CN102631473B - Wound caring composition after anorectal operation - Google Patents
Wound caring composition after anorectal operation Download PDFInfo
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- CN102631473B CN102631473B CN 201210093885 CN201210093885A CN102631473B CN 102631473 B CN102631473 B CN 102631473B CN 201210093885 CN201210093885 CN 201210093885 CN 201210093885 A CN201210093885 A CN 201210093885A CN 102631473 B CN102631473 B CN 102631473B
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- kaolin
- spina gleditsiae
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Abstract
The invention discloses a wound caring composition after anorectal operation. The composition is characterized by comprising the following raw material drugs in parts by weight: 8 to 12 parts of common jasminorange leaf and twig, 8 to 12 parts of acutangular anisodus root, 8 to 12 parts of Chinese honey locust spine, 8 to12 parts of caulophyllum robustum, 8 to 12 parts of colophony powder, 4 to 6 parts of portulaca oleracea, 1 part of kaolinite, and 14 to 20 parts of tea oil. Clinical tests prove that: the caring composition is used after anorectal operation, local blood circulation can be improved, tissue repair can be accelerated, the wound healing quality can be remarkably improved, the healing time is shortened, postoperative pain can be relieved, the curative effect is reliable, and use is safe.
Description
[technical field]
The present invention relates to the field of Chinese medicines, be specifically related to be used for the wound care composition of anorectal postoperative.
[background technology]
The anus anorectal disease patient needs operative treatment mostly, and postoperative mostly is open otch, and there is bigger damage in operation, and wound healing time is longer, is prone to symptoms such as hemorrhage, infection, pain.Especially pain behind the anal-surgery has a strong impact on rehabilitation of patients and quality of life, is the difficult problem that doctor and patient is very paid close attention to.The main cause of anorectal postoperative pain is complicated and special: anus local nerve tip is very abundant, the following receptor innervation of tooth trace, and sensation is very sharp, particularly pain is had special sensitivity.When the traumatic postoperative of pathological change of anorectal, or be upset in diagnosis and treatment process, prostaglandin, histamine, 5-tryptamines, Kallidin I etc. cause disengaging of painful material, stimulate sphincter muscle of rectum, and it is twin to make it constantly to shrink convulsion, produces pain.Especially open art formula is adopted in podex operation more, postoperative sphincter, the easy activity of elephant skin flesh or spasm, and pain easily takes place even has an intense pain in reasons such as postoperative defecation, brings big painful to the patient.Patient's feared state of mind in addition, hypertonicity, to hyperalgesia, touch i.e. sense acute painful unbearably.Therefore, the pain of anus postoperative causes jointly owing to its physiologic factor and Nervous and Mental Factors.The anal-surgery otch belongs to II class otch, and clinical processing mode commonly used is a water preparation class medicine water yarn flap coverage at present, as hydrogen peroxide flushing back Rhizoma Coptidis water or the soak of nitrofural water yarn etc.But because new granulation tissue is to external world a little less than the physicochemical irritation opposing, subject to damage, the disinfectant of this class though bacteriostastis is arranged, simultaneously can disorganize be unfavorable for that wound surface grows.
[summary of the invention]
Technical assignment of the present invention is at above the deficiencies in the prior art, provides a kind of curative effect that is used for the anorectal postoperative to affirm, can improve the wound healing quality, and can alleviate the wound care composition of postoperative pain.
The technical scheme that the present invention solves its technical problem is: a kind of wound care composition that is used for the anorectal postoperative is characterized in that being made by following materials of weight proportions medicine: 8～12 parts of Folium Et Cacumen Murrayae, 8～12 parts of Radix Anisodi Acutangulis, 8～12 parts of Spina Gleditsiae, 8～12 parts of Radix Caulophyllis, 8～12 parts of Colophonium powder, 4～6 parts of Herba Portulacaes, 1 part of Kaolin, 14～20 parts of Oleum Camelliae.
Chinese medicine of the present invention is prepared from by following optimum weight part proportion raw material:
10 parts of Folium Et Cacumen Murrayae, 10 parts of Radix Anisodi Acutangulis, 10 parts of Spina Gleditsiae, 10 parts of Radix Caulophyllis, 10 parts of Colophonium powder, 5 parts of Herba Portulacaes, 1 part of Kaolin, 16 parts of Oleum Camelliae.
Wherein said:
Folium Et Cacumen Murrayae is dried leaves and the band leaf twig of rutaceae Folium Et Cacumen Murrayae Murraya exotica L. and Murraya paniculata (L.) Jack. Murraya paniculata (L.) xJack.Hot, little hardship, temperature.Promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, anesthesia, removing toxic substances and promoting subsidence of swelling.
Radix Anisodi Acutanguli is Solanaceae Radix scopoliae carniolicoidis platymiscium Radix Anisodi Acutanguli Anisodus acutangulus C.Y.Wu et C.Chen and scopolia lurida Dunal Scopolia lurida Dunal[Anisodusluridus Link et Otto], be used as medicine with root, stem and leaf and seed.Hot, bitter, temperature.The analgesia, expelling wind and removing dampness.
Spina Gleditsiae is the dry Spina jujubae of leguminous plant Fructus Gleditsia.The nature and flavor suffering, temperature.Return liver, stomach warp.The merit poison holding of can subsiding a swelling, evacuation of pus, parasite killing.
Radix Caulophylli is Berberidaceae Paeonia suffruticosa grass platymiscium leontice robustumDiels root stock.Nature and flavor hardship, suffering, temperature.But the merit regulating QI to relieve pain, expelling wind and activating blood circulation.
Colophonium powder is the oleoresin of obtaining in pinaceae plant Pinus massoniana Lamb or its congener trunk, the powder that the legacy after volatile oil is removed in distillation is made.But the merit dispeiling pathogenic wind and removing dampness, evacuation of pus is drawn out pus by applying a plaster to the affected part, the granulation promoting pain relieving.
Herba Portulacae is the herb of portulacaceous plant Herba Portulacae Portulaca oleracea L..Nature and flavor acid, cold.Go into large intestine channel.But the merit clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.
Kaolin is the silicates mineral.Main component is an aluminium silicate hydrate, silicon oxide-containing 46.5%, aluminium oxide 39.5%, water 14.0%.Nature and flavor are sweet, sour, and are flat.But merit astringing intestine to stop diarrhea; Hemostasis; Admittedly take off; Removing dampness is held back skin ulcer.
Oleum Camelliae, the fatty oil that obtains with milling process for the mature seed of plant of theaceae oil tea Camellia oleifera Abel or lobule oil tea Camellia meiocarpa Hu.ms..Sweet, cold.Return large intestine channel.Clearing away heat and eliminating dampness, the parasite killing detoxifcation.
Composition principle: the pathomechanism of anorectal postoperative pain mainly is two approach: the one, and the sphincter ani internus spasmic pain, the 2nd, the postoperative skin edema is pain caused, the local organization edema, microcirculation disturbance, teleneuron blood forms the ischemic neuralgia for reducing.So the present invention is directed to etiology and pathogenesis, outward in order to promoting the circulation of QI to relieve pain, the dampness of invigorating blood circulation, removing toxic substances and promoting subsidence of swelling is to eliminate symptom.So we get the Folium Et Cacumen Murrayae promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, anesthesia, removing toxic substances and promoting subsidence of swelling is monarch drug; Radix Anisodi Acutanguli has the effect of analgesia; Spina Gleditsiae, Colophonium powder detumescence promoting pus discharge and tissue regeneration strengthening; The pain relieving of Radix Caulophylli vital energy regualting and blood circulation-promoting; Herba Portulacae goes into large intestine channel clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; The Kaolin removing dampness is held back skin ulcer; The Oleum Camelliae clearing away heat and eliminating dampness is detoxified, and decocts medicament with Oleum Camelliae, also has the effect of granulation promoting meat, the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin.All medicine reinforcement and elimination in combination, evident in efficacy.
Modern pharmacological research shows: by relexation, the spasm that causes for histamine and barium chloride has antagonism to Folium Et Cacumen Murrayae extract to exsomatize white mouse small intestinal and large intestine.The root of Radix Anisodi Acutanguli contains multiple alkaloids such as hyoscyamine and Cuscohygrine, and the former effect is similar to atropine, and the Radix Anisodi Acutanguli fluid extract has effects such as the smooth muscle spasm of releasing.The main component thaspine of Radix Caulophylli has apparent bacteriostasis.Herba Portulacae all has inhibitory action to staphylococcus aureus and Hemolytic streptococcus.The Spina Gleditsiae external can promote epidermal growth and granulation tissue hyperplasia, improves local blood circulation, promotes the wound surface slough to come off, and quickens wound repair.Colophonium powder can strengthen the huge phagocytic activity of biting group born of the same parents and NK cell, and edema diminishes inflammation.
