CN102656282B - 用于控制生物反应器中的培养参数的方法 - Google Patents

用于控制生物反应器中的培养参数的方法 Download PDF

Info

Publication number
CN102656282B
CN102656282B CN201080058768.4A CN201080058768A CN102656282B CN 102656282 B CN102656282 B CN 102656282B CN 201080058768 A CN201080058768 A CN 201080058768A CN 102656282 B CN102656282 B CN 102656282B
Authority
CN
China
Prior art keywords
bioreactor
information
bag
control unit
parameter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201080058768.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN102656282A (zh
Inventor
K.格鲍尔
E.林德斯科格
L.马格努森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
GE Healthcare Bio Sciences AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44196030&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102656282(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GE Healthcare Bio Sciences AB filed Critical GE Healthcare Bio Sciences AB
Publication of CN102656282A publication Critical patent/CN102656282A/zh
Application granted granted Critical
Publication of CN102656282B publication Critical patent/CN102656282B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Computer Hardware Design (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201080058768.4A 2009-12-22 2010-12-20 用于控制生物反应器中的培养参数的方法 Active CN102656282B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0951006-6 2009-12-22
SE0951006 2009-12-22
PCT/SE2010/051425 WO2011078773A1 (en) 2009-12-22 2010-12-20 A method for controlling culture parameters in a bioreactor

Publications (2)

Publication Number Publication Date
CN102656282A CN102656282A (zh) 2012-09-05
CN102656282B true CN102656282B (zh) 2015-09-02

Family

ID=44196030

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080058768.4A Active CN102656282B (zh) 2009-12-22 2010-12-20 用于控制生物反应器中的培养参数的方法

Country Status (7)

