JP5847085B2 - チアゾリジンジオンエネルギー制限模倣剤 - Google Patents

チアゾリジンジオンエネルギー制限模倣剤 Download PDF

Info

Publication number
JP5847085B2
JP5847085B2 JP2012533376A JP2012533376A JP5847085B2 JP 5847085 B2 JP5847085 B2 JP 5847085B2 JP 2012533376 A JP2012533376 A JP 2012533376A JP 2012533376 A JP2012533376 A JP 2012533376A JP 5847085 B2 JP5847085 B2 JP 5847085B2
Authority
JP
Japan
Prior art keywords
thiazolidine
dione
benzylidene
trifluoromethyl
ampk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2012533376A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013507397A5 (https=
JP2013507397A (ja
Inventor
チン−シー チェン,
チン−シー チェン,
ジー−ファ グー,
ジー−ファ グー,
Original Assignee
ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション, ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション filed Critical ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
Publication of JP2013507397A publication Critical patent/JP2013507397A/ja
Publication of JP2013507397A5 publication Critical patent/JP2013507397A5/ja
Application granted granted Critical
Publication of JP5847085B2 publication Critical patent/JP5847085B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2012533376A 2009-10-09 2010-10-11 チアゾリジンジオンエネルギー制限模倣剤 Expired - Fee Related JP5847085B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25004509P 2009-10-09 2009-10-09
US61/250,045 2009-10-09
US30488110P 2010-02-16 2010-02-16
US61/304,881 2010-02-16
PCT/US2010/052151 WO2011044548A1 (en) 2009-10-09 2010-10-11 Thiazolidinedione energy restriction-mimetic agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015036155A Division JP2015098492A (ja) 2009-10-09 2015-02-26 チアゾリジンジオンエネルギー制限模倣剤

Publications (3)

Publication Number Publication Date
JP2013507397A JP2013507397A (ja) 2013-03-04
JP2013507397A5 JP2013507397A5 (https=) 2013-11-14
JP5847085B2 true JP5847085B2 (ja) 2016-01-20

Family

ID=43855337

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012533376A Expired - Fee Related JP5847085B2 (ja) 2009-10-09 2010-10-11 チアゾリジンジオンエネルギー制限模倣剤
JP2015036155A Withdrawn JP2015098492A (ja) 2009-10-09 2015-02-26 チアゾリジンジオンエネルギー制限模倣剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015036155A Withdrawn JP2015098492A (ja) 2009-10-09 2015-02-26 チアゾリジンジオンエネルギー制限模倣剤

Country Status (6)

Country Link
US (1) US8383656B2 (https=)
EP (1) EP2488027A4 (https=)
JP (2) JP5847085B2 (https=)
CN (1) CN102638980A (https=)
CA (1) CA2777406A1 (https=)
WO (1) WO2011044548A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6014816B2 (ja) * 2011-05-10 2016-10-26 国立大学法人神戸大学 Ras機能阻害作用を有するチオキソチアゾリジン誘導体
WO2013148994A1 (en) * 2012-03-28 2013-10-03 The Ohio State University Research Foundation Glucose transporter inhibitors
AU2014207272A1 (en) * 2013-01-18 2015-07-30 Neal D. Andruska Estrogen receptor inhibitors
CN105315223B (zh) * 2015-11-06 2017-08-25 河南大学 一种高立体和高对映选择性噻唑烷二酮类化合物、其制备方法及应用
CN111675673B (zh) * 2020-06-22 2022-06-24 郑州大学 3,4-二羟基肉桂酸酯类衍生物及其制备方法和应用
US12150935B1 (en) 2024-04-16 2024-11-26 Imam Mohammad Ibn Saud Islamic University 3-(3-(1,3-dioxoisoindolin-2-yl) propyl)-5-(4-fluorobenzylidene) thiazolidine-2,4-dione as a potential antitumor and apoptotic inducer

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1003083A (en) 1961-01-21 1965-09-02 Toshiyasu Kasai Novel 4-alkoxynaphthalimides
GB962019A (en) 1961-04-12 1964-06-24 Mitsubishi Chem Ind Naphthalimide optical whitening agents
JPS4957048A (https=) 1972-10-04 1974-06-03
JPS5697277A (en) 1980-01-07 1981-08-05 Takeda Chem Ind Ltd Thiazolidine derivative
US4814366A (en) 1986-10-07 1989-03-21 Mitsubishi Chemical Industries Limited Thermoplastic polyester resin composition
JPS6424852A (en) 1987-07-21 1989-01-26 Mitsubishi Chem Ind Polyamide resin composition
DE68915844T2 (de) 1988-03-29 1994-10-06 Mitsubishi Chem Ind Thermoplastische Polyesterharzmischung und daraus hergestellte Formgegenstände.
JP2792111B2 (ja) 1989-06-16 1998-08-27 三菱化学株式会社 ポリエステル樹脂成形体の製造方法
ATE205206T1 (de) 1990-04-27 2001-09-15 Sankyo Co Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren
JP3020353B2 (ja) 1992-07-21 2000-03-15 ポーラ化成工業株式会社 化粧料
US6046222A (en) 1993-09-15 2000-04-04 Warner-Lambert Company Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus
JPH07247978A (ja) 1994-03-14 1995-09-26 Hitachi Ltd 冷媒ポンプ
ES2225833T3 (es) 1994-05-12 2005-03-16 Ciba Specialty Chemicals Holding Inc. Tratamiento textil.
GB9409466D0 (en) 1994-05-12 1994-06-29 Ciba Geigy Ag Textile treatment
US5801173A (en) 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
JP2817708B2 (ja) 1996-05-29 1998-10-30 日本電気株式会社 有機非線形光学材料及び有機非線形光学素子
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
NZ517993A (en) 1999-08-31 2004-03-26 Incyte San Diego Inc Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes
DE10353328A1 (de) 2003-11-14 2005-06-16 Basf Ag Verwendung von Naphthalin-1,8-dicarbonsäuremonoimiden
US20060014812A1 (en) * 2004-07-14 2006-01-19 Player Mark R Use of estrogen related receptor-modulating aryl ethers
US7566787B2 (en) 2004-12-22 2009-07-28 The Ohio State University Small molecule cyclin D1 ablative agents
US7714005B2 (en) * 2004-12-22 2010-05-11 The Ohio State University Research Foundation Small molecule Bcl-xL/Bcl-2 binding inhibitors
US7608715B2 (en) 2005-11-21 2009-10-27 Sabic Innovative Plastics Ip B.V. Fluorescent brighteners, methods of preparation thereof, fluorescent brightener compositions, and methods of preparation and uses thereof
TW200902508A (en) * 2007-03-07 2009-01-16 Janssen Pharmaceutica Nv Substituted phenoxy thiazolidinediones as estrogen related receptor-α modulators
GB0715284D0 (en) * 2007-08-06 2007-09-12 Medical Res Council Crystal structure of ampk and uses thereof
EP2217235A4 (en) * 2007-11-15 2011-01-12 Musc Found For Res Dev INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
US7973062B2 (en) * 2008-02-22 2011-07-05 The Ohio State University Research Foundation Androgen receptor-ablative agents

Also Published As

Publication number Publication date
WO2011044548A1 (en) 2011-04-14
US8383656B2 (en) 2013-02-26
EP2488027A1 (en) 2012-08-22
CN102638980A (zh) 2012-08-15
JP2015098492A (ja) 2015-05-28
EP2488027A4 (en) 2013-04-17
JP2013507397A (ja) 2013-03-04
US20110086895A1 (en) 2011-04-14
CA2777406A1 (en) 2011-04-14

Similar Documents

Publication Publication Date Title
Liu et al. Emerging roles of SIRT6 in human diseases and its modulators
Ma et al. BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16
Xia et al. Aldehyde dehydrogenase in solid tumors and other diseases: Potential biomarkers and therapeutic targets
Choi et al. PPARγ antagonist Gleevec improves insulin sensitivity and promotes the browning of white adipose tissue
Nelson et al. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells
Rattan et al. Metformin attenuates ovarian cancer cell growth in an AMP‐kinase dispensable manner
Xu et al. Discovery and modification of in vivo active Nrf2 activators with 1, 2, 4-oxadiazole core: hits identification and structure–activity relationship study
Huang et al. Histone deacetylase 3 inhibition alleviates type 2 diabetes mellitus-induced endothelial dysfunction via Nrf2
Qu et al. SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc
JP2015098492A (ja) チアゾリジンジオンエネルギー制限模倣剤
Li et al. Epigallocatechin gallate inhibits hepatic glucose production in primary hepatocytes via downregulating PKA signaling pathways and transcriptional factor FoxO1
Voelkel-Johnson et al. Interdiction of sphingolipid metabolism revisited: focus on prostate cancer
Liu et al. Zingerone attenuates aortic banding‐induced cardiac remodelling via activating the eNOS/Nrf2 pathway
Pil Hwang et al. 3‐Caffeoyl, 4‐dihydrocaffeoylquinic acid from S alicornia herbacea attenuates high glucose‐induced hepatic lipogenesis in human H ep G 2 cells through activation of the liver kinase B 1 and silent information regulator T 1/AMPK‐dependent pathway
Tao et al. Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin
US20180318298A1 (en) Method of Treating Obesity
Lee et al. Betulinic acid induces eNOS expression via the AMPK-dependent KLF2 signaling pathway
US20250099438A1 (en) Small molecule inhibitors of gpcr gpr68 and related receptors for treating cancer, glioblastoma, and other indications
JP7466534B2 (ja) 代謝性疾患及び/又はその臨床状態を抑制及び/又は処置するための組成物及び方法
US9937173B2 (en) Method of treating obesity
Maucort et al. Differentiation of cancer stem cells by using synthetic small molecules: toward new therapeutic strategies against therapy resistance
Choi et al. Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model
Zhou et al. Hypoxia-activated prodrugs with dual COX-2/CA inhibitory effects on attenuating cardiac inflammation under hypoxia
Liu et al. Resveratrol suppresses hepatic fatty acid synthesis and increases fatty acid β-oxidation via the microRNA-33/SIRT6 signaling pathway
Men et al. IL-6/gp130/STAT3 signaling contributed to the activation of the PERK arm of the unfolded protein response in response to chronic β-adrenergic stimulation

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130927

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130927

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140929

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141225

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150226

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150529

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150828

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150918

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20151027

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20151124

R150 Certificate of patent or registration of utility model

Ref document number: 5847085

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees