CN102670820B - Antibacterial medicament of a kind of external application containing camptothecine and its production and use - Google Patents
Antibacterial medicament of a kind of external application containing camptothecine and its production and use Download PDFInfo
- Publication number
- CN102670820B CN102670820B CN201210170556.6A CN201210170556A CN102670820B CN 102670820 B CN102670820 B CN 102670820B CN 201210170556 A CN201210170556 A CN 201210170556A CN 102670820 B CN102670820 B CN 102670820B
- Authority
- CN
- China
- Prior art keywords
- parts
- camptothecine
- external application
- application containing
- antibacterial medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Antibacterial medicament of a kind of external application containing camptothecine and its production and use, belongs to traditional Chinese medicine for external application technical field.It is characterized in that the following material containing percentage by weight：8~17 parts of camptothecine, 3~11 parts of leech, 6~15 parts of cordate houttuynia, 5~13 parts of scorpio, 8~15 parts of the capsule of weeping forsythia, 5~12 parts of hippocampus, 3~9 parts of ground beetle, 5~12 parts of oriental wormwood, 4~11 parts of tortoiseshell, 3~8 parts of borneol, 8~17 parts of beeswax, 10~20 parts of medicinal alcohol.Above-mentioned antibacterial medicament of a kind of external application containing camptothecine and its production and use, with bacterio static itching-relieving, relieve pain the effects such as tinea of dispelling, removing toxic substances eliminating dampness, anti-inflammation detumescence, improvement affected part microcirculation, itch to ringworm of the body, jock itch, tinea of feet and hands, tinea versicolor, dermatophytids etc. the disease such as swell and ache has significant curative effect, cure rate is high, toxic side effect is small, and preparation method is simple, safe and effective, low production cost.
Description
Technical field
The invention belongs to traditional Chinese medicine for external application technical field, and in particular to a kind of antibacterial medicament of external application containing camptothecine and its
Preparation method and purposes.
Background technology
Camptothecine is a kind of pyrroles's quinoline alkaloid, and it is distinctive to be mainly derived from China, is distributed in the Yangtze river basin and west
The Nyssaceae deciduous tree camplotheca acuminata of southern each province.Pharmacological activity both at home and abroad to camptothecine, clinical practice have carried out numerous studies, send out
Existing camptothecine is a kind of antineoplastic specific drug.It HeLa cells and L1210 cells and rodent are shown in vitro compared with
Strong active anticancer.The effect target of camptothecine is topoisomerase I（topoI）, its mechanism of action is to block topoI, so as to hinder
Disconnected DNA synthesizes and reached the effect for killing cancer cell, and preclinical study shows, animal tumor and shifting of the camptothecine to various transplanting
The stomach cancer with nude mice is planted, colorectal cancer has significant curative effect, it is also quite effective to the indefatigable tumour of multi-medicament.Currently,
The U.S., Japan, Canada and China, actively input camptothecine exploitation, have synthesized hundreds of derivatives and have carried out biochemical screening, much
Clinical practice has been carried out in the anticancer mechanism of medicine, is the various medicaments that raw material is made with camptothecine.But to being at present
Only, the research about camptothecine in the exploitation of external application inhibiting-bacteria preparation is also seldom, it has been found that camptothecine is to fungi, bacterium, mould corruption
Bacterium, virus, which have, to be suppressed and kills effect, can be shared with a series of active Chinese drug component material, bacteriostatic activity be improved, to psoriasis
Etc. evident in efficacy.
The content of the invention
For the above-mentioned problems in the prior art, it is an object of the invention to design to provide a kind of outer containing camptothecine
With the technical scheme of antibacterial medicament and its production and use, its preparation method is simple, safely and effectively, low production cost,
Treat both principal and secondary aspect of disease, evident in efficacy, difficulty in relapse after healing, using simplicity.
A kind of antibacterial medicament of described external application containing camptothecine, it is characterised in that the following material containing percentage by weight：
8~17 parts of camptothecine, 3~11 parts of leech, 6~15 parts of cordate houttuynia, 5~13 parts of scorpio, 8~15 parts of the capsule of weeping forsythia, 5~12 parts of hippocampus,
3~9 parts of ground beetle, 5~12 parts of oriental wormwood, 4~11 parts of tortoiseshell, 3~8 parts of borneol, 8~17 parts of beeswax, 10~20 parts of medicinal alcohol.
The antibacterial medicament of described a kind of external application containing camptothecine, it is characterised in that be preferably：10~15 parts of camptothecine, leech
5~10 parts, 7~13 parts of cordate houttuynia, 7~11 parts of scorpio, 9~13 parts of the capsule of weeping forsythia, 7~10 parts of hippocampus, 5~8 parts of ground beetle, oriental wormwood 6
~10 parts, 5~9 parts of tortoiseshell, 4~6 parts of borneol, 10~15 parts of beeswax, 13~18 parts of medicinal alcohol.
The preparation method of the antibacterial medicament of described a kind of external application containing camptothecine, it is characterised in that comprise the following steps：
1）Camptothecine, leech, cordate houttuynia, scorpio, the capsule of weeping forsythia, hippocampus, ground beetle, mattress are weighed in ratio described in claim 1
Old, tortoiseshell, borneol, beeswax, are well mixed, 100-200 mesh fine powders are ground into together, standby；
2）By step 1）Medicinal material powder soaks 8-15h after middle mixing, after be heated to extract 20-40min at 80-110 DEG C,
Be filtered by vacuum the removing dregs of a decoction again, collect filtrate, then by filtrate in enrichment facility flash concentration, be dried to dry powder, finally grind
The extract fine powder of 80-100 mesh is worn into, it is standby；
3）By step 2）The medicinal alcohol mixed dissolution of extract obtained fine powder and the ratio, produces external application bacteriostatic
Agent.
A kind of preparation method of the antibacterial medicament of described external application containing camptothecine, it is characterised in that step 2）In：Medicinal material powder
The time is soaked for 9-13h, preferably 10-11h.
A kind of preparation method of the antibacterial medicament of described external application containing camptothecine, it is characterised in that step 2）In：Heating temperature
Spend for 90-105 DEG C, preferably 95-100 DEG C.
A kind of preparation method of the antibacterial medicament of described external application containing camptothecine, it is characterised in that step 2）In：During extraction
Between be 25-35min, preferably 28-32min.
A kind of antibacterial medicament of described external application containing camptothecine prevents and treats ringworm of the body, jock itch, tinea of feet and hands, tinea versicolor, tinea in preparation
Application in the medicament of microbid.
A kind of antibacterial medicament of described external application containing camptothecine is in preventing and treating fungi, bacterium, the medicament of mould rotten bacterium is prepared
Using.
Above-mentioned antibacterial medicament of a kind of external application containing camptothecine and its production and use, the traditional Chinese medicine for external application contains many
Active component is planted, the work in terms of dispelled with bacterio static itching-relieving, analgesic tinea, removing toxic substances eliminating dampness, anti-inflammation detumescence, improvement affected part microcirculation
With the itch to ringworm of the body, jock itch, tinea of feet and hands, tinea versicolor, dermatophytids etc. swells and ache etc., and disease has significant curative effect, and cure rate is high, poison
Small side effects, preparation method is simple, safe and effective, low production cost.This preparation is with the effect combatted poison with poison, and sample is simultaneous
Control, evident in efficacy, difficulty in relapse after healing, using simplicity the features such as.
Unless otherwise indicated, others are that the weight percent of pure material contains to the percentage composition being related in present specification
Amount.
Embodiment
Below by way of specific embodiment, the invention will be further described, and further illustrates the present invention with reference to the test of pesticide effectiveness
Beneficial effect.
Embodiment 1
Added into clean 2L containers 130g camptothecines, 80g leech, 110g cordate houttuynias, 100g scorpios, the 110g capsules of weeping forsythia,
90g hippocampus, 70g ground beetles, 90g oriental wormwoods, 80g tortoiseshells, 50g borneols and 130g beeswaxs, are well mixed, are ground into 100 mesh fine powders,
Again plus enough water immersion 8h, it is heated at 80 DEG C extract 20min after, then is filtered by vacuum the removing dregs of a decoction, collects filtrate, then will
Filtrate in enrichment facility flash concentration, be dried to dry powder, finally grind to form the extract fine powder of 80 mesh, be eventually adding 170g doctor
Use alcohol mixed dissolution, final products.
Embodiment 2
100g camptothecines, 50g leech, 70g cordate houttuynias, 70g scorpios, the 90g capsules of weeping forsythia, 70g are added into clean 2L containers
Hippocampus, 50g ground beetles, 60g oriental wormwoods, 50g tortoiseshells, 40g borneols and 100g beeswaxs, are well mixed, are ground into 200 mesh fine powders, then
Plus enough water immersion 15h, after be heated at 110 DEG C extract 40min, then be filtered by vacuum the removing dregs of a decoction, collect filtrate, then will
Filtrate in enrichment facility flash concentration, be dried to dry powder, finally grind to form the extract fine powder of 100 mesh, be eventually adding 130g
Medicinal alcohol mixed dissolution, final products.
