CN102670693A - Application of integripetal rhodiola herb and ginkgo leaf composition to preparation of anti-hypoxia medicament or health-care food - Google Patents
Application of integripetal rhodiola herb and ginkgo leaf composition to preparation of anti-hypoxia medicament or health-care food Download PDFInfo
- Publication number
- CN102670693A CN102670693A CN2012101439835A CN201210143983A CN102670693A CN 102670693 A CN102670693 A CN 102670693A CN 2012101439835 A CN2012101439835 A CN 2012101439835A CN 201210143983 A CN201210143983 A CN 201210143983A CN 102670693 A CN102670693 A CN 102670693A
- Authority
- CN
- China
- Prior art keywords
- extract
- radix rhodiolae
- folium ginkgo
- application
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to application of an integripetal rhodiola herb and ginkgo leaf composition to the preparation of anti-hypoxia medicaments or health-care food. The composition consists of an integripetal rhodiola herb extract and a ginkgo leaf extract in a weight ratio of (2-10):1. By adopting the ratio, the integripetal rhodiola herb and ginkgo leaf composition is superior to the prior art in an anti-hypoxia aspect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to Radix Rhodiolae, compositions extracted from gingko biloba leaves in the medicine of preparation anoxia enduring or the application in the health food.
Background technology
Anoxia is the total pathological process of clinical multiple disease, is that numerous disease causes dead major reason.Oxygen in the atmosphere gets into alveolar through breathing, and disperse goes into blood, combines with hemoglobin, is transported to whole body by blood circulation, at last by tissue, cellular uptake utilization.Wherein any one link generation obstacle can both cause anoxia.When tissue, cell can not get sufficient oxygen, in the time of maybe can not making full use of oxygen, the pathological process of metabolism, function and the morphosis generation ANOMALOUS VARIATIONS of tissue, cell is called anoxia.
Anoxia can be divided into four types of hypoxic hypoxia, hemic hypoxia, circulatory hypoxia and histogenous hypoxias, and its reason and characteristics have nothing in common with each other.
1, hypoxic hypoxia (oxygen picked-up obstacle): be reduced to the anoxia of basic feature with arterial partial pressure of oxygen, main cause is for sucking pneumatic arteries and veins partial pressure of oxygen low excessively (plateau of height above sea level more than 3000 meters), external respiration dysfunction (changes of lung tissue pathology), venous blood inflow arterial blood (congenital heart disease).
2, hemic hypoxia (blood carries oxygen or release oxygen obstacle): because hemoglobin matter or amount change, so that blood carries the ability reduction of oxygen.Main cause is anemia, carbon monoxide poisoning and nitrite poisoning.
3, circulatory hypoxia (oxygen transportation obstacle): organize oxygen supply not enough because of what the minimizing of tissue blood amount caused.Main cause is tissue ischemia and organizes congestion.
4, histogenous hypoxia (oxygen utilizes obstacle): because of cell can not effectively utilize the anoxia that oxygen causes.Be common in the mitochondria dysfunction that poisoning (potassium cyanide, sodium azide etc.) causes.
The variation that anoxia mainly causes:
Blood system changes---and compensatory response: erythrocyte and hemoglobin increase, and 2,3-DPG increases, and erythrocyte oxygen release ability strengthens.
The central nervous system changes---and brain is very responsive to anoxia, but the function of anoxia coup injury CNS.Excitement, sense of euphoria can appear in acute anoxia, disorientation, and headache, it is inharmonious to move etc., and very the person can faint from fear, go into a coma, death.Chronic hypoxia then has symptoms such as fatiguability, drowsiness, absent minded and spirit depressing.