Country Link
US (1) US20120258441A1 (https=)
EP (1) EP2516682B1 (https=)
JP (1) JP6169847B2 (https=)
CN (1) CN102656282B (https=)
CA (1) CA2784519A1 (https=)
IN (1) IN2012DN05207A (https=)
WO (1) WO2011078773A1 (https=)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10914698B2 (en) 2006-11-16 2021-02-09 General Electric Company Sensing method and system
US10260388B2 (en) 2006-11-16 2019-04-16 General Electric Company Sensing system and method
US10018613B2 (en) 2006-11-16 2018-07-10 General Electric Company Sensing system and method for analyzing a fluid at an industrial site
US9536122B2 (en) 2014-11-04 2017-01-03 General Electric Company Disposable multivariable sensing devices having radio frequency based sensors
US9538657B2 (en) 2012-06-29 2017-01-03 General Electric Company Resonant sensor and an associated sensing method
US9658178B2 (en) 2012-09-28 2017-05-23 General Electric Company Sensor systems for measuring an interface level in a multi-phase fluid composition
US9589686B2 (en) 2006-11-16 2017-03-07 General Electric Company Apparatus for detecting contaminants in a liquid and a system for use thereof
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
US8542023B2 (en) 2010-11-09 2013-09-24 General Electric Company Highly selective chemical and biological sensors
US8365462B2 (en) 2011-05-31 2013-02-05 Heliae Development, Llc V-Trough photobioreactor systems
USD682637S1 (en) 2011-06-10 2013-05-21 Heliae Development, Llc Aquaculture vessel
USD679965S1 (en) 2011-06-10 2013-04-16 Heliae Development, Llc Aquaculture vessel
USD661164S1 (en) 2011-06-10 2012-06-05 Heliae Development, Llc Aquaculture vessel
US10598650B2 (en) 2012-08-22 2020-03-24 General Electric Company System and method for measuring an operative condition of a machine
JP6251270B2 (ja) 2012-08-22 2017-12-20 ゼネラル・エレクトリック・カンパニイ 機械の動作状態を測定するためのワイヤレスシステムおよび方法
JPWO2014033889A1 (ja) * 2012-08-31 2016-08-08 株式会社日立製作所 自動培養装置及び自動培養方法
US10684268B2 (en) 2012-09-28 2020-06-16 Bl Technologies, Inc. Sensor systems for measuring an interface level in a multi-phase fluid composition
EP3011007B1 (en) * 2013-06-17 2020-07-29 GE Healthcare Bio-Sciences AB Bioreactor system with a temperature sensor
WO2014204383A1 (en) 2013-06-17 2014-12-24 Ge Healthcare Bio-Sciences Ab A temperature sensor means and a bioreactor system comprising a temperature sensor means
BR122022000294B1 (pt) 2014-03-21 2022-08-16 Life Technologies Corporation Montagem de filtragem e método para filtrar um gás
JP6585615B2 (ja) 2014-03-21 2019-10-02 ライフ テクノロジーズ コーポレイション 流体処理システムのための凝縮器システム
US9617566B2 (en) * 2014-07-11 2017-04-11 Lanzatech New Zealand Limited Control of bioreactor processes
US9457306B2 (en) 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
CN107075439B (zh) * 2014-10-23 2020-09-01 通用电气健康护理生物科学股份公司 生物反应器系统
EP3253863B1 (en) * 2015-02-05 2019-07-10 General Electric Company Bioreactor system for cell cultivation
CN108138114B (zh) * 2015-08-25 2022-03-22 环球生命科技咨询美国有限责任公司 在生物制造设备中和涉及其的改进
WO2017032829A1 (en) * 2015-08-25 2017-03-02 General Electric Company Improvements in and relating to biomanufacturing apparatus
CN108138116A (zh) * 2015-08-25 2018-06-08 通用电气公司 在生物制造设备中和涉及其的改进
US10995310B2 (en) 2015-08-25 2021-05-04 Global Life Sciences Solutions Usa Llc Biomanufacturing apparatus
US9920292B2 (en) * 2015-08-31 2018-03-20 General Electric Company System and method for initiating a cell culture
WO2017116910A1 (en) 2015-12-29 2017-07-06 Life Technologies Corporation Flexible bioprocessing container with partial dividing partition
JP7364334B2 (ja) * 2016-06-24 2023-10-18 ロンザ リミテッド 直径可変型バイオリアクタ
JP6207708B2 (ja) * 2016-10-18 2017-10-04 株式会社日立製作所 自動培養装置、及び細胞培養方法
US12344829B2 (en) 2016-10-28 2025-07-01 Global Life Sciences Solutions Usa Llc Bioreactor tray
US11525113B2 (en) 2016-10-31 2022-12-13 Global Life Sciences Solutions Usa Llc Bioreactor assembly
CN110574117B (zh) * 2017-04-28 2024-02-13 思拓凡瑞典有限公司 用于创建可重新配置生物处理工作流程的方法和系统
WO2018197274A1 (en) 2017-04-28 2018-11-01 Ge Healthcare Bio-Sciences Ab System and method for enabling a single use wireless sensor by optimizing electrical power
WO2018197275A1 (en) 2017-04-28 2018-11-01 Ge Healthcare Bio-Sciences Ab System and method for wirelessly powering a sensor in a bio-processing environment
CN108795754A (zh) * 2018-04-23 2018-11-13 苏州欧飞纳米科技有限公司 生物反应器培养参数的控制系统及方法
GB201810772D0 (en) * 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
EP3985097A1 (en) * 2020-10-14 2022-04-20 Sartorius Stedim Biotech GmbH A method and system for configuring and/or setup of a downstream process for processing a biomass
WO2022202734A1 (ja) * 2021-03-26 2022-09-29 テルモ株式会社 細胞培養システム
GB2616451B (en) * 2022-03-09 2024-11-27 Oribiotech Ltd A cell processing system for housing a bioreactor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009002772A3 (en) * 2007-06-22 2009-03-05 Algaedyne Corportion Bioreactor