Embodiment 3
Added into clean 2L containers 150g camptothecines, 100g leech, 130g cordate houttuynias, 110g scorpios, the 130g capsules of weeping forsythia,
100g hippocampus, 80g ground beetles, 100g oriental wormwoods, 90g tortoiseshells, 60g borneols and 150g beeswaxs, are well mixed, are ground into 150 mesh thin
Powder, then add enough water immersion 10h, after be heated at 100 DEG C extract 30min, then be filtered by vacuum the removing dregs of a decoction, collect filtrate,
Then by filtrate in enrichment facility flash concentration, be dried to dry powder, finally grind to form the extract fine powder of 90 mesh, be eventually adding
180g medicinal alcohol mixed dissolutions, final products.
Embodiment 4
110g camptothecines, 60g leech, 80g cordate houttuynias, 80g scorpios, the 100g capsules of weeping forsythia, 80g are added into clean 2L containers
Hippocampus, 60g ground beetles, 70g oriental wormwoods, 60g tortoiseshells, 58g borneols and 110g beeswaxs, are well mixed, are ground into 120 mesh fine powders, then
Plus enough water immersion 11h, after be heated at 85 DEG C extract 25min, then be filtered by vacuum the removing dregs of a decoction, collect filtrate, then will
Filtrate in enrichment facility flash concentration, be dried to dry powder, finally grind to form the extract fine powder of 85 mesh, be eventually adding 140g doctor
Use alcohol mixed dissolution, final products.
Embodiment 5
125g camptothecines, 75g leech, 85g cordate houttuynias, 95g scorpios, the 105g capsules of weeping forsythia, 95g are added into clean 2L containers
Hippocampus, 75g ground beetles, 85g oriental wormwoods, 85g tortoiseshells, 55g borneols and 135g beeswaxs, are well mixed, are ground into 140 mesh fine powders, then
Plus enough water immersion 12h, after be heated at 95 DEG C extract 35min, then be filtered by vacuum the removing dregs of a decoction, collect filtrate, then will
Filtrate in enrichment facility flash concentration, be dried to dry powder, finally grind to form the extract fine powder of 95 mesh, be eventually adding 165g doctor
Use alcohol mixed dissolution, final products.
Embodiment 6
Added into clean 2L containers 129g camptothecines, 67g leech, 121g cordate houttuynias, 87g scorpios, the 126g capsules of weeping forsythia,
84g hippocampus, 79g ground beetles, 64g oriental wormwoods, 71g tortoiseshells, 58g borneols and 134g beeswaxs, are well mixed, are ground into 180 mesh fine powders,
Again plus enough water immersion 14h, it is heated at 105 DEG C extract 38min after, then is filtered by vacuum the removing dregs of a decoction, collects filtrate, then
By filtrate in enrichment facility flash concentration, be dried to dry powder, finally grind to form the extract fine powder of 88 mesh, be eventually adding 159g
Medicinal alcohol mixed dissolution, final products.
Below by way of the excellent results of the above-mentioned medicament of experiment explanation.
Cure rate result of the tests of the embodiment 1-6 of table 1 to a variety of tinea classes
| Processing | Ringworm of the body（%） | Jock itch（%） | Tinea of feet and hands（%） | Tinea versicolor（%） | Dermatophytids（%） |
| Embodiment 1 | 95.12 | 94.30 | 90.28 | 91.16 | 85.77 |
| Embodiment 2 | 97.24 | 95.72 | 91.33 | 92.31 | 86.79 |
| Embodiment 3 | 91.17 | 93.15 | 92.74 | 91.29 | 83.07 |
| Embodiment 4 | 93.36 | 96.03 | 93.05 | 92.31 | 84.26 |
| Embodiment 5 | 95.28 | 95.32 | 93.19 | 92.34 | 85.34 |
| Embodiment 6 | 94.73 | 93.28 | 91.26 | 90.59 | 83.61 |
Table 1 shows：Embodiment 1-6 has preferable curative effect to ringworm of the body, jock itch, tinea of feet and hands, tinea versicolor, dermatophytids, implements
Example 2 is better than embodiment 1, and embodiment 4 is better than embodiment 3, and embodiment 5 is better than embodiment 6.
