Medical depilation spray and uses thereof
Technical field:
The present invention relates to medical depilation spray, belong to medicine, medical instruments field.
Background technology:
Preserved skin is exactly that skin to operative region carries out that chaeta is removed, cleaning, sterilization, carries out and reduce postoperative infection smoothly to guarantee operation.(understand contamination of incision, cause postoperative infection because of a large amount of antibacterials in skin, the hair, hair is not removed also can cause otch internal memory foreign body, cause infection of incisional wound, disunion).The preserved skin method can be divided into conventional traditional preserved skin and unconventional traditional preserved skin, and at present, what China adopted is conventional traditional razor preserved skin method, and its shortcoming is a lot, but because of no preserved skin substitute technology and product, so use till today always.
The shortcoming of conventional traditional preserved skin method:
1, the razor preserved skin can cause the skin histology damage; Skin histology visible trickle wound, hyperemia, ooze out, redness, patient's pain is felt bad, but also can cause the infection of preserved skin position and operative incision; The infection rate of conventional traditional preserved skin is 5.6%, has increased the risk of operation greatly.
2, razor preserved skin complicated operation, time-consuming, take a lot of work, require great effort, particularly the skinfold place has destroyed skin barrier, skin injury, the wound infection rate is high; Department of obstetrics and gynecology, urology department, oxter preserved skin are operated difficult.
" Guideline For Prevention of Surgical Wound Infections " (prevention of surgical wound infection guide) and U.S. peri-operation period registered nurse association (AORN) research report according to the Center for Disease Control CDC; Using the infection rate of the SSI of razor preserved skin is 5.6%; And use the SSI infection rate of depilatory preserved skin to be merely 0.6%; So; Dispoable medical depilation spray preserved skin can reduce the infection rate of operative site greatly, also is unique method and the approach that reduces NIR.
Summary of the invention:
One aspect of the present invention relates to a kind of medical depilation spray, it is characterized in that containing following components by weight ratio:
1. medical depilation spray is characterized in that containing following components by weight ratio: (%) prescription: (%)
A phase (oil phase) B phase (water)
High viscosity white oil 2.0-5.0 carbamide 5.0-10.0
Silicone oil 1.0-4.0 sodium pyrosulfite 0.2-0.4
Emulsifying agent 4.0-8.0 60% potassium hydroxide solution 3.0-7.0
16-18 alcohol 4.0-8.0 carbomer Carbopol 934 0.1-0.3
Stearic acid 1.0-3.0 glycerol 3.0-7.0
Essence 0-0.4 propylene glycol 3.0-7.0
Methyl p-hydroxybenzoate 0.1-0.3 deionized water adds to 100
Ethyl hydroxybenzoate 0.5-1.0
C phase (chemical agent phase) D phase (biological agent phase)
Three hydration calcium mercaptoacetate 6.0-15.0 triclosan or quaternary ammonium salt 0.1-3
Calcium hydroxide 0.8-1.5 neutral red bisabolol 0.2-0.4
E phase (plant extract phase/skin protection phase)
Mentholum 0.1-0.3
Vitamin E 0.5-1.5
Aloe extraction solution 3.0-7.0
F phase (propellant)
Normal butane, iso-butane and/or n-propane 7-10 or Compressed Gas (nitrogen) 10-30 or dimethyl ether 20-25 or fluoric ether 7-15
In a preferred implementation of the present invention, described emulsifying agent is A25.
In a preferred implementation of the present invention, described depilatory agent is three hydration calcium mercaptoacetates.
In a preferred implementation of the present invention, described propellant is normal butane, iso-butane and/or n-propane 7-10 or Compressed Gas (nitrogen) 10-30 or dimethyl ether 20-25 or fluoric ether 7-15.
In a preferred implementation of the present invention, antibacterial is triclosan and quaternary ammonium salt derivative, complex (polyquaternary ammonium salt, organosilicon quaternary ammonium salt, bi-quaternary ammonium salt polysiloxanes 0.1% one 3%).
In a preferred implementation of the present invention, anti-sensitizer is neutral red bisabolol 0.2%-0.4%.
