CN101596219A - Nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis - Google Patents

Abstract

The present invention relates to nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis and belong to the sick external biologic product technology of external skin field.Psoriasis is a kind of common, obstinate, a kind of chronic dermatosis that very easily recurs after being difficult to cure or cure, discover that essential element such as the interior zinc of it and body, cobalt, lithium is unbalance relevant, enrich comprehensive material with nutrients such as Maifanitum, honeybee series, Chinese medicinal formulae, oxide powder and zinc, dried Concha Ostreae, organic selenium, organic germaniums, make the rubbing alcohol liniment, tincture, cream, powder of nanoscale dry powder preparation etc. with modern ultra-fine grinding technology, can improve drug effect greatly, more effectively curing psoriasis inveterata is psoriasis.

Description

Nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis

Technical field:

The present invention relates to the categories such as traditional Chinese medical science dermatosis " white disease ", " psoriasis ", " chronic eczema ", " psoriasis " of nanotechnology trace element Chinese medicine cross-application, belong to dermatosis biological preparation external treatment technical field.

Background technology:

Psoriasis is a psoriasis, is a kind of common chronic dermatosis, in numerous chronic skin diseases is not only to see but also the obstinate chronic dermatosis of curing of being difficult to more.The representational erythema that mostly is of clinical manifestation, pimple, squama, sickness rate is approximately 0.1-3% in the crowd of nature, be regardless of all directions, men and women, old and young all have morbidity, especially based on person between twenty and fifty, the heavy summer in general winter is light, primary disease is generally Chinese medicine " white disease ", " psoriasis ", " chronic eczema ", categories such as " psoriasiss ", its pathogeneticing characteristic: the beginning part pimple that takes on a red color is expanded into speckle gradually, the bulk speckle can cover whole shoulder back, the out-of-shape of speckle, but boundary is obvious, just like map shape or island shape, the silvery white squama that the surface has one deck thin and thick to differ, so claim psoriasis, the cause of disease of this stupid disease is not clear fully as yet so far, its risk factor is a lot, mainly be that tangible Inheritance tendency is arranged, also have virus and bacteria to infect, the endocrine disturbance, wound and Nervous and Mental Factors etc. are relevant, treatment back relapse rate height, be difficult to treatment clinically, the utmost point allows patient's worry.Clinical diagnosis has: 1. psoriasis vulgaris; 2. pustular psoriasis; 3. psoriasis arthropathica; 4. erythrodermic psoriasis etc.Discover that through modern element essential element such as zinc, cobalt, lithium is unbalance in close relations in psoriasis and the body.Zinc (Zn) is the important element in the skin, can cause a lot of dermatosiss behind the zinc deficiency, is modal as facial acne, also has acrodermatitis enteropathica, psoriasis etc.Psoriasis formation and zinc deficiency relation is very big, because zinc is relevant with the activity of a lot of enzymes, zinc element has direct effect to the structure and the expression of gene of biological nucleic acid synthetic protein in the skin histology, a large amount of zinc enzymes is rised in value, has consumed in the division of cell, will make the intravital zinc deficiency of patient like this, cause the normal keratinization of epidermis behind the zinc deficiency, make skin histology parakeratosis, form the one of the main reasons of psoriasis zinc deficiency.

Cobalt (Co) is to form the activator of important composition of VB12 and various enzymes by the VB12 participation ribonucleic acid of cobalt formation and the metabolism of hemopoietic related substance, can cause the giant cell anemia when lacking cobalt, directly influences the normal function of each tissue of skin and the immunity of body.

It is 0.056-0.066ug/g that lithium (Li) normal person hair contains lithium, general psoriasis lithium content exceeds standard, and can cause psoriatic deterioration, and magnesium elements has antagonism to lithium, increase the weight of and painful psoriatic so Mg supplementation can be got rid of lithium, psoriasis also is due to the in-vivo element imbalance in a word.

Selenium, germanium also are the very important anti-cancers, anticancer of needed by human, raise immunity, promote the metabolism of new one-tenth, the anti-ageing biological element of health care, all generally lack among the crowd, because they relatively lack and rare element on the earth for it, the organic selenium, the organic germanium human body that obtain by yeast or edible mythic fungus bacterium microorganism culturing transformation technology are easy to absorb, and the selenium that the absorbance utilization rate is high, Ge element use the nanorize absorption rate better.

