CN102697929B - Hydrophilic Chinese medicinal patch and preparation method thereof - Google Patents
Hydrophilic Chinese medicinal patch and preparation method thereof Download PDFInfo
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- CN102697929B CN102697929B CN 201210198169 CN201210198169A CN102697929B CN 102697929 B CN102697929 B CN 102697929B CN 201210198169 CN201210198169 CN 201210198169 CN 201210198169 A CN201210198169 A CN 201210198169A CN 102697929 B CN102697929 B CN 102697929B
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Abstract
The invention relates to hydrophilic Chinese medicinal patch and a preparation method thereof, and can effectively solve the problems that the package size of the effective medicines of the conventional patch is small, and the conventional patch is airtight. According to the technical scheme, a gelatin solution, a tragacanth solution and a Chinese herbal compound extraction polysaccharide solution are added into swelled Carbomer and mixed uniformly to prepare a substrate I; glycerin is mixed with propylene glycol uniformly, and sodium carboxy methyl cellulose, medicinal sodium polyacrylate, citric acid, eucalyptus oil, frankincense, myrrh, kaolin and diatomaceous earth are sequentially added into the mixture of the glycerin and propylene glycol and mixed uniformly to prepare a substrate II; the substrate I is mixed with the substrate II uniformly, a Chinese herbal compound alcohol soluble extract, borneol and menthol are added into the mixed substrate of the substrate I and the substrate II, fully and uniformly mixed, coated, cut and packaged to prepare the hydrophilic Chinese medicinal patch. The Chinese medicinal patch is reasonable in compatibility, has an exact reliable in curative effect and big viscosity, and is difficult to fall off, and favorable for transdermal absorption of skin; a manufacturing process is simple, practicable and economic; and the social benefit is obvious.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of hydrophilic Chinese medicine patch and preparation method thereof.
Background technology
Patch is the important component part of China's traditional medicine, and the history in existing more than 2000 year has the incomparable advantage of other dosage form, and is easy to use, sustainable administration, and also interruption of the administration at any time, and do not have GI irritation and liver first-pass effect, blood drug level is steady.Patch in the market mainly with traditional rubber plaster or hot-fusible pressure-sensitive adhesive as host material, these host materials are big and thin in appearance, its shortcoming is that active drug containing amount is little, airtight, the drug transdermal weak effect and stimulate irritated, can't alleviate the efficacy of a drug, generally only with the load fat-soluble medicine, limited the development of patch dramatically.Traditional gel plaster substrate content height, moisture-holding capacity is little, and substrate viscosity is little.
Summary of the invention
At above-mentioned situation, for solving the defective of prior art, content of the present invention just provides a kind of hydrophilic Chinese medicine patch and preparation method thereof, can solve effectively that existing patch active drug containing amount is little, airtight, the drug transdermal weak effect, skin is produced stimulate the problem that causes allergy, the efficacy of a drug to alleviate easily.
Technical scheme of the present invention is, a kind of hydrophilic Chinese medicine patch is by following weight percent meter: medical polypropylene acid sodium 5%-8%, pharmagel or edible Gelatinum oxhide 1.6%-5%, sodium carboxymethyl cellulose 1.0%-5%, citric acid 0.2%-0.8%, carbomer 2%-12%, tragcanth 1%-5%, Olibanum 0.2%-1.5%, Myrrha 0.2%-1.5%, Chinese medicine compound is extracted polysaccharide 2%-10%, Chinese medicine compound ethanol-soluble extractives 2%-15%, Kaolin or kieselguhr 4.5%-5 %, glycerol 10.0%-25%, propylene glycol 3.0%-8.0%, Oleum Eucalypti 0.2%-2 %, Borneolum Syntheticum 0.1%-1.6%, Mentholum 0.1%-2.1%, surplus is water, and total amount is 100% to make;
The preparation method of described hydrophilic Chinese medicine patch may further comprise the steps: (1) adds water-soluble expanding with carbomer, adds triethanolamine again and transfers pH to 7.0-10.0; Add 35-60 ℃ of dissolvings of water of 3-5 times of weight in pharmagel or the edible Gelatinum oxhide, get gelatin solution; Tragcanth adds the water dissolution of 5-10 times of weight, gets tragcanth solution; Chinese medicine compound is extracted the water dissolution that polysaccharide adds 5-10 times of weight, gets polysaccharide solution; Gelatin solution, tragcanth solution and polysaccharide solution are joined the carbomer of swelling, and mix homogeneously gets the substrate I; (2) glycerol and mixed with propylene glycol is even, add the acid of sodium carboxymethyl cellulose, medical polypropylene sodium, citric acid, Oleum Eucalypti successively, be crushed to Olibanum and Myrrha, Kaolin or the kieselguhr of fine powder, behind the mixing the substrate II;
(3) with substrate I and substrate II in 35-60 ℃ of mix homogeneously, and with the Chinese medicine compound ethanol-soluble extractives and pulverize Borneolum Syntheticum, the Mentholum of crossing 80 mesh sieves in the back and join in the mixed-matrix of above-mentioned substrate I and substrate II, fully mix homogeneously is coated with, cut, packing gets final product.
