CN102638980A - 噻唑烷二酮能量限制拟似剂 - Google Patents

噻唑烷二酮能量限制拟似剂 Download PDF

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Publication number
CN102638980A
CN102638980A CN2010800559152A CN201080055915A CN102638980A CN 102638980 A CN102638980 A CN 102638980A CN 2010800559152 A CN2010800559152 A CN 2010800559152A CN 201080055915 A CN201080055915 A CN 201080055915A CN 102638980 A CN102638980 A CN 102638980A
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CN
China
Prior art keywords
thiazolidine
benzylidene
trifluoromethyl
methyl
dione
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Pending
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CN2010800559152A
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English (en)
Chinese (zh)
Inventor
C-S.陈
J-H.古
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Ohio State University Research Foundation
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Ohio State University Research Foundation
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Publication of CN102638980A publication Critical patent/CN102638980A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2010800559152A 2009-10-09 2010-10-11 噻唑烷二酮能量限制拟似剂 Pending CN102638980A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25004509P 2009-10-09 2009-10-09
US61/250045 2009-10-09
US30488110P 2010-02-16 2010-02-16
US61/304881 2010-02-16
PCT/US2010/052151 WO2011044548A1 (en) 2009-10-09 2010-10-11 Thiazolidinedione energy restriction-mimetic agents

Publications (1)

Publication Number Publication Date
CN102638980A true CN102638980A (zh) 2012-08-15

Family

ID=43855337

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800559152A Pending CN102638980A (zh) 2009-10-09 2010-10-11 噻唑烷二酮能量限制拟似剂

Country Status (6)

Country Link
US (1) US8383656B2 (https=)
EP (1) EP2488027A4 (https=)
JP (2) JP5847085B2 (https=)
CN (1) CN102638980A (https=)
CA (1) CA2777406A1 (https=)
WO (1) WO2011044548A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105315223A (zh) * 2015-11-06 2016-02-10 河南大学 一种高立体和高对映选择性噻唑烷二酮类化合物、其制备方法及应用
CN111675673A (zh) * 2020-06-22 2020-09-18 郑州大学 3，4-二羟基肉桂酸酯类衍生物及其制备方法和应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6014816B2 (ja) * 2011-05-10 2016-10-26 国立大学法人神戸大学 Ｒａｓ機能阻害作用を有するチオキソチアゾリジン誘導体
WO2013148994A1 (en) * 2012-03-28 2013-10-03 The Ohio State University Research Foundation Glucose transporter inhibitors
AU2014207272A1 (en) * 2013-01-18 2015-07-30 Neal D. Andruska Estrogen receptor inhibitors
US12150935B1 (en) 2024-04-16 2024-11-26 Imam Mohammad Ibn Saud Islamic University 3-(3-(1,3-dioxoisoindolin-2-yl) propyl)-5-(4-fluorobenzylidene) thiazolidine-2,4-dione as a potential antitumor and apoptotic inducer

Citations (5)

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WO2006069217A2 (en) * 2004-12-22 2006-06-29 The Ohio State Research Foundation Small molecule cyclin d1 ablative agents
CN101014327A (zh) * 2004-07-14 2007-08-08 詹森药业有限公司 用于治疗雌激素相关α受体介导的疾病的亚芳基类物质
WO2009064486A2 (en) * 2007-11-15 2009-05-22 Musc Foundation For Research Development Inhibitors of pim protein kinases, compositions, and methods for treating cancer
WO2009105621A1 (en) * 2008-02-22 2009-08-27 The Ohio State University Research Foundation Androgen receptot-ablative agents

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GB962019A (en) 1961-04-12 1964-06-24 Mitsubishi Chem Ind Naphthalimide optical whitening agents
JPS4957048A (https=) 1972-10-04 1974-06-03
JPS5697277A (en) 1980-01-07 1981-08-05 Takeda Chem Ind Ltd Thiazolidine derivative
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JPS6424852A (en) 1987-07-21 1989-01-26 Mitsubishi Chem Ind Polyamide resin composition
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WO2004033438A1 (en) * 2002-10-08 2004-04-22 Theracos, Inc. Novel heterocyclic analogs of diphenylethylene compounds
CN101014327A (zh) * 2004-07-14 2007-08-08 詹森药业有限公司 用于治疗雌激素相关α受体介导的疾病的亚芳基类物质
WO2006069217A2 (en) * 2004-12-22 2006-06-29 The Ohio State Research Foundation Small molecule cyclin d1 ablative agents
WO2009064486A2 (en) * 2007-11-15 2009-05-22 Musc Foundation For Research Development Inhibitors of pim protein kinases, compositions, and methods for treating cancer
WO2009105621A1 (en) * 2008-02-22 2009-08-27 The Ohio State University Research Foundation Androgen receptot-ablative agents

Non-Patent Citations (4)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105315223A (zh) * 2015-11-06 2016-02-10 河南大学 一种高立体和高对映选择性噻唑烷二酮类化合物、其制备方法及应用
CN111675673A (zh) * 2020-06-22 2020-09-18 郑州大学 3，4-二羟基肉桂酸酯类衍生物及其制备方法和应用
CN111675673B (zh) * 2020-06-22 2022-06-24 郑州大学 3，4-二羟基肉桂酸酯类衍生物及其制备方法和应用

Also Published As

Publication number Publication date
WO2011044548A1 (en) 2011-04-14
US8383656B2 (en) 2013-02-26
EP2488027A1 (en) 2012-08-22
JP2015098492A (ja) 2015-05-28
EP2488027A4 (en) 2013-04-17
JP5847085B2 (ja) 2016-01-20
JP2013507397A (ja) 2013-03-04
US20110086895A1 (en) 2011-04-14
CA2777406A1 (en) 2011-04-14

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Application publication date: 20120815