CN1977876A - Medicinal composition containing rhodiola and ginkgo leaf, and its use - Google Patents
Medicinal composition containing rhodiola and ginkgo leaf, and its use Download PDFInfo
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- CN1977876A CN1977876A CN 200510119026 CN200510119026A CN1977876A CN 1977876 A CN1977876 A CN 1977876A CN 200510119026 CN200510119026 CN 200510119026 CN 200510119026 A CN200510119026 A CN 200510119026A CN 1977876 A CN1977876 A CN 1977876A
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Abstract
The present invention discloses a medicine composition containing rhodiola root extract and ginkgo leaf extract for curing angiocardiopathy and cerebrovascular diseases of cerebral apoplexy, coronary heart disease and angina pectoris, etc. Said medicine composition can be made into oral tablet, capsule, granules and injection preparation.
Description
Technical field
The present invention relates to be used for the treatment of the pharmaceutical composition of cardiovascular and cerebrovascular diseases such as apoplexy, angina pectoris, is a kind of pharmaceutical composition and application thereof that contains Radix Rhodiolae, Folium Ginkgo extract specifically, belongs to field of traditional Chinese.
Background technology
Cardiovascular and cerebrovascular disease such as apoplexy, angina pectoris is first killer of harm humans healthy life in the present worldwide, according to relevant bibliographical information, cardiovascular and cerebrovascular disease seizes nearly 10,000,000 people's life every year, only just has every year more than 300 ten thousand people to die from cardiovascular and cerebrovascular disease in China.Wherein, again with the sickness rate of apoplexy, angina pectoris for the highest, and easily disable easily recurrence.Along with improving constantly of human living standard, the increasing day by day of life and work pressure, its incidence rate is the continuous growth and the trend of rejuvenation more and more.
Radix Rhodiolae is Crassulaceae rhodiola (RhodiolaL.) herbaceos perennial, generally is grown in high and cold, dry, anoxia, strong ultraviolet radiation, high height above sea level area that day and night temperature is big, has extremely strong environmental suitability and indomitable vitality.Radix Rhodiolae is with root and rhizome, or with all herbal medicine, so far the medicinal history in existing more than 1000 year.The main effective ingredient of Radix Rhodiolae be salidroside (rhodioside, salidroside) and tyrosol (tyrosol).Rhodioside is a kind of important active component, often estimates the Rhodida plant medical value with its content.Have special roles such as anti-hypoxia, cold resistance, radioprotective, resisting fatigue, enhancing immunity, can be used for senile heart failure, resisting fatigue, calmness, diabetes etc.
Folium Ginkgo is the dried leaves of Ginkgoaceae plant Ginkgo biloba Ginkgo biloba L..Its main component is Ginkgo total flavones and bilobalide, bilobalide have resist myocardial ischemia, cerebral ischemia, atherosclerosis, antihypertensive effect, the heart, cerebral hypoxia ischemia are had protective effect.Modern clinical being mainly used in: (1) cardio-cerebrovascular ischemic diseases; (2) improve organic nervous symptoms; (3) nervus centralis activates, hypermnesis, control senile dementia; (4) peripheral vessel circulatory disturbance.
Do not find Radix Rhodiolae extract and Folium Ginkgo extract compatibility at present as yet, be used for the treatment of the report of cardiovascular and cerebrovascular diseases such as apoplexy, angina pectoris.
Summary of the invention
An object of the present invention is to provide a kind of evident in efficacy, pharmaceutical composition that contains Radix Rhodiolae, Folium Ginkgo extract that side effect is low.
Pharmaceutical composition of the present invention is under Chinese medical theory instructs, in conjunction with the clinical practice experience, adopt the modern pharmaceutical technology to extract and obtain Radix Rhodiolae extract and Folium Ginkgo extract, be mixed with into solid preparation, the ejection preparation of treatment apoplexy, angina pectoris with pharmaceutic adjuvant.The compound preparation that adopts Radix Rhodiolae extract compatibility Folium Ginkgo extract to make can be from aspect performance synergism such as ischemic myocardial protection, the protection of infraction brain cell, PAF antagonisms.
The objective of the invention is to be achieved through the following technical solutions:
Pharmaceutical composition of the present invention is made by the following weight parts drug regimen:
1～20 part of Radix Rhodiolae extract, 1～20 part of Folium Ginkgo extract.
Be preferably: 2～17 parts of Radix Rhodiolae extracts, 2～17 parts of Folium Ginkgo extract.
More preferably: 4～12 parts of Radix Rhodiolae extracts, 4～12 parts of Folium Ginkgo extract.
Described Radix Rhodiolae extract is the extract of the rhodioside content 10% to 50% that obtains from the Radix Rhodiolae raw material; Folium Ginkgo extract is the extract of the bilobalide content 20% to 90% that obtains from the Folium Ginkgo raw material.
