CN1686293A - Paste preparation for treating oxide lichen and its preparation technology - Google Patents

Abstract

A medicine in the form of ointment for treating psoriasis is prepared from 3 chemical drugs including chlorpheniramine, etc and 4 Chinese-medicinal materials including realger, borneol, etc through pulverizing and mixing with vaseline.

Description

Treatment psoriasis unguentum and preparation technology thereof

Affiliated technical field:

The present invention treats the psoriasis unguentum and preparation technology belongs to dermopathic medicine of treatment and preparation technology thereof, relates in particular to topical drug and technology thereof with the treatment ringworm of Chinese medicine and chemical drugs mixed preparing.

Background technology:

Psoriasis is a kind of chronic dermatosis of common easy recurrence, being covered with silvery white squama with erythema is main clinic symptoms, also claim psoriasis or psoriasis, damage and be erythema, pimple is distributed in extremity mostly and stretches side and scalp position, conscious have a gargalesthesia, psoriasis belongs to the traditional Chinese medical science " in vain " category, and Chinese medical discrimination is divided into blood-heat syndrome, syndrome of blood stasis, syndrome of deficiency of blood is just sent out or is recurred soon, the skin lesion development rapidly, common pimple, maculopapule, the patch that differs in size, mottle is red, is covered with silvery white squama, with pruritus in various degree, after the course of disease was long, skin lesion was thick hard, is the speckle shape, color is dark red, with the passing of time the state of an illness delays again, and skin lesion is attenuation again, often is general whole body of patch shape or skin lesion, light red or the light brown of color, the cause of disease generates from epiderm skin and forms obstacle, automatic control effect damaged, and epidermis cell generates disorderly, pathogenesis has four aspects: the one, and wind and cold, wind heat, the heresy of pathogenic wind-warm is outer attacks, and causes battalion to defend and becomes estranged; The 2nd, internal injury caused by excess of seven emotions, obstruction of QI or eating and drinking without temperance, taste are become estranged, consequently strongly fragrant heat-transformation of a specified duration of functional activity of QI being not smooth, and heat is gone into nutrient blood, then consumes essence for a long time and hinders liquid, and the blood liquid drier is withered, failure of skin and muscle to be nourished; The 3rd, stasis of blood resistance skin disharmony between QI and blood; The 4th, deficiency of the liver and kindey, disharmony of Chong and Conception Channels.Relevant nothing more than, blood stasis dry and deficiency of the liver and kindey etc. with wind, heat, wet, cold, heat in blood, blood, it is numerous that existing market is sold the antipsoriatics thing, be painted with the master outward with chemicals, the Chinese herb compound oral formulations is also arranged, also have the microorganism oral formulations, can not coordinate to treat the defective high with relapse rate but all deposit in vivo with external.

Summary of the invention:

The objective of the invention is: provide scientific formulation to the psoriatic, the Chinese medicine for the treatment of both the principal and secondary aspects of a disease, itch, the effect of dispersing swelling and dissipating binds, the hemopoietic of putting on flesh, with " treatment psoriasis pure Chinese medicine capsule " and the usefulness of my development, can effectively treat dissimilar psoriasiss, and not recur.

