CN114767563A - Mild and mild quick-acting depilatory composition and application thereof - Google Patents

Mild and mild quick-acting depilatory composition and application thereof Download PDF

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Publication number
CN114767563A
CN114767563A CN202210499045.2A CN202210499045A CN114767563A CN 114767563 A CN114767563 A CN 114767563A CN 202210499045 A CN202210499045 A CN 202210499045A CN 114767563 A CN114767563 A CN 114767563A
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China
Prior art keywords
depilatory
mild
bisabolol
composition
alpha
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CN202210499045.2A
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Chinese (zh)
Inventor
黄萍
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Guangzhou Ruixin Biotechnology Co ltd
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Guangzhou Ruixin Biotechnology Co ltd
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Priority to CN202210499045.2A priority Critical patent/CN114767563A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q9/00Preparations for removing hair or for aiding hair removal
    • A61Q9/04Depilatories

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The invention provides a mild, comfortable and quick-depilatory skin care composition. The composition uses calcium thioglycolate as a lower-stimulating basic reducing agent to cleave disulfide bonds of cystine linkages between adjacent polypeptide chains of hair keratin, thereby removing body hair; and preventing the damage of skin and soothing the damaged skin by adding a proper amount of alpha-bisabolol. The invention also provides a preparation method of the depilatory composition, which has simple operation steps and can realize industrial scale production.

