CN102716156A - External sterilization antiphlogistine formula and method for preparing antiphlogistine - Google Patents

Abstract

The invention discloses a formula of antiphlogistine which can treat tinea corporis, tinea manus and pedis, tinea versicolor, tinea capitis, tinea barbae, onychomycosis, angular cheilitis, otitis externa, sore, prickly heat, pruritus vulvue, pustule, wet beriberi and other diseases which are caused by infections of dermatophyte and yeast infection, and a method for preparing the antiphlogistine, wherein the formula is characterized by comprising the following ingredients in parts by weight: 5-20 parts of compound sulfamethoxazole, 5-10 parts of glycerol, 20-40 parts of diosgenin and 1-3 parts of pollen pini. The method for preparing the antiphlogistine is that solid material is ground into fine powder, and talcum powder and the pollen pini are boiled with boiling water, and then are completely fried with honey, the glycerol is finally added and the mixture is stirred to obtain the antiphlogistine. The antiphlogistine has the advantages of broad spectrum and antifungal performance, the defect that the traditional medicine treatment is easy to relapse is overcome, and the function mechanism is inhibiting the cell membrane synthesis through penetrating into cells to interfere the cell metabolism. The antiphlogistine is low in cost, and has small toxic and side effects, high cure rate and very low adverse reaction rate, a patient can be cured within 1-3 weeks for curing, the normal activities are not influenced during the treatment period, pruritus and pain can be quickly relieved, and no scar is left.

Description

Prescription of a kind of external bactericidal antiphlogistic cream and preparation method thereof

Technical field: the present invention relates to external-applied ointment, relate in particular to a kind of prescription of external bactericidal antiphlogistic cream and according to the method for this formulation ointment.

Background technology: because the continuous deterioration of ecological environment, much human is infected by mushroom becomes pruritus disease under tinea class, knot skin ulcer class, the hip.Dermatosis is a kind of commonly encountered diseases and frequently-occurring disease, and existing western medicine method is not good, and not only toxic and side effects is big, and easy relapse; Often weak curative effect, time are long in the tradition Chinese traditional treatment, and common shortcoming is that a kind of medicine can not be treated the various skin disease simultaneously.I have invented this have wide spectrum and specific external bactericidal antiphlogistic cream for this reason.

Summary of the invention: the purpose of this invention is to provide and a kind ofly can cure diseases such as fungi, the microbial ringworm of the body of yeast, tinea of feet and hands, tinea versicolor, favus of the scalp, barber's itch, onychomycosis, first beads disease, angular stomatitis, otitis externa, knot sore, prickly heat, pruritus vulvue, useless fellow, tinea weak foot due to dampness; Spend less, no pain, cure rate are high, have no adverse reaction, can cure in 1-3 week; Do not influence the external application bactericidal antiphlogistic cream of each item normal activity during the treatment, it is characterized in that comprising that following raw materials by weight percent forms: Co-trimoxazole (SMZ-ATP) 5-20 part, glycerine 3-15 part, diosgenin 20-40 part, pollen pini 1-3 part, calcium carbonate 50-70 part, honey 1-5 part, talcum powder 2-8 part, water 4-12 part.

According to formulation external bactericidal antiphlogistic cream of the present invention, its method may further comprise the steps:

(1) takes by weighing various raw materials according to above-mentioned prescription;

(2) Pollen Pini and Pulvis Talci scald with boiled water;

(3) Mel fries;

(4) compound sulfamethoxazole (SMZ-ATP), diosgenin, calcium carbonate mixing porphyrize;

(5) add glycerin furnishing paste.

The ointment of the present invention's preparation has the effect of broad-spectrum anti-fungal infection, can treat the various skin disease, and toxic and side effects is little, and is difficult for recurrence, preventing from scar.

Through trying out of nearly hundred routine patients, evident in efficacy, overcome existing western medicine method not good (not only toxic and side effects is big, and easy relapse), traditional Chinese traditional treatment is weak curative effect, long shortcoming of time often; Existing medicine can not be treated the various skin disease simultaneously, and the present invention can accomplish that a medicine uses more.

Compared with prior art, the present invention is raw materials used to be easy to get, and the Chinese medicine and western medicine collocation brings out the best in each other, and no valuable thing is cheap, alleviates patient economy burden, and safe and efficient simultaneously, difficult recurrence is applicable to that various skin is sick.Clinical symptoms disappears rapidly, and is evident in efficacy, cures the back preventing from scar.

External-applied ointment of the present invention carries and uses very conveniently, even be strayed in the mouth, also has not big harm.

Carry out details in the face of primary raw material down:

Compound sulfamethoxazole (SMZ-ATP), the compound preparation of sulfamethoxazole (SMZ) and trimethoprim (TMP), another name bactrim, compound sulfamethoxazole.Wherein sulfamethoxazole belongs to median acting sulfonamide, and trimethoprim belongs to trimethoprim (TMP), and general prescription is 5: 1, and this prescription has not only alleviated side effect, has also increased antimicrobial spectrum and antibacterial activity greatly.Be the strongest and commonly used antibiotic compound preparation in the present sulfa drugs, the clinical treatment that is usually used in treating respiratory tract, urinary tract infection and typhoid fever, cellularity dysentery, gonorrhea, osteomyelitis, infantile diarrhea, turista, septicemia etc.These article mechanism of action is: SMZ suppresses in dihydrofolate synthetase; Disturb the first step of synthetic folic acid; TMP acts on anabolic second step of folic acid, and selectivity suppresses the effect of dihydrofolate reductase, and the two share and can make the folic acid metabolism of antibacterial receive double blocking.

The popular glycerol that is named as of glycerin is a kind of wetting agent, is well received by the public because of good and cheap.Glycerol has extremely strong hygroscopicity, uses the glycerol skin protection, can make skin keep moistening, soft.And glycerol is wiped on skin, also can form one deck glycerol thin film, and secluding air is invaded, and makes the moisture in the skin be difficult for evaporation, and can absorb airborne moisture and come skin care, thereby prevents chapped skin effectively.

Diosgenin is a kind of important The steroid saponinUnit, molecular formula C ₂₇H ₄₂O ₃, be the important foundation raw material of producing steroid hormone class medicine and contraceptive.Steroid hormone has very strong infection, antiallergic, antiviral and antishock pharmacological action, is treatment rheumatism, cardiovascular, leukemic lymphoblastoid, cellularity encephalitis, dermatosis, antitumor and rescue critical patient's important medication.Diosgenin has cough-relieving, eliminates the phlegm, desensitization, antiinflammation, and the effect of fungus such as insecticide and anti-tinea barbae trichobacteria is extremely also arranged.Plant origin: Rhizoma Dioscoreae Zingiberensis, Dioscorea nipponica Mak. Ningpo Yam Rhizome, Dioscorea panthaica Prain et Burkill, Rhizoma Curcumae Longae etc.Another name: diosgenin, buchu aglucon.Chemical name: different volution-5-alkene-3 β-alcohol.Character: the crystalline powder of white or little Huang, do not have remarkable oil and lose flavor or other foreign odor.

Pollen Pini is the spermatid of life-prolonging pinaster pistil in the world; Undertaking the important task of pinaster procreation, it is the elite of pinaster, the various nutritional labelings that the most long-lived life entity of intension is required; 20 seed amino acids wherein arranged, contain 8 kinds of essential amino acids, 14 kinds of vitamin, 30 kinds of mineral elements, nearly hundred kinds of enzymes and life active compound; Also have nutrition such as cellulose, flavonoid, nucleic acid, unsaturated fatty acid, choline and collocation rationally, have and replenish human nutrition comprehensively, the body of reinforcement metabolism is arranged; The comprehensive function of conditioning, alleviation disease and skin care has good health care to human body EffectParticularly but external is without the Pollen Pini dampness astringing to arrest bleeding of broken wall treatment, and, traumatic hemorrhage dripping to eczema, impetigo, skin erosion, dense water, diaper dermatitis etc. have good therapeutical effect, thereby it is again various skin infection patients' a good medicine.