Radix Rhodiolae Latin formal name used at school Rhodiola rosea, English name Roseroot is Crassulaceae renascent herb or shrub plant, is grown in the rare wild plant in the high and cold pollution-free area of height above sea level 800-2500 rice.The applicating history of Radix Rhodiolae is long, and before more than 2,000 year, the people of Qinghai-Tibet Platean just is used as medicine with it, with building body, and the influence of opposing poor environment.Among the peoplely be commonly used to fry in shallow oil water or steep in wine, to banish fatigue or to resist mountain area cold.Simultaneously and diseases prevention is healthy and strong and nourishing lengthens one's life.Because of it has the magical effect of strengthening healthy qi, benefiting qi and nourishing blood, YIN nourishing lung benefiting, the successive dynasties Tibetan medicine is regarded as it " lucky SANBAO ".The adaptation former state effect of Radix Rhodiolae can promote the nonspecific resistance of human body to destructive stimulus, strengthens the adaptability of human body.See through to strengthen the oxygen diffusion of cells in vivo, or oxygen utilization benefit, antioxidative ability, help and improve the adaptive faculty that health stimulates anoxia.
One Chinese patent application 200610153340.3 discloses Radix Rhodiolae extract and Folium Ginkgo total flavones, and (weight ratio of the two is 3: 1; Wherein Radix Rhodiolae extract 30mg is equivalent to raw-material 1g), (weight ratio of the two is 3: 1 for Radix Rhodiolae extract and bilobalide; Wherein Radix Rhodiolae extract 30mg is equivalent to raw-material 1g), Radix Rhodiolae extract and Folium Ginkgo extract (the two is equivalent to 1: 1.2 of Chinese medicine according to 3: 2 weight ratio compatibility) drug combination is to the influence of mice normal pressure hypoxia-bearing capability.
The inventor carries out proportioning to Radix Rhodiolae extract and Folium Ginkgo extract, finds that unexpectedly effect of the present invention is superior to prior art, therefore proposes the present invention.
Summary of the invention
The invention provides the application in preparation anoxia enduring medicine or health food of Radix Rhodiolae, compositions extracted from gingko biloba leaves, said composition by Radix Rhodiolae extract and Folium Ginkgo extract according to weight ratio 2-10: 1 forms.
Preferably, in the said application, said composition by Radix Rhodiolae extract and Folium Ginkgo extract according to weight ratio 2-8: 1 forms.
Further preferred, in the said application, said composition by Radix Rhodiolae extract and Folium Ginkgo extract according to weight ratio 2-6: 1 forms.
Further preferred, in the said application, said composition by Radix Rhodiolae extract and Folium Ginkgo extract according to weight ratio 2-4: 1 forms.
Further preferred, in the said application, said composition is made up of according to weight ratio Radix Rhodiolae extract and Folium Ginkgo extract at 2.25: 1.
In the above-mentioned application:
Said anoxia is meant myocardial ischemia and cerebral anoxia, and said myocardial ischemia is acute myocardial ischemia.
Cerebral anoxia performance: bradyphrenia, reaction be slack-off, feel sleepy, and not have very big physical demands but to feel tired out, worn out mentally and physically, and anxious state of mind is big, disposition changes, and that is stranded terribly but can't fall asleep, and can follow the described cerebral anoxia in many places to show in the time of seriously.
Myocardial ischemia performance: cardiopalmus, pareordia is uncomfortable, precordialgia or be radiating pain sometimes; Breathe hard, move, be satiated with food or excitement is brought out easily, the whole body is unable; Can suffer a shock when serious.Sometimes atypical symptom is a kind of like uncomfortable in chest, chest constriction, scorching hot or extruding sense.Be not easy during rest to alleviate, the small number of patients painful area is not true to type, and as above abdominal pain can also be radiated to lower jaw part, cervical region, shoulder top.
Said Radix Rhodiolae extract is the alcohol extract of Radix Rhodiolae, can be through commercially available acquisition, and the content of rhodioside＞3% wherein;
Said Folium Ginkgo extract is the alcohol extract of Folium Ginkgo, also can be through commercially available acquisition, and content of total flavone＞24% wherein.
In the said compositions; Radix Rhodiolae extract and Folium Ginkgo extract can be with commercially available prescribed preparation according to proportioning administrations of the present invention, also can Radix Rhodiolae extract and Folium Ginkgo extract and pharmaceutically acceptable carrier or mixing diluents be prepared into the preparation administration.
Said preparation is tablet, capsule, granule, injection or lyophilized injectable powder.
