CN102641373A - Traditional Chinese medicine combination used for treating psoriasis - Google Patents
Traditional Chinese medicine combination used for treating psoriasis Download PDFInfo
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- CN102641373A CN102641373A CN2012101417107A CN201210141710A CN102641373A CN 102641373 A CN102641373 A CN 102641373A CN 2012101417107 A CN2012101417107 A CN 2012101417107A CN 201210141710 A CN201210141710 A CN 201210141710A CN 102641373 A CN102641373 A CN 102641373A
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Abstract
The invention discloses a traditional Chinese medicine combination used for treating psoriasis, which comprises the raw material medicines by weight: 1 part to 19 parts of pepper, 10 to 50 parts of alum, 1 part to 35 parts of zaocys dhumnade, 5 to 25 parts of honeysuckle, 5 to 25 parts of fructus forsythiae and 2 to 10 parts of pig gall. The traditional Chinese medicine combination is simple in formula, and the raw materials are easy to obtain and low in cost. The traditional Chinese medicine combination shows the effect of clearing away heat and toxic materials, dispelling wind and heat, clearing heat, damp-drying drug, welling pain, removing stasis, reliving pain and itching through cooperation of various medicinal materials. The traditional Chinese medicine combination is used for treating psoriasis in both principal and secondary aspect mode, has no toxic and side effects, is high in efficiency, improves efficiency of treatment of psoriasis by traditional Chinese medicine, avoids side effects and expensive medical cost which are generated by treatment of psoriasis by western medicine, and especially enables patients not to diet stimulating food in the medicine using period.
Description
Technical field
The present invention relates to a kind of psoriasic Chinese medicine composition that is used to treat, belong to the field of Chinese medicines.
Background technology
Psoriasis is psoriasis again, is a kind of common chronic dermatosis; It is characterized in that on erythema, occurring repeatedly the silvery white dry squama of multilamellar, it is characterized in that the pimple that occurs differing in size, erythema; Surface coverage silvery white squama, and clear border has the petechia after silvery white squama is stripped off.Good sending out stretched side and back in scalp, extremity.Though psoriasis does not directly influence life, but with physical and mental health direct influence is arranged to healthy.
Psoriasis does not infect, but psoriasis pathogenic factor more complicated, and the cause of disease is not clear and definite as yet.Most in recent years scholars think that with heredity, infection, dysbolismus, immune dysfunction, endocrine disturbance, environment etc. are relevant.Bringing out psoriasic main cause has: make moist catch a cold, local infection, Nervous and Mental Factors, irritated factor, endogenous stimulus etc.
Treating psoriasis medicine commonly used clinically has: steroid hormone, fluorouracil etc. suppress DNA class medicine, antitumor drug, immune formulation, anti-interferon, Chinese medicine etc.Wherein steroid hormone instant effect but life-time service can produce drug resistance and can't effect a radical cure; It is big and can't effect a radical cure to suppress DNA class drug side effect; Antitumor drug has side effect and related drugs to cost an arm and a leg, and the state of an illness has more recurrence after the drug withdrawal; Immune formulation generally has no side effect, but the related drugs price is very expensive, and the state of an illness is prone to recurrence after the drug withdrawal; The anti-interferon side effect is less, and related drugs costs an arm and a leg, and the state of an illness is prone to recurrence after the drug withdrawal; The Chinese medicine side effect is little, but onset is slow.Said medicine needs the diet stimulating food during taking; Generally; Stimulating food mainly is a food; Like bamboo sprout, Caulis et Folium Brassicae junceae, Fructus Cucurbitae moschatae, Herba Spinaciae, mushroom, Lentinus Edodes, Trichiurus haumela, Channa argus, Stromateoides argenteus, cock, Caput Gallus domesticus, pig head meat, Carnis Anseris domestica, chicken wing, chicken feet, Herba Alii fistulosi, Rhizoma Zingiberis Recens, Bulbus Allii, Folium Allii tuberosi etc., cause puzzlement therefore can for patient's diet, take medicine for a long time and also can cause malnutrition.Existing Chinese patent medicine Etretinate granule; Form by Radix Sophorae Flavescentis, Radix Glycyrrhizae, Cortex Dictamni, windproof, Rhizoma Smilacis Glabrae, Periostracum Cicadae, Cortex Phellodendri, Radix Rehmanniae, Flos Lonicerae, Radix Paeoniae Rubra, Fructus Forsythiae, Radix Angelicae Sinensis etc.; Being used to treat psoriasis has certain effect, but clinical cure rate is low, and period in a medicine needs the diet stimulating food.Therefore need to develop the treatment psoriasis medicine that does not need the diet stimulating food more effectively and during taking.