Radix Rhodiolae extract of the present invention, Folium Ginkgo extract are that raw medicinal material Radix Rhodiolae, Folium Ginkgo are obtained after the common process technology of this area is extracted.
1, the preparation of Radix Rhodiolae extract:
Radix Rhodiolae raw material appropriateness is pulverized, made solvent with 50～80% alcoholic solution of 5～20 times of amounts, hot reflux (50～90 ℃) 1～3 time each 1～3 hour, is reclaimed ethanol; Extracting solution adds an amount of purified water dilution, leaves standstill, and merge extractive liquid, filters, and suitably concentrates; Concentrated solution is by absorption with macroporous adsorbent resin, and it is colourless to be washed till effluent with distilled water, and the Diluted Alcohol eluting is collected eluent, and decompression recycling ethanol is to there not being the alcohol flavor; Collect eluent, concentrate, drying, Radix Rhodiolae extract, wherein rhodioside content is not less than 10%, handles through twice macroporous resin adsorption again, can obtain rhodioside content and be not less than 50% Radix Rhodiolae extract.
2, the preparation of Folium Ginkgo extract:
The Folium Ginkgo raw material is cataclasm, and 50～100 ℃ 50～70% alcoholic solution that add 5～20 times of amounts are made solvent, extract 1～3 time, each 1～3 hour, reclaim solvent, the filtering medicinal residues; Filtrate is through macroporous resin adsorption, and it is colourless to be washed till effluent with distilled water, and uses the Diluted Alcohol eluting, and decompression recycling ethanol is collected eluent to there not being pure flavor, and through concentrating, drying gets Folium Ginkgo extract, and wherein the content of bilobalide is not less than 20%.Through twice macroporous resin adsorption, the content that can obtain bilobalide is not less than 90% Folium Ginkgo extract again.
Pharmaceutical composition of the present invention can add proper quantity of medicinal auxiliary material, adopts and well known to a person skilled in the art technology, is prepared into any clinical acceptable forms, as: the tablet of oral solid formulation, capsule, granule etc.; The aqueous injection of ejection preparation, injectable powder, infusion solution etc.
1, the raw material of various preparations prescription is formed:
(1) tablet consists of: Radix Rhodiolae extract 1～20 weight portion, Folium Ginkgo extract 1～20 weight portion, pharmaceutic adjuvant 2～100 weight portions.
(2) capsule consists of: Radix Rhodiolae extract 1～20 weight portion, Folium Ginkgo extract 1～20 weight portion, pharmaceutic adjuvant 2～100 weight portions.
(3) granule consists of: Radix Rhodiolae extract 1～20 weight portion, Folium Ginkgo extract 1～20 weight portion, pharmaceutic adjuvant 2～100 weight portions.
(4) aqueous injection consists of: Radix Rhodiolae extract 1～20 weight portion, Folium Ginkgo extract 1～20 weight portion.
(5) injectable powder consists of: Radix Rhodiolae extract 1～20 weight portion, Folium Ginkgo extract 1～20 weight portion, pharmaceutic adjuvant are 2～100 weight portions.
(6) infusion solution consists of: Radix Rhodiolae extract 1～20 weight portion, Folium Ginkgo extract 1～20 weight portion.
2, the preparation of solid preparation:
The preparation of tablet: get Radix Rhodiolae extract, Folium Ginkgo extract and pharmaceutic adjuvant mixing, pulverize, sieve, granulate, drying, tabletting, check, packing, promptly.
The preparation of capsule: get Radix Rhodiolae extract, Folium Ginkgo extract and pharmaceutic adjuvant mixing, pulverize, sieve, granulate, drying is inserted capsule, check, and packing, promptly.
The preparation of granule: get Radix Rhodiolae extract, Folium Ginkgo extract and pharmaceutic adjuvant mixing, pulverize, sieve, granulate, drying, check, packing, promptly.
3, the preparation of injection:
The preparation of aqueous injection: get Radix Rhodiolae extract, Folium Ginkgo extract, with the water for injection dissolving, accent pH value 5～8 filters, sterilization, and check, packing gets aqueous injection.
The preparation of injectable powder: get Radix Rhodiolae extract, Folium Ginkgo extract,, add excipient with the water for injection dissolving, with 0.22 μ m filtering with microporous membrane, lyophilizing, check, packing gets injectable powder.
The preparation of infusion solution: get Radix Rhodiolae extract, Folium Ginkgo extract, with the water for injection dissolving, adding glucose or normal saline are transferred pH value 5～8, filters, and sterilization, check gets infusion solution.
Medicinal adjuvant is one or more a mixture of starch, magnesium stearate, Pulvis Talci, glucose, lactose, sucrose in the preparation of solid preparation.
The excipient of injectable powder is a kind of in mannitol or glucose or the sucrose.
