CN102639710A - 克罗恩病的基因表达标记 - Google Patents

克罗恩病的基因表达标记 Download PDF

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Publication number
CN102639710A
CN102639710A CN2010800417664A CN201080041766A CN102639710A CN 102639710 A CN102639710 A CN 102639710A CN 2010800417664 A CN2010800417664 A CN 2010800417664A CN 201080041766 A CN201080041766 A CN 201080041766A CN 102639710 A CN102639710 A CN 102639710A
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ibd
expression
expression level
genes
antibody
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A.R.阿巴斯
H.克拉克
L.迪尔
C.李斯
C.L.诺布尔
J.萨特桑吉
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Genentech Inc
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2010800417664A 2009-07-20 2010-07-19 克罗恩病的基因表达标记 Pending CN102639710A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22704909P 2009-07-20 2009-07-20
US61/227,049 2009-07-20
US30208410P 2010-02-05 2010-02-05
US61/302,084 2010-02-05
PCT/US2010/042487 WO2011011339A1 (en) 2009-07-20 2010-07-19 Gene expression markers for crohn's disease

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CN102639710A true CN102639710A (zh) 2012-08-15

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CN2010800417664A Pending CN102639710A (zh) 2009-07-20 2010-07-19 克罗恩病的基因表达标记

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US (2) US20110033486A1 (https=)
EP (3) EP2757160A3 (https=)
JP (1) JP2012533322A (https=)
CN (1) CN102639710A (https=)
AU (1) AU2010276392A1 (https=)
CA (1) CA2768711A1 (https=)
SG (1) SG177699A1 (https=)
WO (1) WO2011011339A1 (https=)

Cited By (7)

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CN105209643A (zh) * 2013-05-17 2015-12-30 豪夫迈·罗氏有限公司 用于诊断和治疗炎性肠病的方法
CN106755293A (zh) * 2016-09-23 2017-05-31 宁波大学 一种与肺癌辅助诊断相关的lncRNA标志物及其应用
CN107541790A (zh) * 2016-06-24 2018-01-05 上海交通大学 一种糖基化检测的人凝集素/类人凝集素芯片及制备方法
CN108893488A (zh) * 2018-06-19 2018-11-27 刘志强 一种重组质粒、dna疫苗及其制备方法和应用
CN112578122A (zh) * 2019-09-27 2021-03-30 成都中医药大学 检测粪钙卫蛋白含量的试剂在制备畸形精子症筛查试剂盒中的用途
CN116168765A (zh) * 2023-04-25 2023-05-26 山东大学 基于改进strobemer的基因序列生成方法及系统
CN117031004A (zh) * 2023-08-09 2023-11-10 四川省医学科学院·四川省人民医院 一种检测网膜素-1的试剂在制备预测或评估ibs患者生活质量的产品中的应用

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WO2012135142A1 (en) 2011-03-25 2012-10-04 Cedars-Sinai Medical Center Methods of diagnosing ulcerative colitis and crohn's disease
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
WO2014009535A2 (en) * 2012-07-12 2014-01-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes
KR102343212B1 (ko) 2013-03-27 2021-12-23 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
WO2015010108A1 (en) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
KR20220065091A (ko) 2014-03-27 2022-05-19 제넨테크, 인크. 염증성 장 질환의 진단 및 치료 방법
EP3137628A4 (en) * 2014-05-02 2018-03-21 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (mruc) requiring colectomy
US11186872B2 (en) 2016-03-17 2021-11-30 Cedars-Sinai Medical Center Methods of diagnosing inflammatory bowel disease through RNASET2
IT201600090052A1 (it) * 2016-09-06 2018-03-06 Univ Degli Studi Padova Peptide per la diagnosi differenziale della Malattia di Crohn
US10890579B2 (en) 2016-10-06 2021-01-12 The Research Foundation For The State University Of New York Methods and kits for detecting a fusion messenger RNA transcript or a polypeptide encoded by the fusion messenger RNA transcript
CN112041933B (zh) * 2018-03-14 2025-05-13 皇家飞利浦有限公司 使用局部独特特征来解释rna测序数据的转录本表达水平的系统和方法
JP2022533956A (ja) 2019-05-14 2022-07-27 プロメテウス バイオサイエンシーズ，インク． Ｔｌ１ａ患者を選択する方法、システム、およびデバイス

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105209643A (zh) * 2013-05-17 2015-12-30 豪夫迈·罗氏有限公司 用于诊断和治疗炎性肠病的方法
CN107541790A (zh) * 2016-06-24 2018-01-05 上海交通大学 一种糖基化检测的人凝集素/类人凝集素芯片及制备方法
CN106755293A (zh) * 2016-09-23 2017-05-31 宁波大学 一种与肺癌辅助诊断相关的lncRNA标志物及其应用
CN106755293B (zh) * 2016-09-23 2020-09-04 宁波大学 一种与肺癌辅助诊断相关的lncRNA标志物及其应用
CN108893488A (zh) * 2018-06-19 2018-11-27 刘志强 一种重组质粒、dna疫苗及其制备方法和应用
CN112578122A (zh) * 2019-09-27 2021-03-30 成都中医药大学 检测粪钙卫蛋白含量的试剂在制备畸形精子症筛查试剂盒中的用途
CN112578122B (zh) * 2019-09-27 2022-08-02 成都中医药大学 检测粪钙卫蛋白含量的试剂在制备畸形精子症筛查试剂盒中的用途
CN116168765A (zh) * 2023-04-25 2023-05-26 山东大学 基于改进strobemer的基因序列生成方法及系统
CN116168765B (zh) * 2023-04-25 2023-08-18 山东大学 基于改进strobemer的基因序列生成方法及系统
CN117031004A (zh) * 2023-08-09 2023-11-10 四川省医学科学院·四川省人民医院 一种检测网膜素-1的试剂在制备预测或评估ibs患者生活质量的产品中的应用
CN117031004B (zh) * 2023-08-09 2024-10-01 四川省医学科学院·四川省人民医院 一种检测网膜素-1的试剂在制备预测或评估ibs患者生活质量的产品中的应用

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SG177699A1 (en) 2012-02-28
EP2584049A3 (en) 2013-08-28
AU2010276392A1 (en) 2012-03-08
EP2757160A2 (en) 2014-07-23
CA2768711A1 (en) 2011-01-27
WO2011011339A1 (en) 2011-01-27
US20110033486A1 (en) 2011-02-10
US20140154275A1 (en) 2014-06-05
EP2584049A2 (en) 2013-04-24
EP2757160A3 (en) 2014-07-30
JP2012533322A (ja) 2012-12-27
EP2456890A1 (en) 2012-05-30
AU2010276392A2 (en) 2012-03-08

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