Description

Mild and mild quick-acting depilatory composition and application thereof
Technical Field
The invention belongs to the technical field of daily chemicals, and particularly relates to a mild and mild rapid depilatory composition and application thereof.
Background
The depilatory cream utilizes chemical substances in the depilatory cream to dissolve the hair structure so as to achieve the aim of depilation. The chemical substances have certain irritation, and are suitable for people who are afraid of pain but have less allergy to skin. The existing depilatory product cannot solve the problem that the specific skin of Asians is easy to be sensitive, and achieves the effects of mild and slow depilation as well as quick depilation. Therefore, there is an urgent need to develop skin care products that have both mild, comfortable and quick depilation.
Disclosure of Invention
It is an object of the present invention to provide a depilatory composition and product which provides both mild, soothing and rapid depilation.
The technical scheme adopted by the invention is as follows:
in a first aspect of the present invention, there is provided an epilatory composition comprising, in mass percent: 3.0-10.0% of calcium thioglycolate, 3.0-5.0% of urea, 3.0-5.0% of cetostearyl alcohol, 1.0-2.0% of sodium hydroxide and 0.2-2.0% of alpha-bisabolol.
The epilatory composition according to the first aspect of the invention preferably comprises the following components in mass percent: 7.0-10.0% of calcium thioglycolate, 3.0-5.0% of urea, 3.0-5.0% of cetostearyl alcohol, 1.0-2.0% of sodium hydroxide and 0.8-2.0% of alpha-bisabolol.
More preferably, the epilatory composition comprises the following ingredients in mass percent: 7.0-10.0% of calcium thioglycolate, 4.0% of urea, 4.0% of cetearyl alcohol, 1.5% of sodium hydroxide and 0.8-1.0% of alpha-bisabolol.
In a second aspect of the invention, there is provided the use of an epilatory composition according to the first aspect of the invention in the manufacture of an epilatory product.
The depilatory product is in any form conventionally used for topical application, particularly as an aqueous, aqueous-alcoholic or oily solution, oil-in-water or water-in-oil or multiple emulsion, hydrogel or oleogel, liquid, paste or solid anhydrous product. These depilatory preparations are prepared according to conventional methods.
The depilatory product may be fluid or have the appearance of a white or coloured cream, ointment, lotion, mousse.
According to the use of the second aspect of the invention, further, the epilation product comprises: depilatory cream, depilatory gel, depilatory wax paper, depilatory spray, depilatory emulsion, depilatory essence.
In a third aspect of the present invention, there is provided a depilatory formulation, consisting essentially of a depilatory composition according to the first aspect of the present invention.
According to the depilatory preparation of the third aspect of the present invention, further, the depilatory preparation further comprises pharmaceutically acceptable excipients.
The adjuvants may include hydrophilic or lipophilic gelling agents, hydrophilic or friendly active agents, preservatives, antioxidants, solvents, fragrances, fillers, pigments, chelating agents, deodorants.
The amount of the auxiliary materials is the amount commonly used in the field, for example, the auxiliary materials account for 0.01-20% of the total weight of the depilatory preparation, and the auxiliary materials select a water phase or an oil phase as a solvent according to the properties of the auxiliary materials.
Further, as the emulsifier and co-emulsifier which can be applied to the present invention, the auxiliary may include, for example, fatty acid esters of polyethylene glycol, steareth and the like.
Further, as the hydrophilic gel that can be applied to the present invention, the supplementary materials may include carbomer, acrylate copolymers, polysaccharides such as hydroxypropylcellulose, natural gums and clays.
In a fourth aspect of the invention, there is provided a process for the preparation of a depilatory formulation according to the third aspect of the invention, comprising the steps of:
s1, weighing the components in proportion, adding the components into water, and heating and stirring the mixture into uniform liquid;
s2, mixing the uniform liquid obtained in the step S1 with pharmaceutically acceptable auxiliary materials to obtain the depilatory preparation.
According to the preparation method of the fourth aspect of the invention, preferably, the temperature of the heating and stirring is 80-85 ℃.
According to the preparation method of the fourth aspect of the present invention, preferably, the heating and stirring is performed at 30 to 60rpm for 30 to 60 min.
The invention has the beneficial effects that:
the invention provides a mild, comfortable and quick-depilatory skin care composition. The composition can swell hair and cleave disulfide bonds of cystine links between adjacent polypeptide chains of hair keratin under the condition of a higher pH value (12.0-12.7) by using calcium thioglycolate as a less-irritant alkaline reducing agent. Finally, the keratin is destroyed (degraded) to form a jelly-like block, and then the residue can be washed or removed by a towel or the like, so as to achieve the effect of removing the body hair; however, the normal skin surface of a human body is slightly acidic, the pH value of the skin is 5.5-7.0, and when the skin contacts with an alkaline reducing agent with a higher pH value, the skin is damaged, the chemical barrier function is lost, and contact dermatitis is caused. So the damage of the skin and the soothing of the damaged skin are prevented by adding a proper amount of alpha-bisabolol.
The invention also provides a preparation method of the depilatory composition, which has simple operation steps and can realize industrial scale production.
Detailed Description
The present invention will be described in further detail with reference to specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention.
Examples
An epilatory composition comprises the following components in percentage by mass: 3.0-10.0% of calcium thioglycolate, 3.0-5.0% of urea, 3.0-5.0% of cetearyl alcohol, 1.0-2.0% of sodium hydroxide, 0.2-2.0% of alpha-bisabolol and the balance of water.
In the range of the mixture ratio, 25 samples (see table 1 below) were prepared, wherein per 100 parts by weight, 4 parts of cetearyl alcohol, 4 parts of urea, 1.5 parts of sodium hydroxide, 5 concentrations of 1 part, 3 parts, 5 parts, 7 parts and 10 parts of calcium thioglycolate were set, 5 concentrations of 0.1 part, 0.2 part, 0.4 part, 0.8 part and 1.0 part of alpha-bisabolol were set, and the balance was water.
The preparation method of the depilatory composition comprises the following steps: heating calcium thioglycolate, urea, cetearyl alcohol, calcium hydroxide, alpha-bisabolol and a solvent to 80-85 ℃ in proportion, stirring at 30-60 rpm for 30-60 min to obtain a uniform liquid, and adjusting the pH value to 12.5.
50 dry skin sensitive volunteers including the staff of the unit are recruited, 8 parts of each sample are prepared, 4 samples are randomly taken by the volunteers on the arms at the same time and are smeared on the skin, and after the retention time is 7 minutes, the depilation effect and the irritation are detected, and the results are shown in the following table 1.
TABLE 125 examination of the depilatory Effect and irritation of the samples of the depilatory composition
Figure BDA0003634512190000031
Figure BDA0003634512190000041
As can be seen from the results in table 1, the composition containing calcium thioglycolate and α -bisabolol mildly and slowly removes human hair, and calcium thioglycolate does not achieve effective depilatory effect in a shorter time at a lower concentration; with the increase of calcium thioglycolate, the depilatory effect is enhanced, but the skin irritation is enhanced. After the alpha-bisabolol is added, the irritation caused by calcium thioglycolate is obviously relieved, but the irritation cannot be completely relieved by increasing the amount of the bisabolol at higher concentration of the calcium thioglycolate.
Wherein, sample 9 can achieve better depilation effect in a specified time, and the addition amount of the alpha-bisabolol is lower, so that the cost can be effectively saved. Achieving better economic value.
The depilatory composition can be used for preparing depilatory preparations in various forms, wherein the auxiliary materials are used in the amount commonly used in the field, for example, 0.01-20% of the total weight of the depilatory preparation, and the auxiliary materials select a water phase or an oil phase as a solvent according to the properties of the auxiliary materials.
In addition, as an emulsifier and a co-emulsifier which can be applied to the composition, the auxiliary may include fatty acid esters of polyethylene glycol, steareth and the like.
As hydrophilic gels that can be applied to the composition, the adjuvants can include carbomers, acrylate copolymers, polysaccharides such as hydroxypropyl cellulose, natural gums, and clays.
Depilatory formulations may be prepared in any form commonly used for topical application, in particular aqueous, aqueous-alcoholic or oily solutions, oil-in-water or water-in-oil or multiple emulsions, hydrogels or oleogels, liquid, paste-like or solid anhydrous products, and may be prepared as conventional depilatory products, including: depilatory cream, depilatory gel, depilatory wax paper, depilatory spray, depilatory emulsion, depilatory essence, etc.
These depilatory formulations are prepared essentially by conventional methods, and generally comprise the steps of:
s1, weighing the components in proportion, adding the components into water, and heating and stirring the mixture to form uniform liquid;
s2, mixing the uniform liquid obtained in the step S1 with pharmaceutically acceptable auxiliary materials to obtain the depilatory preparation.
Although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention.