In a preferred implementation of the present invention, described medical depilation spray is characterized in that containing following components by weight ratio: (%)
A phase (oil phase) B phase (water)
High viscosity white oil 2.0-5.0 carbamide 5.0-10.0
Silicone oil 1.0-4.0 sodium pyrosulfite 0.2-0.4
Emulsifying agent 4.0-8.0 60% potassium hydroxide solution 3.0-7.0
16-18 alcohol 4.0-8.0 carbomer Carbopol 934 0.1-0.3
Stearic acid 1.0-3.0 glycerol 3.0-7.0
Essence 0-0.4 propylene glycol 3.0-7.0
Methyl p-hydroxybenzoate 0.1-0.3 deionized water adds to 100
Ethyl hydroxybenzoate 0.5-1.0
C phase (chemical agent phase) D phase (biological agent phase)
Three hydration calcium mercaptoacetate 6.0-15.0 triclosan or quaternary ammonium salt 0.1-3
Calcium hydroxide 0.8-1.5 neutral red bisabolol 0.2-0.4
E phase (plant extract phase/skin protection phase)
Mentholum 0.1-0.3
Vitamin E 0.5-1.5
Aloe extraction solution 3.0-7.0
F phase (propellant)
Normal butane, iso-butane and/or n-propane 7-10 or Compressed Gas (nitrogen) 10-30 or dimethyl ether 20-25 or fluoric ether 7-15
The method for preparing of depilation spray of the present invention, comprise the steps: A phase (oil phase) and B mutually (water) be heated to respectively more than 80 ℃, then B phase (water) is slowly added in the A phase (oil phase), stir, homogenizing; Add C phase (chemicals phase), D phase (medicine phase), E phase (plant extract phase/skin protection phase) successively; Quantitative filling is to aluminium pot, and evacuation charges into F phase (propellant), sealing.
The present invention also relates to a kind of disposable depilation spray suit on the other hand, and it comprises the above-mentioned medical depilation spray of 25ml-100ml, disposable glove, a pasteurization towelette.
The invention still further relates to the application of above-mentioned medical depilation spray in operation preserved skin (depilation, antibacterial).
The present invention can replace existing traditional preserved skin technology and product; It can be fast, effectively, safety, quickly the patient is carried out unconventional traditional preserved skin; Sterilization, preserved skin be success once, greatly reduces the infection rate of preserved skin position and operative incision, has also reduced the risk of operation simultaneously.
The specific embodiment:
Prescription: (%)
A phase (oil phase) B phase (water)
High viscosity white oil 2.0-5.0 carbamide 5.0-10.0
Silicone oil 1.0-4.0 sodium pyrosulfite 0.2-0.4
Emulsifying agent 4.0-8.0 60% potassium hydroxide solution 3.0-7.0
16-18 alcohol 4.0-8.0 carbomer Carbopol 934 0.1-0.3
Stearic acid 1.0-3.0 glycerol 3.0-7.0
Essence 0-0.4 propylene glycol 3.0-7.0
Methyl p-hydroxybenzoate 0.1-0.3 deionized water adds to 100
Ethyl hydroxybenzoate 0.5-1.0
C phase (chemical agent phase) D phase (biological agent phase)
Three hydration calcium mercaptoacetate 6.0-15.0 triclosan or quaternary ammonium salt 0.1-3
Calcium hydroxide 0.8-1.5 neutral red bisabolol 0.2-0.4
E phase (plant extract phase/skin protection phase)
Mentholum 0.1-0.3
Vitamin E 0.5-1.5
Aloe extraction solution 3.0-7.0
F phase (propellant)
Normal butane, iso-butane and/or n-propane 7-10 or Compressed Gas (nitrogen) 10-30 or dimethyl ether 20-25 or fluoric ether 7-15
Compound method: 1, A phase (oil phase) and B mutually (water) respectively be heated to 85 ℃, then B phase (water) is slowly added in the A phase (oil phase), stir, homogenizing;
2, add C phase (chemicals phase), D phase (medicine phase), E phase (plant extract phase/skin protection phase) successively;
3, quantitative filling is to aluminium pot, and evacuation charges into F phase (gas phase), sealing.
The unit of
each composition is G, can be KG also, is the content of percentage ratio.Wherein A-F is mutually The order and the purpose classification that add successively
Research group use Dispoable medical depilation spray preserved skin, routine shave mao preserved skin respectively (every group of 50 rats) 100 rats have been carried out the experiment of animal preserved skin pain stimulation, preserved skin depilation experiment, preserved skin depilation hair growth experiment after ten days; Preserved skin depilation position is the back; Dispoable medical depilation spray using dosage is 8g, preserved skin area 5cm
2, be 8 minutes action time, experimentation is found:
Research group use Dispoable medical depilation spray preserved skin, routine shave mao preserved skin respectively (every group of 50 rats) 100 rats have been carried out the experiment of animal preserved skin pain stimulation, preserved skin depilation experiment, preserved skin depilation hair growth experiment after ten days; Preserved skin depilation position is the back; Dispoable medical depilation spray using dosage is 8g, preserved skin area 5cm
2, be 8 minutes action time, experimentation is found:
Adopt medical depilation spray of the present invention, the preserved skin position does not have pain, and the preserved skin position is thoroughly clean, does not stay the dead angle, does not seal hair follicle, only rupture hair, depilation back has no adverse effects to the hair follicle root of hair, and the depilation group grows new hair again after ten days, and physiological function is normal.
Should be understood that; The above-mentioned specific embodiment only is the exemplary explanation, rather than limitation of the present invention, concerning those of ordinary skills; Can improve or conversion according to above-mentioned explanation, and all these improvement and conversion all should belong to the protection domain of accompanying claims of the present invention.