When preparation was preferably tablet, said pharmaceutically acceptable carrier or diluent were one or more in microcrystalline Cellulose, starch, magnesium stearate, sucrose, dextrin, the Sodium Hydroxymethyl Stalcs.
The present invention also provides the method for preparing of above-mentioned tablet, may further comprise the steps: after Radix Rhodiolae extract, Folium Ginkgo extract and required carrier pulverize separately are crossed 80 mesh sieves, carry out weighing by proportioning, mixed 20-40 minute; Add the 15-25% starch slurry, consumption is the 10-15% of above-mentioned material gross weight, stirs 10-20 minute; 18 order nylon mesh are granulated, and being dried to moisture under 50-60 ℃ is 3.0%-5.0%, 18 order nylon mesh granulate; Added mixing diluents 20-40 minute, tabletting promptly gets.
Application provided by the invention has the following advantages:
1, in the application of anoxia enduring provided by the invention, compositions is made up of Radix Rhodiolae extract and Folium Ginkgo extract, wherein:
1) Radix Rhodiolae can make the whole keto consumpting speed of human body reduce, and improves brain to anoxybiotic endurance, can increase the oxygen carrying capability of blood simultaneously, increases the resistance against diseases of human body, and pathological tissues is recovered rapidly.
2) Folium Ginkgo has following effect: reduce cholesterol levels in the blood of human body, prevent arteriosclerosis.To be short of physical strength behind the middle-aged and elderly people light activity, palpitating speed, chest pain, the effect of being significantly improved such as feel dizzy; Bring high blood pressure down through increasing passing through property of blood vessel and elasticity, blood pressure lowering effect is preferably arranged; Eliminate the deposition composition on the blood vessel wall, improve blood flow and change, promote erythrocyte deformability, blood viscosity lowering makes blood flow unobstructed, can prevent and treat cerebral hemorrhage and cerebral infarction.The senile dementia that arteriosclerosis is caused also has certain curative effect; Gingko leaf preparation and antidiabetic drug share the treatment diabetes has better curative effect, can be used for the adjuvant of diabetes.
Above-mentioned two kinds of drug combinations can be used for treating cerebral anoxia and myocardial ischemia.
2, find that through experiment provided by the invention is 2-10 according to weight ratio: 1 Radix Rhodiolae extract and Folium Ginkgo extract, can treat cerebral anoxia and myocardial ischemia.
3, it is influential to mice normal pressure hypoxia-bearing capability according to 1.5: 1 (with respect to 1: 1.2 of crude drug) to disclose Radix Rhodiolae extract and Folium Ginkgo extract in the one Chinese patent application 200610153340.3; The inventor carries out the proportioning discovery to Radix Rhodiolae extract and Folium Ginkgo extract; Adopt proportioning of the present invention; The weight ratio that is Radix Rhodiolae extract and Folium Ginkgo extract is 2-10: 1, be superior to prior art aspect anti-cerebral anoxia and the myocardial ischemia.
The specific embodiment
Following examples are used to explain the present invention, but should not be used for limiting scope of the present invention.
Said Radix Rhodiolae extract is the alcohol extract of Radix Rhodiolae, can be through commercially available acquisition, and the content of rhodioside＞3% wherein is available from Xi'an brilliant development in science and technology company limited difficult to understand;
Said Folium Ginkgo extract is the alcohol extract of Folium Ginkgo, also can be through commercially available acquisition, and content of total flavone＞24% wherein is available from Xi'an brilliant development in science and technology company limited difficult to understand.
Embodiment 1: the tablet of Radix Rhodiolae extract and Folium Ginkgo extract (2.25: 1)
1, raw material: Radix Rhodiolae extract 112.5g, Folium Ginkgo extract 50g, microcrystalline Cellulose 235.5g, 20% starch slurry 48g, magnesium stearate 2g.
2, method for preparing: take by weighing Radix Rhodiolae extract, Folium Ginkgo extract, the microcrystalline Cellulose of pulverizing 80 mesh sieves, mixed 30 minutes, add starch slurry; Stirred 20 minutes, 18 order nylon mesh are granulated, and 55 ℃ following dry 30 minutes; Detecting moisture is 4.0%, 18 order nylon mesh granulate, adds magnesium stearate; Mixed 20 minutes, tabletting (0.4g/ sheet) promptly gets.
