JP5847085B2 - チアゾリジンジオンエネルギー制限模倣剤 - Google Patents

チアゾリジンジオンエネルギー制限模倣剤 Download PDF

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Publication number
JP5847085B2
JP5847085B2 JP2012533376A JP2012533376A JP5847085B2 JP 5847085 B2 JP5847085 B2 JP 5847085B2 JP 2012533376 A JP2012533376 A JP 2012533376A JP 2012533376 A JP2012533376 A JP 2012533376A JP 5847085 B2 JP5847085 B2 JP 5847085B2
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Prior art keywords
thiazolidine
dione
benzylidene
trifluoromethyl
ampk
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JP2012533376A
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Japanese (ja)
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JP2013507397A (ja
JP2013507397A5 (https=
Inventor
チン−シー チェン,
チン−シー チェン,
ジー−ファ グー,
ジー−ファ グー,
Original Assignee
ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2012533376A 2009-10-09 2010-10-11 チアゾリジンジオンエネルギー制限模倣剤 Expired - Fee Related JP5847085B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25004509P 2009-10-09 2009-10-09
US61/250,045 2009-10-09
US30488110P 2010-02-16 2010-02-16
US61/304,881 2010-02-16
PCT/US2010/052151 WO2011044548A1 (en) 2009-10-09 2010-10-11 Thiazolidinedione energy restriction-mimetic agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015036155A Division JP2015098492A (ja) 2009-10-09 2015-02-26 チアゾリジンジオンエネルギー制限模倣剤

Publications (3)

Publication Number Publication Date
JP2013507397A JP2013507397A (ja) 2013-03-04
JP2013507397A5 JP2013507397A5 (https=) 2013-11-14
JP5847085B2 true JP5847085B2 (ja) 2016-01-20

Family

ID=43855337

Family Applications (2)

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JP2012533376A Expired - Fee Related JP5847085B2 (ja) 2009-10-09 2010-10-11 チアゾリジンジオンエネルギー制限模倣剤
JP2015036155A Withdrawn JP2015098492A (ja) 2009-10-09 2015-02-26 チアゾリジンジオンエネルギー制限模倣剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015036155A Withdrawn JP2015098492A (ja) 2009-10-09 2015-02-26 チアゾリジンジオンエネルギー制限模倣剤

Country Status (6)

Country Link
US (1) US8383656B2 (https=)
EP (1) EP2488027A4 (https=)
JP (2) JP5847085B2 (https=)
CN (1) CN102638980A (https=)
CA (1) CA2777406A1 (https=)
WO (1) WO2011044548A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9056862B2 (en) * 2011-05-10 2015-06-16 National University Corporation Kobe University Thioxothiazolidine derivative having Ras function inhibitory effect
WO2013148994A1 (en) * 2012-03-28 2013-10-03 The Ohio State University Research Foundation Glucose transporter inhibitors
CA2898732A1 (en) * 2013-01-18 2014-07-24 Mao CHENGJIAN Estrogen receptor inhibitors
CN105315223B (zh) * 2015-11-06 2017-08-25 河南大学 一种高立体和高对映选择性噻唑烷二酮类化合物、其制备方法及应用
CN111675673B (zh) * 2020-06-22 2022-06-24 郑州大学 3,4-二羟基肉桂酸酯类衍生物及其制备方法和应用
US12150935B1 (en) 2024-04-16 2024-11-26 Imam Mohammad Ibn Saud Islamic University 3-(3-(1,3-dioxoisoindolin-2-yl) propyl)-5-(4-fluorobenzylidene) thiazolidine-2,4-dione as a potential antitumor and apoptotic inducer

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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GB1003083A (en) 1961-01-21 1965-09-02 Toshiyasu Kasai Novel 4-alkoxynaphthalimides
GB962019A (en) 1961-04-12 1964-06-24 Mitsubishi Chem Ind Naphthalimide optical whitening agents
JPS4957048A (https=) 1972-10-04 1974-06-03
JPS5697277A (en) 1980-01-07 1981-08-05 Takeda Chem Ind Ltd Thiazolidine derivative
US4814366A (en) 1986-10-07 1989-03-21 Mitsubishi Chemical Industries Limited Thermoplastic polyester resin composition
JPS6424852A (en) 1987-07-21 1989-01-26 Mitsubishi Chem Ind Polyamide resin composition
EP0335595B1 (en) 1988-03-29 1994-06-08 Mitsubishi Kasei Corporation Thermoplastic polyester resin composition and molded articles produced therefrom
JP2792111B2 (ja) 1989-06-16 1998-08-27 三菱化学株式会社 ポリエステル樹脂成形体の製造方法
ATE205206T1 (de) 1990-04-27 2001-09-15 Sankyo Co Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren
JP3020353B2 (ja) 1992-07-21 2000-03-15 ポーラ化成工業株式会社 化粧料
US6046222A (en) 1993-09-15 2000-04-04 Warner-Lambert Company Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus
JPH07247978A (ja) 1994-03-14 1995-09-26 Hitachi Ltd 冷媒ポンプ
EP0682145B1 (en) 1994-05-12 2004-08-25 Ciba SC Holding AG Textile treatment
GB9409466D0 (en) 1994-05-12 1994-06-29 Ciba Geigy Ag Textile treatment
US5801173A (en) 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
JP2817708B2 (ja) 1996-05-29 1998-10-30 日本電気株式会社 有機非線形光学材料及び有機非線形光学素子
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
JP2003508391A (ja) 1999-08-31 2003-03-04 マキシア・ファーマシューティカルズ・インコーポレイテッド ベンジリデン−チアゾリジンジオン類およびアナログ類ならびに糖尿病の治療におけるその使用
DE10353328A1 (de) 2003-11-14 2005-06-16 Basf Ag Verwendung von Naphthalin-1,8-dicarbonsäuremonoimiden
CN101014327A (zh) * 2004-07-14 2007-08-08 詹森药业有限公司 用于治疗雌激素相关α受体介导的疾病的亚芳基类物质
WO2006069186A2 (en) 2004-12-22 2006-06-29 The Ohio State Research Foundation Small molecule bcl-xl/bcl-2 binding inhibitors
WO2006069217A2 (en) 2004-12-22 2006-06-29 The Ohio State Research Foundation Small molecule cyclin d1 ablative agents
US7608715B2 (en) 2005-11-21 2009-10-27 Sabic Innovative Plastics Ip B.V. Fluorescent brighteners, methods of preparation thereof, fluorescent brightener compositions, and methods of preparation and uses thereof
NZ579372A (en) * 2007-03-07 2012-02-24 Janssen Pharmaceutica Nv Substituted phenoxy thiazolidinediones as estrogen related receptor-alpha modulators
GB0715284D0 (en) * 2007-08-06 2007-09-12 Medical Res Council Crystal structure of ampk and uses thereof
EP2217235A4 (en) * 2007-11-15 2011-01-12 Musc Found For Res Dev INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
EP2254576B1 (en) * 2008-02-22 2013-08-28 The Ohio State University Research Foundation Androgen receptor-ablative agents

Also Published As

Publication number Publication date
CA2777406A1 (en) 2011-04-14
WO2011044548A1 (en) 2011-04-14
US20110086895A1 (en) 2011-04-14
JP2013507397A (ja) 2013-03-04
JP2015098492A (ja) 2015-05-28
EP2488027A4 (en) 2013-04-17
EP2488027A1 (en) 2012-08-22
CN102638980A (zh) 2012-08-15
US8383656B2 (en) 2013-02-26

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