[specific embodiment]
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: 8 parts of Folium Et Cacumen Murrayae, 8 parts of Radix Anisodi Acutangulis, 8 parts of Spina Gleditsiae, 8 parts of Radix Caulophyllis, 8 parts of Colophonium powder, 4 parts of Herba Portulacaes, 1 part of Kaolin, 14 parts of Oleum Camelliae.
Embodiment 2, the crude drug weight proportion: 12 parts of Folium Et Cacumen Murrayae, 12 parts of Radix Anisodi Acutangulis, 12 parts of Spina Gleditsiae, 12 parts of Radix Caulophyllis, 12 parts of Colophonium powder, 6 parts of Herba Portulacaes, 1 part of Kaolin, 20 parts of Oleum Camelliae.
Embodiment 3, the crude drug weight proportion: 10 parts of Folium Et Cacumen Murrayae, 10 parts of Radix Anisodi Acutangulis, 10 parts of Spina Gleditsiae, 10 parts of Radix Caulophyllis, 10 parts of Colophonium powder, 5 parts of Herba Portulacaes, 1 part of Kaolin, 16 parts of Oleum Camelliae.
Chinese medicine of the present invention can be prepared from by following method:
(1), with Folium Et Cacumen Murrayae, Radix Anisodi Acutanguli, Spina Gleditsiae, Radix Caulophylli, Herba Portulacae clean, dry, pulverize, become compound standby after 100 mesh sieves;
(2), get the filtering of Oleum Camelliae oil plant, be heated to 200 ℃～220 ℃, drop into the compound that step 1 produced, stir, heat after 10～15 minutes, the oil plant filtering is heated to 80 ℃～100 ℃, add Colophonium powder, Kaolin powder, continue to stir, boil when dripping beading, surface spray cold water, remove noxious water, be cooled to room temperature and get ointment.
All medicine compositions are coordinated mutually, are used for the anorectal postoperative, effectively reach the purpose that improves the wound healing quality, and can alleviate postoperative pain.Outward appearance is yellow semi-solid ointment, uniform and smooth, and stretchability is good, and is easy to use.The above results is that clinical data proves that fully interrelated data is as follows, wherein studies drug use and is the crude drug weight proportion among the embodiment 1.
1 object and method
1.1 object: years 22 months in January, 20010 to 2010, hemorrhoid, anal fistula, anal fissure and abscess anal-surgery patient totally 193 examples are collected in outpatient service, are divided into matched group 95 examples at random; Man's 63 examples, women 32 examples, at 13～59 years old age, 98 examples are organized in treatment; Man's 58 examples, women 40 examples, 15～61 years old age; Two groups of sexes, age treatments have comparability.
1.2 method
1.2.1 research method: the conventional auxiliary examinations of all patient's art previous crops, comprise routine blood test, blood glucose, liver function, B ultrasonic goes out, clotting time, electrocardiogram etc.Full group case does not have the Chronic consumptions history.The outer pressure method of stripping was handled in hemorrhoid adopted, and anal fissure adds the internal sphincter art with excision; Anal fistula adopts simple excision or hanging wire art; Perianal abscess adopts disposable incision and drainage.All patient's postoperatives are suitably used antibiotic and are avoided infection, and the heavier person of pain symptom adds analgesic drug product.Matched group postoperative wound external MAYINGLONGZHICHUANGGAO.The embodiment of the invention 1 product application of treatment group, after the debridement of infective wound surface elder generation, reuse this product is coated on topical application on the gauze.5d was 1 course of treatment, carried out efficacy evaluation behind the treatment 10d.
1.2.2 efficacy assessment standard: according to " anorectal disease diagnosis criterion of therapeutical effect ", produce effects: local nothing infects, and distending pain disappears, and anus edge edema disappears, and wound surface does not have sepage, no oozing of blood, no pruritus.Effectively: local nothing infects, and swelling pain alleviates, and wound surface has a small amount of sepage, slight pruritus.Invalid: symptom does not have obvious improvement.