3, the detection of tablet: according to an appendix XII of Chinese Pharmacopoeia version in 2010 A inspection technique disintegration inspection tablet disintegration time, according to two appendix X of Chinese Pharmacopoeia version in 2010 G tablet friability inspection technique inspection tablet friability.The result is:
The gained tablet, smooth surface, compressibility is strong, and hardness is better, and disintegration time is 14 minutes, and friability is 0.127%.
Embodiment 2: the tablet of Radix Rhodiolae extract and Folium Ginkgo extract (2: 1)
1, raw material: Radix Rhodiolae extract 170g, Folium Ginkgo extract 85g, microcrystalline Cellulose 110g, starch 210g, hydroxymethyl starch 40g, 25% starch slurry 85g, magnesium stearate 4g.
2, method for preparing:
Take by weighing Radix Rhodiolae extract, Folium Ginkgo extract, microcrystalline Cellulose, starch, the hydroxymethyl starch of pulverizing 80 mesh sieves, mixed 20 minutes, add 25% starch slurry; Stirred 10 minutes, 18 mesh sieves are granulated excessively, and 60 ℃ following dry 40 minutes; Detecting moisture is 4.3%, crosses 18 mesh sieve granulate, adds magnesium stearate; Mixed 30 minutes, tabletting (0.4g/ sheet) promptly gets.
3, detect: detection method reference implementation example 1, the result:
The gained tablet, smooth surface, compressibility is strong, and hardness is better, and disintegration time is 15 minutes, and friability is 0.168%.
Embodiment 3: the tablet of Radix Rhodiolae extract and Folium Ginkgo extract (3: 1)
1, raw material: Radix Rhodiolae extract 360g, Folium Ginkgo extract 120g, microcrystalline Cellulose 485g, starch 200g, 15% starch slurry 155g, magnesium stearate 6g
2, method for preparing:
Take by weighing Radix Rhodiolae extract, Folium Ginkgo extract, microcrystalline Cellulose, the starch of pulverizing 80 mesh sieves, mixed 40 minutes, add 15% starch slurry; Stirred 15 minutes, 18 mesh sieves are granulated excessively, and 50 ℃ following dry 60 minutes; Detecting moisture is 3.8%, crosses 18 mesh sieve granulate, adds magnesium stearate; Mixed 40 minutes, tabletting (0.4g/ sheet) promptly gets.
3, detect: detection method is with embodiment 1, and the result is:
The gained tablet, smooth surface, compressibility is strong, and hardness is better, and disintegration time is 18 minutes, and friability is 0.106%.
Embodiment 4: the tablet of Radix Rhodiolae extract and Folium Ginkgo extract (5: 1)
1, raw material: Radix Rhodiolae extract 450g, Folium Ginkgo extract 90g, sucrose 148g, dextrin 430g, starch 240g, 18% starch slurry 125g, magnesium stearate 8g.
2, method for preparing:
Take by weighing Radix Rhodiolae extract, Folium Ginkgo extract, sucrose, dextrin, the starch of pulverizing 80 mesh sieves, mixed 35 minutes, add 18% starch slurry; Stirred 18 minutes, 18 mesh sieves are granulated excessively, and 56 ℃ following dry 50 minutes; Detecting moisture is 4.5%, crosses 18 mesh sieve granulate, adds magnesium stearate; Mixed 35 minutes, tabletting (0.4g/ sheet) promptly gets.
3, detect: detection method is with embodiment 1, and the result is:
The gained tablet, smooth surface, compressibility is strong, and hardness is better, and disintegration time is 16 minutes, and friability is 0.235%.
Embodiment 5: the tablet of Radix Rhodiolae extract and Folium Ginkgo extract (6: 1)
1, raw material: Radix Rhodiolae extract 600g, Folium Ginkgo extract 100g, microcrystalline Cellulose 325g, starch 755g, 23% starch slurry 140g, magnesium stearate 12g.
