CN102639999B - 存活预后分析 - Google Patents

存活预后分析 Download PDF

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Publication number
CN102639999B
CN102639999B CN201080036734.5A CN201080036734A CN102639999B CN 102639999 B CN102639999 B CN 102639999B CN 201080036734 A CN201080036734 A CN 201080036734A CN 102639999 B CN102639999 B CN 102639999B
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CN
China
Prior art keywords
flc
light chains
free light
free
amount
Prior art date
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Active
Application number
CN201080036734.5A
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English (en)
Chinese (zh)
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CN102639999A (zh
Inventor
G·P·米德
A·R·布拉德韦尔
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Binding Site Group Ltd
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Binding Site Group Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41171642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102639999(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CN201080036734.5A 2009-08-19 2010-08-19 存活预后分析 Active CN102639999B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0914535.0 2009-08-19
GBGB0914535.0A GB0914535D0 (en) 2009-08-19 2009-08-19 Prognosis assay
GB1001079.1 2010-01-22
GBGB1001079.1A GB201001079D0 (en) 2009-08-19 2010-01-22 Prognostic assay
PCT/GB2010/051373 WO2011021041A2 (en) 2009-08-19 2010-08-19 Survival prognostic assay

Publications (2)

Publication Number Publication Date
CN102639999A CN102639999A (zh) 2012-08-15
CN102639999B true CN102639999B (zh) 2016-08-31

Family

ID=41171642

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080036734.5A Active CN102639999B (zh) 2009-08-19 2010-08-19 存活预后分析

Country Status (11)

Country Link
US (1) US20120220052A1 (enExample)
EP (2) EP2799879A3 (enExample)
JP (3) JP2013502569A (enExample)
CN (1) CN102639999B (enExample)
DE (1) DE202010018327U1 (enExample)
DK (1) DK2467724T3 (enExample)
ES (1) ES2517922T3 (enExample)
GB (3) GB0914535D0 (enExample)
PL (1) PL2467724T3 (enExample)
PT (1) PT2467724E (enExample)
WO (1) WO2011021041A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0914535D0 (en) * 2009-08-19 2009-09-30 Binding Site Group The Ltd Prognosis assay
GB2478520A (en) * 2010-03-02 2011-09-14 Binding Site Group Ltd Kidney prognostic assay
GB201012049D0 (en) 2010-07-19 2010-09-01 Binding Site Group The Ltd Competition assay
GB201202964D0 (en) 2012-02-21 2012-04-04 Binding Site Group The Ltd Correction method
GB201203938D0 (en) 2012-03-06 2012-04-18 Binding Site Group The Ltd Assay system
CN102636653A (zh) * 2012-04-19 2012-08-15 上海蓝怡科技有限公司 复合胶乳粒子包被胱抑素c检测试剂盒
GB201212900D0 (en) * 2012-07-20 2012-09-05 Binding Site Group The Ltd Triage scoring system
GB201218137D0 (en) * 2012-10-10 2012-11-21 Binding Site Group The Ltd Chronic kidney disease assay
CN103175964B (zh) * 2013-02-21 2015-08-26 武汉华美生物工程有限公司 神经元特异性烯醇化酶含量检测试剂盒及其制备方法
US10267806B2 (en) 2014-04-04 2019-04-23 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass
GB201603359D0 (en) 2016-02-26 2016-04-13 Binding Site Group The Ltd Improved assay
GB201708262D0 (en) * 2017-05-23 2017-07-05 Binding Site Group Ltd Assay for plasma cell associated disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336472A1 (en) * 1988-04-01 1989-10-11 New Scientific Company S.P.A. Method for determining the presence of free light chains in urine samples, complex of preparations for performance of the method and related reagent
WO2006079816A1 (en) * 2005-01-27 2006-08-03 The Binding Site Limited Method of detecting or monitoring a malignant plasma cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044219A1 (en) * 1980-07-16 1982-01-20 Unilever Plc Methods of immuno analysis using monoclonal antibodies
EP0862584B1 (en) 1995-11-03 2004-12-22 The Binding Site Limited Production of antibodies
JP4438455B2 (ja) * 2004-03-04 2010-03-24 ヤマサ醤油株式会社 遊離ヒトイムノグロブリン軽鎖の測定法及びキット
WO2005103717A1 (en) * 2004-04-21 2005-11-03 Fornix Biosciences N.V. Measuring free light chains of immunoglobulin
DE102004038726B4 (de) * 2004-07-15 2006-05-18 Levin, Felix, Dr. Testsystem und Verfahren zur schnellen Bestimmung von Bence Jones Protein in biologischen Flüssigkeiten
EP2267449B1 (en) * 2005-04-12 2014-01-08 Akira Matsumori Biomarker for diagnosing heart failure and the use thereof
GB0608446D0 (en) * 2006-04-27 2006-06-07 Binding Site The Ltd Assay
GB0819720D0 (en) * 2008-10-28 2008-12-03 Univ Birmingham Methods and products
GB0914535D0 (en) * 2009-08-19 2009-09-30 Binding Site Group The Ltd Prognosis assay

