10份，木香12份，陈皮10份，半夏12份，
甘草9份，黄连10份，焦三仙各25份。
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