Compatibility of the present invention is reasonable, and determined curative effect is reliable, the big difficult drop-off of patch viscosity, and contain hydroaropic substances such as a large amount of moisture, glycerol, propylene glycol, and being conducive to medicine through the skin Transdermal absorption, processing technology is simple, and economic and social benefit is remarkable.
The specific embodiment
Elaborate below in conjunction with the specific embodiment of the present invention of embodiment.
A kind of hydrophilic Chinese medicine patch of the present invention is by following weight percent meter: medical polypropylene acid sodium 5%-8%, pharmagel or edible Gelatinum oxhide 1.6%-5%, sodium carboxymethyl cellulose 1.0%-5%, citric acid 0.2%-0.8%, carbomer 2%-12%, tragcanth 1%-5%, Olibanum 0.2%-1.5%, Myrrha 0.2%-1.5%, Chinese medicine compound is extracted polysaccharide 2%-10%, Chinese medicine compound ethanol-soluble extractives 2%-15%, Kaolin or kieselguhr 4.5%-5 %, glycerol 10.0%-25.0%, propylene glycol 3.0%-8.0%, Oleum Eucalypti 0.2%-2 %, Borneolum Syntheticum 0.1%-1.6%, Mentholum 0.1%-2.1%, surplus are water, and total amount is 100% to make;
Described Chinese medicine compound ethanol-soluble extractives is by following weight percent meter: Radix Aconiti 5%--13%, Radix Aconiti Kusnezoffii 5%--13%, Semen Strychni (processed) 4%--16%, Radix Notoginseng 5%--15%, Herba speranskiae tuberculatae 7%--14%, Herba Aristolochiae Mollissimae 7%--14%, Radix Angelicae Sinensis 7%--12%, Rhizoma Chuanxiong 7%--12%, Radix Clematidis 7%--18%, Radix Angelicae Pubescentis 8%--14%, Cortex Phellodendri 8%--14% makes as crude drug, wherein will pulverize behind the above-mentioned raw materials medicine mixing earlier, cross sieve for No. one coarse powder, the volumetric concentration that adds 10 times of coarse powder weight is 75% ethanol, reflux, extract, 2 times each 3 hours, is filtered, the extracting solution decompression recycling ethanol gets the Chinese medicine compound ethanol-soluble extractives;
Described Chinese medicine compound is extracted polysaccharide: said extracted is crossed medicinal residues behind the Chinese medicine compound ethanol-soluble extractives, add the water of 10 times of medicinal residues weight again, 90-100 ℃ are extracted 3 times, each 3 hours, filter, merging filtrate, being evaporated to proportion is 1.1-1.3, the ethanol that adds volumetric concentration again and be 95%--100% to the volumetric concentration of alcohol reaches 80%(v/v), 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, get Chinese medicine compound and extract polysaccharide.
Put down in writing according to pharmacopeia: described coarse powder is can be no more than 20% powder by No. three sieves but be mixed with all by a sieve; Described fine powder is can be all by No. six sieves, and contains and can be no less than 95% powder by No. seven sieves; A described sieve is 2000 μ m ± 70 μ m for sieve aperture internal diameter (meansigma methods), and order number is 10 orders; Described No. three sieves are 355 μ m ± 13 μ m for sieve aperture internal diameter (meansigma methods), and order number is 50 orders; Described No. six sieves are 150 μ m ± 6.6 μ m for sieve aperture internal diameter (meansigma methods), and order number is 100 orders; Described No. seven sieves are 125 μ m ± 5.8 μ m for sieve aperture internal diameter (meansigma methods), and order number is 120 orders;
The preparation method of described hydrophilic Chinese medicine patch may further comprise the steps: (1) adds water-soluble expanding with carbomer, adds triethanolamine again and transfers pH to 7.0-10.0; Add 35-60 ℃ of dissolvings of water of 3-5 times of weight in pharmagel or the edible Gelatinum oxhide, get gelatin solution; Tragcanth adds the water dissolution of 5-10 times of weight, gets tragcanth solution; Chinese medicine compound is extracted the water dissolution that polysaccharide adds 5-10 times of weight, gets polysaccharide solution; Gelatin solution, tragcanth solution and polysaccharide solution are joined the carbomer of swelling, and mix homogeneously gets the substrate I;
(2) glycerol and mixed with propylene glycol is even, add the acid of sodium carboxymethyl cellulose, medical polypropylene sodium, citric acid, Oleum Eucalypti successively, be crushed to Olibanum and Myrrha, Kaolin or the kieselguhr of fine powder, behind the mixing the substrate II;
(3) with substrate I and substrate II in 35-60 ℃ of mix homogeneously, and with the Chinese medicine compound ethanol-soluble extractives and pulverize Borneolum Syntheticum, the Mentholum of crossing 80 mesh sieves in the back and join in the mixed-matrix of above-mentioned substrate I and substrate II, fully mix homogeneously is coated with, cut, packing gets final product.