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6029101A (en) 1996-11-18 2000-02-22 Scius Corporation Process control system user interface
US6673008B1 (en) * 1998-04-28 2004-01-06 Ronald J. Thompson Fallopian tube and method of in vitro fertilization and embryo development
JP2000121511A (ja) * 1998-10-13 2000-04-28 Hitachi Koki Co Ltd 自動分離抽出装置及びその制御方法
EP1295393A2 (en) * 2000-06-13 2003-03-26 Azoteq (PTY) Limited Intelligent switch for connecting power to a load
US6934861B2 (en) * 2001-11-06 2005-08-23 Crosscheck Identification Systems International, Inc. National identification card system and biometric identity verification method for negotiating transactions
US6997043B2 (en) * 2002-08-15 2006-02-14 The Boeing Company Integration of atmospheric intrusion sensors in electronic component packages
US7604987B2 (en) * 2003-02-06 2009-10-20 National University Of Singapore Bioreactor for growing cell or tissue cultures
US20050051723A1 (en) * 2003-07-23 2005-03-10 Neagle Bradley D. Examination systems for biological samples
US20050015884A1 (en) * 2003-07-23 2005-01-27 Conaway Kenneth L. Self-interlocking resinous frame for sleeping mattresses
US7435581B2 (en) 2003-11-26 2008-10-14 Broadley-James Corporation Integrated bio-reactor monitor and control system
NZ551640A (en) * 2004-05-20 2010-05-28 Id Biomedical Corp Process for the production of an influenza vaccine
EP1602715B1 (en) * 2004-06-02 2008-06-11 Millipore Corporation Disposable bioreactor
MXPA06014099A (es) * 2004-06-04 2007-05-09 Xcellerex Inc Sistemas biorreactores desechables y metodos.
US7771988B2 (en) * 2005-03-24 2010-08-10 Hitachi, Ltd. Control device for fermenter
US20060275858A1 (en) * 2005-06-02 2006-12-07 Saucedo Victor M Optimization of Process Variables in Oxygen Enriched Fermentors Through Process Controls
WO2007052716A1 (ja) 2005-11-01 2007-05-10 Medinet Co., Ltd. 細胞培養装置、細胞培養方法、細胞培養プログラム、及び細胞培養システム
SG176507A1 (en) * 2006-05-13 2011-12-29 Advanced Tech Materials Disposable bioreactor
EP2027247B1 (en) * 2006-05-22 2011-01-26 Biovest International, Inc. Extra-capillary fluid cycling system and method
WO2008106193A1 (en) 2007-02-28 2008-09-04 Xcellerex, Inc. Weight measurements of liquids in flexible containers
US20100203624A1 (en) * 2007-09-26 2010-08-12 Ge Healthcare Bioscience Bioprocess Corp. Three dimensional disposable bioreactor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009002772A3 (en) * 2007-06-22 2009-03-05 Algaedyne Corportion Bioreactor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
生物反应器与相关生物工程探讨;王洪跃等;《中国医药生物技术》;20090430;第4卷(第2期);第158-159页 *

Also Published As

Publication number Publication date
EP2516682B1 (en) 2020-02-26
JP6169847B2 (ja) 2017-07-26
US20120258441A1 (en) 2012-10-11
EP2516682A1 (en) 2012-10-31
EP2516682A4 (en) 2016-07-13
CA2784519A1 (en) 2011-06-30
WO2011078773A1 (en) 2011-06-30
CN102656282A (zh) 2012-09-05
IN2012DN05207A (https=) 2015-10-23
JP2013514804A (ja) 2013-05-02

Similar Documents

Publication Publication Date Title
CN102656282B (zh) 用于控制生物反应器中的培养参数的方法
Klöckner et al. Correlation between mass transfer coefficient kLa and relevant operating parameters in cylindrical disposable shaken bioreactors on a bench-to-pilot scale
Stettler et al. Novel orbital shake bioreactors for transient production of CHO derived IgGs
US20230123126A1 (en) Control Systems For A Fluid Mixing Apparatus
Sagmeister et al. Soft sensor assisted dynamic bioprocess control: Efficient tools for bioprocess development
EP3839036A1 (en) A digital twin for monitoring and controlling an industrial bioprocess
De Wilde et al. Superior scalability of single-use bioreactors
US11603517B2 (en) Method for monitoring a biotechnological process
JP7338971B2 (ja) バイオリアクターにおける状態逸脱のモニタリング
CN100342021C (zh) 发酵工艺的最优化
Bonvillani et al. Theoretical and experimental study of the effects of scale-up on mixing time for a stirred-tank bioreactor
Obom et al. Operation of a benchtop bioreactor
Dewasme et al. Linear robust control of S. cerevisiae fed-batch cultures at different scales
Schmid et al. Benchtop bioreactors in mammalian cell culture: overview and guidelines
Seletzky et al. An experimental comparison of respiration measuring techniques in fermenters and shake flasks: exhaust gas analyzer vs. RAMOS device vs. respirometer
US11773358B2 (en) Method for controlling culture parameters in a bioreactor
Wu et al. Modelling and simulation of a U-loop reactor for single cell protein production
JP2014528246A (ja) 流体処理制御システムおよび対応する方法
Amicarelli et al. Including dissolved oxygen dynamics into the Bt δ-endotoxins production process model and its application to process control
Dorceus Cell culture scale-up in stirred-tank single-use bioreactors
Yu et al. A 3D analysis of oxygen transfer in a low-cost micro-bioreactor for animal cell suspension culture
Maischberger Optimized process and bioreactor characterization
Warr Microbioreactors and scale-down models: Growth of CHO cells using the Pall Micro24 MicroReactor system
Julien et al. Getting the most from your bioreactor
Chen et al. Anaerobic yeast fermentation for the production of ethanol in a versatile lab fermentor

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CP01 Change in the name or title of a patent holder
CP01 Change in the name or title of a patent holder

Address after: uppsala

Patentee after: Stoivan Sweden Limited

Address before: uppsala

Patentee before: GE HEALTHCARE BIO-SCIENCES AB