CN102600365B - Drug for treatment of oral ulcers - Google Patents
Drug for treatment of oral ulcers Download PDFInfo
- Publication number
- CN102600365B CN102600365B CN 201210091494 CN201210091494A CN102600365B CN 102600365 B CN102600365 B CN 102600365B CN 201210091494 CN201210091494 CN 201210091494 CN 201210091494 A CN201210091494 A CN 201210091494A CN 102600365 B CN102600365 B CN 102600365B
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- China
- Prior art keywords
- parts
- treatment
- fructus
- drug
- oral ulcers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 20
- 208000007117 Oral Ulcer Diseases 0.000 title claims abstract description 18
- 229940079593 drug Drugs 0.000 title claims abstract description 9
- 241001164374 Calyx Species 0.000 claims abstract description 6
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims abstract description 4
- 208000002399 aphthous stomatitis Diseases 0.000 claims description 15
- 241000959626 Calvatia Species 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims description 5
- 244000064622 Physalis edulis Species 0.000 claims description 5
- 240000001972 Gardenia jasminoides Species 0.000 claims description 2
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims description 2
- 241000245240 Lonicera Species 0.000 claims description 2
- 241001078983 Tetradium ruticarpum Species 0.000 claims description 2
- 229940097275 indigo Drugs 0.000 claims description 2
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 4
- 235000001674 Agaricus brunnescens Nutrition 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 241001313857 Bletilla striata Species 0.000 abstract 1
- 235000010254 Jasminum officinale Nutrition 0.000 abstract 1
- 240000005385 Jasminum sambac Species 0.000 abstract 1
- 241000133231 Marshallia caespitosa Species 0.000 abstract 1
- 241001465382 Physalis alkekengi Species 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 5
- 208000025865 Ulcer Diseases 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 208000001387 Causalgia Diseases 0.000 description 2
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 2
- 210000000589 cicatrix Anatomy 0.000 description 2
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000003780 keratinization Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 208000008630 Sialorrhea Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- -1 instant Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 208000030208 low-grade fever Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 201000003265 lymphadenitis Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a drug for treatment of oral ulcers, which is prepared with raw materials in part by weight: 10-20 parts of asarum, 20-30 parts of lantern plant calyx, 10-30 parts of jasmine, 20-50 parts of honeysuckle, 5-15 parts of bletilla striata, 5-15 parts of fructus evodiae, 5-10 parts of indigo naturalis, 10-20 parts of radix scutellariae and 10-20 parts of puffball mushroom. Natural herbs are used in the drug for treatment of oral ulcers, so the drug for treatment of oral ulcers has the advantages of quick and good effects and no toxic or side effects.
Description
Technical field
The present invention relates to the field, oral cavity, specifically, relate to a kind of medicament for the treatment of oral ulcer.
Background technology
Oral ulcer is a kind of aphtha that occurs in the oral cavity thin film, and the lighter's causalgia is obvious, affects diet; Heavy produce mucosa adenitis or necrosis, the course of disease is slow, leaves cicatrix after more.
The treatment oral ulcer has the methods such as antibiotic medicine for oral administration, mealy medicine external application at present, but therapeutic effect is not obvious, particularly uses application, and the pain increased, sialorrhea is more than, and patient is difficult to accept.
Summary of the invention
The purpose of this invention is to provide a kind of medicament for the treatment of oral ulcer.
In order to realize purpose of the present invention, the invention provides a kind of medicament for the treatment of oral ulcer, it is to be made by weight by following bulk drugs: Herba Asari 10-20 part, Calyx seu Fructus physalis 20-30 part, Fructus Gardeniae 10-30 part, Flos Lonicerae 20-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Fructus Evodiae 5-15 part, Indigo Naturalis 5-10 part, Radix Scutellariae 10-20 part and Lasiosphaera Seu Calvatia 10-20 part.
Preferably, it is to be made by weight by following bulk drugs: 15 parts of 15 parts of Herba Asaris, 25 parts of Calyx seu Fructus physaliss, 20 parts of Fructus Gardeniaes, 30 parts of Flos Loniceraes, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts of Fructus Evodiaes, 8 parts of Indigo Naturaliss, 15 parts of Radix Scutellariae and Lasiosphaera Seu Calvatia.
Preferably, described medicament is tablet, dispersible tablet, instant, powder or granule.
Use natural drug in the medicament for the treatment of oral ulcer of the present invention, so it have advantages of instant effect, good effect, has no side effect.
The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not to be limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within the scope of the present invention.
The preparation of embodiment 1 powder of the present invention
Get Herba Asari 150 grams, Calyx seu Fructus physalis 250 grams, Fructus Gardeniae 200 grams, Flos Lonicerae 300 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 100 grams, Fructus Evodiae 100 grams, Indigo Naturalis 80 grams, Radix Scutellariae 150 grams and Lasiosphaera Seu Calvatia 150 grams, pulverize, cross 100 mesh sieves, then add sucrose 250 grams, mixing is packed in 100 bags and get final product.