Table 2 shows：Embodiment 1-6 has preferable fungistatic effect to staphylococcus aureus, and embodiment 1 is better than embodiment 2,
Embodiment 3 is better than embodiment 4, and embodiment 6 is better than embodiment 5.
The inhibiting rate of several bacteriums of embodiment 1-6 of table 3（%）
| Processing | Hemolytic streptococcus | Proteus | Bacillus | Pseudomonas |
| Embodiment 1 | 82.2 | 84.1 | 85.3 | 82.1 |
| Embodiment 2 | 83.5 | 85.3 | 87.3 | 84.6 |
| Embodiment 3 | 81.1 | 82.4 | 83.3 | 81.5 |
| Embodiment 4 | 83.6 | 85.5 | 85.6 | 82.3 |
| Embodiment 5 | 80.8 | 82.5 | 81.1 | 82.4 |
| Embodiment 6 | 81.3 | 83.1 | 82.5 | 83.1 |
| CK | 0.0 | 0.0 | 0.0 | 0.0 |
Table 3 shows：Suppressions of the embodiment 1-6 to bacteriums such as hemolytic streptococcus, proteus, bacillus, pseudomonas
System has preferable effect, and embodiment 2 is better than embodiment 1, and embodiment 4 is better than embodiment 3, and embodiment 6 is better than embodiment 5.
Claims (5)
1. the antibacterial medicament of a kind of external application containing camptothecine, it is characterised in that be made up of the following material of parts by weight：Camptothecine 8~17
Part, 3~11 parts of leech, 6~15 parts of cordate houttuynia, 5~13 parts of scorpio, 8~15 parts of the capsule of weeping forsythia, 5~12 parts of hippocampus, ground beetle 3~9
Part, 5~12 parts of oriental wormwood, 4~11 parts of tortoiseshell, 3~8 parts of borneol, 8~17 parts of beeswax, 10~20 parts of medicinal alcohol；
The medicament is prepared using following methods：
1）Weigh according to the above ratio camptothecine, leech, cordate houttuynia, scorpio, the capsule of weeping forsythia, hippocampus, ground beetle, oriental wormwood, tortoiseshell, borneol,
Beeswax, is well mixed, 100-200 mesh fine powders is ground into together, standby；
2）By step 1）Medicinal material powder soaks 8-15h after middle mixing, after be heated at 80-110 DEG C extract 20-40min, then very
Empty suction filtration removes the dregs of a decoction, collects filtrate, then by filtrate in enrichment facility flash concentration, be dried to dry powder, finally grind to form
The extract fine powder of 80-100 mesh, it is standby；
3）By step 2）The medicinal alcohol mixed dissolution of extract obtained fine powder and the ratio, produces the antibacterial medicament of external application.
2. the antibacterial medicament of a kind of external application containing camptothecine as claimed in claim 1, it is characterised in that be preferably：Camptothecine 10~
15 parts, 5~10 parts of leech, 7~13 parts of cordate houttuynia, 7~11 parts of scorpio, 9~13 parts of the capsule of weeping forsythia, 7~10 parts of hippocampus, ground beetle 5~8
Part, 6~10 parts of oriental wormwood, 5~9 parts of tortoiseshell, 4~6 parts of borneol, 10~15 parts of beeswax, 13~18 parts of medicinal alcohol.
3. a kind of preparation method of the antibacterial medicament of external application containing camptothecine as claimed in claim 1, it is characterised in that step 2）
In：Medicinal material powder soaks the time for 9-13h.
4. a kind of preparation method of the antibacterial medicament of external application containing camptothecine as claimed in claim 1, it is characterised in that step 2）
In：Heating-up temperature is 90-105 DEG C.