In order to realize the foregoing invention purpose, the technology used in the present invention route is: treatment psoriasis unguentum is according to the main etiology and pathogenesis of psoriasis skin lesion, to kill tinea bacterium, scrubbing evacuation of pus, granulation promoting is antipruritic, the skin moistening that nourishes blood is a principle of treatment, raw material is by 20 of Realgar 5 grams, Borneolum Syntheticum 5 grams, Indigo Naturalis 15 grams, Rhizoma Coptidis 12 grams, prednisoni acetas sheet, 30 of chlorpheniramine maleate tabletses, the vaseline composition of 20 and 2 times crude drug weight of Co-trimoxazole Tablet in the prescription.Compound method is divided into Chinese crude drug and chemical tablet crushing screening powder process medicine and powder medicine and base material and grinds well and make unguentum twice technology, at first take by weighing Realgar by formula ratio, Borneolum Syntheticum, Indigo Naturalis, Rhizoma Coptidis four flavor Chinese crude drugs, being ground into fine powder respectively crosses 80 mesh sieves and becomes the fine powder medicine standby, get 20 of every prednisoni acetas sheets that contains prednisoni acetas 5mg more respectively, 30 of every chlorpheniramine maleate tabletses that contains chlorphenamine 4mg, every sulfamethoxazole 0.4 gram, 20 of the Co-trimoxazole Tablet of metopycide 0.08 gram mix porphyrize to be crossed 80 mesh sieves and becomes the fine powder medicine standby, at last various fine powder medicines are mixed the heavy vaseline of back and 2 times of amounts grind well unguentum.Though modern medicine thinks that blood deficiency in psoriasis and the body, blood are dry, heat in blood, wind, heat, wet, cold, deficiency of the liver and kindey, hypoimmunity are relevant, but external skin lesion place prolongs living directly related with antibacterial, fungus, in treatment psoriasis unguentum, Realgar has antibacterial action, various skin funguses such as trichophyton there is in various degree antibacterial and killing action, have the effect of bright poison, parasite killing, dampness and scrubbing evacuation of pus, dispersing swelling and dissipating binds, cure mainly insane cellulitis furuncle, scabies, eczema of lower limb; Borneolum Syntheticum has antiinflammatory, antibiotic, the refreshment of having one's ideas straightened out, granulation promoting analgesic effect, cures mainly that rheumatism is gathered, calentura coma, aphtha, carbuncle, hemorrhoid; Indigo Naturalis has stronger bacteriostasis to seven dermatophytes such as microsporum canis, trichophyton tonsurans, purple tinea bacterium, has anti-inflammation, the effect of heat-clearing and toxic substances removing, the liver pathogenic fire purging that disappears, and it is swollen to cure mainly epidemic febrile disease maculopapulae due to toxic heat, bleb; Rhizoma Coptidis is inhibitory action to multiple gram positive bacteria and multiple tinea bacterium, has clearing away heat-fire, dampness, detoxifies, puts on flesh, hemostasia effect, cures mainly pathopyretic ulcer, furunculosis septicemia, swelling of the vulva, eczema; The prednisoni acetas sheet has the antiallergic effect, is mainly used in the treatment lupus erythematosus, anaphylaxis illness such as serious dermatitis, and chlorpheniramine maleate tablets belongs to antihistaminic, and anti-allergic effects is strong, and toxic and side effects is little, is used for stiff reaction, is applicable to the sick treatment of various skin; Co-trimoxazole Tablet belongs to the sulfonamides antibiosis anti-inflammatory drug, contained sulfamethoxazole (SVZ) is a Trimethoprim, has very wide antibacterial activity, can make potentiation reach 10 times with the sulfa drugs use in conjunction, contained trimethoxy card ammonia phonetic noisy (TMP) is broad spectrum antimicrobicide, its antimicrobial spectrum is similar to sulfa drugs, Co-trimoxazole Tablet with being that SMZ has suppressed dioxy folic acid synzyme, make it not synthesize dioxy folic acid to amino benzoic Acid and dioxy pteridine, TMP has then further suppressed dihydrofolate reductase, make it not be reduced into four oxygen folic acid to dioxyacetic acid, by the dual continuous metabolism of blocking antibacterial, make antibacterial can not synthesize necessary ribonic acid of its life and desoxyribose, reach antibiotic sterilization effect.Each pharmaceutically active ingredient is played altogether and is killed tinea bacterium, scrubbing evacuation of pus, antipruritic, the skin moistening effect that nourishes blood of granulation promoting in one in prescription, with " treatment psoriasis pure Chinese medicine capsule " outer being coated with for oral administration of my invention, treating both the principal and secondary aspects of a disease, effectively cure psoriasis, and do not recur, treatment psoriasis unguentum preparation technology only adopts fine powder medicine and base material porphyrize paste manufacture process, preparation technology is easy, low production cost, this unguentum is a medicine for external use, is applied to skin and decreases the affected part, changed in three days and be coated with once, be coated with convenient.

The invention has the beneficial effects as follows: the scientific formulation novelty, preparation technology is easy, and low production cost is coated with convenient, and therapy of combining Chinese and Western medicine has the tinea of killing bacterium, scrubbing evacuation of pus, antipruritic, the skin moistening effect that nourishes blood of granulation promoting, can effectively cure psoriasis, and not recur.

Specific embodiments:

1, takes by weighing Realgar, Borneolum Syntheticum, Indigo Naturalis, Rhizoma Coptidis four flavor Chinese crude drugs with the existing decoction pieces standard of Chinese crude drug by formula ratio, be ground into fine powder respectively and cross 80 mesh sieves and become Chinese medicine fine powder medicine standby.

2, purchase the prednisoni acetas sheet with chemical drugs standard in the prescription, chlorpheniramine maleate tablets, bright tablet of three kinds of chemical drugss of compound recipe promise are crossed 80 mesh sieves by formula ratio mixing porphyrize and are become chemical medicine fine powder standby.

3, it is standby to take by weighing vaseline with 2 times of prescription medicinal raw material (four flavor Chinese crude drug and three kinds of chemical medicines) gross weights.

4, get part vaseline and add whole Chinese medicine fine powder medicines and chemical medicine fine powder medicine grinds to uniform and smooth, add residue vaseline again and grind well in fusion below 50 ℃, in the container of packing into unguentum.

Claims (2)

1, a kind of treatment psoriasis unguentum is characterized in that: raw material is by 20 of Realgar 5 grams, Borneolum Syntheticum 5 grams, Indigo Naturalis 15 grams, Rhizoma Coptidis 12 grams, prednisoni acetas sheet, 30 of chlorpheniramine maleate tabletses, the vaseline composition of 20 and 2 times crude drug weight of Co-trimoxazole Tablet in the prescription.

2, treat the preparation technology of psoriasis unguentum according to claim 1, it is characterized in that: at first take by weighing Realgar by formula ratio, Borneolum Syntheticum, Indigo Naturalis, Rhizoma Coptidis four flavor Chinese crude drugs, being ground into fine powder respectively crosses 80 mesh sieves and becomes the fine powder medicine standby, get 20 of every prednisoni acetas sheets that contains prednisoni acetas 5mg more respectively, 30 of every chlorpheniramine maleate tabletses that contains chlorphenamine 4mg, 20 of every Co-trimoxazole Tablet that contains sulfamethoxazole 0.4 gram and metopycide 0.08 gram, mix porphyrize and cross 80 mesh sieves and become the fine powder medicine standby, at last various fine powder medicines are mixed the heavy vaseline of back and 2 times of amounts grind well unguentum.