CN102600048B - Preparation method of medical antibiosis washing-protection liquid - Google Patents
Preparation method of medical antibiosis washing-protection liquid Download PDFInfo
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- CN102600048B CN102600048B CN 201210070687 CN201210070687A CN102600048B CN 102600048 B CN102600048 B CN 102600048B CN 201210070687 CN201210070687 CN 201210070687 CN 201210070687 A CN201210070687 A CN 201210070687A CN 102600048 B CN102600048 B CN 102600048B
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Abstract
The invention discloses a preparation method of a medical antibiosis washing-protection liquid. The preparation method is characterized in that the preparation method comprises the following steps of: (1) preparing a compound essential oil by using Lindera erythrocarpa Makinl, folium eucalypti, Rhododendron dauricum and elecampane through a supercutical fluid CO2 extraction method; (2) adding water which is four-six times of medicinal materials in papaya, Stephania tetrandra S, rhizoma kaempferiae, and viola hamiltoniana to boil and decoct two times, one-two hours for one time, filtering, combining filter liquor decocted in two times, and concentrating the filter liquor; (3) slowly stirring the filter liquor and adding propylene glycol, refrigerating and standing so as to obtain the filter liquor through the filtration; and (4) using a centrifugal machine to centrifuge filter liquor obtained through the step 3, taking a supernatant liquor, adding the obtained compound essential oil in the step 1, uniformly mixing, carrying out sterilization on circulated steam for 30 minutes at 100 DEG C, and packaging. The clinical experiment proves that the products prepared by the preparation method provided by the invention can carry out rapid disinfection on the hand, and can keep a longer bacteriostasis state.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of preparation method of medical antibacterial cleansing liquid.
Background technology
Usually carry pathogenic bacteria on the patient skin, pathogen such as staphylococcus aureus or enterococcus, in addition also like this during with it without wound or skin injury at them.Nurse, doctor and other the staff of medical institutions may cause both hands to pollute because surveying the work such as patient's blood pressure or pulse, contact patient body, sick clothes or sheet, then pollute other sufferers by curative activity.So medical personnel can often use common soap and washing hands, this cleaning mode has following defective: although 1. common soap can be removed skin contamination thing, dirt and oils and fats, but bad for hand pathogenic microorganism removal effect; 2. the basic lotion chafe causes natural moisture and oil content to run off, damage medical personnel hand skin; 3. effective antibacterial time is short.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, and a kind of medical antibacterial cleansing liquid is provided, can be effectively antibiotic, and alleviate alkaline rinse to the stimulation of skin and can reach the long antibacterial time.
The technical scheme that the present invention solves its technical problem is: a kind of medical antibacterial cleansing liquid is characterized in that raw material comprises the Chinese medicine of following weight proportion: 8 parts of Fructus Caricae, 15 parts of Radix Cissi Kerrii, fragrant 15 parts of Zhan's sugar, 8 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 15 parts of Rhizoma Kaempferiae, 10 parts of Viola arcuata, 12 parts of Folium Rhododendri Daurici, 6 parts of Radix Inulaes.
In the prioritization scheme, raw material comprises that also weight proportion is 3 parts propylene glycol.
Above-mentioned a kind of medical antibacterial cleansing liquid preparation method is comprised of following steps:
(1) with Zhan's sugar perfume, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Rhododendri Daurici, Radix Inulae process supercritical fluid CO
2Extraction gets mixed essential oil;
(2) the water boiling that Fructus Caricae, Radix Cissi Kerrii, Rhizoma Kaempferiae, Viola arcuata is added 4～6 times of medical material weight decocts 2 times, and each 1～2 hour, filter, merge filtrate twice, filtrate is concentrated;
(3) filtrate is slowly stirred lower adding propylene glycol, and cold preservation is left standstill and filtered to get filtrate;
(4) filtrate of step 3 gained is centrifugal with centrifuge, gets supernatant, adds the mixed essential oil of step 1 gained, mix homogeneously, 100 ℃ of circulation steam sterilizations 30 minutes, packing.
Between step (3) and (4), the active carbon that can also add step 3 gained filtrate weight ratio 0.5% is heated with stirring to and boils, and filters carbon removal to clear and bright.
Wherein said:
Fructus Caricae is the fruit of Caricaceae plant Fructus Caricae.Sweet in the mouth; Property is put down.But merit eliminating dampness and dredging channels; The detoxifcation anthelmintic.
Radix Cissi Kerrii is the tuber of vitaceae Cissus repens.Bitter; Little suffering; Cool in nature.GUIXIN; Kidney channel.But merit promoting blood circulation to remove obstruction in the collateral; Dissipating phlegm and resolving masses; Removing toxicity for eliminating carbuncles.
Zhan's sugar is fragrant, is bark or the leaf of canella Cortex Linderae Fragrantis.Hot; Tepor.But merit expelling wind and removing dampness; The detoxifcation parasite killing.
Folium eucalypti globueli (Eucalyptus globulus Labill.) is the leaf of myrtle Eucalyptus globulus Labill.Toil, cold.But merit dispelling wind to relieve the exterior syndrome; Heat-clearing and toxic substances removing; Phlegm-eliminiating and qi-regulating; Killing parasites for relieving itching.
Rhizoma Kaempferiae is the dry rhizome of zingiberaceous plant Rhizoma Kaempferiae.Suffering, temperature.Return the stomach warp.In the feasible temperature of merit, help digestion pain relieving.
Viola arcuata is the herb of Violaceae plant common violet.Cool in nature, mildly bitter flavor.Heat-clearing and toxic substances removing; Cough-relieving; Hemostasis.
Folium Rhododendri Daurici is the leaf of ericad Folium Cuculus polioephalus.Hot; Bitter; Cold in nature.Return lung meridian.But merit cough-relieving; Eliminate the phlegm.
Radix Inulae is the dry root of feverfew Radix Inulae or Radix Inulae.Hot, bitter, temperature.Return liver, spleen channel.But the merit invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, pain relieving is antiabortive.
Propylene glycol as lubricant and solvent, helps above-mentioned Chinese medicine water extraction composition dissolving.
Modern pharmacological research shows: Fructus Caricae has the antibiotic and parasiticide effect of spectrum, and carpaine slightly has inhibitory action to tubercule bacillus (H37RV) in vitro, and the effect of killing ameba is arranged, and its hydrochlorate subcutaneous injection of clinical practice is also effective; Juice and papain are used for driving away cestode, ascarid and whipworm etc. effectively; Isolated benzyl isothiocyanate drives the ascarid effect from seed.Rhizoma Kaempferiae is all had in various degree inhibitory action to permitting 10 kinds of common pathomycetes such as Lan Shi trichophyton and Mongolian mutation thereof, homocentricity trichophyton, trichophyton in vitro.The Radix Cissi Kerrii water decoction has the effect of inhibition and inactivating influenza virus in Embryo Gallus domesticus.The volatile oil that Zhan sugar is fragrant has antifungal (such as the Venezuela Streptothrix etc.) effect.Alantolactone and derivant thereof contained in the Radix Inulae volatile oil have anthelmintic action, and external all have inhibitory action to tubercule bacillus, dysentery bacterium, staphylococcus aureus, bacillus pyocyaneus, Common Pathogenic dermatophytes.Viola arcuata can shorten the blood coagulation time of rabbit, and the growth of staphylococcus aureus is had inhibitory action.Folium Rhododendri Daurici volatile oil has inhibitory action to staphylococcus aureus.Folium eucalypti globueli (Eucalyptus globulus Labill.) volatile oil local topical can make local vascular dilation, and blood circulation accelerates, and relaxes muscle spasm pain, has broad-spectrum antibacterial action.
Good effect of the present invention is:
1, the product fungistatic effect prepared of preparation method of the present invention is obvious, to staphylococcus aureus, and escherichia coli, the common bacterias such as Candida albicans all have bactericidal action.
2, nonirritant, without sensitivity response, skin care effect is obvious, comfortable feel, lubricated after using uses interdependence high, is fit to medical worker's life-time service.
3, the product prepared of preparation method of the present invention carries out antibacterial processing except being applicable to behind medical personnel's hand cleaning, can be used for also that patient skin is antibacterial, the easy infection article are antibacterial.
The technique that preparation method of the present invention adopts active component to extract has respectively been guaranteed effective reservation medical material effective ingredient.And propylene glycol both can have been made solvent to the effective components of Chinese medicinal solubilising, can exist as lubricant again.By activated carbon filtration foreign body, constant product quality.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, comprises the raw material of following weight proportion: 8 parts of Fructus Caricae, 15 parts of Radix Cissi Kerrii, fragrant 15 parts of Zhan's sugar, 8 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 15 parts of Rhizoma Kaempferiae, 10 parts of Viola arcuata, 12 parts of Folium Rhododendri Daurici, 6 parts of Radix Inulaes, 3 parts of propylene glycol.Preparation method is comprised of following steps:
(1) Zhan's sugar perfume, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Rhododendri Daurici, Radix Inulae are got mixed essential oil through supercritical fluid CO2 extraction;
(2) the water boiling that Fructus Caricae, Radix Cissi Kerrii, Rhizoma Kaempferiae, Viola arcuata is added 4～6 times of medical material weight decocts 2 times, and each 1～2 hour, filter, merge filtrate twice, filtrate is concentrated;
(3) filtrate is slowly stirred lower adding propylene glycol, and cold preservation is left standstill and filtered to get filtrate;
(4) filtrate of step 3 gained is centrifugal with centrifuge, gets supernatant, adds the mixed essential oil of step 1 gained, mix homogeneously, 100 ℃ of circulation steam sterilizations 30 minutes, packing.
Embodiment 2, comprise the raw material of following weight proportion: 8 parts of Fructus Caricae, 15 parts of Radix Cissi Kerrii, fragrant 15 parts of Zhan's sugar, 8 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 15 parts of Rhizoma Kaempferiae, 10 parts of Viola arcuata, 12 parts of Folium Rhododendri Daurici, 6 parts of Radix Inulaes, 3 parts of propylene glycol.Preparation method is comprised of following steps:
Preparation method is comprised of following steps:
(1) Zhan's sugar perfume, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Rhododendri Daurici, Radix Inulae are got mixed essential oil through supercritical fluid CO2 extraction;
(2) the water boiling that Fructus Caricae, Radix Cissi Kerrii, Rhizoma Kaempferiae, Viola arcuata is added 4～6 times of medical material weight decocts 2 times, and each 1～2 hour, filter, merge filtrate twice, filtrate is concentrated;
(3) filtrate is slowly stirred lower adding propylene glycol, and cold preservation is left standstill and filtered to get filtrate;
(4) active carbon of adding step 3 gained filtrate weight ratio 0.5% is heated with stirring to and boils, and filters carbon removal to clear and bright.
(5) filtrate of step 4 gained is centrifugal with centrifuge, gets supernatant, adds the mixed essential oil of step 1 gained, mix homogeneously, 100 ℃ of circulation steam sterilizations 30 minutes, packing.
The physical and chemical index of products obtained therefrom meets the Pharmacopoeia of the People's Republic of China about the requirement of wash and maintenance liquid.
Beneficial effect of the present invention is the clinical data sufficient proof, and interrelated data is as follows, contains crude drug amount 4～5g in the every ml liquid of wherein said finished product.
1 object and method
1.1 object: be chosen at random the medical personnel of institute 100 examples, be divided at random 5 groups, get at random 2 groups, use respectively the product of the embodiment of the invention 1 and embodiment 2.Using method: conventional common soap is washed one's hands and is washed with tap water, uses this product q.s in both hands, evenly rubs and wipes in hand, especially between finger tip and the finger, keeps 30 seconds time of contact, natural drying.