The present invention can be realized by following examples.
Embodiment 1
By following weight percent meter: medical polypropylene acid sodium 5%, pharmagel or edible Gelatinum oxhide 5%, sodium carboxymethyl cellulose 1.0%, citric acid 0.2%, carbomer 12%, tragcanth 1%, Olibanum 0.2%, Myrrha 0.2%, Chinese medicine compound is extracted polysaccharide 2%, Chinese medicine compound ethanol-soluble extractives 15%, Kaolin or kieselguhr 4.5%, glycerol 10%, propylene glycol 3.0%%, Oleum Eucalypti 0.2%, Borneolum Syntheticum 1.6%, Mentholum 0.1%, water 39% is made;
Described Chinese medicine compound ethanol-soluble extractives is by following weight percent meter: Radix Aconiti 5%, Radix Aconiti Kusnezoffii 13%, Semen Strychni (processed) 16%, Radix Notoginseng 15%, Herba speranskiae tuberculatae 7%, Herba Aristolochiae Mollissimae 7%, Radix Angelicae Sinensis 7%, Rhizoma Chuanxiong 7%, Radix Clematidis 7%, Radix Angelicae Pubescentis 8%, Cortex Phellodendri 8% is made as crude drug, wherein will pulverize behind the above-mentioned raw materials medicine mixing earlier, cross sieve for No. one coarse powder, the volumetric concentration that adds 10 times of coarse powder weight is 75% ethanol, reflux, extract, 2 times, each 3 hours, filter, the extracting solution decompression recycling ethanol, namely;
Described Chinese medicine compound is extracted polysaccharide: said extracted is crossed medicinal residues behind the Chinese medicine compound ethanol-soluble extractives, add the water of 10 times of medicinal residues weight, 90-100 ℃ of heating extraction 3 times, each 3 hours, filter, merging filtrate, being evaporated to proportion is 1.1-1.3, the ethanol that adds percentage by volume and be 95%--100% to the volumetric concentration of alcohol reaches 80%(v/v), 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, namely.
Embodiment 2
The present invention is by following weight percent meter: by following weight percent meter: medical polypropylene acid sodium 8%, pharmagel or edible Gelatinum oxhide 1.6%, sodium carboxymethyl cellulose 3%, citric acid 0.8%, carbomer 2%, tragcanth 5%, Olibanum 1.5%, Myrrha 1.5%, Chinese medicine compound is extracted polysaccharide 10%, Chinese medicine compound ethanol-soluble extractives 2%, Kaolin or kieselguhr 5 %, glycerol 25%, propylene glycol 8%, Oleum Eucalypti 2 %, Borneolum Syntheticum 0.1%, Mentholum 2.1%, water are 22.4% to make;
Described Chinese medicine compound ethanol-soluble extractives is by following weight percent meter: Radix Aconiti 13%, Radix Aconiti Kusnezoffii 5%, Semen Strychni (processed) 4%, Radix Notoginseng 5%, Herba speranskiae tuberculatae 13.4%, Herba Aristolochiae Mollissimae 13.5%, Radix Angelicae Sinensis 11.5%, Rhizoma Chuanxiong 11.6%, Radix Clematidis 7%, Radix Angelicae Pubescentis 8%, Cortex Phellodendri 8% is made as crude drug, wherein will pulverize behind the above-mentioned raw materials medicine mixing earlier, cross sieve for No. one coarse powder, the volumetric concentration that adds 10 times of coarse powder weight is 75% ethanol, reflux, extract, 2 times each 3 hours, is filtered, the extracting solution decompression recycling ethanol, namely;
Described Chinese medicine compound is extracted polysaccharide: said extracted is crossed medicinal residues behind the Chinese medicine compound ethanol-soluble extractives, add the water of 10 times of medicinal residues weight, 90-100 ℃ of heating extraction 3 times, each 3 hours, filter, merging filtrate, being evaporated to proportion is 1.1-1.3, the ethanol that adds percentage by volume and be 95%--100% to the volumetric concentration of alcohol reaches 80%(v/v), 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, namely.