2, method for preparing:
Take by weighing Radix Rhodiolae extract, Folium Ginkgo extract, microcrystalline Cellulose, the starch of pulverizing 80 mesh sieves, mixed 20 minutes, add 23% starch slurry; Stirred 15 minutes, 18 mesh sieves are granulated excessively, and 55 ℃ following dry 60 minutes; Detecting moisture is 4.1%, crosses 18 mesh sieve granulate, adds magnesium stearate; Mixed 20 minutes, tabletting (0.4g/ sheet) promptly gets.
3, detect: the detection method of reference implementation example 1 detects, and the result is:
The gained tablet, smooth surface, compressibility is strong, and hardness is better, and disintegration time is 17 minutes, and friability is 0.035%.
Embodiment 6: the tablet of Radix Rhodiolae extract and Folium Ginkgo extract (8: 1)
1, raw material: Radix Rhodiolae extract 800g, Folium Ginkgo extract 100g, dextrin 860g, starch 515g, 20% starch slurry 190g, magnesium stearate 15g.
2, method for preparing: take by weighing Radix Rhodiolae extract, Folium Ginkgo extract, dextrin, the starch of pulverizing 80 mesh sieves, mixed 40 minutes, add 20% starch slurry; Stirred 20 minutes, 18 mesh sieves are granulated excessively, and 50 ℃ following dry 40 minutes; Detecting moisture is 3.6%, crosses 18 mesh sieve granulate, adds magnesium stearate; Mixed 30 minutes, tabletting (0.4g/ sheet) promptly gets.
3, detect: the detection method of reference implementation example 1 detects, and the result is:
The gained tablet, smooth surface, compressibility is strong, and hardness is better, and disintegration time is 19 minutes, and friability is 0.061%.
Embodiment 7: the tablet of Radix Rhodiolae extract and Folium Ginkgo extract (4: 1)
1, raw material: Radix Rhodiolae extract 240g, Folium Ginkgo extract 60g, dextrin 167g, starch 219g, 20% starch slurry 140g, magnesium stearate 2g.
2, method for preparing:
Take by weighing Radix Rhodiolae extract, Folium Ginkgo extract, dextrin, the starch of pulverizing 80 mesh sieves, mixed 30 minutes, add 20% starch slurry; Stirred 20 minutes, 18 mesh sieves are granulated excessively, and 60 ℃ following dry 30 minutes; Detecting moisture is 4.0%, crosses 18 mesh sieve granulate, adds the 2g magnesium stearate; Mixed 40 minutes, tabletting (0.4g/ sheet) promptly gets.
3, detect: the detection method of reference implementation example 1 detects, and the result is:
The gained tablet, smooth surface, compressibility is strong, and hardness is better, and disintegration time is 20 minutes, and friability is 0.272%.
Embodiment 8: the tablet of Radix Rhodiolae extract and Folium Ginkgo extract (10: 1)
1, raw material: Radix Rhodiolae extract 200g, Folium Ginkgo extract 20g, dextrin 140g, microcrystalline Cellulose 130g, 20% starch slurry 115g, magnesium stearate 2g.
2, method for preparing:
Take by weighing Radix Rhodiolae extract, Folium Ginkgo extract, dextrin, the microcrystalline Cellulose of pulverizing 80 mesh sieves, mixed 35 minutes, add 20% starch slurry; Stirred 18 minutes, 18 mesh sieves are granulated excessively, and 56 ℃ following dry 45 minutes; Detecting moisture is 3.8%, crosses 18 mesh sieve granulate, adds magnesium stearate; Mixed 35 minutes, tabletting (0.4g/ sheet) promptly gets.
3, detect: the detection method of reference implementation example 1 detects, and the result is:
The gained tablet, smooth surface, compressibility is strong, and hardness is better, and disintegration time is 17 minutes, and friability is 0.23%.
Comparative Examples 1: the tablet of Radix Rhodiolae extract and Folium Ginkgo extract (1.5: 1)
Embodiment 10 with reference to one Chinese patent application 200610153340.3.