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336472A1 (en) * 1988-04-01 1989-10-11 New Scientific Company S.P.A. Method for determining the presence of free light chains in urine samples, complex of preparations for performance of the method and related reagent
WO2006079816A1 (en) * 2005-01-27 2006-08-03 The Binding Site Limited Method of detecting or monitoring a malignant plasma cell disease

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
A new concept for detection of Bence Jones proteinuria in patients with monoclonal gammopathy.;Hofmann W等;《Clin Lab》;20041231;第50卷;摘要 *
Amyloidosis: diagnosis and management.;Morie A. Gertz等;《Clinical Lymphoma & Myeloma》;20051130;第6卷;摘要，第209页左侧栏第1段 *
ELISA双抗体夹心法检测尿中游离轻链及初步临床应用;张文辉 等人;《临床检验杂志》;20011231;第19卷(第1期);第37页材料和方法部分，表1 *
Hepatic amyloidosis: clinical appraisal in 77 patients.;Morie A. Gertz, Robert A. Kyle;《Hepatology》;19971231;第25卷;摘要，表1 *
High serum-free light chain levels and their rapid reduction in response to therapy define an aggressive multiple myeloma subtype with poor prognosis.;Frits van Rhee等;《Blood》;20070406;第110卷;第828页，左侧栏，表1 *
Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy.;Helen J. Lachmann等;《British Journal of Haematology》;20031231;第122卷;第79页右侧栏"血清游离免疫球蛋白轻链测定"，图1 *
Quantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease.;Colin A. Hutchison等;《Clin J Am Soc Nephrol》;20081231;第3卷;摘要，第1685页左侧栏"样品操作和实验室测定"部分 *
Serum reference intervals and diagnostic ranges for free κ and free λ immunoglobulin light chains:relative sensitivity for detection of monoclonal light chains.;Jerry A. Katzmann等;《Clinical Chemistry》;20021231;第48卷;摘要，第1438页右侧栏最后一段 *
Urinary free light chain analysis by the Freelite immunoassay: a preliminary study in multiple myeloma.;Thierry Le Bricon等;《Clinical Biochemistry》;20021231;第35卷;第566页左侧栏倒数第2段，第566页右侧栏倒数第2段 *
多发性骨髓瘤血清游离轻链的测定及其临床意义;冒晓蓓;《中国优秀硕士学位论文全文数据库》;20080215(第2008年02期);第29页第2.1节 *

Also Published As

Publication number Publication date
DK2467724T3 (da) 2014-08-25
GB2472518B (en) 2011-11-16
EP2467724A2 (en) 2012-06-27
GB0914535D0 (en) 2009-09-30
CN102639999A (zh) 2012-08-15
US20120220052A1 (en) 2012-08-30
EP2799879A3 (en) 2015-02-18
PL2467724T3 (pl) 2015-04-30
EP2467724B1 (en) 2014-07-23
WO2011021041A2 (en) 2011-02-24
EP2799879A2 (en) 2014-11-05
JP2015092190A (ja) 2015-05-14
EP2467724B8 (en) 2014-10-29
PT2467724E (pt) 2014-10-14
GB201001079D0 (en) 2010-03-10
GB2472518A (en) 2011-02-09
JP2013502569A (ja) 2013-01-24
DE202010018327U1 (de) 2015-10-26
WO2011021041A3 (en) 2011-04-14
ES2517922T3 (es) 2014-11-04
JP2012198248A (ja) 2012-10-18
GB201013891D0 (en) 2010-10-06

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