CN103006815B - Traditional Chinese medicine external use film agent for treating pain diseases caused by rheumatoid bone diseases, cervical muscle and lumbar muscle degeneration, and scapulohumeral periarthritis - Google Patents
Traditional Chinese medicine external use film agent for treating pain diseases caused by rheumatoid bone diseases, cervical muscle and lumbar muscle degeneration, and scapulohumeral periarthritis Download PDFInfo
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- CN103006815B CN103006815B CN201310014114.7A CN201310014114A CN103006815B CN 103006815 B CN103006815 B CN 103006815B CN 201310014114 A CN201310014114 A CN 201310014114A CN 103006815 B CN103006815 B CN 103006815B
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Abstract
The invention relates to a traditional Chinese medicine external use film agent for treating pain diseases caused by rheumatoid bone diseases, cervical muscle and lumbar muscle degeneration, and scapulohumeral periarthritis, which can effectively solve the problem of a medicine for treating the pain diseases caused by rheumatism, the cervical muscle and lumbar muscle degeneration, and the scapulohumeral periarthritis. The technical scheme is that the traditional Chinese medicine external use film agent is prepared from following medicines by weight: 20-30 g of radix aconiti preparata, 20-30 g of prepared kusnezoff monkshood root, 20-30 g of pseudo-ginseng, 30-40 g of ledebouriella seseloides wolff, 30-40 g of cassia twig, 30-40 g of ligusticum wallichii, 30-40 g of lycopodium clavatum, 30-40 g of garden balsam stem, 30-40 g of polygonum cuspidatum, 30-40 g of cacumen biotae, 30-40 g of rhizoma corydalis, 30-40 g of radix angelicae, 30-40 g of syzygium aromaticum, 10-20 g of prepared frankincense, 10-20 g of prepared myrrh, 5-10 g of borneol, 5-10 g of menthol and 5-10 g of methyl salicylate. The traditional Chinese medicine external use film agent disclosed by the invention has the advantages of reasonable compatibility, accurate and reliable curative effect, no side effect, no skin irritation, rapid effect, good transdermal absorption effect, simple and feasible manufacturing process, strong controllability, and obvious economic and social benefits.
Description
Technical field
The present invention relates to medicine, particularly a kind of Chinese medicine external membrane for the treatment of the antalgesic that rheumatic osteopathia, neck lumbar muscle strain, scapulohumeral periarthritis cause.
Background technology
Rheumatic osteopathia, neck lumbar muscle strain, the antalgesic that scapulohumeral periarthritis causes, a kind of commonly encountered diseases and frequently-occurring disease of serious harm health, because its state of an illness is touching, repeatedly difficult, and the Chinese medicine preparation without the prompt speed of proving effective, rheumatism particularly, in daily life and work, all caused to patient very large handicapped, and disability rate is high, give patient's physiology, psychology causes very big impact, there are clinically at present many treatment rheumatic osteopathia, neck lumbar muscle strain, the Chinese medicine preparation of the antalgesic that scapulohumeral periarthritis causes, but clinical effectiveness is all not satisfactory, and there are certain sense of discomfort and side effect.Therefore, seek the novel form that a kind of clinical effectiveness is good, to meet an important problem of needs ，Shi this area of people.
Summary of the invention
For above-mentioned situation, for overcoming the defect of prior art, the present invention's object is just to provide a kind of Chinese medicine external membrane for the treatment of the antalgesic that rheumatic osteopathia, neck lumbar muscle strain, scapulohumeral periarthritis cause, can effectively solve the medication problem of the antalgesic that treatment rheumatism, neck lumbar muscle strain, scapulohumeral periarthritis causes.
The technical scheme that the present invention solves is, rheumatic osteopathia, neck lumbar muscle strain, the antalgesic that scapulohumeral periarthritis causes belongs to arthromyodynia in traditional Chinese medical science field, due to wind and cold, blockage of main and collateral channels, due to QI and blood is obstructed, therefore its treatment should be with expelling wind and cold, spasmolytic dredging collateral, activating blood circulation to dissipate blood stasis, antiinflammatory relieves the pain as principle, accordingly, external membrane of the present invention is made by the medicine of following weighing scale: Radix Aconiti Preparata 20-30g, Radix Aconiti Kusnezoffii Preparata 20-30g, Radix Notoginseng 20-30g, Radix Saposhnikoviae 30-40g, Ramulus Cinnamomi 30-40g, Rhizoma Chuanxiong 30-40g, Herba Lycopodii 30-40g, Herba speranskiae tuberculatae 30-40g, Rhizoma Polygoni Cuspidati 30-40g, Cacumen Platycladi 30-40g, Rhizoma Corydalis 30-40g, the Radix Angelicae Dahuricae 30-40g, Flos Caryophylli 30-40g, Olibanum (processed) 10-20g, Myrrha (processed) 10-20g, Borneolum Syntheticum 5-10g, Mentholum 5-10g, methyl salicylate 5-10g, wherein, by Olibanum (processed), Myrrha (processed), Radix Notoginseng powder is broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby, Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum that at 50 ℃, proportion is 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use, Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid, separately get filmogen (I) 20g, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time, get filmogen (II) 10g, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time, get glycerol 10ml, add mixture for the second time, mix, obtain.
Described filmogen (I): be one or more the combination in polyvinyl alcohol, Pioloform, polyvinyl acetal, polyvinylpyrrolidone; Filmogen (II): be one or more combination of sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, ethyl cellulose, sodium polyacrylate, gelatin.
Compatibility of the present invention is reasonable, and determined curative effect is reliable, has no side effect, and without skin irritation, rapidly, Transdermal absorption is effective in effect, and processing technology is simple, and controllability is strong, and economic and social benefit is remarkable.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is elaborated.
Embodiment 1
The present invention is in concrete enforcement, can be made by the medicine of following weighing scale: Radix Aconiti Preparata 25g, Radix Aconiti Kusnezoffii Preparata 25g, Radix Notoginseng 25g, Radix Saposhnikoviae 35g, Ramulus Cinnamomi 35g, Rhizoma Chuanxiong 35g, Herba Lycopodii 35g, Herba speranskiae tuberculatae 35g, Rhizoma Polygoni Cuspidati 35g, Cacumen Platycladi 35g, Rhizoma Corydalis 40g, Radix Angelicae Dahuricae 35g, Flos Caryophylli 40g, Olibanum (processed) 15g, Myrrha (processed) 15g, Borneolum Syntheticum 7.5g, Mentholum 7.5g, methyl salicylate 7.5g, wherein, Olibanum (processed), Myrrha (processed), Radix Notoginseng powder are broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby; Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby; Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum that at 50 ℃, proportion is 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use; Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid; Separately get polyvinyl alcohol 20g, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time; Get sodium carboxymethyl cellulose 10g, add water 200ml and make to dissolve, add mixture for the first time, mix, to mixture for the second time; Get glycerol 10ml, add mixture for the second time, mix, obtain.
Embodiment 2
The present invention also can be made by the medicine of following weighing scale: Radix Aconiti Preparata 30g, Radix Aconiti Kusnezoffii Preparata 30g, Radix Notoginseng 30g, Radix Saposhnikoviae 40g, Ramulus Cinnamomi 40g, Rhizoma Chuanxiong 40g, Herba Lycopodii 40g, Herba speranskiae tuberculatae 40g, Rhizoma Polygoni Cuspidati 40g, Cacumen Platycladi 40g, Rhizoma Corydalis 40g, Radix Angelicae Dahuricae 40g, Flos Caryophylli 40g, Olibanum (processed) 20g, Myrrha (processed) 20g, Borneolum Syntheticum 10g, Mentholum 10g, methyl salicylate 10g, wherein, Olibanum (processed), Myrrha (processed), Radix Notoginseng powder are broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby; Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby; Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum that at 50 ℃, proportion is 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use; Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid; Separately get Pioloform, polyvinyl acetal 20g, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time; Get hydroxypropyl emthylcellulose 10g, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time; Get glycerol 10ml, add mixture for the second time, mix, obtain.