Summary of the invention
Technical problem to be solved by this invention is that to be used to treat psoriasic Chinese medicine composition effective percentage in the prior art low; And period in a medicine needs the problem of diet stimulating food; Provide a kind of treatment psoriasis effective percentage high, do not need Chinese medicine composition of diet stimulating food and preparation method thereof during taking.
The invention provides a kind of Chinese medicine composition, the weight portion of said composition crude drug is: Pericarpium Zanthoxyli 1-19 part, Alumen 10-50 part, Zaocys 1-35 part, Flos Lonicerae 5-25 part, Fructus Forsythiae 5-25 part, Fel Sus domestica 2-10 part.
The weight portion of preferred crude drug of the present invention is: Pericarpium Zanthoxyli 5-15 part, Alumen 20-40 part, Zaocys 10-26 part, Flos Lonicerae 10-20 part, Fructus Forsythiae 10-20 part, Fel Sus domestica 4-8 part.
The weight portion of best crude drug of the present invention is: 10 parts in Pericarpium Zanthoxyli, 30 parts of Alumens, 18 parts of Zaocyss, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 6 parts of Fel Sus domestica.
Chinese medicine composition of the present invention is made into unguentum, suppository, patch, pill, tablet, capsule, syrup, granule.
The method for preparing of Chinese medicine composition of the present invention comprises the steps:
A) it is for use to take by weighing each crude drug of specified weight part;
B) with Pericarpium Zanthoxyli, Alumen, Zaocys, Flos Lonicerae, Fructus Forsythiae, Fel Sus domestica pulverize separately, pulverize;
C) above-mentioned powder mixes is even, add adjuvant, process preparation by common process.
The invention still further relates to the purposes of this Chinese medicine composition in preparation treatment psoriasis medicine.
Theory of Chinese medical science thinks that psoriasis mainly by feelings will internal injury, intemperance of taking food, causes the spleen kidney to become estranged, in distemper is arranged, outer wind-engaging pyretic toxicity is wet and cause, with the passing of time the course of disease delays, and consumes cloudy blood trouble, and it is dry to cause deficiency of YIN blood.Skin loses it and supports, wind syndrome due to dryness of blood and play white scales layer by layer, and more because of QI and blood stasis, gradually to skin, erythra can be greatly like the map patch, dialectical Analyses, it has resembling of " blood being dry, heat in blood, blood deficiency ".
The Chinese traditional treatment psoriasis is main with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, cooling blood for hemostasis, anti-inflammatory anti-itch.
Alumen is cold in nature, and sour-puckery flavor is returned lung, spleen, liver, large intestine, urinary bladder channel, gets the effect of its heat clearing and damp drying, detoxifcation; Flos Lonicerae is cold in nature, and sweet in the mouth is returned lung, the heart, stomach, large intestine channel, the effect of tool heat-clearing and toxic substances removing, dispelling wind and heat pathogens; The Fructus Forsythiae cold nature, bitter in the mouth, GUIXIN, lung, small intestine meridian, the effect of tool heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens; With Alumen, Flos Lonicerae mutually 5, play heat-clearing and toxic substances removing, dispelling wind and heat pathogens, heat clearing and damp drying, dispersing swelling and dissipating binds effect, be monarch drug altogether; Pericarpium Zanthoxyli is warm in nature, and acrid in the mouth is returned spleen, stomach, kidney channel; Tool warming spleen and stomach for dispelling cold, removing damp and stopping pain, parasite killing detoxifcation, antipruritic effect of separating raw meat, Fel Sus domestica is cold in nature, bitter in the mouth; Return liver, gallbladder, lung, large intestine channel, the tool heat clearing away, moisturize, detoxicating functions, with Pericarpium Zanthoxyli mutually 5; For being ministerial drug, strengthen heat-clearing and toxic substances removing, heat clearing and damp drying effect altogether; Zaocys property is flat, and sweet in the mouth is returned Liver Channel, and tool dispels the wind, the effect of collateral dredging, relieving convulsion, as adjuvant drug, and performance dispelling, collateral-activating, analgesic effect.
Above Six-element medicine fit applications, the effect of playing heat-clearing and toxic substances removing, dispelling wind and heat pathogens, heat clearing and damp drying, dispersing swelling and dissipating binds, antalgesic-antipruritic altogether, evident in efficacy to psoriasis.