Embodiment 3
The present invention is by following weight percent meter: medical polypropylene acid sodium 6.5%, pharmagel or edible Gelatinum oxhide 3.5%, sodium carboxymethyl cellulose 5%, citric acid 0.4%, carbomer 6%, tragcanth 3%, Olibanum 0.5%, Myrrha 0.5%, Chinese medicine compound is extracted polysaccharide 6%, Chinese medicine compound ethanol-soluble extractives 8%, Kaolin or kieselguhr 4.6%, glycerol 15%, propylene glycol 5%, Oleum Eucalypti 1 %, Borneolum Syntheticum 0.8%, Mentholum 1.0%, water are 33.2% to make;
Described Chinese medicine compound ethanol-soluble extractives is by following weight percent meter: Radix Aconiti 6.4%, Radix Aconiti Kusnezoffii 7.1%, Semen Strychni (processed) 6.2%, Radix Notoginseng 8.3%, Herba speranskiae tuberculatae 7%, Herba Aristolochiae Mollissimae 7%, Radix Angelicae Sinensis 7%, Rhizoma Chuanxiong 7%, Radix Clematidis 17.2%, Radix Angelicae Pubescentis 13.4%, Cortex Phellodendri 13.4% is made as crude drug, wherein will pulverize behind the above-mentioned raw materials medicine mixing earlier, cross sieve for No. one coarse powder, the volumetric concentration that adds 10 times of coarse powder weight is 75% ethanol, reflux, extract, 2 times each 3 hours, is filtered, the extracting solution decompression recycling ethanol, namely;
Described Chinese medicine compound is extracted polysaccharide: said extracted is crossed medicinal residues behind the Chinese medicine compound ethanol-soluble extractives, add the water of 10 times of medicinal residues weight, 90-100 ℃ of heating extraction 3 times, each 3 hours, filter, merging filtrate, being evaporated to proportion is 1.1-1.3, the ethanol that adds percentage by volume and be 95%--100% to the volumetric concentration of alcohol reaches 80%(v/v), 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, namely.
Embodiment 4
The present invention is by following weight percent meter: medical polypropylene acid sodium 8%, pharmagel or edible Gelatinum oxhide 5%, sodium carboxymethyl cellulose 4%, citric acid 0.4%, carbomer 6%, tragcanth 4%, Olibanum 0.5%, Myrrha 0.5%, Chinese medicine compound is extracted polysaccharide 6%, Chinese medicine compound ethanol-soluble extractives 8%, Kaolin or kieselguhr 4.6%, glycerol 20%, propylene glycol 5%, Oleum Eucalypti 1 %, Borneolum Syntheticum 1%, Mentholum 2%, water are 24% to make;
Described Chinese medicine compound ethanol-soluble extractives is by following weight percent meter: Radix Aconiti 6.4%, Radix Aconiti Kusnezoffii 7.1%, Semen Strychni (processed) 6.2%, Radix Notoginseng 8.3%, Herba speranskiae tuberculatae 7%, Herba Aristolochiae Mollissimae 7%, Radix Angelicae Sinensis 7%, Rhizoma Chuanxiong 7%, Radix Clematidis 17.2%, Radix Angelicae Pubescentis 13.4%, Cortex Phellodendri 13.4% is made as crude drug, wherein will pulverize behind the above-mentioned raw materials medicine mixing earlier, cross sieve for No. one coarse powder, the volumetric concentration that adds 10 times of coarse powder weight is 75% ethanol, reflux, extract, 2 times each 3 hours, is filtered, the extracting solution decompression recycling ethanol, namely;
Described Chinese medicine compound is extracted polysaccharide: said extracted is crossed medicinal residues behind the Chinese medicine compound ethanol-soluble extractives, add the water of 10 times of medicinal residues weight, 90-100 ℃ of heating extraction 3 times, each 3 hours, filter, merging filtrate, being evaporated to proportion is 1.1-1.3, the ethanol that adds percentage by volume and be 95%--100% to the volumetric concentration of alcohol reaches 80%(v/v), 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, namely.
Embodiment 5
Chinese medicine compound ethanol-soluble extractives of the present invention is by any multiple following weight meter or its part by weight: Radix Aconiti 8, Radix Aconiti Kusnezoffii 8g, Semen Strychni (processed) 7g, Radix Notoginseng 10g, Herba speranskiae tuberculatae 12g, Herba Aristolochiae Mollissimae 11g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 10g, Radix Clematidis 16g, Radix Angelicae Pubescentis 12g, Cortex Phellodendri 11g makes as crude drug.