Experimental example
Diagnostic criteria
1, light-duty oral ulcer: the most common, account for 80%, general diameter 2-4mm, round or oval, clear on every side, isolated being dispersed in, number is few, each 1～5 is not waited, be apt to occur in keratinization degree relatively poor zone, as lip cheek mucosa, the gum palatine that the keratinization degree is high is less, during outbreak, ulcer has " recessed, red, yellow, feature bitterly ", it is the ulcer concavity, substrate is not hard, periphery is with the approximately congested blush band of 1mm, the surface is covered with light yellow pseudomembrane, the causalgia sense is obvious, infecting serious time companion's submandibular lymph nodes swells and ache, heating, general lasting 1-2 week, intermission is different in size, because the thorn Severe Pain affects language, feed, mood, thereby quality of life is had a negative impact, 2, heavy oral ulcer: during outbreak, ulcer is large and dark, and " like the crater " diameter 10-30mm reaches tela submucosa deeply until the flesh layer, the red and swollen protuberance of periphery, the substrate of laying one's hand on is harder, but neat in edge is clear, normal single generation, stage of attack, can reach more than the moon the even several months, and pain is heavier, more can stay cicatrix after, rare 3, herpes sample oral ulcer: ulcer is little and many, and diameter 2mm can reach more than dozens of, but the symptoms such as companioned with headache, low grade fever, general malaise, regional nodes's enlargement are rare.
Close patient's 50 examples of the standard of stating of selector, male 25 examples wherein, female's 25 examples; 25～52 years old age, average 34 years old.
Treat with the medicine that makes in embodiment 1, wherein one day 2 times, each one bag, treating 3 days is a course for the treatment of.
Criterion of therapeutical effect: pain disappears, the oral ulcer surface healing.
Through the observation of a course for the treatment of, find that the equal pain of all patients disappears, the oral ulcer surface healing, and do not observe obvious untoward reaction during whole treatment.
Claims (2)
1. medicament for the treatment of oral ulcer, it is characterized in that, it is to be made by weight by following bulk drugs: Herba Asari 10-20 part, Calyx seu Fructus physalis 20-30 part, Fructus Gardeniae 10-30 part, Flos Lonicerae 20-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Fructus Evodiae 5-15 part, Indigo Naturalis 5-10 part, Radix Scutellariae 10-20 part and Lasiosphaera Seu Calvatia 10-20 part.
2. the medicament for the treatment of oral ulcer according to claim 1, it is characterized in that, it is to be made by weight by following bulk drugs: 15 parts of 15 parts of Herba Asaris, 25 parts of Calyx seu Fructus physaliss, 20 parts of Fructus Gardeniaes, 30 parts of Flos Loniceraes, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts of Fructus Evodiaes, 8 parts of Indigo Naturaliss, 15 parts of Radix Scutellariae and Lasiosphaera Seu Calvatia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210091494 CN102600365B (en) | 2012-03-31 | 2012-03-31 | Drug for treatment of oral ulcers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210091494 CN102600365B (en) | 2012-03-31 | 2012-03-31 | Drug for treatment of oral ulcers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102600365A CN102600365A (en) | 2012-07-25 |
| CN102600365B true CN102600365B (en) | 2013-06-05 |
Family
ID=46518384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210091494 Expired - Fee Related CN102600365B (en) | 2012-03-31 | 2012-03-31 | Drug for treatment of oral ulcers |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102600365B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623385B (en) * | 2013-12-17 | 2016-03-02 | 王少华 | A kind of Chinese medicine for the treatment of oral ulcer |
| CN105232821A (en) * | 2015-11-19 | 2016-01-13 | 赵岱 | Gum base chewable tablet for treating oral inflammation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101121013A (en) * | 2006-08-07 | 2008-02-13 | 郭占友 | Medicine for treating intractable oral cavity ulcer, Baiser's disease and sjogren syndrome and manufacturing method |
| CN101422579B (en) * | 2008-12-09 | 2011-06-15 | 郭璟璟 | Traditional Chinese medicine preparation for treating oral ulcer |
-
2012
- 2012-03-31 CN CN 201210091494 patent/CN102600365B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102600365A (en) | 2012-07-25 |
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Owner name: TIANJIANG PHARMACEUTICAL INDUSTRY CO., LTD., JIANG Free format text: FORMER OWNER: KONG DEHONG Effective date: 20130731 |
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Free format text: CORRECT: ADDRESS; FROM: 272000 JINING, SHANDONG PROVINCE TO: 214400 WUXI, JIANGSU PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20130731 Address after: 214400 Jiangyin Economic Development Zone, Jiangsu, Qin Shan Road, No. 8 Patentee after: Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin Address before: 272000 Jining Maternal and Child Health-Care Hospital, 12 supply and marketing road, Shandong, Jining Patentee before: Kong Dehong |
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Effective date of registration: 20170503 Address after: 226500, No. 999, Wanshou South Road, Rugao City, Jiangsu province (room 3A08-26, building 8, hi tech Zone, Nantong) Patentee after: Jiangsu hundred sword Pharmaceutical Technology Co., Ltd. Address before: 214400 Jiangyin Economic Development Zone, Jiangsu, Qin Shan Road, No. 8 Patentee before: Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130605 Termination date: 20190331 |
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| CF01 | Termination of patent right due to non-payment of annual fee |