CN102648279B - 用于治疗药物诱发的手足综合征的组合物与方法 - Google Patents

用于治疗药物诱发的手足综合征的组合物与方法 Download PDF

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Publication number
CN102648279B
CN102648279B CN201080057133.2A CN201080057133A CN102648279B CN 102648279 B CN102648279 B CN 102648279B CN 201080057133 A CN201080057133 A CN 201080057133A CN 102648279 B CN102648279 B CN 102648279B
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ppe
drug
patient
phosphodiesterase inhibitor
use according
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Chinese (zh)
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CN102648279A (zh
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H.赫维茨
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Duke University
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Duke University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080057133.2A 2009-10-16 2010-10-15 用于治疗药物诱发的手足综合征的组合物与方法 Active CN102648279B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27909109P 2009-10-16 2009-10-16
US61/279091 2009-10-16
PCT/US2010/052836 WO2011047256A1 (en) 2009-10-16 2010-10-15 Compositions and methods for the treatment of drug-induced hand-foot syndrome

Publications (2)

Publication Number Publication Date
CN102648279A CN102648279A (zh) 2012-08-22
CN102648279B true CN102648279B (zh) 2015-11-25

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CN201080057133.2A Active CN102648279B (zh) 2009-10-16 2010-10-15 用于治疗药物诱发的手足综合征的组合物与方法

Country Status (6)

Country Link
US (2) US9220713B2 (https=)
EP (1) EP2488642B1 (https=)
JP (2) JP2013508295A (https=)
CN (1) CN102648279B (https=)
AU (1) AU2010306671B2 (https=)
WO (1) WO2011047256A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2488642B1 (en) * 2009-10-16 2015-03-11 Duke University Compositions and methods for the treatment of drug-induced hand-foot syndrome
US20140127295A1 (en) * 2011-03-14 2014-05-08 Cellworks Group, Inc Compositions, process of preparation of said compositions and method of treating inflammatory diseases
CA2914815A1 (en) * 2013-06-11 2014-12-18 Kala Pharmaceuticals, Inc. Urea derivatives and uses thereof
WO2016144230A1 (en) * 2015-03-06 2016-09-15 Telefonaktiebolaget Lm Ericsson (Publ) Method, network device, computer program and computer program product for mobile service chaining
EP3444337B1 (en) * 2017-08-18 2024-12-18 The Procter & Gamble Company Method of cleaning
WO2019114705A1 (zh) 2017-12-13 2019-06-20 上海小午医药科技有限公司 一种用于预防或治疗与egfr被抑制相关疾病的方法
CN111989095A (zh) 2018-04-16 2020-11-24 上海岸阔医药科技有限公司 预防或治疗肿瘤疗法副作用的方法

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US9004A (en) * 1852-06-08 Improvement in seed-planters
US2002A (en) * 1841-03-12 Tor and planter for plowing
US9019A (en) * 1852-06-15 Charles fleischbl
US20020028237A1 (en) 2000-04-20 2002-03-07 Colbern Gail T. Method for reducing toxicity of a cytotoxic agent
MXPA03006936A (es) * 2001-02-02 2003-11-18 Pfizer Tratamiento de diabetes mellitus.
WO2006091542A2 (en) * 2005-02-22 2006-08-31 Cedars-Sinai Medical Center Use of sildenafil, vardenafil and other 5-phosphodiesterase inhibitors to enhance permeability of the abnormal blood-brain barrier
US20090048179A1 (en) * 2005-02-22 2009-02-19 Cedars-Sinai Medical Center Use of 5-phosphodiesterase inhibitors to enhance the permeability of the blood-brain barrier of abnormal brain tissue and the blood-tumor barrier
WO2007056457A2 (en) 2005-11-09 2007-05-18 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
WO2007087575A2 (en) * 2006-01-24 2007-08-02 University Of Chicago Compositions and methods for treating pulmonary hypertension
US7973046B2 (en) 2006-06-01 2011-07-05 Nobera Pharma, S.L. Use of allopurinol for the treatment of palmar plantar erythrodysesthesia
EP2246057A1 (en) 2009-04-29 2010-11-03 Nobera Pharma, S.L. Use of allopurinol for the treatment of hand foot skin reaction
EP2488642B1 (en) * 2009-10-16 2015-03-11 Duke University Compositions and methods for the treatment of drug-induced hand-foot syndrome

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
almar-plantar erythrodysesthesia(PPE):A literature review with commentary on experience in a cancer centre;Joan D. Webster-Gandy et al.;《European Jouranl of Oncology Nursing》;20071231;全文 *
Severe refractory fingertip ulcerations in a patient with scleroderma:successful treatment with sildenafil;CL Colglazier et al.;《The journal of rheumatology》;20051231;第32卷(第12期);全文 *
Sildenafil attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity;KangWook Lee et al.;《Toxicology》;20081230;第257卷;摘要 *

Also Published As

Publication number Publication date
EP2488642A4 (en) 2013-03-06
AU2010306671B2 (en) 2015-12-17
AU2010306671A1 (en) 2012-05-10
CN102648279A (zh) 2012-08-22
JP2013508295A (ja) 2013-03-07
US20120258970A1 (en) 2012-10-11
EP2488642A1 (en) 2012-08-22
EP2488642B1 (en) 2015-03-11
WO2011047256A1 (en) 2011-04-21
JP6063550B2 (ja) 2017-01-18
US9220713B2 (en) 2015-12-29
US9629845B2 (en) 2017-04-25
US20160074405A1 (en) 2016-03-17
JP2016094450A (ja) 2016-05-26

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