Embodiment 6
Chinese medicine compound ethanol-soluble extractives of the present invention is by any multiple following weight meter or its part by weight: Radix Aconiti 7g, Radix Aconiti Kusnezoffii 9g, Semen Strychni (processed) 10g, Radix Notoginseng 12g, Herba speranskiae tuberculatae 11g, Herba Aristolochiae Mollissimae 10g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 10g, Radix Clematidis 12g, Radix Angelicae Pubescentis 13g, Cortex Phellodendri 14g makes as crude drug.
Embodiment 7
The preparation method of hydrophilic Chinese medicine patch of the present invention may further comprise the steps:
(1) carbomer 1kg is added water 2kg swelling, add triethanolamine again and transfer pH to 7.5; Add water 5kg to pharmagel 1kg, 35 ℃ of dissolvings get gelatin solution; Tragcanth 1.1kg adds water 11kg dissolving, gets tragcanth solution; Chinese medicine compound is extracted polysaccharide 1kg and is added water 6kg dissolving, gets polysaccharide solution; With the carbomer of gelatin solution, tragcanth solution and polysaccharide solution adding swelling, mix homogeneously gets the substrate I;
(2) with glycerol 10kg and propylene glycol 1.5kg mix homogeneously, add sodium carboxymethyl cellulose 0.5kg, sodium polyacrylate 3kg, citric acid 0.2kg, Oleum Eucalypti 0.3kg successively, be crushed to Olibanum and each 0.2kg of Myrrha of fine powder, Kaolin 2.3kg mixing gets the substrate II;
(3) with substrate I and substrate II in 40 ℃ of mix homogeneously, and with Chinese medicine compound ethanol-soluble extractives 2.4kg and pulverize Borneolum Syntheticum, each 0.1kg of Mentholum of crossing 80 mesh sieves in the back and join in the mixed-matrix of above-mentioned substrate I and substrate II, fully mix homogeneously is coated with, cut, packing gets final product.
Embodiment 8
The preparation method of hydrophilic Chinese medicine patch of the present invention may further comprise the steps:
(1) carbomer 2.7kg is added water 5kg swelling, add triethanolamine again and transfer pH to 10; Pharmagel 2.5kg is added water 7.5kg, and 60 ℃ of dissolvings get gelatin solution; Tragcanth 2.7kg adds water 27kg dissolving, gets tragcanth solution; Chinese medicine compound is extracted polysaccharide 2.3kg and is added water 13.2kg dissolving, gets polysaccharide solution; With the carbomer of gelatin solution, tragcanth solution and polysaccharide solution adding swelling, mix homogeneously gets the substrate I;
(2) with glycerol 26kg and propylene glycol 4kg mix homogeneously, add sodium carboxymethyl cellulose 1.4kg, sodium polyacrylate 6.6kg, citric acid 0.5kg, Oleum Eucalypti 0.9kg successively, be crushed to Olibanum and each 0.4kg of Myrrha of fine powder, Kaolin 5.2kg mixing gets the substrate II;
(3) with substrate I and substrate II in 60 ℃ of mix homogeneously, and with Chinese medicine compound ethanol-soluble extractives 5.1kg and pulverize Borneolum Syntheticum, each 0.2kg of Mentholum of crossing 80 mesh sieves in the back and join in the mixed-matrix of above-mentioned substrate I and substrate II, fully mix homogeneously is coated with, cut, packing gets final product.
Embodiment 9
The preparation method of hydrophilic Chinese medicine patch of the present invention may further comprise the steps:
(1) carbomer 2.7kg is added water 5kg swelling, add triethanolamine again and transfer pH to 8; Pharmagel 2.5kg is added 50 ℃ of dissolvings of water 12.5kg, get gelatin solution; Tragcanth 2.7kg adds water 13.5kg dissolving, gets tragcanth solution; Chinese medicine compound is extracted polysaccharide 2.4kg and is added water 23kg dissolving, gets polysaccharide solution; With the carbomer of gelatin solution, tragcanth solution and polysaccharide solution adding swelling, mix homogeneously gets the substrate I;
(2) with glycerol 26kg and propylene glycol 4kg mix homogeneously, add sodium carboxymethyl cellulose 1.4kg, sodium polyacrylate 6.6kg, citric acid 0.5kg, Oleum Eucalypti 0.9kg successively, be crushed to Olibanum and each 0.4kg of Myrrha of fine powder, Kaolin 5.2kg mixing gets the substrate II;
(3) with substrate I and substrate II in 50 ℃ of mix homogeneously, and with Chinese medicine compound ethanol-soluble extractives 5.1kg and pulverize Borneolum Syntheticum, each 0.2kg of Mentholum of crossing 80 mesh sieves in the back and join in the mixed-matrix of above-mentioned substrate I and substrate II, fully mix homogeneously is coated with, cut, packing gets final product.