Claims (10)

1. An epilatory composition comprises the following components in percentage by mass: 3.0-10.0% of calcium thioglycolate, 3.0-5.0% of urea, 3.0-5.0% of cetearyl alcohol, 1.0-2.0% of sodium hydroxide and 0.2-2.0% of alpha-bisabolol.
2. An epilatory composition according to claim 1, comprising the following components in mass percent: 7.0-10.0% of calcium thioglycolate, 3.0-5.0% of urea, 3.0-5.0% of cetostearyl alcohol, 1.0-2.0% of sodium hydroxide and 0.8-2.0% of alpha-bisabolol.
3. An epilatory composition according to claim 1, comprising the following components in mass percent: 7.0-10.0% of calcium thioglycolate, 4.0% of urea, 4.0% of cetostearyl alcohol, 1.5% of sodium hydroxide and 0.8-1.0% of alpha-bisabolol.
4. Use of a depilatory composition according to any of claims 1 to 3 in the manufacture of a depilatory product.
5. Use according to claim 4, wherein the depilatory product comprises: depilatory cream, depilatory gel, depilatory wax paper, depilatory spray, depilatory emulsion, depilatory essence.
6. A depilatory formulation consisting essentially of the depilatory composition of any of claims 1 to 3.
7. The depilatory formulation of claim 6, further comprising a pharmaceutically acceptable excipient.
8. A process for the preparation of a depilatory formulation as claimed in claim 7, comprising the steps of:
s1, weighing the components in proportion, adding the components into water, and heating and stirring the mixture to form uniform liquid;
s2, mixing the uniform liquid obtained in the step S1 with pharmaceutically acceptable auxiliary materials to obtain the depilatory preparation.
9. The method according to claim 8, wherein the temperature of the heating and stirring is 80 to 85 ℃.
10. The method according to claim 8, wherein the heating and stirring is performed at 30 to 60rpm for 30 to 60 min.
CN202210499045.2A 2022-05-09 2022-05-09 Mild and mild quick-acting depilatory composition and application thereof Pending CN114767563A (en)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030180242A1 (en) * 2001-11-01 2003-09-25 The Procter & Gamble Company Personal care compositions containing a water-disintegratable polymeric foam
US20030183658A1 (en) * 2002-03-29 2003-10-02 Sartin Cary Michael Hair removal cream dispenser
CN102600049A (en) * 2012-03-22 2012-07-25 徐克之 Medical unhairing spray and purpose of medical unhairing spray
US20150202140A1 (en) * 2012-08-02 2015-07-23 Reckitt & Colman (Overseas) Limited Depilatory Formulations And Methods Of Using Same
CN109745247A (en) * 2019-02-22 2019-05-14 南昌欧泉琳化妆品有限公司 A kind of moisturizing depilation paste formulation and preparation method thereof
CN112006958A (en) * 2020-09-10 2020-12-01 广州市逸轩精细化工有限公司 Depilatory cream and preparation method thereof
CN112156039A (en) * 2020-11-11 2021-01-01 广州德芙化妆品有限公司 Depilatory preparation and preparation method thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030180242A1 (en) * 2001-11-01 2003-09-25 The Procter & Gamble Company Personal care compositions containing a water-disintegratable polymeric foam
US20030183658A1 (en) * 2002-03-29 2003-10-02 Sartin Cary Michael Hair removal cream dispenser
CN102600049A (en) * 2012-03-22 2012-07-25 徐克之 Medical unhairing spray and purpose of medical unhairing spray
US20150202140A1 (en) * 2012-08-02 2015-07-23 Reckitt & Colman (Overseas) Limited Depilatory Formulations And Methods Of Using Same
CN109745247A (en) * 2019-02-22 2019-05-14 南昌欧泉琳化妆品有限公司 A kind of moisturizing depilation paste formulation and preparation method thereof
CN112006958A (en) * 2020-09-10 2020-12-01 广州市逸轩精细化工有限公司 Depilatory cream and preparation method thereof
CN112156039A (en) * 2020-11-11 2021-01-01 广州德芙化妆品有限公司 Depilatory preparation and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
彭冠杰等: "《美白化妆品科学与技术》", vol. 1, 中国轻工业出版社, pages: 193 *

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Application publication date: 20220722