The check and analysis method of each extract in the pharmaceutical composition of the present invention:
1, the check and analysis method of rhodioside
The chromatographic condition chromatographic column: with octadecylsilane chemically bonded silica is filler; Mobile phase: water-methanol-acetonitrile (70: 25: 5); Flow velocity: 0.5ml/min; Detect wavelength 275nm.
The preparation precision of reference substance solution takes by weighing 105 ℃ of rhodioside reference substance 5mg that are dried to constant weight, puts in the 10ml measuring bottle, with dissolve with methanol and be diluted to scale, shakes up, promptly.
The preparation precision of need testing solution takes by weighing 105 ℃ of Radix Rhodiolae extract 10mg that are dried to constant weight and puts in the 10ml measuring bottle, with dissolve with methanol and be diluted to scale, shakes up, promptly.
The algoscopy precision is measured need testing solution and each 20 μ l of reference substance solution, injects chromatograph of liquid respectively, measures.
2, the check and analysis method of bilobalide
Chromatographic condition and system suitability experiment are filler with octadecylsilane chemically bonded silica, with isopropyl alcohol-methanol-water (8: 24: 80) is mobile phase, detect wavelength 220nm, theoretical cam curve should be not less than 7000 by ginkalide B, and ginkalide B and adjacent peak-to-peak separating degree and tailing factor should meet the requirements.
The preparation precision of reference substance solution takes by weighing 105 ℃ of ginkalide A, each 10mg of B reference substance of being dried to constant weight, puts in the 10ml measuring bottle, with 50% acetone solution and be diluted to scale, shakes up, promptly.
The preparation precision of need testing solution takes by weighing 105 ℃ of Folium Ginkgo extract 20mg that are dried to constant weight and puts in the 10ml measuring bottle, with 50% acetone solution and be diluted to scale, shakes up, promptly.
The algoscopy precision is measured need testing solution and each 20 μ l of reference substance solution, injects chromatograph of liquid respectively, measures.
Another object of the present invention provides the application of this pharmaceutical composition in the medicine of preparation treatment cardiovascular and cerebrovascular disease.
Pharmaceutical composition of the present invention has the synergism of aspects such as ischemic myocardial protection, the protection of infraction brain cell, PAF antagonism; evident in efficacy; the pharmacological toxicology test shows that this pharmaceutical composition toxic and side effects is little, safe in utilization, meets medication requirement safely and effectively.
The specific embodiment
Below by test example and embodiment the present invention and beneficial effect thereof are further described.But the present invention is not limited to embodiment, and those of ordinary skills do some modification, all in protection domain of the present invention.
Pharmacological test example 1
Pharmaceutical composition 10mg/kg of the present invention, 30mg/kg, 90mg/kg intravenous injection can make the apoplexy scoring of MCAO rat reduce, and the MCAO infarction size dwindles, and brain water content reduces (P＜0.01), and its action intensity significantly is better than the Ginaton injection.
Pharmacological test example 2
Pharmaceutical composition 10mg/kg of the present invention, 30mg/kg, 90mg/kg intravenous injection can make the interior MDA of cerebral tissue of focal cerebral ischemia rat reperfusion injury, the LA equal size reduces (P＜0.01), shows that cerebral tissue hypoxic-ischemic and peroxidating degree are subjected to obvious inhibition; SOD and GSH content increase (P＜0.01) simultaneously, have reflected that medicine has raising to antioxidant ability of organism and the ability of removing free radical.
Pharmacological test example 3
The cerebral tissue structure of focal cerebral ischemia rat reperfusion injury can be obviously protected in pharmaceutical composition 10mg/kg of the present invention, 30mg/kg, 90mg/kg intravenous injection; the karyopycnosis of cerebral cortex pyramidal cell and brain essence neurocyte, karyolysis degree alleviate than ischemic control is obvious, and softening kitchen range reduces.
Pharmacological test example 4
Pharmaceutical composition 10mg/kg of the present invention, 30mg/kg, 90mg/kg intravenous injection compare with model group that the EEG that can make diffusivity global brain ischemia rat recovers normal time and recovery time is obviously shortened (P＜0.01) in righting reflex, make the azovan blue permeability significantly reduce (P＜0.01).
Pharmacological test example 5
Pharmaceutical composition intravenous injection 8min of the present invention promptly begins onset, and about peak time 20min, the persistent period can reach more than the 100min; And this medicine intramuscular injection onset time 20～25min, about peak time 42min, the persistent period can reach more than the 120min.The intravenous effect of same dosage group is better than intramuscular injection.
Pharmacological test example 6
But pharmaceutical composition 15mg/kg of the present invention, 30mg/kg, the 60mg/kg intravenous injection significant prolongation mice time-to-live (P＜0.01) under anaerobic condition.