The effect that hydrophilic Chinese medicine patch of the present invention has diseases such as treatment rheumatic arthritis, scapulohumeral periarthritis, neck lumbar muscle strain through repeatedly clinical trial, has obtained identical or similar result, and the related experiment data is as follows:
One, the clinical selection standard of case:
1, rheumatic arthritis
Cardinal symptom: multi-joint migration pain, arthralgia, joint motion is ineffective when heavy; Pain and climate change have obvious relation, and be cold or increase the weight of when touching ice cold water, and weather alleviates when fine or warm.
2, scapulohumeral periarthritis
Cardinal symptom: shoulder arthralgia, or show as twinge, movable unfavorable; Local joint swelling; The local joint amyotrophy; How to fall ill person in middle and old age, cervical region, shoulder, flank pain, movable ineffective, increase the weight of gradually; The shoulder activity is limited gradually, especially with abduction, after stretch, outward turning is for very, shoulder at last becomes to condense.
3, neck lumbar muscle strain
Cardinal symptom: neck, spinal column portion pain or distending pain, it is then light to have a rest, and fatigue increases the weight of, if suitably movable or often improve sign and also can make sx;
4, hyperosteogeny
There is obvious pain in the affected part, and pain was obvious when pressure pain point, activity were arranged, and the X sheet shows that only there is hyperosteogeny in the affected part and does not have other unusual performance;
Two, curative effect determinate standard:
1, the recovery from illness: clinical symptoms, sign disappears substantially, does not influence activity and work, joint motion freely, functional rehabilitation;
2, produce effects: clinical symptoms, sign is obviously improved, and only mild occurs under tired situation, and functional rehabilitation does not influence work, or the state of an illness is transferred to slightly by severe;
3, effective: clinical symptoms, sign has the improvement of alleviating, but unstable condition, the time recurrence is arranged, but do not increase the weight of, influential to heavy physical labour;
4, invalid: as not reach effective standard;
Three, Therapeutic Method:
The external of this preparation, the cleaning illing skin removes the separate paper of plaster, is affixed on affected part or acupuncture point, once-a-day, whenever sticks 24 hours, and 7 days was 1 course for the treatment of, 3 courses for the treatment of of continuous use.Ban use of Chinese medicine, Western medicine or other drug and the therapy of other pain relievings during the clinical trial.
Four, therapeutic outcome
1, rheumatic arthritis
2, scapulohumeral periarthritis
3, neck lumbar muscle strain
4, hyperosteogeny
Clinical effectiveness shows, external use plaster of the present invention uses safety, does not occur local skin pruritus, redness in the test, and the total effective rate of rheumatic arthritis, scapulohumeral periarthritis, neck lumbar muscle strain, hyperosteogeny treating is reached more than 90%, has application value widely.
The present invention compared with prior art has the following advantages: the polysaccharide component with certain viscosity that Chinese crude drug itself is contained extracts, be used for the preparation of patch substrate, not only strengthened the viscosity of patch itself, solved little, the caducous shortcoming of viscosity that the aqueous patch exists always, and the polysaccharide that medical material itself extracts can keep a large amount of moisture, water content and the drug loading of substrate have been increased, solved conventional gel patch water content height then viscosity little, break away from, improved the therapeutic efficiency of patch; Scientific formulation of the present invention is reasonable, and is simple for process, and determined curative effect is reliable, has very big social benefit and economic benefit, is beneficial to popularization.
Claims (5)
1. hydrophilic Chinese medicine patch, it is characterized in that, by following weight percent meter: medical polypropylene acid sodium 5%-8%, pharmagel or edible Gelatinum oxhide 1.6%-5%, sodium carboxymethyl cellulose 1.0%-5%, citric acid 0.2%-0.8%, carbomer 2%-12%, tragcanth 1%-5%, Olibanum 0.2%-1.5%, Myrrha 0.2%-1.5%, Chinese medicine compound is extracted polysaccharide 2%-10%, Chinese medicine compound ethanol-soluble extractives 2%-15%, Kaolin or kieselguhr 4.5%-5 %, glycerol 10.0%-25%, propylene glycol 3.0%-8.0%, Oleum Eucalypti 0.2%-2 %, Borneolum Syntheticum 0.1%-1.6%, Mentholum 0.1%-2.1%, surplus are water, and total amount is 100% to make;
Described Chinese medicine compound ethanol-soluble extractives is by following weight percent meter: Radix Aconiti 5%--13%, Radix Aconiti Kusnezoffii 5%--13%, Semen Strychni (processed) 4%--16%, Radix Notoginseng 5%--15%, Herba speranskiae tuberculatae 7%--14%, Herba Aristolochiae Mollissimae 7%--14%, Radix Angelicae Sinensis 7%--12%, Rhizoma Chuanxiong 7%--12%, Radix Clematidis 7%--18%, Radix Angelicae Pubescentis 8%--14%, Cortex Phellodendri 8%--14% makes as crude drug, wherein will pulverize behind the above-mentioned raw materials medicine mixing earlier, cross sieve for No. one coarse powder, the volumetric concentration that adds 10 times of coarse powder weight is 75% ethanol, reflux, extract, 2 times each 3 hours, is filtered, the extracting solution decompression recycling ethanol gets the Chinese medicine compound ethanol-soluble extractives;
Described Chinese medicine compound is extracted polysaccharide: said extracted is crossed medicinal residues behind the Chinese medicine compound ethanol-soluble extractives, add the water of 10 times of medicinal residues weight again, 90-100 ℃ are extracted 3 times, each 3 hours, filter, merging filtrate, being evaporated to proportion is 1.1-1.3, the ethanol that adds volumetric concentration again and be 95%--100% to the volumetric concentration of alcohol reaches 80%, 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, get Chinese medicine compound and extract polysaccharide.