Embodiment 3
The present invention also can be made by the medicine of following weighing scale: Radix Aconiti Preparata 20g, Radix Aconiti Kusnezoffii Preparata 20g, Radix Notoginseng 30g, Radix Saposhnikoviae 30g, Ramulus Cinnamomi 30g, Rhizoma Chuanxiong 30g, Herba Lycopodii 30g, Herba speranskiae tuberculatae 30g, Rhizoma Polygoni Cuspidati 30g, Cacumen Platycladi 30g, Rhizoma Corydalis 30g, Radix Angelicae Dahuricae 30g, Flos Caryophylli 30g, Olibanum (processed) 10g, Myrrha (processed) 10g, Borneolum Syntheticum 5g, Mentholum 5g, methyl salicylate 5g, wherein, Olibanum (processed), Myrrha (processed), Radix Notoginseng powder are broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby; Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby; Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum of proportion 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use; Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid; Get polyvinylpyrrolidone 20g, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time; Get hydroxypropyl cellulose 10g, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time; Get glycerol 10ml, add mixture for the second time, mix, obtain.
Embodiment 4
The present invention also can be made by the medicine of following weighing scale: Radix Aconiti Preparata 23g, Radix Aconiti Kusnezoffii Preparata 28g, Radix Notoginseng 23g, Radix Saposhnikoviae 38g, Ramulus Cinnamomi 32g, Rhizoma Chuanxiong 38g, Herba Lycopodii 33g, Herba speranskiae tuberculatae 37g, Rhizoma Polygoni Cuspidati 32g, Cacumen Platycladi 38g, Rhizoma Corydalis 32g, Radix Angelicae Dahuricae 38g, Flos Caryophylli 32g, Olibanum (processed) 18g, Myrrha (processed) 12g, Borneolum Syntheticum 8g, Mentholum 6g, methyl salicylate 8g, wherein, Olibanum (processed), Myrrha (processed), Radix Notoginseng powder are broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby; Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby; Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum that at 50 ℃, proportion is 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use; Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid; Separately get polyvinyl alcohol 10g, Pioloform, polyvinyl acetal 10g and mix, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time; Get into hydroxypropyl cellulose 5g, ethyl cellulose 5g and mix, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time; Get glycerol 10ml, add mixture for the second time, mix, obtain.
Embodiment 5
The present invention is made by the medicine of following weighing scale: Radix Aconiti Preparata 28g, Radix Aconiti Kusnezoffii Preparata 22g, Radix Notoginseng 28g, Radix Saposhnikoviae 32g, Ramulus Cinnamomi 38g, Rhizoma Chuanxiong 32g, Herba Lycopodii 38g, Herba speranskiae tuberculatae 32g, Rhizoma Polygoni Cuspidati 38g, Cacumen Platycladi 32g, Rhizoma Corydalis 38g, Radix Angelicae Dahuricae 32g, Flos Caryophylli 38g, Olibanum (processed) 12g, Myrrha (processed) 18g, Borneolum Syntheticum 6g, Mentholum 8g, methyl salicylate 6g, wherein, Olibanum (processed), Myrrha (processed), Radix Notoginseng powder are broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby; Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby; Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum that at 50 ℃, proportion is 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use; Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid; Separately get polyvinyl alcohol 10g, Pioloform, polyvinyl acetal 10g and mix, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time; Get sodium polyacrylate 5g, gelatin 5g and mix, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time; Get glycerol 10ml, add mixture for the second time, mix, obtain.
Effective combination of above-mentioned each component, supports mutually, and through science preparation, has expelling wind and cold, spasmolytic dredging collateral, the effect that activating blood circulation to dissipate blood stasis, antiinflammatory relieve the pain, and obtained satisfied effect through clinical experiment, interrelated data is as follows:
One, the clinical selection standard of case
Rheumatic arthritis
Cardinal symptom: multi-joint migration pain, arthralgia, when heavy, joint motion is ineffective; Pain and climate change have obvious relation, cold or increase the weight of while touching ice cold water, and weather alleviates when fine or warm.
Scapulohumeral periarthritis
Cardinal symptom: shoulder arthralgia, or show as twinge, movable unfavorable; Local joint swelling; Local joint amyotrophy; How person in middle and old age, to fall ill, cervical region, shoulder, flank pain, movable ineffective, increase the weight of gradually; Shoulder activity is limited gradually, especially with abduction, after stretch, outward turning is for very, shoulder finally becomes to condense.