Pharmacological test example 7
Pharmaceutical composition 5mg/kg of the present invention, 10mg/kg, 20mg/kg induce the rabbit extracorporeal platelet aggregation that obvious inhibitory action (P＜0.01) is all arranged to PAF, and obvious depolymerisation (P＜0.01) is arranged.To ADP induced platelet aggregation weak (P＜0.05 or P＜0.01), there is not obvious depolymerisation (P＞0.05).Platelet aggregation all had obvious inhibitory action (P＜0.01) in intravenous injection 3mg/kg, 6mg/kg, 12mg/kg carried the inductive rabbit of PAF, and middle and high dosage group also has obvious depolymerisation (P＜0.01).The rabbit platelet number there is not obvious effect (P＞0.05).
Pharmacological test example 8
Pharmaceutical composition 5mg/kg of the present invention, 10mg/kg, 20mg/kg can obviously suppress the thrombosis (P＜0.01) of rabbit artery-vein bypass.
Pharmacological test example 9
Pharmaceutical composition 5mg/kg of the present invention, 15mg/kg, 45mg/kg have obvious thrombolytic effect (P＜0.01) to rat artery-vein bypass thrombosis.
Pharmacological test example 10
Just can obviously suppress PAF after the pharmaceutical composition 8mg/kg of the present invention intravenous injection immediately induces the interior platelet aggregation of rabbit body and obvious depolymerisation is arranged, effect continues 35min, be 5min during its peak, platelet aggregation inhibition rate can reach about 75%, and depolymerization in 1 minute is about 80%.30min can obviously suppress PAF and induces in the rabbit body platelet aggregation and obvious depolymerisation is arranged after the intramuscular injection 20mg/kg administration, continues 70 minutes, is about 42min when playing the peak, and platelet is maximum, and to assemble suppression ratio be about 45%, and the depolymerization rate was about 40% in 1 minute.
The pharmacological results shows; Radix Rhodiolae and Folium Ginkgo extract compatibility; can make this pharmaceutical composition all be better than two kinds of constituents use and commercially available similar medicine separately from aspect synergism such as ischemic myocardial protection, the protection of infraction brain cell, PAF antagonisms in curative effect and safety aspect the diseases such as treatment apoplexy, angina pectoris.
Embodiment 1
(1) preparation of Radix Rhodiolae extract: Radix Rhodiolae raw material appropriateness is pulverized, selected for use the alcoholic solution of solvent 70%, consumption is 8 times, hot reflux (80 ℃) 3 times, each 2 hours, reclaim ethanol, extracting solution adds an amount of purified water dilution, leaves standstill, merge extractive liquid, filters, and suitably concentrates, concentrated solution is by absorption with macroporous adsorbent resin, and it is colourless to be washed till effluent with distilled water, the Diluted Alcohol eluting, collect eluent, decompression recycling ethanol is collected eluent to there not being the alcohol flavor, concentrate, drying gets Radix Rhodiolae extract.
(2) preparation of Folium Ginkgo extract: the Folium Ginkgo raw material is cataclasm, and the concentration that adds an amount of temperature and be 80 ℃ is that 65% alcoholic solution extracts 2 times, and solvent load is 6 times, each 2 hours, reclaim solvent, the filtering medicinal residues, last 724 absorption with macroporous adsorbent resin of filtrate, it is colourless to be washed till effluent with distilled water, and uses the Diluted Alcohol eluting, and decompression recycling ethanol is to there not being the alcohol flavor, collect eluent, through concentrating, drying gets Folium Ginkgo extract.
(3) preparation of solid preparation:
The preparation of tablet: Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 25 grams, pharmaceutic adjuvant starch, magnesium stearate 125 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, tabletting, check, packing gets 1000 in tablet.
The preparation of capsule: Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 25 grams, pharmaceutic adjuvant starch 125 grams.Mix homogeneously, pulverizing is sieved, and granulates, and drying is inserted capsule, check, packing gets 1000 of capsules.
The preparation of granule: Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 25 grams, pharmaceutic adjuvant starch, sucrose 125 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, check, packing gets 1000 bags of granules.
(4) preparation of ejection preparation:
The preparation of aqueous injection: get Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 25 grams, with the water for injection dissolving, accent pH value to 6 filters, sterilization, check, packing gets 1000 of aqueous injection.
The preparation of injectable powder: get Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 25 grams dissolve with water for injection, add excipient mannitol 125 grams, with 0.22 μ m filtering with microporous membrane, lyophilizing, and check, packing gets 1000 of injectable powder.
The preparation of infusion solution: get Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 25 grams with the water for injection dissolving, add glucose, and accent pH value to 6 filters, sterilization, and check, packing gets 500 bottles of infusion solutions.