The present invention has following advantage:
It is raw material that the present invention selects Pericarpium Zanthoxyli, Alumen, Zaocys, Flos Lonicerae, Fructus Forsythiae, Fel Sus domestica for use, and prescription is simple, raw material be easy to get and cost low; Effect through the collaborative performance of each flavor medical material heat-clearing and toxic substances removing, dispelling wind and heat pathogens, heat clearing and damp drying, dispersing swelling and dissipating binds, antalgesic-antipruritic; Be used to treat psoriasis, treating both the principal and secondary aspects of a disease, and have no side effect; Effective percentage is high; Improved the psoriasic effective percentage of treatment by Chinese herbs, avoided the side effect of western medicine psoriasis generation and high medical expense, especially made the patient during medication, need not diet stimulating food again.
The specific embodiment
Embodiment 1
Take by weighing Pericarpium Zanthoxyli 1g, Alumen 10g, Zaocys 1g, Flos Lonicerae 5g, Fructus Forsythiae 5g, Fel Sus domestica 2g, pulverize separately, pulverize; Above-mentioned powder mixes is even, add Oviductus Ranae 8g, stirring promptly gets externally used paste.
Embodiment 2
Claim Pericarpium Zanthoxyli 19g, Alumen 50g, Zaocys 35g, Flos Lonicerae 25g, Fructus Forsythiae 25g, Fel Sus domestica 10g, pulverize separately, pulverize; Above-mentioned powder mixes is even, add Adeps melis 55g, stirring promptly gets externally used paste.
Embodiment 3
Claim Pericarpium Zanthoxyli 10g, Alumen 30g, Zaocys 18g, Flos Lonicerae 15g, Fructus Forsythiae 15g, Fel Sus domestica 6g, pulverize separately, pulverize; Above-mentioned powder mixes is even, add vaseline oil 45g, stirring promptly gets externally used paste.
Embodiment 4
Claim Pericarpium Zanthoxyli 5g, Alumen 20g, Zaocys 10g, Flos Lonicerae 10g, Fructus Forsythiae 10g, Fel Sus domestica 4g, pulverize separately, pulverize; Above-mentioned powder mixes is even, incapsulate, promptly make capsule.
Embodiment 5
Claim Pericarpium Zanthoxyli 15g, Alumen 40g, Zaocys 26g, Flos Lonicerae 20g, Fructus Forsythiae 20g, Fel Sus domestica 8g, pulverize separately, pulverize; Above-mentioned powder mixes is even, add tween-61, make suppository by common process.
Embodiment 6
Claim Pericarpium Zanthoxyli 12g, Alumen 35g, Zaocys 20g, Flos Lonicerae 18g, Fructus Forsythiae 18g, Fel Sus domestica 10g, pulverize separately, pulverize; Above-mentioned powder mixes is even, add starch, make granule.
Embodiment 7
Claim Pericarpium Zanthoxyli 8g, Alumen 25g, Zaocys 15g, Flos Lonicerae 12g, Fructus Forsythiae 12g, Fel Sus domestica 5g, pulverize separately, pulverize; Above-mentioned powder mixes is even, add vaseline, evenly on coating and the cotton, prepare patch.
Experimental example
In order to show that this Chinese medicine composition is to the psoriasis treatment effect; The present invention is through the clinical observation of 100 routine systems, erythroderma type psoriatic 20 examples, pustule type psoriatic 30 examples; Acute psoriasis punctata patient 30 examples of homeliness type, the chronic patch shape of homeliness type psoriatic 20 examples.In the process of above-mentioned clinical observation, and the work of above-mentioned patient being write down its medical history, the state of an illness, age and curative effect.
The criterion of clinical therapeutic efficacy is:
Clinical cure: skin lesion complete obiteration or only stay several unconspicuous point erythra.
Produce effects: erythra disappears more than 85%, and pruritus obviously alleviates.
Effectively: between the deflorescence 30%-80%, pruritus alleviates.
Invalid: deflorescence is not obvious or increase the weight of.
Medication is: stick the unguentum of embodiment 3 preparations for patient's affected part.
The course of treatment: 15 days is a course of treatment, uses every day twice.
Clinical experiment is the result show, only uses this Chinese medicine composition of a course of treatment, and original symptom obviously alleviates.According to statistics, the light patient of 5% symptom can once cure, use a course of treatment after, reach 95% cure rate, 5% produce effects or improvement, no invalid situation (seeing table 1).
For verifying other dosage forms of the present invention, to the granule of oral embodiment 6 preparations of 100 routine patients of identical body constitution, state of an illness state to the psoriasis treatment effect.
The course of treatment: 15 days is a course of treatment, takes twice every day, each 30g.
Clinical experiment is the result show, only uses this Chinese medicine composition of a course of treatment, and original symptom obviously alleviates.According to statistics, the light patient of 5% symptom can once cure, use a course of treatment after, reach 95% cure rate, 5% produce effects or improvement, no invalid situation (seeing table 2).