The technology of the present invention solution:

Utilize nanotechnology ultrasound wave drying and crushing, modern superfine process technology such as pulverizing at ultralow temperature, nutrients such as Maifanitum, Serpentis honeybee series, Chinese medicinal formulae, dried Concha Ostreae (containing the 1210mg zinc element among every 1000g) organic selenium, germanium are enriched comprehensive material make the nanoscale dry powder and cross 600 mesh sieves, medium particle diameter reaches about 1um (pore of skin, sweat pore are 2um) and is convenient to dermal osmosis and absorbs.Because after nanoparticle entered in the body, its size ratio erythrocyte particle diameter (6-9um) was much smaller, can freely-movable in blood, can successfully nanoparticle be delivered into that partes corporis humani's tissue is treated and replenished, adjusting, antagonist interior element balance.

It is good that Maifanitum contains 19 kinds of element dissolving out capability to the human body beneficial such as silicon dioxide, ferrum oxide, calcium, magnesium, titanium, manganese, selenium, it is strong especially to discharge beneficial element absorption harmful element ability, Maifanitum is ground into also littler 3 times than a grain powder, promptly the following fine-powder of 325 orders is got the one grain and is very clearly observed this grain as coral reef, spongy, porous under ultramicroscope.Also can hold Serpentis fully in the hole of this maifanite particle, honeybee, the Chinese medicine trace element, organic selenium, nanometer fine particles such as germanium, Maifanitum is comprising these multiple nutrients materials just as capsule shell, Maifanitum itself can discharge nutrient exactly, make simultaneously human body obtain important nutrient source again, be described as " cleaning agent of cell ", its energy enhancing human body immunity function, improve the anti-infection ability of health, absorption is plumbous, hydrargyrum, arsenic, odorous gas such as heavy metal elements such as cadmium and hydrogen sulfide, regulate the metabolism of new one-tenth, increase biological effects such as blood circulation, nutrient mass-energy such as the effective trace elements that holds in the hole are effectively regulated, replenish, antagonist interior element balance and psoriatic therapeutic effect, just as miniature nanometer medicine capsule has high-drug-effect, the effectiveness of high-absorbility can be cured psoriasis inveterata effectively.

Below in conjunction with embodiment, the present invention is further described:

Embodiment one:

Scolopendra powder, Ophidia black snake powder, each 60g of bee pollen respectively account for 8%; Fel Agkistrodon halys or Agkistrodon gallbladder, organic selenium, each 15g of organic germanium respectively account for 2%; Fructus Mume, Pericarpium Granati, Flos Carthami, rhizoma sparganic, MAOSHU, each 40g of the Radix Aucklandiae respectively account for 5.3%; Radix Arnebiae (Radix Lithospermi), Cortex Phellodendri, each 60g of Caulis Lonicerae respectively account for 8%; Maifanitum 100g accounts for 13.4%, amounts to 745g.

Implement two:

Cortex Pseudolaricis 620g accounts for 14.2%; Nidus Vespae powder 600g accounts for 13.8%; Radix Sophorae Flavescentis, Cortex cercis chinensis, each 310g of Camphora account for 7.1%; Radix Sangusorbae, each 150g of melia account for 3.4%; Dried Concha Ostreae (1000g contains zinc 1210mg) 500g accounts for 11.5%; Scolopendra 210g accounts for 4.8%; Maifanitum 800g accounts for 18%; Semen Euphorbiae, Mylabris, organic selenium, each 100g of organic germanium, each is 2% years old; Amount to 4360g.

Implement three:

Radix Sangusorbae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Fructus Cnidii, Fructus Gardeniae, Alumen, each 20g of Fel Agkistrodon halys respectively account for 2%; Dermis Agkistrodon halys, oxide powder and zinc, Tinea Apis and adult mixed powder, Flos Sophorae, the Fructus Kochiae, the Radix Rehmanniae, each 60g of Radix Paeoniae Rubra respectively account for 6.4%; Radix Sophorae Flavescentis, each 40g of Semen Armeniacae Amarum respectively account for 4.3%; Five robust and sturdy sons, Olibanum, each 30g of Myrrha respectively account for 3.2%; Organic selenium, each 20g of organic germanium respectively account for 2%; Maifanitum 150g accounts for 16%, adds up to 940g.

Illustrate: can grind the white body of superfine preparation.

Implement four:

Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, raw pearl barley, each 30g of the Fructus Kochiae respectively account for 3.3%; WUSHEROU, Caulis Spatholobi, Rhizoma Imperatae, Radix Rubiae, Flos Sophorae, Cortex Dictamni, Rhizoma Smilacis Glabrae, bee pollen, propolis, each 60g of Lac regis apis, each is 6% years old; Caulis Akebiae, each 15g of Rhizoma Coptidis respectively account for 1.6%; Maifanitum 100g accounts for 4%; Rhizoma Alismatis, organic selenium, each 20g of organic germanium respectively account for 2%, amount to 910g.

Implement five:

Zaocys, the Radix Rehmanniae, Rhizoma Chuanxiong, Semen Persicae, Fructus Cnidii, Cortex Dictamni, Fructus Forsythiae, Herba Schizonepetae, Radix Saposhnikoviae, Herba Spirodelae, Fructus Tribuli, Corium Erinacei Seu Hemiechianus, Dermis Agkistrodon halys, Cortex Pseudolaricis, cattle hide, Cortex Dictamni, each 20g of honeybee respectively account for 4%; The Fructus Kochiae, Flos Carthami, organic selenium, each 15g of organic germanium respectively account for 3%; Radix Salviae Miltiorrhizae 30g accounts for 6%; Maifanitum 70g accounts for 14%, altogether 500g.

Implement six:

Radix Glycyrrhizae 6g accounts for 1.2%; Radix Platycodonis, each 10g of Radix Sophorae Tonkinensis respectively account for 2%; Fructus Forsythiae, Cortex Moutan, Radix Paeoniae Rubra, organic selenium, each 12g of organic germanium respectively account for 2.9%; Radix Scrophulariae, Radix Ophiopogonis, Radix Isatidis, Folium Isatidis, each 18g of Fel Serpentis, each is 3.6% years old; Flos Lonicerae, Cortex Dictamni, Zaocys skin, Lac regis apis, Rhizoma Phragmitis, each 25g of bee pollen account for 5%; The Radix Rehmanniae, Herba Taraxaci, each 30g of oxide powder and zinc respectively account for 6%; Maifanitum 86g accounts for 17.2%; Be applicable to the heat in blood removing heat from blood, children's's psoriasis.

Implement seven:

Rhizoma Cimicifugae, Semen Hydnocarpi, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Cornu Bubali powder, agkistrodon acutus powder, each 18g of Agkistrodon halys gallbladder powder, each is 3% years old; Radix Paeoniae Rubra 20g accounts for 3.3%; Radix Puerariae, the Radix Rehmanniae, oxide powder and zinc, Nidus Vespae powder, each 60g of bee pollen respectively account for 10%; Borneolum Syntheticum, organic selenium, each 12g of organic germanium, each is 2% years old; Maifanitum 100g accounts for 16.7%; Propolis 18g accounts for 3%; Heavy altogether 600g.

Above each side adopts the modern superfine process technology of ultralow temperature or Ultrasonic Pulverization to cross 600 orders or 700 mesh sieves, the nanoscale of medium particle diameter 1～5um, tincture, liniment, powder agent, the cream made with ethanol or medical ventolin etc.

Claims (8)

1, nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis, it is characterized in that: the nanoscale dry powder that the ultrasonic drying and crushing of usefulness such as Maifanitum, Serpentis honeybee series, Chinese medicinal formulae, oxide powder and zinc, dried Concha Ostreae, organic selenium, organic germanium or the modern ultra-fine grinding process technology of pulverizing at ultralow temperature are made is crossed 400～800 mesh sieves, medium particle diameter 0.1～20um.

2, according to claims 1: nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis is characterized in that having following composition material %: Scolopendra powder, Ophidia black snake powder, each 30～90g of bee pollen respectively account for 5～13%; Fel Agkistrodon halys or Agkistrodon gallbladder, organic selenium, each 10～20g of organic germanium, each is 0.5～4% years old; Fructus Mume, Pericarpium Granati, Flos Carthami, rhizoma sparganic, Rhizoma Curcumae, each 20～80g of the Radix Aucklandiae respectively account for 3～8%; Radix Arnebiae (Radix Lithospermi), Cortex Phellodendri, each 30～90g of Caulis Lonicerae respectively account for 3～13%; Maifanitum 50～150g respectively accounts for 8～18%.

3, according to claims 1,2: nanometer selenium, germanium, zinc element, external therapy of Chinese herb psoriasis, it is characterized in that having following composition material %: Cortex Pseudolaricis 570～670g accounts for 10～18%; Nidus Vespae powder 100～700g accounts for 10～15%; Radix Sophorae Flavescentis, Cortex cercis chinensis, each 240～400g of Camphora respectively account for 2～10%; Radix Sangusorbae, each 100～200g of melia respectively account for 1～5%; Dried Concha Ostreae (100g zinc content 1210mg) 400～600g, 5～16%; Scolopendra 150～260g accounts for 1～10%; Maifanitum 700～900g accounts for 10～30%; Semen Euphorbiae, Mylabris, organic selenium, each 50～150g of organic germanium, each is 0.5～5% years old.

4, according to claims 1,2,3: nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis, it is characterized in that having following active ingredient %: Radix Sangusorbae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Fructus Cnidii, Fructus Gardeniae, Alumen, each 10～30g of Fel Agkistrodon halys respectively account for 0.5～4%; Dermis Agkistrodon halys, oxide powder and zinc, Tinea Apis adult mixture, Flos Sophorae, the Fructus Kochiae, the Radix Rehmanniae, each 20～100g of Radix Paeoniae Rubra respectively account for 1～10%; Radix Sophorae Flavescentis, each 10～70g of Semen Armeniacae Amarum respectively account for 1～8%; Galla Chinensis, Olibanum, each 10～50g of Myrrha respectively account for 0.5～5%; Organic selenium, each 10～30g of organic germanium respectively account for 0.5～4%; Maifanitum 100～200g accounts for 10～20%; Be ground into the nanoscale fine powder during preparation and make cream.

5, according to claims 1,2,3,4: nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis is characterized in that also having following active ingredient %: Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, business rice, each 10～50g of the Fructus Kochiae, and each is 0.5～5% years old; WUSHEROU, Caulis Spatholobi, Rhizoma Imperatae, Radix Rubiae, Flos Sophorae, Cortex Dictamni, Rhizoma Smilacis Glabrae, Nidus Vespae, propolis, each 20～100g of Lac regis apis, each is 1～10% years old; Caulis Akebiae, each 10～20g of Rhizoma Coptidis respectively account for 0.5～3%; Rhizoma Alismatis, organic selenium, each 10～30g of organic germanium, each is 0.5～4% years old; Maifanitum 50～150g accounts for 5～15%.

6, according to claims 1,2,3,4,5: nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis, it is characterized in that also having following active ingredient %: Zaocys, the Radix Rehmanniae, Rhizoma Chuanxiong, Semen Persicae, Fructus Cnidii, Cortex Dictamni, Fructus Forsythiae, Herba Schizonepetae, Radix Saposhnikoviae, Herba Spirodelae, Fructus Tribuli, Corium Erinacei Seu Hemiechianus, Dermis Agkistrodon halys, Cortex Pseudolaricis, cattle hide, each 10～30g of propolis, each is 1～7% years old; Radix Salviae Miltiorrhizae 20～40g accounts for 2～10%; The Fructus Kochiae, Flos Carthami, organic selenium, each 10～30g of organic germanium, each is 1～5% years old; Maifanitum 20～120g accounts for 9～20%.

7, according to claims 1,2,3,4,5,6: nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis, it is characterized in that also having following active ingredient %: Radix Glycyrrhizae 1～10g accounts for 0.5～3%; Radix Platycodonis, each 5～15g of Radix Sophorae Tonkinensis respectively account for 0.5～4%; Fructus Forsythiae, Cortex Moutan, Radix Paeoniae Rubra, organic selenium, each 7～17g of organic germanium, each is 0.5～5% years old; Radix Scrophulariae, Radix Ophiopogonis, Radix Isatidis, Folium Isatidis, each 13～23g of Fel Serpentis, each is 1～5% years old; Flos Lonicerae, Cortex Dictamni, Zaocys skin, Lac regis apis, Rhizoma Phragmitis, each 15～35g of bee pollen account for 1～10%; The Radix Rehmanniae, Herba Taraxaci, each 20～40g of oxide powder and zinc, each is 1～10% years old; Maifanitum 50～120g, each is 12～22% years old; Be applicable to heat in blood removing heat from blood children's psoriasis.

8, according to claims 1,2,3,4,5,6,7: nanometer selenium, germanium, zinc element external therapy of Chinese herb psoriasis, it is characterized in that also having following active ingredient %: Rhizoma Cimicifugae, Semen Hydnocarpi, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Cornu Bubali powder, Agkistrodon powder, each 10～26g of Agkistrodon halys gallbladder powder, each is 1～5% years old; Radix Paeoniae Rubra 10～30g accounts for 1～5%; Radix Puerariae, the Radix Rehmanniae, oxide powder and zinc, Nidus Vespae powder, each 20～100g of bee pollen account for 5～15%; Propolis 10～26g accounts for 0.5～6%; Each 7～17g of Borneolum Syntheticum, organic selenium, organic germanium, each 0.5～4%, Maifanitum 50～150g accounts for 10～20%.