Embodiment 2
(1) preparation of Radix Rhodiolae extract: Radix Rhodiolae raw material appropriateness is pulverized, selected for use the alcoholic solution of solvent 65%, consumption is 6 times, hot reflux (85 ℃) 2 times, each 2 hours, reclaim ethanol, extracting solution adds an amount of purified water dilution, leaves standstill, merge extractive liquid, filters, and suitably concentrates, concentrated solution is by absorption with macroporous adsorbent resin, and it is colourless to be washed till effluent with distilled water, the Diluted Alcohol eluting, collect eluent, decompression recycling ethanol is collected eluent to there not being the alcohol flavor, concentrate, drying gets Radix Rhodiolae extract.
(2) preparation of Folium Ginkgo extract: the Folium Ginkgo raw material is cataclasm, and the concentration that adds an amount of temperature and be 70 ℃ is that 50% alcoholic solution extracts 2 times, and solvent load is 10 times, each 3 hours, reclaim solvent, the filtering medicinal residues, suitably concentrate, last 724 absorption with macroporous adsorbent resin of filtrate, it is colourless to be washed till effluent with distilled water, and use the Diluted Alcohol eluting, decompression recycling ethanol is collected eluent to there not being the alcohol flavor, through concentrating, drying gets Folium Ginkgo extract.
(3) preparation of solid preparation:
The preparation of tablet: Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 50 grams, pharmaceutic adjuvant starch, magnesium stearate 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, tabletting, check, packing gets 1000 in tablet.
The preparation of capsule: Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 50 grams, pharmaceutic adjuvant starch 100 grams.Mix homogeneously, pulverizing is sieved, and granulates, and drying is inserted capsule, check, packing gets 1000 of capsules.
The preparation of granule: Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 50 grams, pharmaceutic adjuvant starch, sucrose 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, check, packing gets 1000 bags of granules.
(4) preparation of ejection preparation:
The preparation of aqueous injection: get Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 50 grams, with the water for injection dissolving, accent pH value to 6 filters, sterilization, check, packing gets 1000 of aqueous injection.
The preparation of injectable powder: get Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 50 grams dissolve with water for injection, add excipient mannitol 100 grams, with 0.22 μ m filtering with microporous membrane, lyophilizing, and check, packing gets 1000 of injectable powder.
The preparation of infusion solution: get Radix Rhodiolae extract 50 grams, Folium Ginkgo extract 50 grams with the water for injection dissolving, add glucose, and accent pH value to 6 filters, sterilization, and check, packing gets 500 bottles of infusion solutions.
Embodiment 3
(1) preparation of Radix Rhodiolae extract: Radix Rhodiolae raw material appropriateness is pulverized, selected for use the alcoholic solution of solvent 75%, consumption is 10 times, hot reflux (70 ℃) 2 times, each 3 hours, reclaim ethanol, extracting solution adds an amount of purified water dilution, leaves standstill, merge extractive liquid, filters, and suitably concentrates, concentrated solution is by absorption with macroporous adsorbent resin, and it is colourless to be washed till effluent with distilled water, the Diluted Alcohol eluting, collect eluent, decompression recycling ethanol is collected eluent to there not being the alcohol flavor, concentrate, drying gets Radix Rhodiolae extract.
(2) preparation of Folium Ginkgo extract: the Folium Ginkgo raw material is cataclasm, and the concentration that adds an amount of temperature and be 75 ℃ is that 60% alcoholic solution extracts 2 times, and solvent load is 10 times, each 2 hours, reclaim solvent, the filtering medicinal residues, last 724 absorption with macroporous adsorbent resin of filtrate, it is colourless to be washed till effluent with distilled water, and uses the Diluted Alcohol eluting, and decompression recycling ethanol is to there not being the alcohol flavor, collect eluent, through concentrating, drying gets Folium Ginkgo extract.
(3) preparation of solid preparation:
The preparation of tablet: Radix Rhodiolae extract 75 grams, Folium Ginkgo extract 25 grams, pharmaceutic adjuvant starch, magnesium stearate 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, tabletting, check, packing gets 1000 in tablet.
The preparation of capsule: Radix Rhodiolae extract 75 grams, Folium Ginkgo extract 25 grams, pharmaceutic adjuvant starch 100 grams.Mix homogeneously, pulverizing is sieved, and granulates, and drying is inserted capsule, check, packing gets 1000 of capsules.
The preparation of granule: Radix Rhodiolae extract 75 grams, Folium Ginkgo extract 25 grams, pharmaceutic adjuvant starch, sucrose 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, check, packing gets 1000 bags of granules.
(4) preparation of ejection preparation:
The preparation of aqueous injection: get Radix Rhodiolae extract 75 grams, Folium Ginkgo extract 25 grams, with the water for injection dissolving, accent pH value to 6 filters, sterilization, check, packing gets 1000 of aqueous injection.
The preparation of injectable powder: get Radix Rhodiolae extract 75 grams, Folium Ginkgo extract 25 grams dissolve with water for injection, add excipient mannitol 100 grams, with 0.22 μ m filtering with microporous membrane, lyophilizing, and check, packing gets 1000 of injectable powder.
