CN102600446B - 一种治疗脑梗阻的中药 - Google Patents
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Abstract
本发明涉及一种治疗脑梗阻的中药，其特征在于，它是由以下重量份的药材组成：纳豆10-20份、半夏10-20份、胆南星4-6份、橘红4-6份、枳实4-6份、茯苓4-6份、甘草4-6份、生姜10-20份。实验证明，本发明能够安全有效治疗脑梗阻。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗脑梗阻的中药。
背景技术
脑梗塞是脑血管严重狭窄或闭塞，导致脑血流阻断而使脑组织发生缺血坏死和软化，属于临床常见病，约占全部急性脑血管疾病的50％－60％。目前的治疗药物成本较高，且疗效不理想。因此研究开发一种安全有效治疗脑梗阻的中药非常有实用价值。
本发明中药所涉及药材的研究现状如下：
纳豆：【来源】为大豆经纳豆菌发酵而成的一种食品。【功能主治】具化瘀溶栓之功效。
半夏：【来源】本品为天南星科植物半夏Pinellia ternata （Thunb.） Breit. 的干燥块茎。【功能主治】燥湿化痰，降逆止呕，消痞散结。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛，呕吐反胃，胸脘痞闷，梅核气；生用外治痈肿痰核。姜半夏多用于降逆止呕。
胆南星：【来源】为天南星用牛胆汁拌制而成的加工品。【功能主治】清火化痰，镇惊定痼。治中风痰迷，惊风癫痫，痰火喘嗽，头风眩晕。
橘红：【来源】本品为芸香科植物化州桔Citrus grandis Osbeck var. tomentosa Hort.或橘Citrus reticulata Blanco 及其栽培变种的干燥外层果皮。【功能主治】散寒，燥湿，利气，消痰。用于风寒咳嗽，喉痒痰多，食积伤酒，呕恶痞闷。
枳实：【来源】本品为芸香科植物酸橙Citrus aurantium L. 及其栽培变种或甜橙Citrus sinensis Osbeck 的干燥幼果。 【功能主治】破气消积，化痰散痞。用于积滞内停，痞满胀痛，泻痢后重，大便不通，痰滞气阻胸痹，结胸；胃下垂，脱肛，子宫脱垂。
茯苓：【来源】本品为多孔菌科真菌茯苓 Poria cocos （Schw.） Wolf 的干燥菌核。【功能主治】利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
甘草：【来源】本品为豆科植物甘草 Glycyrrhiza uralensis Fisch.、胀果甘草 Glycyrrhiza inflata Bat. 或光果甘草 Glycyrrhiza glabra L. 的干燥根。【功能主治】补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
生姜：【来源】本品为姜科植物姜Zingiber officinale Rosc.的新鲜根茎。【功能主治】解表散寒，温中止呕，化痰止咳。用于风寒感冒，胃寒呕吐，寒痰咳嗽。
发明内容
本发明旨在提供一种治疗脑梗阻的中药，通过选择合适的药材及其配比，达到安全有效治愈脑梗阻的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗脑梗阻的中药，其特征在于，它是由以下重量份的药材组成：纳豆10-20份、半夏10-20份、胆南星4-6份、橘红4-6份、枳实4-6份、茯苓4-6份、甘草4-6份、生姜10-20份。
其中优选：纳豆15份，半夏15份、胆南星5份、橘红5份、枳实5份、茯苓5份，甘草5份，生姜15份。
本发明具体使用方法：正常成年患者每日需服用使用“纳豆10-20克，半夏10-20克、胆南星4-6克、橘红4-6克、枳实4-6克、茯苓4-6克，甘草4-6克，生姜10-20克”按照常规制药工艺，制得的成药。
下面结合中医理论说明本发明的有益效果：
发明人在实践中发现，脑梗阻大多是由于痰湿内盛，加之恼怒气逆，引动肝风，上扰清窍所致。本发明运用：茯苓、甘草、生姜健脾祛湿；半夏、胆南星、橘红、枳实燥湿化痰；纳豆活血化瘀。诸药合用，从而燥湿化痰，熄风，降逆，调中，溶栓，有效治疗脑梗阻。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年10月-2011年4月间共收集75例脑梗阻的门诊患者，其中男40例，女35例，年龄35-65岁，病程2天-3年。随机分为：治疗组50例，对照组25例。两组性别、年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗方法
对照组使用国产尿激酶2万～5万单位加入0.56摩尔/升10%葡萄糖液中静滴，每日1次，疗程1周。
治疗组口服本发明优选实施方式按照具体实施例1制得的胶囊，每日2次。疗程1周。
2.2观察项目：对头疼，头晕，口眼歪斜，半身麻木等症状进行观察。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
| 治疗组 | 50 | 42 | 6 | 2 | 0（0%） | 96% |
| 对照组 | 25 | 10 | 13 | 2 | 0（0%） | 92% |
可见，本发明优选实施方式制得的药物能够安全有效治疗脑梗阻。
根据上述临床实验数据，结合本发明治疗脑梗阻的中医学机理分析和本领域公知常识，本领域技术人员容易推知，运用本发明中的药材，在其最佳重量份附近取值，至少在“纳豆10-20份、半夏10-20份、胆南星4-6份、橘红4-6份、枳实4-6份、茯苓4-6份、甘草4-6份、生姜10-20份”的范围内，可以取得与本发明优选实施方式制得的药物类似的技术效果。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取半夏15克、胆南星5克、橘红5克、枳实5克、茯苓5克，甘草5克，生姜15克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，加入纳豆粉15克，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗脑梗阻。口服，每日分早晚两次服用。
具体实施例2
称取半夏10克、胆南星4克、橘红4克、枳实4克、茯苓4克，甘草4克，生姜10克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，加入纳豆粉10克克，包装，即得符合正常成人一天用量的散剂。
用于治疗脑梗阻。口服，每日一次。
具体实施例3
称取半夏20克、胆南星6克、橘红6克、枳实6克、茯苓6克，甘草6克，生姜20克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，加入纳豆粉20克，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人一天用量的颗粒剂。
用于治疗脑梗阻。口服，每日分早中晚三次服用。
Claims (1)
1.一种治疗脑梗阻的中药，其特征在于，它是由以下重量份的药材组成：纳豆15份，半夏15份、胆南星5份、橘红5份、枳实5份、茯苓5份，甘草5份，生姜15份。
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