In above-mentioned clinical experiment, hematuria routine before and after patient's medication, hepatic and renal function, electrocardiogram etc. have been done inspection and record, contrast no abnormally, visible this Chinese medicine composition has no side effect, and after 2 years above-mentioned case is paid a return visit, and nothing recurs the patient.
Contrast experiment's example
Buy the Etretinate granule, every bottle of 100g, the accurate word Z22026008 of traditional Chinese medicines, Li Hua pharmaceutical Co. Ltd in Changchun produces.Use this product that 100 routine patients of identical body constitution, state of an illness state are carried out clinic trial, medication is a 33g, 2 times on the one, and the diet irritable food.
After taking 15 days continuously, the result is as shown in table 3, and its average cure rate can only reach 58%, and needs the diet irritable food, brings inconvenience for patient's diet.
Though the present invention has carried out detailed elaboration through above-mentioned specific embodiment to it; But; Any form that does not exceed the claim protection domain that those skilled in the art should be understood that on this basis to be made and the variation of details all belong to invention which is intended to be protected.
Claims (6)
1. a Chinese medicine composition is characterized in that, the weight portion of said composition crude drug is: Pericarpium Zanthoxyli 1-19 part, Alumen 10-50 part, Zaocys 1-35 part, Flos Lonicerae 5-25 part, Fructus Forsythiae 5-25 part, Fel Sus domestica 2-10 part.
2. Chinese medicine composition according to claim 1 is characterized in that, the weight portion of said crude drug is: Pericarpium Zanthoxyli 5-15 part, Alumen 20-40 part, Zaocys 10-26 part, Flos Lonicerae 10-20 part, Fructus Forsythiae 10-20 part, Fel Sus domestica 4-8 part.
3. Chinese medicine composition according to claim 2 is characterized in that, the weight portion of said crude drug is: 10 parts in Pericarpium Zanthoxyli, 30 parts of Alumens, 18 parts of Zaocyss, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 6 parts of Fel Sus domestica.
4. according to the arbitrary described Chinese medicine composition of claim 1 to 3, it is characterized in that said Chinese medicine composition is made into unguentum, suppository, patch, pill, tablet, capsule, syrup, granule.
5. the method for preparing of the described Chinese medicine composition of claim 4 comprises the steps:
A) it is for use to take by weighing each crude drug of specified weight part;
B) with Pericarpium Zanthoxyli, Alumen, Zaocys, Flos Lonicerae, Fructus Forsythiae, Fel Sus domestica pulverize separately, pulverize;
C) above-mentioned powder mixes is even, add adjuvant, process preparation by common process.
6. the arbitrary said Chinese medicine composition of claim 1 to 3 is treated the purposes in the psoriasis medicine in preparation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211890A (en) * | 2013-03-28 | 2013-07-24 | 叶立新 | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof |
| CN103394034A (en) * | 2013-07-23 | 2013-11-20 | 中国人民解放军71633部队 | Chinese medicinal preparation for treating psoriasis vulgaris |
| CN112843149A (en) * | 2021-03-17 | 2021-05-28 | 张光敏 | Medicinal and edible formula for tinea and medicinal tea bag packaging process |
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|---|---|---|---|---|
| CN1817361A (en) * | 2004-06-23 | 2006-08-16 | 万荣宏 | Medicine for treating psoriasis |
| CN1883662A (en) * | 2006-06-13 | 2006-12-27 | 马真山 | Pharmaceutical composition for treating psoriasis |
| CN101596219A (en) * | 2009-06-16 | 2009-12-09 | 成钢 | Nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis |
| KR101005972B1 (en) * | 2010-02-24 | 2011-01-05 | 양재열 | Composition for exteneral application to skin and preparation method thereof |
| CN101780216A (en) * | 2010-02-26 | 2010-07-21 | 杨延珍 | Medicine for treating psoriasis |
| CN101757223A (en) * | 2010-03-04 | 2010-06-30 | 李芹 | Externally-applied traditional Chinese medicine for treating psoriasis |
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| CN103211890A (en) * | 2013-03-28 | 2013-07-24 | 叶立新 | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof |
| CN103394034A (en) * | 2013-07-23 | 2013-11-20 | 中国人民解放军71633部队 | Chinese medicinal preparation for treating psoriasis vulgaris |
| CN103394034B (en) * | 2013-07-23 | 2014-08-06 | 中国人民解放军71633部队 | Chinese medicinal preparation for treating psoriasis vulgaris |
| CN112843149A (en) * | 2021-03-17 | 2021-05-28 | 张光敏 | Medicinal and edible formula for tinea and medicinal tea bag packaging process |
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