The preparation of infusion solution: get Radix Rhodiolae extract 75 grams, Folium Ginkgo extract 25 grams with the water for injection dissolving, add glucose, and accent pH value to 6 filters, sterilization, and check, packing gets 500 bottles of infusion solutions.
Embodiment 4
(1) preparation of Radix Rhodiolae extract: Radix Rhodiolae raw material appropriateness is pulverized, selected for use the alcoholic solution of solvent 70%, consumption is 12 times, hot reflux (80 ℃) 3 times, each 3 hours, reclaim ethanol, extracting solution adds an amount of purified water dilution, leaves standstill, merge extractive liquid, filters, and suitably concentrates, concentrated solution is by absorption with macroporous adsorbent resin, and it is colourless to be washed till effluent with distilled water, the Diluted Alcohol eluting, collect eluent, decompression recycling ethanol is collected eluent to there not being the alcohol flavor, concentrate, drying gets Radix Rhodiolae extract.
(2) preparation of Folium Ginkgo extract: the Folium Ginkgo raw material is cataclasm, and the concentration that adds an amount of temperature and be 80 ℃ is that 65% alcoholic solution extracts 3 times, and solvent load is 8 times, each 3 hours, reclaim solvent, the filtering medicinal residues, last 724 absorption with macroporous adsorbent resin of filtrate, it is colourless to be washed till effluent with distilled water, and uses the Diluted Alcohol eluting, and decompression recycling ethanol is to there not being the alcohol flavor, collect eluent, through concentrating, drying gets Folium Ginkgo extract.
(3) preparation of solid preparation:
The preparation of tablet: Radix Rhodiolae extract 25 grams, Folium Ginkgo extract 75 grams, pharmaceutic adjuvant starch, magnesium stearate 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, tabletting, check, packing gets 1000 in tablet.
The preparation of capsule: Radix Rhodiolae extract 25 grams, Folium Ginkgo extract 75 grams, pharmaceutic adjuvant starch 100 grams.Mix homogeneously, pulverizing is sieved, and granulates, and drying is inserted capsule, check, packing gets 1000 of capsules.
The preparation of granule: Radix Rhodiolae extract 25 grams, Folium Ginkgo extract 75 grams, pharmaceutic adjuvant starch, sucrose are 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, check, packing gets 1000 bags of granules.
(4) preparation of ejection preparation:
The preparation of aqueous injection: get Radix Rhodiolae extract 25 grams, Folium Ginkgo extract 75 grams, with the water for injection dissolving, accent pH value to 7 filters, sterilization, check, packing gets 1000 of aqueous injection.
The preparation of injectable powder: get Radix Rhodiolae extract 25 grams, Folium Ginkgo extract 75 grams dissolve with water for injection, add excipient mannitol 100 grams, with 0.22 μ m filtering with microporous membrane, lyophilizing, and check, packing gets 1000 of injectable powder.
The preparation of infusion solution: get Radix Rhodiolae extract 25 grams, Folium Ginkgo extract 75 grams with the water for injection dissolving, add glucose, and accent pH value to 7 filters, sterilization, and check, packing gets 500 bottles of infusion solutions.
Embodiment 5
(1) preparation of Radix Rhodiolae extract, Folium Ginkgo extract is identical with embodiment 1-4.
(2) preparation of solid preparation:
The preparation of tablet: Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 200 grams, pharmaceutic adjuvant starch, magnesium stearate 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, tabletting, check, packing gets 1000 in tablet.
The preparation of capsule: Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 200 grams, pharmaceutic adjuvant starch 100 grams.Mix homogeneously, pulverizing is sieved, and granulates, and drying is inserted capsule, check, packing gets 1000 of capsules.
The preparation of granule: Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 200 grams, pharmaceutic adjuvant starch, sucrose 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, check, packing gets 1000 bags of granules.
(3) preparation of ejection preparation:
The preparation of aqueous injection: get Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 200 grams, with the water for injection dissolving, accent pH value to 7 filters, sterilization, check, packing gets 1000 of aqueous injection.
The preparation of injectable powder: get Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 200 grams dissolve with water for injection, add excipient mannitol 100 grams, with 0.22 μ m filtering with microporous membrane, lyophilizing, and check, packing gets 1000 of injectable powder.
The preparation of infusion solution: get Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 200 grams with the water for injection dissolving, add glucose, and accent pH value to 7 filters, sterilization, and check, packing gets 500 bottles of infusion solutions.
Embodiment 6
(1) preparation of Radix Rhodiolae extract, Folium Ginkgo extract is identical with embodiment 1-4.
(2) preparation of solid preparation:
The preparation of tablet: Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 150 grams, pharmaceutic adjuvant starch, magnesium stearate 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, tabletting, check, packing gets 1000 in tablet.
The preparation of capsule: Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 150 grams, pharmaceutic adjuvant starch 100 grams.Mix homogeneously, pulverizing is sieved, and granulates, and drying is inserted capsule, check, packing gets 1000 of capsules.
