CN102675426A - 一种达托霉素的提取纯化方法 - Google Patents
一种达托霉素的提取纯化方法 Download PDFInfo
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- CN102675426A CN102675426A CN2012101250753A CN201210125075A CN102675426A CN 102675426 A CN102675426 A CN 102675426A CN 2012101250753 A CN2012101250753 A CN 2012101250753A CN 201210125075 A CN201210125075 A CN 201210125075A CN 102675426 A CN102675426 A CN 102675426A
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- daptomycin
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- DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 title claims abstract description 129
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- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 4
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 2
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
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- 241000933218 Streptomyces parvus Species 0.000 description 3
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- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105001305A (zh) * | 2015-04-29 | 2015-10-28 | 利穗科技(苏州)有限公司 | 利用层析技术提取高纯度达托霉素的方法 |
CN105111285A (zh) * | 2015-10-17 | 2015-12-02 | 霍进铭 | 一种达托霉素的提取方法 |
CN105481950A (zh) * | 2016-01-28 | 2016-04-13 | 丽珠集团福州福兴医药有限公司 | 一种达托霉素提取方法 |
CN106518985A (zh) * | 2015-09-15 | 2017-03-22 | 江苏海阔生物医药有限公司 | 一种万古霉素沉淀方法 |
CN112979756A (zh) * | 2019-12-13 | 2021-06-18 | 浙江昌海制药有限公司 | 达托霉素的提纯方法 |
CN113563424A (zh) * | 2021-09-15 | 2021-10-29 | 丽珠集团福州福兴医药有限公司 | 一种达托霉素的纯化方法 |
CN114685610A (zh) * | 2020-12-28 | 2022-07-01 | 杭州中美华东制药有限公司 | 一种达托霉素RS-8a杂质的内酯水解物及制备方法 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106866791A (zh) * | 2015-12-11 | 2017-06-20 | 北大方正集团有限公司 | 一种高纯度达托霉素内酯水解物的制备方法 |
CN106866789A (zh) * | 2015-12-11 | 2017-06-20 | 北大方正集团有限公司 | 一种分离纯化达托霉素rs-8杂质的方法 |
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CN1404487A (zh) * | 2000-01-20 | 2003-03-19 | 卡比斯特制药公司 | 高纯度脂肽、脂肽胶束及其制备方法 |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105001305A (zh) * | 2015-04-29 | 2015-10-28 | 利穗科技(苏州)有限公司 | 利用层析技术提取高纯度达托霉素的方法 |
CN106518985A (zh) * | 2015-09-15 | 2017-03-22 | 江苏海阔生物医药有限公司 | 一种万古霉素沉淀方法 |
CN105111285A (zh) * | 2015-10-17 | 2015-12-02 | 霍进铭 | 一种达托霉素的提取方法 |
CN105481950A (zh) * | 2016-01-28 | 2016-04-13 | 丽珠集团福州福兴医药有限公司 | 一种达托霉素提取方法 |
CN105481950B (zh) * | 2016-01-28 | 2019-01-04 | 丽珠集团福州福兴医药有限公司 | 一种达托霉素提取方法 |
CN112979756A (zh) * | 2019-12-13 | 2021-06-18 | 浙江昌海制药有限公司 | 达托霉素的提纯方法 |
CN112979756B (zh) * | 2019-12-13 | 2023-01-03 | 浙江昌海制药有限公司 | 达托霉素的提纯方法 |
CN114685610A (zh) * | 2020-12-28 | 2022-07-01 | 杭州中美华东制药有限公司 | 一种达托霉素RS-8a杂质的内酯水解物及制备方法 |
CN113563424A (zh) * | 2021-09-15 | 2021-10-29 | 丽珠集团福州福兴医药有限公司 | 一种达托霉素的纯化方法 |
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