Neck lumbar muscle strain
Cardinal symptom: neck, spinal column portion pain or distending pain, to have a rest light, fatigue increases the weight of, if suitably movable or often improve sign and also can make symptom alleviate;
Hyperosteogeny
There is obvious pain in affected part, has pressure pain point, pain is obvious when movable, and X sheet shows that only there is hyperosteogeny in affected part and without other Novel presentation;
Two, efficacy assessment standard
Recovery from illness: clinical symptoms, sign disappears substantially, does not affect activity and work, joint motion freely, functional rehabilitation;
2. effective: clinical symptoms, sign is obviously improved, and only in tired situation, occurs mild, and functional rehabilitation does not affect work, or the state of an illness is transferred to slightly by severe;
3. effective: clinical symptoms, sign has the improvement of alleviating, but unstable condition, time have recurrence, but do not increase the weight of, counterweight physical work is influential;
4. invalid: not reach effective standard;
Three, therapeutic scheme
Preparation external of the present invention, clean illing skin ，Tu affected part or relevant acupoints, every day 2 times, each 1 time sooner or later, continuous use 7 days, adds up curative effect, bans use of Chinese medicine, Western medicine or other drug and the therapy of other pain relievings during clinical trial.
Four, statistical disposition result
By above-mentioned therapeutic scheme, adopt external membrane of the present invention respectively rheumatic arthritis, scapulohumeral periarthritis, neck lumbar muscle strain, each 50 people of hyperosteogeny patient to be treated, after 7 days, statistical result is as follows:
Rheumatic arthritis
Cardinal symptom: multi-joint migration pain, arthralgia, when heavy, joint motion is ineffective; Pain and climate change have obvious relation, cold or increase the weight of while touching ice cold water, and weather alleviates when fine or warm.
Scapulohumeral periarthritis
Cardinal symptom: shoulder arthralgia, or show as twinge, movable unfavorable; Local joint swelling; Local joint amyotrophy; How person in middle and old age, to fall ill, cervical region, shoulder, flank pain, movable ineffective, increase the weight of gradually; Shoulder activity is limited gradually, especially with abduction, after stretch, outward turning is for very, shoulder finally becomes to condense.
Neck lumbar muscle strain
Cardinal symptom: neck, spinal column portion pain or distending pain, to have a rest light, fatigue increases the weight of, if suitably movable or often improve sign and also can make symptom alleviate;
Hyperosteogeny
There is obvious pain in affected part, has pressure pain point, pain is obvious when movable, and X sheet shows that only there is hyperosteogeny in affected part and without other Novel presentation;
During treating, find no untoward reaction, drug safety.
Five, conclusion
Clinical experiment shows, patch of the present invention is used safety, in test, there is not local skin pruritus, redness, total effective rate to rheumatic arthritis, scapulohumeral periarthritis, neck lumbar muscle strain, hyperosteogeny treating reaches more than 90%, there is medical value widely, be the active drug for the treatment of rheumatic arthritis, scapulohumeral periarthritis, neck lumbar muscle strain, hyperosteogeny, there is good clinical meaning.
The present invention compared with prior art has filmogen and adjuvant should be nontoxic, nonirritant, and application is convenient, instant effect, volume is little, lightweight, and portable advantage has very large Social benefit and economic benefit, is beneficial to popularization.
Claims (7)
1. treat rheumatic osteopathia for one kind, neck lumbar muscle strain, the Chinese medicine external membrane of the antalgesic that scapulohumeral periarthritis causes, it is characterized in that, medicine by following weighing scale is made: Radix Aconiti Preparata 20-30g, Radix Aconiti Kusnezoffii Preparata 20-30g, Radix Notoginseng 20-30g, Radix Saposhnikoviae 30-40g, Ramulus Cinnamomi 30-40g, Rhizoma Chuanxiong 30-40g, Herba Lycopodii 30-40g, Herba speranskiae tuberculatae 30-40g, Rhizoma Polygoni Cuspidati 30-40g, Cacumen Platycladi 30-40g, Rhizoma Corydalis 30-40g, the Radix Angelicae Dahuricae 30-40g, Flos Caryophylli 30-40g, Olibanum (processed) 10-20g, Myrrha (processed) 10-20g, Borneolum Syntheticum 5-10g, Mentholum 5-10g, methyl salicylate 5-10g, wherein, by Olibanum (processed), Myrrha (processed), Radix Notoginseng powder is broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby, Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum that at 50 ℃, proportion is 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use, Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid, separately get filmogen (I) 20g, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time, get filmogen (II) 10g, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time, get glycerol 10ml, add mixture for the second time, mix, obtain.
2. the Chinese medicine external membrane of the antalgesic that treatment rheumatic osteopathia according to claim 1, neck lumbar muscle strain, scapulohumeral periarthritis cause, it is characterized in that, described filmogen (I) is one or more the combination in polyvinyl alcohol, Pioloform, polyvinyl acetal, polyvinylpyrrolidone; Filmogen (II) is one or more combination of sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, ethyl cellulose, sodium polyacrylate, gelatin.
3. treatment rheumatic osteopathia according to claim 1, neck lumbar muscle strain, the Chinese medicine external membrane of the antalgesic that scapulohumeral periarthritis causes, it is characterized in that, medicine by following weighing scale is made: Radix Aconiti Preparata 25g, Radix Aconiti Kusnezoffii Preparata 25g, Radix Notoginseng 25g, Radix Saposhnikoviae 35g, Ramulus Cinnamomi 35g, Rhizoma Chuanxiong 35g, Herba Lycopodii 35g, Herba speranskiae tuberculatae 35g, Rhizoma Polygoni Cuspidati 35g, Cacumen Platycladi 35g, Rhizoma Corydalis 40g, Radix Angelicae Dahuricae 35g, Flos Caryophylli 40g, Olibanum (processed) 15g, Myrrha (processed) 15g, Borneolum Syntheticum 7.5g, Mentholum 7.5g, methyl salicylate 7.5g, wherein, by Olibanum (processed), Myrrha (processed), Radix Notoginseng powder is broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby, Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum that at 50 ℃, proportion is 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use, Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid, separately get polyvinyl alcohol 20g, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time, get sodium carboxymethyl cellulose 10g, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time, get glycerol 10ml, add mixture for the second time, mix, obtain.
4. treatment rheumatic osteopathia according to claim 1, neck lumbar muscle strain, the Chinese medicine external membrane of the antalgesic that scapulohumeral periarthritis causes, it is characterized in that, medicine by following weighing scale is made: Radix Aconiti Preparata 30g, Radix Aconiti Kusnezoffii Preparata 30g, Radix Notoginseng 30g, Radix Saposhnikoviae 40g, Ramulus Cinnamomi 40g, Rhizoma Chuanxiong 40g, Herba Lycopodii 40g, Herba speranskiae tuberculatae 40g, Rhizoma Polygoni Cuspidati 40g, Cacumen Platycladi 40g, Rhizoma Corydalis 40g, Radix Angelicae Dahuricae 40g, Flos Caryophylli 40g, Olibanum (processed) 20g, Myrrha (processed) 20g, Borneolum Syntheticum 10g, Mentholum 10g, methyl salicylate 10g, wherein, by Olibanum (processed), Myrrha (processed), Radix Notoginseng powder is broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby, Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum that at 50 ℃, proportion is 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use, Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid, separately get Pioloform, polyvinyl acetal 20g, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time, get hydroxypropyl emthylcellulose 10g, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time, get glycerol 10ml, add mixture for the second time, mix, obtain.
5. treatment rheumatic osteopathia according to claim 1, neck lumbar muscle strain, the Chinese medicine external membrane of the antalgesic that scapulohumeral periarthritis causes, it is characterized in that, medicine by following weighing scale is made: Radix Aconiti Preparata 20g, Radix Aconiti Kusnezoffii Preparata 20g, Radix Notoginseng 30g, Radix Saposhnikoviae 30g, Ramulus Cinnamomi 30g, Rhizoma Chuanxiong 30g, Herba Lycopodii 30g, Herba speranskiae tuberculatae 30g, Rhizoma Polygoni Cuspidati 30g, Cacumen Platycladi 30g, Rhizoma Corydalis 30g, Radix Angelicae Dahuricae 30g, Flos Caryophylli 30g, Olibanum (processed) 10g, Myrrha (processed) 10g, Borneolum Syntheticum 5g, Mentholum 5g, methyl salicylate 5g, wherein, by Olibanum (processed), Myrrha (processed), Radix Notoginseng powder is broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby, Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum of proportion 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use, Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid, get polyvinylpyrrolidone 20g, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time, get hydroxypropyl cellulose 10g, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time, get glycerol 10ml, add mixture for the second time, mix, obtain.
6. treatment rheumatic osteopathia according to claim 1, neck lumbar muscle strain, the Chinese medicine external membrane of the antalgesic that scapulohumeral periarthritis causes, it is characterized in that, medicine by following weighing scale is made: Radix Aconiti Preparata 23g, Radix Aconiti Kusnezoffii Preparata 28g, Radix Notoginseng 23g, Radix Saposhnikoviae 38g, Ramulus Cinnamomi 32g, Rhizoma Chuanxiong 38g, Herba Lycopodii 33g, Herba speranskiae tuberculatae 37g, Rhizoma Polygoni Cuspidati 32g, Cacumen Platycladi 38g, Rhizoma Corydalis 32g, Radix Angelicae Dahuricae 38g, Flos Caryophylli 32g, Olibanum (processed) 18g, Myrrha (processed) 12g, Borneolum Syntheticum 8g, Mentholum 6g, methyl salicylate 8g, wherein, by Olibanum (processed), Myrrha (processed), Radix Notoginseng powder is broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby, Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum that at 50 ℃, proportion is 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use, Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid, separately get polyvinyl alcohol 10g, Pioloform, polyvinyl acetal 10g and mix, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time, get into hydroxypropyl cellulose 5g, ethyl cellulose 5g and mix, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time, get glycerol 10ml, add mixture for the second time, mix, obtain.
7. treatment rheumatic osteopathia according to claim 1, neck lumbar muscle strain, the Chinese medicine external membrane of the antalgesic that scapulohumeral periarthritis causes, it is characterized in that, medicine by following weighing scale is made: Radix Aconiti Preparata 28g, Radix Aconiti Kusnezoffii Preparata 22g, Radix Notoginseng 28g, Radix Saposhnikoviae 32g, Ramulus Cinnamomi 38g, Rhizoma Chuanxiong 32g, Herba Lycopodii 38g, Herba speranskiae tuberculatae 32g, Rhizoma Polygoni Cuspidati 38g, Cacumen Platycladi 32g, Rhizoma Corydalis 38g, Radix Angelicae Dahuricae 32g, Flos Caryophylli 38g, Olibanum (processed) 12g, Myrrha (processed) 18g, Borneolum Syntheticum 6g, Mentholum 8g, methyl salicylate 6g, wherein, by Olibanum (processed), Myrrha (processed), Radix Notoginseng powder is broken into coarse powder, with the ethanol that volumetric concentration is 75%--95%, make the fluid extract that at 50 ℃, proportion is 1.05-1.15, standby, Flos Caryophylli powder is broken into coarse powder, adds the water distillation 5 hours of its 6-10 times of weight, collect volatile oil, Flos Caryophylli volatile oil, Flos Caryophylli medicinal residues are standby, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Saposhnikoviae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Lycopodii, Herba speranskiae tuberculatae, Rhizoma Polygoni Cuspidati, Cacumen Platycladi, Rhizoma Corydalis, the Radix Angelicae Dahuricae are added to the water of 8 times of weight of water together with Flos Caryophylli medicinal residues, with spirit of vinegar, regulate pH value to 4-5, decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the extractum that at 50 ℃, proportion is 1.14-1.20, merges with above-mentioned fluid extract, adding ethanol makes to reach 60% containing alcohol amount, placement is spent the night, and filters filtrate for later use, Borneolum Syntheticum, Mentholum, methyl salicylate, Flos Caryophylli volatile oil are added to filtrate, mix, make to dissolve completely, obtain standby medicinal liquid, separately get polyvinyl alcohol 10g, Pioloform, polyvinyl acetal 10g and mix, adding volumetric concentration is that 50% ethanol 400ml makes to dissolve, and adds standby medicinal liquid, mix, mixture for the first time, get sodium polyacrylate 5g, gelatin 5g and mix, add water 200ml and make to dissolve, add mixture for the first time, mix, obtain mixture for the second time, get glycerol 10ml, add mixture for the second time, mix, obtain.
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| 本书编委会-北京:学苑出版社.《筋骨葛根汤》.《二十世纪中医药最佳处方/骨伤科卷》.学苑出版社,2003,第334页. * |
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