The preparation of granule: Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 150 grams, pharmaceutic adjuvant starch, sucrose 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, check, packing gets 1000 bags of granules.
(3) preparation of ejection preparation:
The preparation of aqueous injection: get Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 150 grams, with the water for injection dissolving, accent pH value to 7 filters, sterilization, check, packing gets 1000 of aqueous injection.
The preparation of injectable powder: get Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 150 grams dissolve with water for injection, add excipient mannitol 100 grams, with 0.22 μ m filtering with microporous membrane, lyophilizing, and check, packing gets 1000 of injectable powder.
The preparation of infusion solution: get Radix Rhodiolae extract 10 grams, Folium Ginkgo extract 150 grams with the water for injection dissolving, add glucose, and accent pH value to 7 filters, sterilization, and check, packing gets 500 bottles of infusion solutions.
Embodiment 7
(1) preparation of Radix Rhodiolae extract, Folium Ginkgo extract is identical with embodiment 1-4.
(2) preparation of solid preparation:
The preparation of tablet: Radix Rhodiolae extract 160 grams, Folium Ginkgo extract 15 grams, pharmaceutic adjuvant starch, magnesium stearate 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, tabletting, check, packing gets 1000 in tablet.
The preparation of capsule: Radix Rhodiolae extract 160 grams, Folium Ginkgo extract 15 grams, pharmaceutic adjuvant starch 100 grams.Mix homogeneously, pulverizing is sieved, and granulates, and drying is inserted capsule, check, packing gets 1000 of capsules.
The preparation of granule: Radix Rhodiolae extract 160 grams, Folium Ginkgo extract 15 grams, pharmaceutic adjuvant starch, sucrose 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, check, packing gets 1000 bags of granules.
(3) preparation of ejection preparation:
The preparation of aqueous injection: get Radix Rhodiolae extract 160 grams, Folium Ginkgo extract 15 grams, with the water for injection dissolving, accent pH value to 7 filters, sterilization, check, packing gets 1000 of aqueous injection.
The preparation of injectable powder: get Radix Rhodiolae extract 160 grams, Folium Ginkgo extract 15 grams dissolve with water for injection, add excipient mannitol 100 grams, with 0.22 μ m filtering with microporous membrane, lyophilizing, and check, packing gets 1000 of injectable powder.
The preparation of infusion solution: get Radix Rhodiolae extract 160 grams, Folium Ginkgo extract 15 grams with the water for injection dissolving, add glucose, and accent pH value to 7 filters, sterilization, and check, packing gets 500 bottles of infusion solutions.
Embodiment 8
(1) preparation of Radix Rhodiolae extract, Folium Ginkgo extract is identical with embodiment 1-4.
(2) preparation of solid preparation:
The preparation of tablet: Radix Rhodiolae extract 200 grams, Folium Ginkgo extract 10 grams, pharmaceutic adjuvant starch, magnesium stearate 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, tabletting, check, packing gets 1000 in tablet.
The preparation of capsule: Radix Rhodiolae extract 200 grams, Folium Ginkgo extract 10 grams, pharmaceutic adjuvant starch 100 grams.Mix homogeneously, pulverizing is sieved, and granulates, and drying is inserted capsule, check, packing gets 1000 of capsules.
The preparation of granule: Radix Rhodiolae extract 200 grams, Folium Ginkgo extract 10 grams, pharmaceutic adjuvant starch, sucrose 100 grams.Mix homogeneously is pulverized, and sieves, granulate, and drying, check, packing gets 1000 bags of granules.
(3) preparation of ejection preparation:
The preparation of aqueous injection: get Radix Rhodiolae extract 200 grams, Folium Ginkgo extract 10 grams, with the water for injection dissolving, accent pH value to 7 filters, sterilization, check, packing gets 1000 of aqueous injection.
The preparation of injectable powder: get Radix Rhodiolae extract 200 grams, Folium Ginkgo extract 10 grams dissolve with water for injection, add excipient mannitol 100 grams, with 0.22 μ m filtering with microporous membrane, lyophilizing, and check, packing gets 1000 of injectable powder.
The preparation of infusion solution: get Radix Rhodiolae extract 200 grams, Folium Ginkgo extract 10 grams with the water for injection dissolving, add glucose, and accent pH value to 7 filters, sterilization, and check, packing gets 500 bottles of infusion solutions.
Claims (7)
1, a kind of pharmaceutical composition that contains Radix Rhodiolae, Folium Ginkgo extract is characterized in that this pharmaceutical composition is to be made by the following weight parts drug regimen:
1～20 part of Radix Rhodiolae extract, 1～20 part of Folium Ginkgo extract.
2, a kind of pharmaceutical composition according to claim 1 is characterized in that this pharmaceutical composition is to be made by the following weight parts drug regimen:
2～17 parts of Radix Rhodiolae extracts, 2～17 parts of Folium Ginkgo extract.