1.2.3 statistical analysis SPSS 13.0 carries out statistical analysis.Measurement data adopts mean ± standard deviation to carry out descriptive statistics.
2 results
2.1 two groups of efficacy evaluations: two groups of patient's curative effects relatively see the following form, and credit is analysed by statistics, and two groups are compared χ
2=11.54, treatment group effective percentage is apparently higher than matched group, significant difference (p＜0.01).
2.2 two groups of healing times are relatively: treatment group average out to 14.35 ± 9.49d, matched group is 21.86 ± 14.32d, and the two compares, and difference has statistical significance (p＜0.05).
2.3 take the analgesic situation relatively for two groups: the aftertreatment group is taken analgesic 5 examples, and matched group is 12 examples, and difference has obvious statistical significance (p＜0.01).
3. conclusion: this result of study shows that the anorectal postoperative uses care composition of the present invention, can improve local blood circulation, and acceleration of tissue repair obviously improves the wound healing quality, shortens healing time, and can alleviate postoperative pain, and curative effect is reliable and safe in utilization.
Claims (2)
1. a wound care composition that is used for the anorectal postoperative is characterized in that being made by following materials of weight proportions medicine: 8～12 parts of Folium Et Cacumen Murrayae, 8～12 parts of Radix Anisodi Acutangulis, 8～12 parts of Spina Gleditsiae, 8～12 parts of Radix Caulophyllis, 8～12 parts of Colophonium powder, 4～6 parts of Herba Portulacaes, 1 part of Kaolin, 14～20 parts of Oleum Camelliae; The preparation method of described wound care composition is: (1), with Folium Et Cacumen Murrayae, Radix Anisodi Acutanguli, Spina Gleditsiae, Radix Caulophylli, Herba Portulacae clean, dry, pulverize, become compound standby after 100 mesh sieves; (2), get the filtering of Oleum Camelliae oil plant, be heated to 200 ℃～220 ℃, drop into the compound that step 1 produced, stir, heat after 10～15 minutes, the oil plant filtering is heated to 80 ℃～100 ℃, add Colophonium powder, Kaolin powder, continue to stir, boil when dripping beading, surface spray cold water, remove noxious water, be cooled to room temperature and get ointment.
2. a kind of wound care composition that is used for the anorectal postoperative according to claim 1 is characterized in that being made by following materials of weight proportions medicine: 10 parts of Folium Et Cacumen Murrayae, 10 parts of Radix Anisodi Acutangulis, 10 parts of Spina Gleditsiae, 10 parts of Radix Caulophyllis, 10 parts of Colophonium powder, 5 parts of Herba Portulacaes, 1 part of Kaolin, 16 parts of Oleum Camelliae.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210093885 CN102631473B (en) | 2012-04-01 | 2012-04-01 | Wound caring composition after anorectal operation |
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| CN 201210093885 CN102631473B (en) | 2012-04-01 | 2012-04-01 | Wound caring composition after anorectal operation |
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| CN102631473A CN102631473A (en) | 2012-08-15 |
| CN102631473B true CN102631473B (en) | 2013-07-24 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103272149B (en) * | 2013-05-30 | 2015-03-11 | 李伟丽 | Medicine composition for preventing and treating postoperative complication of anorectal diseases |
| CN105832903A (en) * | 2016-03-22 | 2016-08-10 | 王慧丽 | Composition for anorectal postoperative wound care |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101979031B (en) * | 2010-10-28 | 2011-11-09 | 李桂宾 | Medicament for treating hemorrhoids and preparation method thereof |
| CN102266471A (en) * | 2010-06-04 | 2011-12-07 | 王风权 | Carbuncle eliminating and ulcer treating traditional Chinese medicine ointment |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266471A (en) * | 2010-06-04 | 2011-12-07 | 王风权 | Carbuncle eliminating and ulcer treating traditional Chinese medicine ointment |
| CN101979031B (en) * | 2010-10-28 | 2011-11-09 | 李桂宾 | Medicament for treating hemorrhoids and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 徐慧岩等.远兴痔疮水治疗直肠肛窦炎180例.《陕西中医》.2009,86-87. |
| 远兴痔疮水治疗直肠肛窦炎180例;徐慧岩等;《陕西中医》;20091231;86-87 * |
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