1, forms: Radix Rhodiolae extract 30g, Folium Ginkgo extract 20g, microcrystalline Cellulose 70g, 20% starch slurry 17g, magnesium stearate 1g.
2, method for preparing:
Get Folium Ginkgo extract 20g, Radix Rhodiolae extract 30g, microcrystalline Cellulose 70g, 20% starch slurry 17g, magnesium stearate 1g, the method for preparing tablet by embodiment 1 is prepared into tablet.
Experimental example 1: to the influence of sodium nitrite induced mice cerebral anoxia
1, laboratory animal: Kunming mouse, male and female half and half, body weight 18 ± 2g.
2, experiment is divided into groups:
Get 100 of mices, be divided into 10 groups at random, be respectively 1 group of negative control group (give normal saline, irritate stomach every day 1 time), embodiment 1-8 group and Comparative Examples according to 15ml/kg.
3, experimental technique:
In experiment beginning in preceding 3 days, according to grouping, every day, gastric infusion was 1 time, and dosage is 10mg/kg, and last 1 administration in the 4th day is after 15 minutes, and lumbar injection 25% sodium nitrite solution, dosage are 250mg/kg.
Record begins to mouse diing time from the injection sodium nitrite, is the mice time-to-live.
4, statistical method: the gained data are handled with Excel, adopt single blind method and t check that test data is carried out statistical analysis, represent with mean ± SD (mean+SD).
5, experimental result is seen table 1.
Table 1: to the influence of mice time-to-live
| Group | N (quantity) | T (time-to-live)/minute |
| Negative control group | 10 | 17.15±3.01 |
| 1 group of embodiment | 10 | 32.45±1.14** # |
| 2 groups of embodiment | 10 | 31.66±1.55** # |
| 3 groups of embodiment | 10 | 32.28±1.48** # |
| 4 groups of embodiment | 10 | 31.89±1.32** # |
| 5 groups of embodiment | 10 | 31.80±2.06** # |
| 6 groups of embodiment | 10 | 31.46±1.87** # |
| 7 groups of embodiment | 10 | 32.12±1.80** # |
| 8 groups of embodiment | 10 | 31.21±2.11** # |
| 1 group of Comparative Examples | 10 | 28.34±2.48* |
Annotate: compare with negative control group, * representes P＜0.05, and * * representes P＜0.01, compare for 1 group with Comparative Examples,
#Expression P＜0.05.
Table 1 result shows: compares with negative control group, but the time-to-live (P＜0.05) after 1 group of significant prolongation mice of Comparative Examples sodium nitrite poisons, but the time-to-live (P＜0.01) after embodiment of the invention 1-8 group utmost point significant prolongation mice sodium nitrite poisons.Compare for 1 group with Comparative Examples, embodiment 1-8 has organized mice time-to-live significant prolongation the time-to-live of mice (P＜0.05).
Brief summary: the compositions that Radix Rhodiolae extract provided by the invention and Folium Ginkgo extract are formed can be treated cerebral anoxia, and effect is superior to prior art.
Experimental example 2: to the protective effect of the impatient property of mouse experiment myocardial ischemia
1, laboratory animal: Kunming mouse, male and female half and half, body weight 18 ± 2g.
2, experimental drug: the sample of the sample of embodiment 1-8, Comparative Examples 1
3, experiment is divided into groups: get 100 of healthy Kunming mouses, be divided into 1 group of normal control group, embodiment 1-8 group and Comparative Examples at random.
4, test method:
The normal control group is irritated stomach and is given normal saline; Embodiment group and Comparative Examples group are irritated the sample that stomach gives each group respectively; Dosage is 2mg/10g, every day 1 time, continuous 6 days; After 1 hour mice being placed the capacity of continuous oxygen consumption detector respectively in the last administration is that 125ml is placed with in the vial of 5g Calx sodium, airtight observed and recorded 1-5 minute myocardial oxygen consumption.
5, statistical method: the gained data are handled with Excel, adopt single blind method and t check that test data is carried out statistical analysis, represent with mean ± SD (mean+SD).
6, experimental result: see table 2.