5. a kind of preparation method of the antibacterial medicament of external application containing camptothecine as claimed in claim 1, it is characterised in that step 2）
In：Extraction time is 25-35min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210170556.6A CN102670820B (en) | 2012-05-29 | 2012-05-29 | Antibacterial medicament of a kind of external application containing camptothecine and its production and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210170556.6A CN102670820B (en) | 2012-05-29 | 2012-05-29 | Antibacterial medicament of a kind of external application containing camptothecine and its production and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102670820A CN102670820A (en) | 2012-09-19 |
| CN102670820B true CN102670820B (en) | 2017-09-26 |
Family
ID=46803805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210170556.6A Expired - Fee Related CN102670820B (en) | 2012-05-29 | 2012-05-29 | Antibacterial medicament of a kind of external application containing camptothecine and its production and use |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102670820B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105802774A (en) * | 2016-04-07 | 2016-07-27 | 苏州市天灵中药饮片有限公司 | Antibacterial facial soap and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1285200A (en) * | 2000-08-02 | 2001-02-28 | 朱项英 | External medicine for treating sore caused by shell wound all bullet wound |
| CN1537557A (en) * | 2003-04-17 | 2004-10-20 | 邹宇超 | Drug for external use with functions of sterilizing and relieving itching, and its prepn. method |
| CN102453036A (en) * | 2010-10-27 | 2012-05-16 | 李红玉 | Camptothecin compound and preparation method and application in pesticide thereof |
-
2012
- 2012-05-29 CN CN201210170556.6A patent/CN102670820B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1285200A (en) * | 2000-08-02 | 2001-02-28 | 朱项英 | External medicine for treating sore caused by shell wound all bullet wound |
| CN1537557A (en) * | 2003-04-17 | 2004-10-20 | 邹宇超 | Drug for external use with functions of sterilizing and relieving itching, and its prepn. method |
| CN102453036A (en) * | 2010-10-27 | 2012-05-16 | 李红玉 | Camptothecin compound and preparation method and application in pesticide thereof |
Non-Patent Citations (2)
| Title |
|---|
| 中药熏蒸结合喜树碱软膏治疗点滴状银屑病56例;吴祖兰等;《四川中医》;20101231;第28卷(第1期);第107页右栏第1-28行 * |
| 凉血消银汤加减治疗银屑病303例疗效观察;买合木提°艾则孜等;《山西中医》;20010630;第17卷(第3期);第21-22页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102670820A (en) | 2012-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112007135A (en) | Natural botanical insecticide for aquatic products and preparation method thereof | |
| CN104013878B (en) | A kind of lavipeditum medicine vinegar and preparation method thereof for treating tinea pedis | |
| CN104288634A (en) | Traditional Chinese medicine for treating peritus ani and preparation method thereof | |
| CN103877229B (en) | A kind of compound Chinese medicine extract and application thereof preventing and treating an avian colibacillosis | |
| Hamidpour et al. | Chemistry, pharmacology and medicinal property of Russian olive (Elaeagnus angustifolia L.) | |
| CN102670820B (en) | Antibacterial medicament of a kind of external application containing camptothecine and its production and use | |
| CN102579709B (en) | Scar preventing and removing burn oil and preparation method thereof | |
| CN107519328A (en) | A kind of radix tetrastigme antimicrobial fluid and preparation method thereof | |
| CN107961363B (en) | Shell powder nano antibacterial foot bath effervescent tablet and preparation method thereof | |
| KR20030055154A (en) | A composition for treating a dermatitis and a method of preparing the same | |
| CN105031553A (en) | Medicine composition for treating dog dermatomycosis and preparation method and application thereof | |
| CN108785374A (en) | Faint scent cassia bark skin bacteriostatic gel and preparation method thereof | |
| CN101780235A (en) | Nano traditional Chinese medicine of silver-carrying nano titanium dioxide (AT) antimicrobial for external treatment of tinea versicolor | |
| CN107669956A (en) | Treat dog, the Chinese medicine preparation and preparation method thereof of cat otopathy | |
| CN101653503A (en) | Gonglao quhuo capsules for treating various inflammation, heat-clearing and detoxifying and preparation method thereof | |
| CN100427099C (en) | Juglans mandshurica maxim pdysaccharide preparation capable of effectively treating brain cancer and its preapring method | |
| CN110150486A (en) | A kind of feed addictive for preventing and treating the intestines problems such as milking sow constipation diarrhea | |
| CN102416087A (en) | Chinese medicinal composition for treating pelvic inflammatory disease and preparation method as well as application thereof | |
| CN104840747B (en) | Chinese medicine composition with antithyroid cancer activity and its preparation method and application | |
| CN102579629B (en) | Chinese medicinal preparation for treating vaginitis and preparation method thereof | |
| CN102526266B (en) | Chinese medicinal preparation for treating vaginitis and preparation method thereof | |
| CN107982301A (en) | A kind of preparation method of antibacterial anti-inflammatory Chinese medicine composite film agent and its film of preparation | |
| CN110025643B (en) | Compound with anticancer activity and preparation method and application thereof | |
| CN107296858B (en) | Antibacterial infection pharmaceutical composition and application thereof | |
| CN101015680B (en) | Use of F-Glucoside peptide in preparing medicine for treating tumour |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170926 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |