CN102597780B - K2p钾通道的激活剂作为止痛药的用途 - Google Patents

K2p钾通道的激活剂作为止痛药的用途 Download PDF

Info

Publication number
CN102597780B
CN102597780B CN201080050386.7A CN201080050386A CN102597780B CN 102597780 B CN102597780 B CN 102597780B CN 201080050386 A CN201080050386 A CN 201080050386A CN 102597780 B CN102597780 B CN 102597780B
Authority
CN
China
Prior art keywords
trek
potassium channel
morphine
effect
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080050386.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN102597780A (zh
Inventor
A·爱斯查理尔
J·布瑟罗勒斯
A·阿罗伊
M·拉兹顿斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Clermont Auvergne
Original Assignee
Universite Clermont Auvergne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Clermont Auvergne filed Critical Universite Clermont Auvergne
Publication of CN102597780A publication Critical patent/CN102597780A/zh
Application granted granted Critical
Publication of CN102597780B publication Critical patent/CN102597780B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201080050386.7A 2009-09-21 2010-09-21 K2p钾通道的激活剂作为止痛药的用途 Expired - Fee Related CN102597780B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0956477 2009-09-21
FR0956477A FR2950362B1 (fr) 2009-09-21 2009-09-21 Utilisation d'activateurs de canaux potassiques k2p en tant qu'antalgiques.
PCT/FR2010/051968 WO2011033241A1 (fr) 2009-09-21 2010-09-21 Utilisation d'activateurs de canaux potassiques k2p en tant qu'antalgiques

Publications (2)

Publication Number Publication Date
CN102597780A CN102597780A (zh) 2012-07-18
CN102597780B true CN102597780B (zh) 2014-11-12

Family

ID=42115665

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080050386.7A Expired - Fee Related CN102597780B (zh) 2009-09-21 2010-09-21 K2p钾通道的激活剂作为止痛药的用途

Country Status (9)

Country Link
US (1) US9448242B2 (enExample)
EP (1) EP2480893B1 (enExample)
CN (1) CN102597780B (enExample)
CA (1) CA2774861C (enExample)
DK (1) DK2480893T3 (enExample)
ES (1) ES2517925T3 (enExample)
FR (1) FR2950362B1 (enExample)
IN (1) IN2012DN02433A (enExample)
WO (1) WO2011033241A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10214476B2 (en) 2011-12-30 2019-02-26 Ecole Nationale Superieure De Chimie De Clermont Ferrand Pain relief compounds
WO2024126778A1 (en) * 2022-12-16 2024-06-20 Centre National De La Recherche Scientifique Process for reversibly inhibiting two-pore potassium channels and inducing nociception, with light spatiotemporal resolution

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112403B1 (en) * 1998-09-01 2006-09-26 Centre National De La Recherche Scientifique Method for the identification of anesthetics
CN1898378A (zh) * 2003-12-18 2007-01-17 基尔大学 利用磁性颗粒的干细胞靶向

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1192126A (en) * 1967-10-05 1970-05-20 Centre Nat Rech Scient Indole Derivatives and their production
FR2623498B1 (fr) * 1987-11-24 1990-04-06 Bioprojet Soc Civ Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques
US20030165806A1 (en) * 1997-03-11 2003-09-04 Mark H. Pausch Potassium channels, nucleotide sequences encoding them, and methods of using same
US5919473A (en) * 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
US7955616B2 (en) * 2003-09-23 2011-06-07 Orthocon, Inc. Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
EP2077126A1 (en) * 2008-01-07 2009-07-08 Graftys Analgesic apatitic calcium-phosphate cement

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112403B1 (en) * 1998-09-01 2006-09-26 Centre National De La Recherche Scientifique Method for the identification of anesthetics
CN1898378A (zh) * 2003-12-18 2007-01-17 基尔大学 利用磁性颗粒的干细胞靶向

Also Published As

Publication number Publication date
CA2774861A1 (fr) 2011-03-24
CN102597780A (zh) 2012-07-18
EP2480893A1 (fr) 2012-08-01
DK2480893T3 (da) 2014-09-29
US9448242B2 (en) 2016-09-20
ES2517925T3 (es) 2014-11-04
WO2011033241A1 (fr) 2011-03-24
EP2480893B1 (fr) 2014-08-27
IN2012DN02433A (enExample) 2015-08-21
FR2950362B1 (fr) 2011-10-21
CA2774861C (fr) 2017-08-08
US20120260354A1 (en) 2012-10-11
FR2950362A1 (fr) 2011-03-25

Similar Documents

Publication Publication Date Title
Bilsky et al. Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.
Liu et al. Neural basis of opioid-induced respiratory depression and its rescue
Montandon et al. G-protein-gated inwardly rectifying potassium channels modulate respiratory depression by opioids
Pasternak Molecular biology of opioid analgesia
Bourinet et al. Calcium-permeable ion channels in pain signaling
Knowlton et al. A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia
Tibbs et al. Voltage-gated ion channels in the PNS: novel therapies for neuropathic pain?
Levitt et al. μ opioid receptor activation hyperpolarizes respiratory‐controlling Kölliker–Fuse neurons and suppresses post‐inspiratory drive
Ding et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
Lalley Opioidergic and dopaminergic modulation of respiration
Morgan et al. Sensitivity to the discriminative stimulus and antinociceptive effects of μ opioids: role of strain of rat, stimulus intensity, and intrinsic efficacy at the μ opioid receptor
Zielińska et al. Role of transient receptor potential channels in intestinal inflammation and visceral pain: novel targets in inflammatory bowel diseases
Baldo et al. Opioid toxicity: histamine, hypersensitivity, and MRGPRX2
Levy-Cooperman et al. Abuse potential and pharmacodynamic characteristics of oral and intranasal eluxadoline, a mixed μ-and κ-opioid receptor agonist and δ-opioid receptor antagonist
Molinari et al. [Dmt1] N/OFQ (1–13)‐NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist
Banks et al. Antisecretory actions of a novel vasoactive intestinal polypeptide (VIP) antagonist in human and rat small intestine
Hough et al. Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice
Mogil et al. One or two genetic loci mediate high opiate analgesia in selectively bred mice
Robinson et al. Reduced MC4R signaling alters nociceptive thresholds associated with red hair
Jang et al. Impairment of proprioceptive movement and mechanical nociception in Drosophila melanogaster larvae lacking Ppk30, a Drosophila member of the Degenerin/Epithelial Sodium Channel family
Zhuang et al. Intravenous bolus injection of fentanyl triggers an immediate central and upper airway obstructive apnea via activating vagal sensory afferents
Lattanzi et al. Pharmacological activity of a Bv8 analogue modified in position 24
Garduño-Gutiérrez et al. Different amounts of ejaculatory activity, a natural rewarding behavior, induce differential mu and delta opioid receptor internalization in the rat's ventral tegmental area
Tambeli et al. Inhibition of tonic spinal glutamatergic activity induces antinociception in the rat
Nunn et al. Elevated blood pressure, heart rate and body temperature in mice lacking the XLαs protein of the Gnas locus is due to increased sympathetic tone

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20141112

CF01 Termination of patent right due to non-payment of annual fee