2. hydrophilic Chinese medicine patch according to claim 1 is characterized in that, by following weight percent meter: medical polypropylene acid sodium 5%, pharmagel or edible Gelatinum oxhide 5%, sodium carboxymethyl cellulose 1.0%, citric acid 0.2%, carbomer 12%, tragcanth 1%, Olibanum 0.2%, Myrrha 0.2%, Chinese medicine compound is extracted polysaccharide 2%, Chinese medicine compound ethanol-soluble extractives 15%, Kaolin or kieselguhr 4.5%, glycerol 10%, propylene glycol 3.0%, Oleum Eucalypti 0.2%, Borneolum Syntheticum 1.6%, Mentholum 0.1%, water 39% is made;
Described Chinese medicine compound ethanol-soluble extractives is by following weight percent meter: Radix Aconiti 5%, Radix Aconiti Kusnezoffii 13%, Semen Strychni (processed) 16%, Radix Notoginseng 15%, Herba speranskiae tuberculatae 7%, Herba Aristolochiae Mollissimae 7%, Radix Angelicae Sinensis 7%, Rhizoma Chuanxiong 7%, Radix Clematidis 7%, Radix Angelicae Pubescentis 8%, Cortex Phellodendri 8% is made as crude drug, wherein will pulverize behind the above-mentioned raw materials medicine mixing earlier, cross sieve for No. one coarse powder, the volumetric concentration that adds 10 times of coarse powder weight is 75% ethanol, reflux, extract, 2 times, each 3 hours, filter, the extracting solution decompression recycling ethanol, namely;
Described Chinese medicine compound is extracted polysaccharide: said extracted is crossed medicinal residues behind the Chinese medicine compound ethanol-soluble extractives, add the water of 10 times of medicinal residues weight, 90-100 ℃ of heating extraction 3 times, each 3 hours, filter, merging filtrate, being evaporated to proportion is 1.1-1.3, the ethanol that adds percentage by volume and be 95%--100% to the volumetric concentration of alcohol reaches 80%, 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, namely.
3. hydrophilic Chinese medicine patch according to claim 1 is characterized in that, by following weight percent meter: medical polypropylene acid sodium 8%, pharmagel or edible Gelatinum oxhide 1.6%, sodium carboxymethyl cellulose 3%, citric acid 0.8%, carbomer 2%, tragcanth 5%, Olibanum 1.5%, Myrrha 1.5%, Chinese medicine compound is extracted polysaccharide 10%, Chinese medicine compound ethanol-soluble extractives 2%, Kaolin or kieselguhr 5 %, glycerol 25%, propylene glycol 8%, Oleum Eucalypti 2 %, Borneolum Syntheticum 0.1%, Mentholum 2.1%, water are 22.4% to make;
Described Chinese medicine compound ethanol-soluble extractives is by following weight percent meter: Radix Aconiti 13%, Radix Aconiti Kusnezoffii 5%, Semen Strychni (processed) 4%, Radix Notoginseng 5%, Herba speranskiae tuberculatae 13.4%, Herba Aristolochiae Mollissimae 13.5%, Radix Angelicae Sinensis 11.5%, Rhizoma Chuanxiong 11.6%, Radix Clematidis 7%, Radix Angelicae Pubescentis 8%, Cortex Phellodendri 8% is made as crude drug, wherein will pulverize behind the above-mentioned raw materials medicine mixing earlier, cross sieve for No. one coarse powder, the volumetric concentration that adds 10 times of coarse powder weight is 75% ethanol, reflux, extract, 2 times each 3 hours, is filtered, the extracting solution decompression recycling ethanol, namely;
Described Chinese medicine compound is extracted polysaccharide: said extracted is crossed medicinal residues behind the Chinese medicine compound ethanol-soluble extractives, add the water of 10 times of medicinal residues weight, 90-100 ℃ of heating extraction 3 times, each 3 hours, filter, merging filtrate, being evaporated to proportion is 1.1-1.3, the ethanol that adds percentage by volume and be 95%--100% to the volumetric concentration of alcohol reaches 80%, 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, namely.