Table 2: to the influence of the impatient property of mouse experiment myocardial ischemia
Annotate: compare with the normal control group, * representes P＜0.05, and * * representes P＜0.01, compare for 1 group with Comparative Examples,
#Expression P＜0.05.
Table 2 result shows: under the normal pressure airtight condition, compare with the normal control group, embodiment 1-8 group all can reduce the oxygen consumption (P＜0.01) of 1-5 minute period mice, 1 group of oxygen consumption (P＜0.05) that can significantly reduce the day part mice of Comparative Examples extremely significantly.1-5 minute record slot embodiment 1-8 group reduction oxygen consumption all obviously is superior to 1 group of Comparative Examples between the medication group.
Brief summary: the compositions that Radix Rhodiolae extract provided by the invention and Folium Ginkgo extract are formed can be treated myocardial ischemia, and effect is superior to prior art.
Though, used general explanation, the specific embodiment and test in the preceding text, the present invention has been done detailed description, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (10)
1. Radix Rhodiolae, the compositions extracted from gingko biloba leaves application in preparation anoxia enduring medicine or health food, said composition by Radix Rhodiolae extract and Folium Ginkgo extract according to weight ratio 2-10: 1 forms.
2. application according to claim 1 is characterized in that said anoxia is meant myocardial ischemia and cerebral anoxia.
3. application according to claim 1 is characterized in that, said composition by Radix Rhodiolae extract and Folium Ginkgo extract according to weight ratio 2-8: 1 forms.
4. application according to claim 1 is characterized in that, said composition by Radix Rhodiolae extract and Folium Ginkgo extract according to weight ratio 2-6: 1 forms.
5. application according to claim 1 is characterized in that, said composition by Radix Rhodiolae extract and Folium Ginkgo extract according to weight ratio 2-4: 1 forms.
6. application according to claim 1 is characterized in that, said composition is made up of according to weight ratio Radix Rhodiolae extract and Folium Ginkgo extract at 2.25: 1.
7. according to each described application of claim 1-6, it is characterized in that Radix Rhodiolae extract is the ethanol extract of Radix Rhodiolae, wherein the content of rhodioside＞3%.
8. according to each described application of claim 1-6, it is characterized in that said Folium Ginkgo extract is the alcohol extract of Folium Ginkgo, wherein content of total flavone＞24%.
9. according to each described application of claim 1-6, it is characterized in that said compositions is the preparation of Radix Rhodiolae extract and Folium Ginkgo extract and pharmaceutically acceptable carrier or diluent composition.
10. application according to claim 9 is characterized in that, said preparation is tablet, capsule, granule, injection or lyophilized injectable powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101439835A CN102670693A (en) | 2012-05-10 | 2012-05-10 | Application of integripetal rhodiola herb and ginkgo leaf composition to preparation of anti-hypoxia medicament or health-care food |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101439835A CN102670693A (en) | 2012-05-10 | 2012-05-10 | Application of integripetal rhodiola herb and ginkgo leaf composition to preparation of anti-hypoxia medicament or health-care food |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102670693A true CN102670693A (en) | 2012-09-19 |
Family
ID=46803679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101439835A Pending CN102670693A (en) | 2012-05-10 | 2012-05-10 | Application of integripetal rhodiola herb and ginkgo leaf composition to preparation of anti-hypoxia medicament or health-care food |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102670693A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102987393A (en) * | 2012-12-05 | 2013-03-27 | 无锡市天赐康生物科技有限公司 | Health food with immunity-improving and anti-hypoxia functions and preparation method thereof |
| CN103005448A (en) * | 2013-01-08 | 2013-04-03 | 湖南麓山天然植物制药有限公司 | Health-care food composition for improving anoxia endurance and preparation method thereof |
| CN104306877A (en) * | 2014-09-26 | 2015-01-28 | 江苏奇力康皮肤药业有限公司 | Swollen sore throat medicine and preparation method thereof |
| CN104489651A (en) * | 2014-11-27 | 2015-04-08 | 杨宪铭 | Health food taking rhodiola rosea, gingko leaves and American ginseng as active components |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931217A (en) * | 2005-09-14 | 2007-03-21 | 蔡军 | Medicine composition of gingko leaf and rhodiola root |
| CN1977876A (en) * | 2005-11-29 | 2007-06-13 | 杨石 | Medicinal composition containing rhodiola and ginkgo leaf, and its use |
| CN101053396A (en) * | 2007-03-06 | 2007-10-17 | 屈跃曾 | Altitude sickness prevention food composition and its preparation method |
-
2012
- 2012-05-10 CN CN2012101439835A patent/CN102670693A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931217A (en) * | 2005-09-14 | 2007-03-21 | 蔡军 | Medicine composition of gingko leaf and rhodiola root |
| CN1977876A (en) * | 2005-11-29 | 2007-06-13 | 杨石 | Medicinal composition containing rhodiola and ginkgo leaf, and its use |
| CN101053396A (en) * | 2007-03-06 | 2007-10-17 | 屈跃曾 | Altitude sickness prevention food composition and its preparation method |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102987393A (en) * | 2012-12-05 | 2013-03-27 | 无锡市天赐康生物科技有限公司 | Health food with immunity-improving and anti-hypoxia functions and preparation method thereof |
| CN103005448A (en) * | 2013-01-08 | 2013-04-03 | 湖南麓山天然植物制药有限公司 | Health-care food composition for improving anoxia endurance and preparation method thereof |
| CN104306877A (en) * | 2014-09-26 | 2015-01-28 | 江苏奇力康皮肤药业有限公司 | Swollen sore throat medicine and preparation method thereof |
| CN104489651A (en) * | 2014-11-27 | 2015-04-08 | 杨宪铭 | Health food taking rhodiola rosea, gingko leaves and American ginseng as active components |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6305407B2 (en) | Chinese medicine composition for regulating immunity and method for producing the same | |
| CN101890040B (en) | Composition with anti-fatigue effect and application thereof | |
| CN101632827B (en) | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof | |
| CN101711810B (en) | Preparation used for improving sleep and enhancing immunity | |
| CN102727706A (en) | Composition for preventing and treating diabetes | |
| CN102670693A (en) | Application of integripetal rhodiola herb and ginkgo leaf composition to preparation of anti-hypoxia medicament or health-care food | |
| CN103417846A (en) | Hypoglycemic traditional Chinese medicine composition and preparation method thereof | |
| CN103301178B (en) | Prevention and the oral drugs for the treatment of fatigue syndrome | |
| CN1939521B (en) | Medicine for treating gout | |
| CN103705774A (en) | Compound composition with effect of treating depression as well as preparation method and application thereof | |
| CN105410941A (en) | Serene Tablet health-care food capable of increasing bone density and strengthening immunity and preparation method thereof | |
| CN101732301B (en) | Application of chlorogenic acid in preparing medicines for preventing and curing senile dementia | |
| CN101249097B (en) | Applications of ash tree flowers polysaccharide for preparing preventing and controlling pig virosis medicament | |
| CN100457144C (en) | Compound capsule of Chinese date kernel, and preparation method | |
| CN103110761A (en) | Yang invigorating function of iridaceous eleutherine plant eleutherine and extracts thereof | |
| CN102091155B (en) | Traditional Chinese medicine preparation for preventing and treating fatigue due to sub-health | |
| CN102327304B (en) | Drug for preventing and controlling chronic mountain sickness and preparation method thereof | |
| CN101653445A (en) | Application of tyrosol galactoside in preparing anoxia-resistant and anti-fatigue medicament | |
| CN104857180A (en) | Anti-fatigue and immunity-improving composition as well as preparation method and application thereof | |
| EP3943095A1 (en) | Traditional chinese medicine laxative composition for treating constipation, preparation method therefor and application thereof | |
| CN1814214A (en) | Chinese medicine composition for treating body thin and delicate coustitution, and preparing method | |
| CN103933376B (en) | Medicinal composition for treating chronic bronchitis | |
| CN102836354A (en) | Medicament for treating depression | |
| CN102100729A (en) | Oral administration medicament for treating and preventing radiation damage | |
| CN101822805B (en) | Traditional Chinese medicine composite, tablet treating hepatitis B residual jaundice and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120919 |