CA2774861C - Utilisation d'activateurs de canaux potassiques k2p en tant qu'antalgiques - Google Patents

Utilisation d'activateurs de canaux potassiques k2p en tant qu'antalgiques Download PDF

Info

Publication number
CA2774861C
CA2774861C CA2774861A CA2774861A CA2774861C CA 2774861 C CA2774861 C CA 2774861C CA 2774861 A CA2774861 A CA 2774861A CA 2774861 A CA2774861 A CA 2774861A CA 2774861 C CA2774861 C CA 2774861C
Authority
CA
Canada
Prior art keywords
effect
trek
compound
constipating
respiratory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2774861A
Other languages
English (en)
French (fr)
Other versions
CA2774861A1 (fr
Inventor
Alain Eschalier
Jerome Busserolles
Abdelkrim Alloui
Michel Lazdunski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Clermont Auvergne
Original Assignee
Universite Clermont Auvergne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Clermont Auvergne filed Critical Universite Clermont Auvergne
Publication of CA2774861A1 publication Critical patent/CA2774861A1/fr
Application granted granted Critical
Publication of CA2774861C publication Critical patent/CA2774861C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2774861A 2009-09-21 2010-09-21 Utilisation d'activateurs de canaux potassiques k2p en tant qu'antalgiques Active CA2774861C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0956477 2009-09-21
FR0956477A FR2950362B1 (fr) 2009-09-21 2009-09-21 Utilisation d'activateurs de canaux potassiques k2p en tant qu'antalgiques.
PCT/FR2010/051968 WO2011033241A1 (fr) 2009-09-21 2010-09-21 Utilisation d'activateurs de canaux potassiques k2p en tant qu'antalgiques

Publications (2)

Publication Number Publication Date
CA2774861A1 CA2774861A1 (fr) 2011-03-24
CA2774861C true CA2774861C (fr) 2017-08-08

Family

ID=42115665

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2774861A Active CA2774861C (fr) 2009-09-21 2010-09-21 Utilisation d'activateurs de canaux potassiques k2p en tant qu'antalgiques

Country Status (9)

Country Link
US (1) US9448242B2 (enExample)
EP (1) EP2480893B1 (enExample)
CN (1) CN102597780B (enExample)
CA (1) CA2774861C (enExample)
DK (1) DK2480893T3 (enExample)
ES (1) ES2517925T3 (enExample)
FR (1) FR2950362B1 (enExample)
IN (1) IN2012DN02433A (enExample)
WO (1) WO2011033241A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10214476B2 (en) 2011-12-30 2019-02-26 Ecole Nationale Superieure De Chimie De Clermont Ferrand Pain relief compounds
WO2024126778A1 (en) * 2022-12-16 2024-06-20 Centre National De La Recherche Scientifique Process for reversibly inhibiting two-pore potassium channels and inducing nociception, with light spatiotemporal resolution

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1192126A (en) * 1967-10-05 1970-05-20 Centre Nat Rech Scient Indole Derivatives and their production
FR2623498B1 (fr) * 1987-11-24 1990-04-06 Bioprojet Soc Civ Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques
US20030165806A1 (en) * 1997-03-11 2003-09-04 Mark H. Pausch Potassium channels, nucleotide sequences encoding them, and methods of using same
US5919473A (en) * 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
US7112403B1 (en) * 1998-09-01 2006-09-26 Centre National De La Recherche Scientifique Method for the identification of anesthetics
US7955616B2 (en) * 2003-09-23 2011-06-07 Orthocon, Inc. Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
GB0329310D0 (en) * 2003-12-18 2004-01-21 Univ Keele Method
EP2077126A1 (en) * 2008-01-07 2009-07-08 Graftys Analgesic apatitic calcium-phosphate cement

Also Published As

Publication number Publication date
CA2774861A1 (fr) 2011-03-24
CN102597780A (zh) 2012-07-18
EP2480893A1 (fr) 2012-08-01
DK2480893T3 (da) 2014-09-29
US9448242B2 (en) 2016-09-20
ES2517925T3 (es) 2014-11-04
WO2011033241A1 (fr) 2011-03-24
EP2480893B1 (fr) 2014-08-27
IN2012DN02433A (enExample) 2015-08-21
FR2950362B1 (fr) 2011-10-21
US20120260354A1 (en) 2012-10-11
FR2950362A1 (fr) 2011-03-25
CN102597780B (zh) 2014-11-12

Similar Documents

Publication Publication Date Title
Blanchard et al. Inhibition of voltage‐gated Na+ currents in sensory neurones by the sea anemone toxin APETx2
Hardie TRP channels and lipids: from Drosophila to mammalian physiology
Etherington et al. Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent
Grilli et al. Somatostatin inhibits glutamate release from mouse cerebrocortical nerve endings through presynaptic sst2 receptors linked to the adenylyl cyclase–protein kinase A pathway
Chaki Group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia
Karaman et al. Lack of effect of ceftriaxone, a GLT-1 transporter activator, on spatial memory in mice
ES2689922T3 (es) Métodos para tratar y/o limitar el desarrollo de diabetes
Tian et al. The TRP channels serving as chemical-to-electrical signal converter
Copeland et al. Potentiation of neuronal activity by tonic GluD1 current in brain slices
EP2480893B1 (fr) Utilisation d'activateurs de canaux potassiques k2p en tant qu'antalgiques
Sinha et al. Fast A‐type currents shape a rapidly adapting form of delayed short latency firing of excitatory superficial dorsal horn neurons that express the neuropeptide Y Y1 receptor
Jin et al. Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons
He et al. Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis
Fazal et al. Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium‐dependent re‐uptake in rat cerebrocortical minislices
Choi et al. Multiple effects of bisphenol A, an endocrine disrupter, on GABAA receptors in acutely dissociated rat CA3 pyramidal neurons
Miyakawa et al. Action of neuropeptide Y on nociceptive transmission in substantia gelatinosa of the adult rat spinal dorsal horn
Lee et al. Ionotropic and metabotropic receptor mediated airway sensory nerve activation
Steinmetz et al. A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands
Tanaka et al. GABAergic modulation of hippocampal glutamatergic neurons: an in vivo microdialysis study
Wright et al. Ethanol-induced suppression of LTP can be attenuated with an angiotensin IV analog
Chin et al. Nociceptin/orphanin FQ modulation of ionic conductances in rat basal forebrain neurons
Vieira et al. GABA modulates day–night variation in melatonin levels in the cerebral ganglia of the damselfly Ischnura graellsii and the grasshopper Oedipoda caerulescens
de Novellis et al. Type I and II metabotropic glutamate receptors modulate periaqueductal grey glycine release: interaction between mGlu2/3 and A1 adenosine receptors
Choi et al. Transient receptor potential (TRP) A1 activated currents in TRPV1 and cholecystokinin-sensitive cranial visceral afferent neurons
Nakamura et al. Cytosolic calcium elevation induced by orexin/hypocretin in granule cell domain cells of the rat cochlear nucleus in vitro

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150824

H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20250321