3, a kind of pharmaceutical composition according to claim 1 is characterized in that this pharmaceutical composition is to be made by the following weight parts drug regimen:
4～12 parts of Radix Rhodiolae extracts, 4～12 parts of Folium Ginkgo extract.
4,, it is characterized in that described Radix Rhodiolae extract is the extract of the rhodioside content 10% to 50% that obtains from the Radix Rhodiolae raw material according to the described pharmaceutical composition of claim 1 to 3.
5,, it is characterized in that described Folium Ginkgo extract is the extract of the bilobalide content 20% to 90% that obtains from the Folium Ginkgo raw material according to the described pharmaceutical composition of claim 1 to 3.
6, according to the described pharmaceutical composition of claim 1 to 3, it is characterized in that this pharmaceutical composition can add proper quantity of medicinal auxiliary material, make any clinical acceptable forms: the tablet of oral solid formulation, capsule, granule: the aqueous injection of ejection preparation, injectable powder, infusion solution.
7, the described pharmaceutical composition of claim 1 is in preparation treatment apoplexy, coronary heart disease and angina.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510119026 CN1977876A (en) | 2005-11-29 | 2005-11-29 | Medicinal composition containing rhodiola and ginkgo leaf, and its use |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510119026 CN1977876A (en) | 2005-11-29 | 2005-11-29 | Medicinal composition containing rhodiola and ginkgo leaf, and its use |
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| CN 200510119026 Pending CN1977876A (en) | 2005-11-29 | 2005-11-29 | Medicinal composition containing rhodiola and ginkgo leaf, and its use |
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| WO2010119346A2 (en) * | 2009-04-17 | 2010-10-21 | Integrated Chinese Medicine Holdings Ltd. | Herbal compositions and methods for enhancing vital energy and athletic performance |
| CN102670693A (en) * | 2012-05-10 | 2012-09-19 | 哈尔滨珍宝制药有限公司 | Application of integripetal rhodiola herb and ginkgo leaf composition to preparation of anti-hypoxia medicament or health-care food |
| CN104225286A (en) * | 2013-06-24 | 2014-12-24 | 山东明仁福瑞达制药股份有限公司 | Traditional Chinese medicine preparation for treating hypertension and preventing stroke and preparation method of traditional Chinese medicine preparation |
| CN105166085A (en) * | 2015-07-08 | 2015-12-23 | 蚌埠市江淮粮油有限公司 | Antioxidant health rice bran oil and preparation method thereof |
| CN105380985A (en) * | 2016-01-22 | 2016-03-09 | 陈淼 | Medicinal composition for treating cerebral ischemic stoke |
| CN108013450A (en) * | 2017-12-01 | 2018-05-11 | 绵阳正耀久生物科技有限公司 | It is a kind of that there are the health products for improving immune function |
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2005
- 2005-11-29 CN CN 200510119026 patent/CN1977876A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7906159B2 (en) | 2008-04-17 | 2011-03-15 | Vivien Chou | Herbal compositions and methods for enhancing vital energy and athletic performance |
| US8119170B2 (en) | 2008-04-17 | 2012-02-21 | Wen Hsien Chou | Herbal compositions and methods for enhancing vital energy and athletic performance |
| WO2010119346A2 (en) * | 2009-04-17 | 2010-10-21 | Integrated Chinese Medicine Holdings Ltd. | Herbal compositions and methods for enhancing vital energy and athletic performance |
| WO2010119346A3 (en) * | 2009-04-17 | 2010-12-02 | Integrated Chinese Medicine Holdings Ltd. | Herbal compositions and methods for enhancing vital energy and athletic performance |
| CN102670693A (en) * | 2012-05-10 | 2012-09-19 | 哈尔滨珍宝制药有限公司 | Application of integripetal rhodiola herb and ginkgo leaf composition to preparation of anti-hypoxia medicament or health-care food |
| CN104225286A (en) * | 2013-06-24 | 2014-12-24 | 山东明仁福瑞达制药股份有限公司 | Traditional Chinese medicine preparation for treating hypertension and preventing stroke and preparation method of traditional Chinese medicine preparation |
| CN105166085A (en) * | 2015-07-08 | 2015-12-23 | 蚌埠市江淮粮油有限公司 | Antioxidant health rice bran oil and preparation method thereof |
| CN105380985A (en) * | 2016-01-22 | 2016-03-09 | 陈淼 | Medicinal composition for treating cerebral ischemic stoke |
| CN105380985B (en) * | 2016-01-22 | 2020-08-11 | 陈淼 | Pharmaceutical composition for treating cerebral arterial thrombosis |
| CN108013450A (en) * | 2017-12-01 | 2018-05-11 | 绵阳正耀久生物科技有限公司 | It is a kind of that there are the health products for improving immune function |
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Open date: 20070613 |