The present invention is applied to routine clinical observation in nearly 3 years 100, and statistical data is following: minimum 3 years old of age, maximum 72 years old; Male's 42 examples, women's 58 examples; The external used medicine time is the shortest 6 days, the longest 70 days (Chang Xinjia); Significant curative effect person 94 examples, responder's 6 examples, nonresponder's 0 example.

Model case:

1, all xx, the woman, 15 years old, the tinea beriberi caused by pathogenic damp for many years, she is very painful for this reason.After the ward mate recommends, immediately antipruritic with the treatment of this ointment, the back recovery from illness of two weeks is used in continuation.

2, Zhao xx, the man, 48 years old, tinea unguium, therapeutic effect was not good time and again in the past, used this ointment to take effect after two weeks, and it is surplus that the trouble first continues the coating moon, new first growth, the patient is indebted forever.

3, Lee xx, the woman, 33 years old, candidal vaginitis, with go to bed every day before ointment is clamp-oned the vagina depths, the synchronism companion also gives corresponding treatment, logotype obtains remarkable result after two weeks.

The specific embodiment:

Embodiment 1, get compound sulfamethoxazole (SMZ-ATP) 10 gram, glycerin 8 grams, diosgenin 28 grams, Pollen Pini 2 grams, calcium carbonate 52 grams, Mel 3 grams, Pulvis Talci 4 grams, water 6 grams; With compound sulfamethoxazole, diosgenin and calcium carbonate porphyrize; Pollen Pini and Pulvis Talci scald with boiled water; Mel fries, and gets final product with glycerin furnishing paste.

Usage and dosage: miliaria or skin ulcer class infect, and directly coating is in the affected part, and every day 2-3 time is to recovery from illness.

Embodiment 2, get compound sulfamethoxazole (SMZ-ATP) 15 gram, glycerin 10 grams, diosgenin 35 grams, Pollen Pini 2.6 grams, calcium carbonate 55 grams, Mel 2 grams, Pulvis Talci 4 grams, water 7 grams; With compound sulfamethoxazole, diosgenin and calcium carbonate porphyrize; Pollen Pini and Pulvis Talci scald with boiled water; Mel fries, and gets final product with glycerin furnishing paste.

Usage and dosage: tinea unguium patient's trouble first is cut short, change dressings once every day in Tu Benpin and affected part as far as possible, with the gauze wrapping, grow new first after about two weeks.

Claims (4)

1. external bactericidal antiphlogistic cream is characterized in that comprising that following raw materials by weight percent forms: 520 parts of compound sulfamethoxazoles (SMZ-ATP), glycerin 3-15 part, diosgenin 20-40 part, Pollen Pini 1-3 part.

2. external bactericidal antiphlogistic cream as claimed in claim 1 is characterized in that also comprising that following raw materials by weight percent forms: calcium carbonate 50-70 part, Mel 1-5 part, Pulvis Talci 2-8 part, water 4-12 part.

3. external bactericidal antiphlogistic cream as claimed in claim 2 is characterized in that comprising that following raw materials by weight percent forms: 10 parts of compound sulfamethoxazoles (SMZ-ATP), 8 parts of glycerin, 30 parts of diosgenins, 2.5 parts of Pollen Pinis, 60 parts of calcium carbonate, 4 parts of Mel, 6 parts of Pulvis Talci, 7 parts in water.

4. the method for a formulation external bactericidal antiphlogistic cream as claimed in claim 1 is characterized in that may further comprise the steps:

(1) according to the described recipe configuration raw material of claim 1;

(2) Pollen Pini and Pulvis Talci scald with boiled water;

(3) Mel fries;

(4) compound sulfamethoxazole (SMZ-ATP), diosgenin, calcium carbonate mixing porphyrize;

(5) add glycerin furnishing paste.