1.2 test condition and method: according to Disease Control and Prevention Center (CDC), the method for testing in People's Republic of China's hand disinfection technical specification 2002 that the infection control tissue proposes.Under 37 ℃ of temperature, test organisms is dust Xi Shi escherichia coli, staphylococcus aureus, bacillus pyocyaneus, each test organisms content all not 10
7/ ml, be 1 minute time of contact.
1.3 the requirement by detection: the minimum microorganism (killing rate＞99.9%) of killing 3 logarithms.
2 results
2.1 product Quick disinfection test result: qualified.For dust Xi Shi escherichia coli, staphylococcus aureus, bacillus pyocyaneus, 2 groups of 1 group of embodiment and embodiment kill logarithm value all greater than 8.
2.2 product long-acting bacteriostatic test result: use the hand natural bacteria average kill ratio after 3 minutes, after 3 hours, after 4 hours to see the following form.
Table hand natural bacteria average kill ratio (%)
| After 3 minutes | After 3 hours | After 4 hours | |
| Embodiment 1 | 100％ | 98.88％ | 93.43％ |
| Embodiment 2 | 100％ | 99.47％ | 99.16％ |
2.3 untoward reaction: all testers have no the untoward reaction performance.
3. the product prepared of conclusion preparation method of the present invention can carry out Quick disinfection to hand, and can keep long bacteriostasis.
Claims (2)
1. medical antibacterial cleansing liquid preparation method, described medical antibacterial cleansing liquid is made by following raw material: 8 parts of Fructus Caricae, 15 parts of Radix Cissi Kerrii, fragrant 15 parts of Zhan's sugar, 8 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 15 parts of Rhizoma Kaempferiae, 10 parts of Viola arcuata, 12 parts of Folium Rhododendri Daurici, 6 parts of Radix Inulaes, 3 parts of propylene glycol is characterized in that: preparation method is:
(1) with Zhan's sugar perfume, Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Rhododendri Daurici, Radix Inulae process supercritical fluid CO
2Extraction gets mixed essential oil;
(2) the water boiling that Fructus Caricae, Radix Cissi Kerrii, Rhizoma Kaempferiae, Viola arcuata is added 4～6 times of medical material weight decocts 2 times, and each 1～2 hour, filter, merge filtrate twice, filtrate is concentrated;
(3) filtrate is slowly stirred lower adding propylene glycol, and cold preservation is left standstill and filtered to get filtrate;
(4) filtrate of step (3) gained is centrifugal with centrifuge, gets supernatant, adds the mixed essential oil of step (1) gained, mix homogeneously, 100 ℃ of circulation steam sterilizations 30 minutes, packing.
2. medical antibacterial cleansing liquid preparation method according to claim 1 is characterized in that: between step (3) and (4), the active carbon that adds step (3) gained filtrate weight 0.5% is heated with stirring to and boils, and filters carbon removal to clear and bright.
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| CN 201210070687 CN102600048B (en) | 2012-03-16 | 2012-03-16 | Preparation method of medical antibiosis washing-protection liquid |
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| CN 201210070687 CN102600048B (en) | 2012-03-16 | 2012-03-16 | Preparation method of medical antibiosis washing-protection liquid |
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| CN102600048B true CN102600048B (en) | 2013-04-10 |
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| CN102920885B (en) * | 2012-11-20 | 2014-09-17 | 沙同叶 | Medicine for treating bacterial vaginosis in gestation period |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615989A (en) * | 2004-09-10 | 2005-05-18 | 中国科学院武汉植物园 | Antiseptic and pest killing skin cleaning agent and preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615989A (en) * | 2004-09-10 | 2005-05-18 | 中国科学院武汉植物园 | Antiseptic and pest killing skin cleaning agent and preparing method |
Non-Patent Citations (2)
| Title |
|---|
| 中药抗菌作用研究进展;蔡燕等;《中国医药导报》;20110228;第8卷(第6期);第9页至第10页 * |
| 蔡燕等.中药抗菌作用研究进展.《中国医药导报》.2011,第8卷(第6期), |
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