4. hydrophilic Chinese medicine patch according to claim 1 is characterized in that, by following weight percent meter: medical polypropylene acid sodium 6.5%, pharmagel or edible Gelatinum oxhide 3.5%, sodium carboxymethyl cellulose 5%, citric acid 0.4%, carbomer 6%, tragcanth 3%, Olibanum 0.5%, Myrrha 0.5%, Chinese medicine compound is extracted polysaccharide 6%, Chinese medicine compound ethanol-soluble extractives 8%, Kaolin or kieselguhr 4.6%, glycerol 15%, propylene glycol 5%, Oleum Eucalypti 1 %, Borneolum Syntheticum 0.8%, Mentholum 1.0%, water are 33.2% to make;
Described Chinese medicine compound ethanol-soluble extractives is by following weight percent meter: Radix Aconiti 6.4%, Radix Aconiti Kusnezoffii 7.1%, Semen Strychni (processed) 6.2%, Radix Notoginseng 8.3%, Herba speranskiae tuberculatae 7%, Herba Aristolochiae Mollissimae 7%, Radix Angelicae Sinensis 7%, Rhizoma Chuanxiong 7%, Radix Clematidis 17.2%, Radix Angelicae Pubescentis 13.4%, Cortex Phellodendri 13.4% is made as crude drug, wherein will pulverize behind the above-mentioned raw materials medicine mixing earlier, cross sieve for No. one coarse powder, the volumetric concentration that adds 10 times of coarse powder weight is 75% ethanol, reflux, extract, 2 times each 3 hours, is filtered, the extracting solution decompression recycling ethanol, namely;
Described Chinese medicine compound is extracted polysaccharide: said extracted is crossed medicinal residues behind the Chinese medicine compound ethanol-soluble extractives, add the water of 10 times of medicinal residues weight, 90-100 ℃ of heating extraction 3 times, each 3 hours, filter, merging filtrate, being evaporated to proportion is 1.1-1.3, the ethanol that adds percentage by volume and be 95%--100% to the volumetric concentration of alcohol reaches 80%, 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, namely.
5. hydrophilic Chinese medicine patch according to claim 1 is characterized in that, by following weight percent meter: medical polypropylene acid sodium 8%, pharmagel or edible Gelatinum oxhide 5%, sodium carboxymethyl cellulose 4%, citric acid 0.4%, carbomer 6%, tragcanth 4%, Olibanum 0.5%, Myrrha 0.5%, Chinese medicine compound is extracted polysaccharide 6%, Chinese medicine compound ethanol-soluble extractives 8%, Kaolin or kieselguhr 4.6%, glycerol 20%, propylene glycol 5%, Oleum Eucalypti 1 %, Borneolum Syntheticum 1%, Mentholum 2%, water are 24% to make;
Described Chinese medicine compound ethanol-soluble extractives is by following weight percent meter: Radix Aconiti 6.4%, Radix Aconiti Kusnezoffii 7.1%, Semen Strychni (processed) 6.2%, Radix Notoginseng 8.3%, Herba speranskiae tuberculatae 7%, Herba Aristolochiae Mollissimae 7%, Radix Angelicae Sinensis 7%, Rhizoma Chuanxiong 7%, Radix Clematidis 17.2%, Radix Angelicae Pubescentis 13.4%, Cortex Phellodendri 13.4% is made as crude drug, wherein will pulverize behind the above-mentioned raw materials medicine mixing earlier, cross sieve for No. one coarse powder, the volumetric concentration that adds 10 times of coarse powder weight is 75% ethanol, reflux, extract, 2 times each 3 hours, is filtered, the extracting solution decompression recycling ethanol, namely;
Described Chinese medicine compound is extracted polysaccharide: said extracted is crossed medicinal residues behind the Chinese medicine compound ethanol-soluble extractives, add the water of 10 times of medicinal residues weight, 90-100 ℃ of heating extraction 3 times, each 3 hours, filter, merging filtrate, being evaporated to proportion is 1.1-1.3, the ethanol that adds percentage by volume and be 95%--100% to the volumetric concentration of alcohol reaches 80%, 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, namely.
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| CN1118285C (en) * | 2000-08-28 | 2003-08-20 | 赵芳可 | Shubi plaster for treating arthralgia due to wind-cold-dampness |
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